Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in miceYan Li
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
BMC Neurosci 8:19. 2007
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- Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice
Joel A Dietz
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
BMC Neurosci 9:74. 2008
..To assess this further, we bred and phenotyped a large population of F2 mice derived from a resistant inbred strain (DBA/2J) and a susceptible strain (BALB/cByJ)...
- Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
Cassandra L Schlamp
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
BMC Neurosci 7:66. 2006
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- A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death
Sheila J Semaan
Department of Opthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, U S A
ASN Neuro 2:e00032. 2010
..These studies implicated quantitative expression of the Bax gene as playing a possible role in neuronal susceptibility to damaging stimuli...
- Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous disease
Robert W Nickells
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
Exp Eye Res 84:729-36. 2007
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Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutantZheng Li
Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Lett 236:58-63. 2006
..Notably, we demonstrate a treatment efficacy by using CCK/Mpd-Bik-DD/liposome in a nude mice xenograft model, suggesting the feasibility of PCSP-based gene therapy in pancreatic cancer treatment...
- [Effect of peroxisome proliferator-activated receptor-alpha agonist on adipokines expression in rats fed with high-fat diet]
Yan Li
Department of Endocrinology, The Second Affiliated Hospital of Sun Yat sen University, Guangzhou 510120, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:761-5. 2006
..To explore the effect of peroxisome proliferator-activated receptor-alpha ( PPAR-alpha) agonist fenofibrate on adipokines expression in high-fat diet fed SD rats and its relationship to insulin resistance (IR)...
- Risk factors for mortality after coronary artery bypass grafting in patients with low left ventricular ejection fraction
Jin Wang
Department of Cardiac Surgery, Peking University First Hospital, Beijing 100034, China
Chin Med J (Engl) 120:317-22. 2007
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Double-root translocation for double-outlet right ventricle with noncommitted ventricular septal defect or double-outlet right ventricle with subpulmonary ventricular septal defect associated with pulmonary stenosis: an optimized solutionShengshou Hu
Cardiovascular Surgery Department, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Ann Thorac Surg 89:1360-5. 2010
..Here we present an early result of an alternative solution for these anomalies by double-root translocation technique...
- IL-6 inhibits apoptosis of human myeloma cell line XG-7 through activation of JAK/STAT pathway and up-regulation of Mcl-1
Lun Song
Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, P R China
Ai Zheng 21:113-6. 2002
....
- Influence of tripolyphosphate cross-linking on the physical stability and lipase digestibility of chitosan-coated lipid droplets
Min Hu
Biopolymers and Colloids Laboratory, Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Agric Food Chem 58:1283-9. 2010
..This study has important implications for the design of structured emulsions with controlled lipid digestibility and for the targeted delivery of lipophilic functional components to specific regions within the gastrointestinal tract...
- Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta
Gencheng Han
Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China
Immunology 129:197-206. 2010
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- Mcl-1 mediates cytokine deprivation induced apoptosis of human myeloma cell line XG-7
Lun Song
Department of Molecular Immunology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China
Chin Med J (Engl) 115:1241-3. 2002
..To investigate apoptosis in XG-7, a human myeloma cell line, induced by IL-6 deprivation and the function of three anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-kappa(L), Mcl-1) in the apoptotic process...
- Compositional and thermal effect on upconversion luminescence of Ho3+/Yb3+-codoped oxyfluoride glasses
Li Feng
Institute of Materials Science and Engineering, Shijiazhuang University of Economics, 136 Huaian East Road, Shijiazhuang, 050031, PR China
Spectrochim Acta A Mol Biomol Spectrosc 73:41-3. 2009
..The dependence of the upconversion emission intensity upon the excitation power was also examined, and the upconversion mechanisms were discussed...
- The functional roles of lipid rafts in T cell activation, immune diseases and HIV infection and prevention
Cheng Luo
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China
Cell Mol Immunol 5:1-7. 2008
....
- Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice
Cassandra L Schlamp
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53704, USA
Mol Cell Biol 24:3794-803. 2004
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- p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate
Yan Li
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53706, USA
Mol Vis 8:341-50. 2002
..Examination of the cleavage of PARP, which is a substrate for caspases, suggests that the p53-dependent pathway utilizes these proteases, but the p53-independent pathway does not...
- Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest
Yan Li
Molecular Biology Research Center, School of Biological Science and Technology, Central South University, Hunan 410078, P R China
Oncol Rep 17:377-84. 2007
..In summary, lycorine can suppress the proliferation of KM3 cells and reduce cell survival by arresting cell cycle progression as well as inducing cell apoptosis...
- Intraperitoneal chemotherapy with hydroxycamptothecin reduces peritoneal carcinomatosis: results of an experimental study
Peng cheng Li
Department of Oncology, Zhongnan Hospital and Cancer Center of Wuhan University, 169 Donghu Road, Wuhan 430071, Hubei Province, China
J Cancer Res Clin Oncol 134:37-44. 2008
..We studied the efficacy and safety of intraperitoneal chemotherapy with hydroxycamptothecin (HCPT) for the treatment of peritoneal carcinomatosis in animal model...
- Inhibition of Hepatitis B virus gene expression by single and dual small interfering RNA treatment
Kai-Lang Wu
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, PR China
Virus Res 112:100-7. 2005
..Therefore, this dual siRNA system provides a more powerful tool for the study of gene function and implicates a potential application in the treatment of viral infection...
- Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin
Qingqing Ding
Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell 19:159-70. 2005
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- Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China
Zhiming Dong
Department of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
J Clin Gastroenterol 42:910-5. 2008
..Investigated the association of DNA repair gene xeroderma pigmentosum group A(XPA) and C(XPC) polymorphisms with the risk of gastric cardiac adenocarcinoma (GCA) in a high incidence region in north China...
- Benzoylurea derivatives as a novel class of antimitotic agents: synthesis, anticancer activity, and structure-activity relationships
Dan Qing Song
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Med Chem 51:3094-103. 2008
..The mechanism of 14b is to inhibit microtubule assembly, followed by the M-phase arrest, bcl-2 inactivation, and then apoptosis. We consider 14b promising for further anticancer investigation...
- [Expression of somatostatin receptor reporter gene and its correlation with targeted imaging in vivo for detection of pancreas carcinoma]
Zi zheng Wang
Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
Zhonghua Zhong Liu Za Zhi 27:663-6. 2005
..To evaluate the value of (99 m)Tc-sandostatin scintigraphy in targeted diagnosis of pancreas carcinoma and the correlation with expression of somatostatin receptor (SSTR) reporter gene in tumor tissue...
- The rational designed antagonist derived from the complex structure of interleukin-6 and its receptor affectively blocking interleukin-6 might be a promising treatment in multiple myeloma
Jiannan Feng
Institute of Basic Medical Sciences, Taiping Road, Beijing 100850, China
Biochimie 88:1265-73. 2006
..In conclusion, PT could induce interleukin-6-dependent XG-7 and SKO-007 cells to apoptosis while inhibit interleukin-6-stimulated apoptosis in M1 cells...
- Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
Fang Hua
Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
J Immunol 178:7317-24. 2007
..These data also suggest that modulation of TLR4/PI3K/Akt-dependent signaling pathways may be a viable strategy for reducing myocardial I/R injury...
- Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro
Gang Xue
Department of General Surgery, Chengdu Army General Hospital, Chengdu, China
Cancer Immunol Immunother 56:1831-43. 2007
..Herein we report the investigation of the specific CTL responses elicited by adenoviral 6Ckine/IFNgamma fusion gene-modified DCs in vitro...
- [Correlation of XPC Ala499Val and Lys939Gln polymorphisms to risks of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]
Rong Miao Zhou
Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, Shijiazhuang, Hebei, 050011, P R China
Ai Zheng 25:1113-9. 2006
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- Immunofluorescence detection with quantum dot bioconjugates for hepatoma in vivo
Xuefeng Yu
Wuhan University, Key Laboratory of Acoustic and Photonic Materials and Devices of Ministry of Education, Department of Physics, Wuhan 430072, China
J Biomed Opt 12:014008. 2007
..These results demonstrate the practicality of QD bioconjugates as attractive fluorescent probes for biomedical detection...
- Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors
Laixing Hu
Department of Chemistry, Georgia State University, Atlanta, Georgia 30303-3083, USA
J Med Chem 49:6273-82. 2006
..Also, the SAR information gleaned from ring A-substituted analogues varies significantly from that of 1. Carbazole sulfonamides are a novel promising class of antimitotic agents with clinical development potential...
- Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization
Zhiqiang Li
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
Biochim Biophys Acta 1771:1186-94. 2007
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- [Alteration of the malignant phenotype of human hepatocellular carcinoma cell line Hep3B by specially synthesized oligodeoxynucleotides]
Yan Li
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Gan Zang Bing Za Zhi 13:347-50. 2005
..CONCLUSION: SODN has inhibitory effect on IGF-2 expression in Hep3B cells as a molecular switch, which partially alterates the malignant phenotype of this cell line...
- From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis
Shi Jian Ding
Research Center for Proteome Analysis, Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, People s Republic of China
Mol Cell Proteomics 3:73-81. 2004
..Serum CK19 level might reflect the pathological progression in some HCC and may be a useful marker for predicting tumor metastasis and a therapeutic target for the treatment of HCC patients with metastases...
- Lineage-dependent NF-kappaB activation contributes to the resistance of human macrophages to apoptosis
Jiyan Zhang
Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, People s Republic of China
Hematol J 4:277-84. 2003
..Thus lineage-dependent activation of NF-kappaB is responsible at least in part for the resistance of mature macrophages to 'spontaneous' apoptosis in vitro...
- [Transfection of the exogenous PTEN-induced growth inhibition of the highly metastatic mucoepidermoid carcinoma cell line M3SP2 in vitro]
Bin Liu
Department of Oral Biology, Stomatological College, Fourth Military Medical University
Hua Xi Kou Qiang Yi Xue Za Zhi 20:361-3, 373. 2002
..CONCLUSION: These data provide evidence that the exogenous wild-type PTEN have remarkably inhibitory effects on in vitro proliferation of the highly metastatic mucoepidermoid carcinoma cell line M3SP2...
- [Studies on antitumor activity of rhEndostatin]
Hong-yan Li
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Yao Xue Xue Bao 37:763-6. 2002
..The action mechanisms may be that it can inhibit endothelial cell proliferation, thereby inhibiting the formation of new blood vessel in tumor, leading the tumor to stop grow...
- Imaging paclitaxel (chemotherapy)-induced tumor apoptosis with 99mTc C2A, a domain of synaptotagmin I: a preliminary study
Feng Wang
Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
Nucl Med Biol 35:359-64. 2008
..To evaluate the dynamics and feasibility of imaging non-small cell lung cancer (NSCLC) apoptosis induced by paclitaxel treatment using 99mTc-labeled C2A domain of synaptotagmin I in a mouse model...
- [Study on the biological activity and molecular mechanism of IFNalpha on human myeloma cell line Sko-007]
Lun Song
Institute of Basic Medical Science, Academy of Military Medical Science, Beijing 100850, China
Zhonghua Xue Ye Xue Za Zhi 23:517-9. 2002
..CONCLUSION: The inhibitory effect of IFNalpha on the proliferation of Sko-007 cells was mediated by gp130 down-regulation, degradation of Bcl-2 family anti-apoptotic proteins and inhibition of ERK activation...
- Double blockade of cell cycle at g(1)-s transition and m phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand
Jian-Dong Jiang
Division of Medical Oncology, Mount Sinai School of Medicine-New York University, New York 10029, USA
Cancer Res 62:6080-8. 2002
..Besides being a novel lead for the design of new anticancer tubulin ligands, the activity of 3-IAABE in the cell cycle may also help us to understand the molecular pharmacology of microtubule-active drugs...
- beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer
Jiong Deng
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Cell 2:323-34. 2002
..Thus, beta-catenin may play an important role in oncogenesis through the crossregulation of NF-kappa B...
- [Establishment of human hepatocellular carcinoma cell line with spontaneous pulmonary metastasis through in vivo selection]
Yan Li
Liver Cancer Institute and Zhong Shan Hospital of Fudan University, Shanghai, 200032, China
Zhonghua Yi Xue Za Zhi 82:601-5. 2002
..CONCLUSION: A new HCC cell line has been established, which is characterized by high pulmonary metastasis via both subcutaneous and orthotopic inoculation. It provides a new model for the study of liver cancer metastasis...
- [Mechanism of the mitogen-activated protein kinase phosphatase-5 regulating the growth and invasion of a human prostate cancer cell line]
Hui-ying He
Department of Pathology, Peking University Health Science Center, Beijing 100083, China
Zhonghua Yi Xue Za Zhi 83:1812-7. 2003
..The p38 pathway may be more important in the invasive capability of 1E8 cells. MKP5 plays an important role in the regulation of p38 action...
