Alternative expression of TCRζ related genes in patients with chronic myeloid leukemiaXianfeng Zha
Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, China
J Hematol Oncol 5:74. 2012
..The characteristics of TCRζ 3'-UTR alternative splicing may be a novel immunological marker for the evaluation of the CML immune status...
Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AMLLi Shi
Institute of Hematology, Jinan University, Guangzhou, 510632, China
Cancer Cell Int 13:37. 2013
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- New insights into antigen specific immunotherapy for chronic myeloid leukemia
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, China
Cancer Cell Int 12:52. 2012
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- The differential expression pattern of the BMI-1, SALL4 and ABCA3 genes in myeloid leukemia
Qi Shen
Institute of Hematology, Jinan University, Guangzhou, 510632, China
Cancer Cell Int 12:42. 2012
..abstract:..
- The role of A20 in the pathogenesis of lymphocytic malignancy
Fan Zhang
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
Cancer Cell Int 12:44. 2012
..The identification of A20 mutations and deletions in lymphocytic malignancy and the predictive significance of these aberrations are also reviewed...
- The role of BCL11B in hematological malignancy
Xin Huang
Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, China
Exp Hematol Oncol 1:22. 2012
..This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies...
- Mutations increased overexpression of Notch1 in T-cell acute lymphoblastic leukemia
Chunlan Lin
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, People s Republic of China
Cancer Cell Int 12:13. 2012
..abstract:..
- Reduced levels of recent thymic emigrants in acute myeloid leukemia patients
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, 510632 Guangzhou, China
Cancer Immunol Immunother 58:1047-55. 2009
..In the present study, in order to further characterize the T cell immunity in acute myeloid leukemia (AML) patients, the level of recent thymic emigrants (RTE) was analyzed...
- Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, China
J Transl Med 8:47. 2010
..Based on our previous finding, to further characterize the immune status, T cell proliferative history was analyzed in CD4+ and CD8+ T cells from chronic myeloid leukemia (CML) patients...
- TRGV and TRDV repertoire distribution and clonality of T cells from umbilical cord blood
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
Transpl Immunol 20:155-62. 2009
..However, this study will definitively contribute to understand the cellular immune features better and to exploit more efficiently the therapeutic potentials of CB...
TRAV and TRBV repertoire, clonality and the proliferative history of umbilical cord blood T-cellsYangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, China
Transpl Immunol 18:151-8. 2007
..The incomplete repertoire and naivety of CB T-cells might be the reason that CB hematopoietic stem cells transplant recipients are less likely to develop graft vs host disease...
- Alterations in the expression pattern of TCR zeta chain in T cells from patients with hematological diseases
Yangqiu Li
Institute of Hematology, Medical College and Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou 510632, China
Hematology 13:267-75. 2008
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- The TCR Vbeta repertoire usage of T-cells from cord blood induced by chronic myelogenous leukemia associated antigen
Yangqiu Li
Institute of Hematology, Medical College of Jinan University, Guangzhou, China
Hematology 10:387-92. 2005
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- Recent thymic output function in patients with hematological malignancy
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
Hematology 10:297-305. 2005
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- Gene expression profiles in BCL11B-siRNA treated malignant T cells
Xin Huang
Institute of Hematology, Medical College, Jinan University, Guangzhou, PR China
J Hematol Oncol 4:23. 2011
..The expression profiles of several genes were further validated in the BCL11B-siRNA -treated Molt-4 cells and primary T-ALL cells...
- [The feature of TCR V alpha40 with Jdelta1, Ddelta3 or psiJalpha gene rearrrangements in T cells]
Yang qiu Li
Institute of Hematology, Medical College of Jinan University, Guangzhou 510632, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 10:52-5. 2002
..It is concluded that the TCR V alpha40-psi Jalpha was the most frequent rearrangement in mature and immature T cells, whereas TCR Valpha40-Ddelta3 was more frequently rearranged in immature T cells..
- Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 16:143-50. 2011
..This study contributes to a better understanding of the cellular immune features in MM patients...
- The role of BCL11B in regulating the proliferation of human naive T cells
Si Chen
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, People s Republic of China
Hum Immunol 73:456-64. 2012
..In conclusion, BCL11B is required for T-cell survival; its overexpression could effectively increase the T-cell activation and proliferation abilities and Th-cell differentiation as well...
- BCL11B suppression does not influence CD34(+) cell differentiation and proliferation
Qi Shen
Institute of Hematology, Medical College, Jinan University, Guangzhou, PR China
Hematology 17:329-33. 2012
..In conclusion, the BCL11B-siRNA935 used in this study may be safe, and BCL11B may be considered a new candidate for targeted gene therapy in T-cell malignancies...
