Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cellsYangxin Li
Laboratory of Heart Failure and Stem Cell, Texas Heart Institute, Houston, TX 77030, USA
Biochem Biophys Res Commun 356:780-4. 2007
..These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies...
MicroRNA-221 regulates high glucose-induced endothelial dysfunctionYangxin Li
Texas Heart Institute and The University of Texas Medical School, Heart Failure and Stem Cell, P O Box 20345, MC 2 255, 6770 Bertner Avenue, Houston, TX 77030, USA
Biochem Biophys Res Commun 381:81-3. 2009
..These findings suggest that manipulation of the miR-221-c-kit pathway may offer a novel strategy for treatment of vascular dysfunction in diabetic patients...
Insulin-like growth factor-1 receptor activation prevents high glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosisYangxin Li
Texas Heart Institute and The University of Texas Medical School, Houston, TX 77030, USA
Biochem Biophys Res Commun 384:259-64. 2009
..These results may have therapeutic implications in preventing/reducing diabetes associated endothelial dysfunction...
Clusterin induces CXCR4 expression and migration of cardiac progenitor cellsYangxin Li
Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
Exp Cell Res 316:3435-42. 2010
..Thus, CST expression may increase CPCs migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner...
A potential role for insulin-like growth factor signaling in induction of pluripotent stem cell formationYangxin Li
Texas Heart Institute, Houston, TX 77030, USA
Growth Horm IGF Res 20:391-8. 2010
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IGF-1 prevents oxidative stress induced-apoptosis in induced pluripotent stem cells which is mediated by microRNA-1Yangxin Li
The Texas Heart Institute and Center for Cardiovascular and Atherosclerosis Research, Department of Internal Medicine, University of Texas Medical School at Houston, TX 77030, USA
Biochem Biophys Res Commun 426:615-9. 2012
..In conclusion, IGF-1 inhibits H(2)O(2)-induced mitochondrial dysfunction, cytochrome-c release and apoptosis. IGF-1's effect is, at least partially, regulated by miR-1 in iPS cells...
Apolipoprotein-J prevention of fetal cardiac myoblast apoptosis induced by ethanolYangxin Li
Texas Heart Institute and The University of Texas Health Science Center, Houston, TX 77030, USA
Biochem Biophys Res Commun 357:157-61. 2007
..Thus, ApoJ serves as a cytoprotective protein that protects cardiac stem cells against EtOH cytotoxicity...