- [Expression of PTEN protein in oromaxillofacial tumor cell lines]
Bin Liu
Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi an 710032, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 19:35-7. 2003
..To investigate expression of PTEN protein in oromaxillofacial tumor cell lines and to compare the difference of PTEN protein expression between highly metastatic cancer cell lines and their parent cell lines...
- Structure-based design and characterization of a Novel IL-6 antagonist peptide
Zhenhui Yang
Institute of Basic Medical Sciences, P.O. Box 130 (3, Taiping Road, Beijing 100850, PR China
Mol Immunol 42:1015-21. 2005
..PT possessed potential bioactivity to antagonize the function of hIL-6 and could efficiently induce the growth arrest and apoptosis of XG-7 cells in a dose-dependent manner...
- Molecular cytogenetic characteristics of the human hepatocellular carcinoma cell line HCCLM3 with high metastatic potential: comparative genomic hybridization and multiplex fluorescence in situ hybridization
Jiong Yang
Liver Cancer Institute and Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, People's Republic of China
Cancer Genet Cytogenet 158:180-3. 2005
..The analysis of this cell line through a combination of molecular cytogenetic techniques provides information on the possible molecular mechanisms involved in the metastatic process of HCC...
- Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study
Fang Zheng
Department of Oncology, Zhongnan Hospital of Wuhan University and Cancer Center of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan, 430071, China
Life Sci 80:388-96. 2007
..TMCO-60%/pDNA nanoparticles had better in vitro and in vivo transfection activity than the other two, and with minimal toxicity, which made it a desirable non-viral vector for gene therapy via oral administration...
- In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways
Yong-Hong Shi
Department of Pathology, Peking University Health Science Center, Beijing, China
J Pathol 205:530-6. 2005
..Further studies will pinpoint whether HIF-1 is the transcriptional factor responsible for the increased VEGF production following bFGF treatment of breast tumour cells...
- Reduction in p48-ISGFgamma levels confers resistance to interferon-alpha2a in MHCC97 cells
Wei Zhong Wu
Liver Cancer Institute and Zhongshan Hospital, Shanghai, P R China
Oncology 67:428-40. 2004
..Elucidation of the mechanism underlying the defective response of MHCC97 to IFN-alpha may help to explain and possibly to overcome clinical failures of this form of tumor therapy...
- [Tumor necrosis factor-alpha gene polymorphisms and risk of coronary heart disease]
Ping Xia Xiang
Department of Medical Laboratory Science, Renmin Hospital of Wuhan University, Wuhan 430060, China
Yi Chuan 26:807-10. 2004
..We found the serum level of TNF-alpha of CHD is higher than that of controls(P<0.05),-863 genotype and allele have significant difference between two groups(P<0.05),and there are no difference in two groups at -857 site...
- Immunohistochemical analysis of the expression of FATE/BJ-HCC-2 antigen in normal and malignant tissues
Xiao Ang Yang
Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Lab Invest 85:205-13. 2005
..Thus, FATE/BJ-HCC-2 may be a valuable candidate CT antigen for polyvalent vaccines in tumor immunotherapy and an assisting diagnostic marker for prognosis of the disease...
- A mouse mammary tumor virus-like long terminal repeat superantigen in human breast cancer
Yue Wang
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Cancer Res 64:4105-11. 2004
..Because the T-cell responses in vitro are considered similar to those in vivo, these results suggest that the human LTR SAg might also play a role in human breast carcinogenesis...
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
Ralph Brandenberger
Geron Corporation, Menlo Park, California 94025, USA
Nat Biotechnol 22:707-16. 2004
..The genomic data presented here may facilitate the derivation of clinically useful cell types from hES cells...
- Establishment of green fluorescent protein-expressing hepatocellular carcinoma cell lines with different metastatic potential: relevant models for in vivo monitoring of metastasis and angiogenesis
Yang Xu
Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032 Shanghai, China
J Cancer Res Clin Oncol 130:375-82. 2004
..CONCLUSIONS: These two stable GFP-expressing HCC cell lines with the same genetic background and different metastatic potential were established, which could be useful models for monitoring metastasis and angiogenesis of HCC...