- A change in CD3γ, CD3δ, CD3ϵ, and CD3ζ gene expression in T-lymphocytes from benzene-exposed and benzene-poisoned workers
Bo Li
Institute of Hematology, Medical College, Jinan University, Guangzhou, PR China
J Immunotoxicol 9:160-7. 2012
..For now, it is hoped that this study may contribute to a better understanding of the disorders in cellular immunity frequently found with benzene-exposed workers...
- Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia
Xin Huang
Institute of Hematology, Medical College, Jinan University, and Department of Hematology, Guangdong General Hospital, Guangzhou, 510632, PR China
J Hematol Oncol 3:44. 2010
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- Gene expression profiling of CD3gamma, delta, epsilon, and zeta chains in CD4(+) and CD8(+) T cells from human umbilical cord blood
Shaohua Chen
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 15:230-5. 2010
..Higher expression of CD3 genes in CD4(+) T cells might relate to the strong ability of activation of TCR-mediated signals, and suggests that this is one of the features responsible for the low allo-reactivity of CB T cells...
- Upregulated TCRζ enhances interleukin-2 production in T-cells from patients with CML
Xianfeng Zha
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
DNA Cell Biol 31:1628-35. 2012
..It is possible that TCRζ chain reconstitution in leukemia-specific, clonally expanded T cells will effectively increase their activation of antileukemia cytotoxicity...
- Expression and distribution of PPP2R5C gene in leukemia
Haitao Zheng
Institute of Hematology, Medical College, Jinan University, Guangzhou, People s Republic of China
J Hematol Oncol 4:21. 2011
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- Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia
Bo Li
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
J Hematol Oncol 5:6. 2012
..However, primary and secondary failure after immunosuppressive therapy is frequent. Thus, knowledge of the immune mechanisms leading to AA is crucial to fundamentally understand the disease...
- The expression pattern of CD3 chain genes in fetal/maternal interface
Xiaoye Lu
Department of Histology and Embryology, Medical College, Jinan University, Guangzhou, China
Hematology 16:185-9. 2011
..In conclusion, the present study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta...
- Characterization of the CDR3 structure of the Vβ21 T cell clone in patients with P210(BCR-ABL)-positive chronic myeloid leukemia and B-cell acute lymphoblastic leukemia
Xianfeng Zha
Institute of Hematology, Medical College, Jihan University, Guangzhou, China
Hum Immunol 72:798-804. 2011
..The characterization of the CDR3 structure was complex. Regrettably, at this time it was not possible to confirm that the Vβ21 T cell clones were derived from the stimulation of p210(BCR-ABL) protein...
- Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia
Liang Wang
Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, PR China
J Hematol Oncol 3:14. 2010
..The features of restrictive usage and absence of partial T cell clones have been found in patients with CML. However, the T-cell clonal evolution of Ph-negative malignancies during treatment for CML is still unknown...
- Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation
Xiuli Wu
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, PR China
J Hematol Oncol 4:19. 2011
..To assess the proliferative history in different T-cell receptor beta variable region (TRBV) subfamilies of T cells after HSCT, expansion of TRBV subfamily-naive T cells was determined by analysis of a series of TRBV-BD1 sjTRECs...
- The feature of TRGV and TRDV repertoire distribution and clonality in patients with immune thrombocytopenic purpura
Xueli Zhang
Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China
Hematology 14:237-44. 2009
..In conclusion, the alteration of peripheral TRGV and TRDV repertoire pattern might play a role in the pathogenesis of immune-mediated platelet destruction in some cases with ITP...
- Down regulation of BCL11B expression inhibits proliferation and induces apoptosis in malignant T cells by BCL11B-935-siRNA
Xin Huang
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 16:236-42. 2011
..Suppression of BCL11B by RNA interference could inhibit the proliferation and induce the apoptosis effectively in leukemic T cells, which might be considered as a new target therapeutic strategy in T-cell malignancies...
- Restricted TRBV repertoire in CD4+ and CD8+ T-cell subsets from CML patients
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 16:43-9. 2011
..In conclusion, the restricted expression of TRBV subfamilies indicates the T-cell immunodeficiency in CML patients; however, clonally expanded T cells suggest a specific immune response to leukemia associated antigens...
- The T-cell receptor Vbeta gene repertoire and clonal expansion from peripheral blood T cells in benzene-exposed workers in China
Bo Li
Institute of Hematology, Medical College, Jinan University, China
Hematology 14:106-10. 2009
..05). The most frequently used Vbeta genes were Vbeta3, Vbeta21, Vbeta6, and Vbeta16. We observed a skewed distribution and clonal expansion of TCR Vbeta subfamilies in benzene-exposed workers...
