Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: patterns of retinal nerve fiber layer progressionChristopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
Ophthalmology 119:1858-66. 2012
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- Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss
Christopher K S Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, P R China
Ophthalmology 119:731-7. 2012
..To investigate age-related changes of the retinal nerve fiber layer (RNFL) imaged by a spectral-domain optical coherence tomography (OCT)...
Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopyChristopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 48:3178-83. 2007
..To evaluate the relationships between optic disc measurements, obtained by an optical coherence tomograph and a confocal scanning laser ophthalmoscope, and myopia...
- Dynamic analysis of dark-light changes of the anterior chamber angle with anterior segment OCT
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 48:4116-22. 2007
..To describe the use of anterior segment optical coherence tomography (OCT) in studying the dynamic dark-light changes of the anterior chamber angle...
- Anterior chamber angle measurement with anterior segment optical coherence tomography: a comparison between slit lamp OCT and Visante OCT
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 49:3469-74. 2008
..To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility...
- Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 49:4893-7. 2008
..To compare macular thickness measurements obtained from time domain optical coherence tomography (OCT) and spectral domain OCT and to evaluate their repeatability and agreement...
- Longitudinal variability of optic disc and retinal nerve fiber layer measurements
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 49:4886-92. 2008
..To evaluate the longitudinal variability of optic disc and retinal nerve fiber layer (RNFL) measurements obtained from optical coherence tomography (OCT), scanning laser polarimetry (SLP), and confocal scanning laser ophthalmoscopy (CSLO)...
- Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
Ophthalmology 116:1257-63, 1263.e1-2. 2009
..Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.)...
- Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
Invest Ophthalmol Vis Sci 51:217-22. 2010
..To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis...
- Comparisons of anterior segment biometry between Chinese and Caucasians using anterior segment optical coherence tomography
C K Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, PR China
Br J Ophthalmol 94:1184-9. 2010
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- Evaluation of retinal nerve fiber layer progression in glaucoma: a comparison between the fast and the regular retinal nerve fiber layer scans
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
Ophthalmology 118:763-7. 2011
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Anterior chamber angle imaging with optical coherence tomographyC K S Leung
Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Hong Kong, PR China
Eye (Lond) 25:261-7. 2011
..This article summarizes the development and application of OCT for anterior chamber angle measurement, detection of angle closure, and investigation of the pathophysiology of primary angle closure...
- Long-term in vivo imaging and measurement of dendritic shrinkage of retinal ganglion cells
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 52:1539-47. 2011
..To monitor and measure dendritic shrinkage of retinal ganglion cells (RGCs) in a strain of transgenic mice (Thy-1 YFP) that expresses yellow fluorescent proteins in neurons under the control of a Thy-1 promoter...
- American Chinese glaucoma imaging study: a comparison of the optic disc and retinal nerve fiber layer in detecting glaucomatous damage
Christopher Kai Shun Leung
Hamilton Glaucoma Center, University of California, San Diego, California, USA
Invest Ophthalmol Vis Sci 48:2644-52. 2007
..To compare the relationships between optic nerve structural measures and visual function, as well as the diagnostic sensitivity for glaucoma detection between the retinal nerve fiber layer (RNFL) and neuroretinal rim measurements...
- Alignment artifacts in optical coherence tomography analyzed images
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
Ophthalmology 114:263-70. 2007
..To compare retinal thickness and retinal height of the original scanned optical coherence tomography (OCT) images with those of the same images after automated retinal thickness analysis...
- Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study
Christopher K S Leung
Department of Ophthalmology, Caritas Medical Centre, Hong Kong, China
Ophthalmology 112:391-400. 2005
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- Visualization of anterior chamber angle dynamics using optical coherence tomography
Christopher K S Leung
Department of Ophthalmology, Caritas Medical Centre, Hong Kong, China
Ophthalmology 112:980-4. 2005
..To describe the technology of optical coherence tomography (OCT) in imaging the anterior chamber angles and its impact on understanding the pathophysiology of angle-closure glaucoma (ACG)...
- Analysis of retinal nerve fiber layer and optic nerve head in glaucoma with different reference plane offsets, using optical coherence tomography
Christopher Kai Shun Leung
Department of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Sham Shui Po, Hong Kong, People s Republic of China
Invest Ophthalmol Vis Sci 46:891-9. 2005
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- Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection
Christopher K S Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
Ophthalmology 117:1684-91. 2010
..46 mm diameter circle scan...
- Evaluation of scanning resolution on retinal nerve fiber layer measurement using optical coherence tomography in normal and glaucomatous eyes
C K S Leung
Department of Ophthalmology, Caritas Medical Centre, Hong Kong, People s Republic of China
J Glaucoma 13:479-85. 2004
..To evaluate the effect of varying the scanning resolution of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) measurement on diagnostic sensitivity and functional correlation in glaucoma...
- Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: structure/function regression analysis in glaucoma
Christopher Kai Shun Leung
Department of Ophthalmology, Caritas Medical Centre, Hong Kong, People s Republic of China
Invest Ophthalmol Vis Sci 46:3702-11. 2005
..Dublin, CA) and GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA)...
- Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, I: correlation analysis in glaucoma
Christopher Kai Shun Leung
Department of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Sham Shui Po, Hong Kong, People s Republic of China
Invest Ophthalmol Vis Sci 46:3214-20. 2005
..Dublin, CA) and GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA)...
- Analysis of bleb morphology after trabeculectomy with Visante anterior segment optical coherence tomography
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, PRC
Br J Ophthalmol 91:340-4. 2007
..To describe the use of anterior segment optical coherence tomography (OCT) in imaging intrableb morphology after trabeculectomy...