- A novel human scFv fragment against TNF-alpha from de novo design method
Hong Chang
Institute of Basic Medical Sciences, Beijing, PR China
Mol Immunol 44:3789-96. 2007
....
- (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells
Yang Meng
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Leuk Lymphoma 48:2204-12. 2007
..These results suggest that (-)gossypol induced apoptosis in K562 cells through a mitochondria pathway and that the combination of imatinib and (-)gossypol might be an effective treatment for CML...
- Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis
Zhao Jun Liu
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 23:14-25. 2003
..This study provides the first evidence for regulation of Notch/Delta gene expression by an angiogenic growth factor and insight into the critical role of Notch signaling in arteriogenesis and angiogenesis...
- Adult asthmatics display exaggerated IFNgamma responses to human metapneumovirus and respiratory syncytial virus
Renée N Douville
CIHR National Training Program in Allergy and Asthma Research, Department of Immunology, University of Manitoba, 603 Basic Medical Sciences Building, 730 William Ave, Winnipeg, MB R3E0W3, Canada
Biochem Cell Biol 85:252-8. 2007
..This distinctive pattern of viral immunity may contribute to a worsening of asthma symptoms during respiratory virus infections...
- Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5
Guoquan Gao
Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29403, USA
J Biol Chem 277:9492-7. 2002
....
- [Study on the relationship between serum cytokeratin 19 level in hepatocellular carcinoma patients and the clinico-pathologic characteristics]
Yan Li
Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Zhonghua Gan Zang Bing Za Zhi 12:341-2. 2004
..chi-square = 13.300, P < 0.005) CONCLUSION: Some HCC patients do have increased serum CK19 level, which could be related to portal vein tumor emboli, poor tumor differentiation and advanced tumor stages...
- A novel hIL-6 antagonist peptide from computer-aided design contributes to suppression of apoptosis in M1 cells
Zhenhui Yang
Institute of Basic Medical Sciences, P.O. Box 130 (3, Taiping Road, Beijing 100850, PR China
Biochem Biophys Res Commun 325:518-24. 2004
..Furthermore, murine M1 myeloid cell line, which was induced by the physiological inducer hIL-6 to undergo apoptosis and growth arrest, could be used as a subtle model system to test hIL-6 antagonist...
- [The expression of heat shock protein 27 in retinal ganglion cells in the rat glaucoma model]
Hong Bin Lu
Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China
Zhonghua Yan Ke Za Zhi 41:533-9. 2005
..To observe the expression of heat shock protein 27 (HSP27) in retinal ganglion cells in experimental rat glaucoma model and to study the relationship between HSP27 expression and hypertension using serum autoantibodies...
- [Inhibitory effects of a novel trimeric of beta peptide (beta3) on migration and invasion of hepatocellular carcinoma cells]
Song-Mei Wang
Laboratory of Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Zhonghua Gan Zang Bing Za Zhi 13:541-2. 2005
- Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China
Yan Li
Hebei Cancer Institute, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, Hebei Province, China
Gynecol Oncol 101:92-6. 2006
....
- Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma
Li Li
State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China
Int J Cancer 118:2064-71. 2006
..Thus, adenovirus-mediated intra-tumoral introduction of the human endostatin gene may form a viable new treatment for NPC, although readministration every 2-3 weeks may be necessary for the best effect...
- [Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
Shu Mei Fang
Lab of Molecular Biology, Hebei Provincial Cancer Institute, Shijiazhuang, Hebei, 050011, P R China
Ai Zheng 24:305-10. 2005
..This study was to investigate correlation of the MMP-3 SNP with genetic susceptibility and lymph node metastasis of non-small cell lung cancer (NSCLC)...
- [Correlation of p73 polymorphisms to genetic susceptibilities to esophageal carcinoma and gastric cardiac carcinoma]
Hui Ge
Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050011, P R China
Ai Zheng 25:1351-5. 2006
..This study was to investigate the correlation of p73 G4C14-A4T14 polymorphisms to susceptibilities to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a high incidence region of Hebei Province...
- Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy
Todd D Nebesio
Department of Pediatrics, Herman B Wells Center for Pediatric Cancer Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
Glia 55:527-36. 2007
....
- Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin
Xuemei Liu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street M C 877, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 16:741-9. 2003
..These data suggest that the 4-fluoroequilenin derivatives have promise as alternatives to traditional estrogen replacement therapy due to their similar estrogenic properties with less overall toxicity...