- Characterization of conserved CDR3 sequence of TCR alpha- and beta-chain genes in peripheral blood T-cells from patients with diffuse large B-cell lymphoma
Qingsong Yin
Institute of Hematology, Jinan University, Guangzhou, China
Hematology 15:48-57. 2010
..These findings revealed the mono/oligoclonally expanded T cells were derived from the stimulation of some antigens in the PB of patients with DLBCL, and may be recognizing an identical antigenic epitope...
- Clonal expanded TCR Vbeta T cells in patients with APL
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
Hematology 10:135-9. 2005
..The clonal expansion of T-cells were considered to be a specific anti-leukemic immune response by host T-cells activated by the leukemia-associated-antigen...
- Enhancement of specific cellular immune response induced by DNA vaccines encoding PML-RARalpha and hIL-2 genes
Dongzhi Cen
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 15:88-95. 2010
..Our results indicate that a DNA vaccine with PML fusion gene segment and hIL-2 together might elicit increased cellular immune responses in mice...
- TCR zeta chain expression in T cells from patients with CML
Si Chen
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 14:95-100. 2009
..Taken together, these results indicate that TCR zeta chain expression was decreased in PBMCs and CD4+ T cells from patients with CML and this could be up-regulated partially by using stimulators...
- Generation of diffuse large B cell lymphoma-associated antigen-specific Vα6/Vβ13+T cells by TCR gene transfer
Qingsong Yin
Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, PR China
J Hematol Oncol 4:2. 2011
..The transfer of T cell receptor (TCR) genes endows T cells with new antigen specificity. Therefore, the aim of this study is to generate diffuse large B cell lymphoma (DLBCL)-specific T cells by T cell receptor (TCR) gene transfer...
- Clonal expansion T cells identified in acute monoblastic leukemia by CDR3 size analysis of TCR V beta repertoire using RT-PCR and genescan
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
Chin Med J (Engl) 115:69-71. 2002
..CONCLUSIONS: T cell clonality expansion was found in AML-M5 cases and were tendentious in the V beta 2 subfamily, suggesting a the specific immune response for leukemia cell (M5) associated antigen and may display antileukemia activity...
- Evaluation of TCR Vbeta subfamily T cell expansion in NOD/SCID mice transplanted with human cord blood hematopoietic stem cells
Chen Lin
Department of Microbiology and Immunology, Medical College of Jinan University, Guangzhou, PR China
Hematology 12:325-30. 2007
..The restricted expression and clonal expansion of some CB T cell clones may be induced by tissue-antigens of NOD/SCID mice...
- Deficiency of CD3gamma, delta, epsilon, and zeta expression in T cells from AML patients
Shaohua Chen
Institute of Hematology, Medical College, Jinan University, Guangzhou, China
Hematology 16:31-6. 2011
..Deficiency of all four CD3 gene expression levels might represent the feature related to T-cell immunodeficiency...
- GATA-1, -2 and -3 genes expression in bone marrow microenviroment with chronic aplastic anemia
Xiuli Wu
Medical College, Institute of Hematology, Jinan University, Guangzhou, PR China
Hematology 12:331-5. 2007
..The change of expression levels of GATA genes may influence the hematopoiesis in BM microenvironment and relate to the pathogenesis and development of aplastic anemia...
- Leukemia associated clonal expansion of TCR Vbeta subfamily T cells
Yangqiu Li
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China
Hematology 8:375-84. 2003
..Understanding such clonality and restricted usage of TCR Vbeta repertoire of leukemia-associated expanded T cells may be useful for the design of new immuno-therapeutic strategy for leukemia...
- [Expression of reconstructed BCR-ABL-pIRES-SEA plasmids in the skeletal muscles of BALB/c mice]
Yongpeng Gao
Department of Microbiology and Immunology, Medical College, Jinan University, Guangzhou 510632, China
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 29:519-23. 2012
..The reconstructed BCR-ABL-pIRES-SEA plasmids can effectively express gene production in the skeletal muscles of mice and have the common features of DNA vaccine...
- The role of peptide and DNA vaccines in myeloid leukemia immunotherapy
Chen Lin
Department of Microbiology and Immunology, Medical College, Jinan University, Guangzhou, 510632, China
Cancer Cell Int 13:13. 2013
..This review will focus on peptides and DNA vaccines in the context of myeloid leukemias, and optimal strategies for enhancing the efficacy of vaccines based on myeloid leukemia immunization are also summarized...
- KDR and Sema3 genes expression in bone marrow stromal cells and hematopoietic cells from leukemia patients and normal individuals
Zhen Wang
Guangdong Provincial Lung Cancer Research Institute, Cancer Center, Guangdong Provincial People s Hospital, Guangzhou 510800, P R China
Hematology 10:307-12. 2005
..Sema3 could also sustain the survival of hematopoietic cells with its high expression, while Sema3 gene expression may be inhibited in AML and CML...