- Novel approach for anterior chamber angle analysis: anterior chamber angle detection with edge measurement and identification algorithm (ACADEMIA)
Christopher Kai Shun Leung
Department of Ophthalmology, Caritas Medical Centre, Hong Kong
Arch Ophthalmol 124:1395-401. 2006
..To describe a novel approach to measuring anterior chamber angle dimensions and configurations...
- Retinal nerve fiber layer measurements in myopia: An optical coherence tomography study
Christopher Kai Shun Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 47:5171-6. 2006
..To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and the axial length/refractive error of the eye...
- Dynamic analysis of iris configuration with anterior segment optical coherence tomography
Carol Yim Lui Cheung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
Invest Ophthalmol Vis Sci 51:4040-6. 2010
..To evaluate dynamic changes in iris configuration and their association with anterior chamber angle width by using anterior segment optical coherence tomography (ASOCT)...
- Longitudinal evaluation of optic disc measurement variability with optical coherence tomography and confocal scanning laser ophthalmoscopy
Dusheng Lin
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PR China
J Glaucoma 18:101-6. 2009
..To evaluate and compare the longitudinal variability of optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO) optic disc measurements...
- Assessment of scleral spur visibility with anterior segment optical coherence tomography
Shu Liu
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PR China
J Glaucoma 19:132-5. 2010
..To develop a grading system to evaluate the scleral spur visibility and to investigate the association between this and the angle width...
- Identification and characterization of a native epitope common to norovirus strains GII/4, GII/7 and GII/8
Xiao Li
South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong 510301, China
Virus Res 140:188-93. 2009
..This is a new native epitope to be reported for norovirus GII/4...
- Epitope mapping and cross-reactivity analysis of the monoclonal antibodies against hexon protein of human adenovirus type 3
Hongling Qiu
Guangzhou Huayin Medical Science Company Limited, Guangzhou, Guangdong, 510663, China
Virus Res 146:58-65. 2009
..The MAbs and the identified epitopes may play roles in clinical serotype-specific diagnosis, viral structure analysis, as well as in the identification of new serotypes of human adenovirus...
- Prevention of rabies virus infection in dogs by a recombinant canine adenovirus type-2 encoding the rabies virus glycoprotein
Rongliang Hu
Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Science, 1068 Qinglong Road, Changchun, Jilin 130062, PR China
Microbes Infect 8:1090-7. 2006
..The immunity lasts for months with a protective level of neutralizing antibody. This recombinant virus would be an alternative to the attenuated and the inactivated rabies vaccines and be prospective in immunizing dogs against rabies...
- Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography
Haitao Li
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong
Br J Ophthalmol 91:1490-2. 2007
..To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography...
- Comparative study of central corneal thickness measurement with slit-lamp optical coherence tomography and visante optical coherence tomography
Haitao Li
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
Ophthalmology 115:796-801.e2. 2008
..To evaluate the repeatability and reproducibility of central corneal thickness (CCT) measurements obtained by 2 anterior segment optical coherence tomography (OCT) imaging systems and to examine their agreements with ultrasound pachymetry...
- Correlation between functional and anatomical assessments by multifocal electroretinography and optical coherence tomography in central serous chorioretinopathy
Yolanda W Y Yip
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, People s Republic of China
Doc Ophthalmol 120:193-200. 2010
..MfERG and OCT can complement each other in the functional and anatomical assessments in CSC...
- First and second-order kernel multifocal electroretinography abnormalities in acute central serous chorioretinopathy
Timothy Y Y Lai
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, People s Republic of China
Doc Ophthalmol 116:29-40. 2008
..To evaluate the first and second-order kernel multifocal electroretinogram (mfERG) response abnormalities in patients with acute central serous chorioretinopathy (CSC)...
- EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes
Haitao Li
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
Mol Vis 14:1698-704. 2008
..We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR)...
- Changes in aqueous vascular endothelial growth factor and pigment epithelial-derived factor levels following intravitreal bevacizumab injections for choroidal neovascularization secondary to age-related macular degeneration or pathologic myopia
Wai Man Chan
Department of Ophthalmology and Visual Science, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong
Retina 28:1308-13. 2008
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- Novel and homozygous BEST1 mutations in Chinese patients with Best vitelliform macular dystrophy
Raymond L M Wong
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong SAR, China
Retina 30:820-7. 2010
..The purpose of this study was to investigate the BEST1 gene mutations in Chinese patients with Best vitelliform macular dystrophy (BVMD)...
- Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist
Haitao Li
Department of Medicinal Chemistry, Research Pharmacology, and Pharmacokenetics, Dynamics and Metabolism, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121, USA
J Med Chem 49:3362-7. 2006
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- Extensive submacular haemorrhage in polypoidal choroidal vasculopathy managed by sequential gas displacement and photodynamic therapy: a pilot study of one-year follow up
Wai Man Chan
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Clin Experiment Ophthalmol 33:611-8. 2005
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- The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists
David R Luthin
Pfizer Global Research and Development La Jolla Agouron Pharmaceuticals, Inc, San Diego, CA 92121, USA
Bioorg Med Chem Lett 12:3467-70. 2002
..These compounds or their analogues may be useful as therapeutic agents for the treatment of hormone-dependent pathologies including prostate, breast and ovarian cancers...
- 2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice
Haitao Li
School of Biological Sciences, The University of Hong Kong, Hong Kong, China
Br J Pharmacol 160:1352-61. 2010
..In the present study, the chemopreventive effect of PMS was evaluated in a mouse model of colitis-associated colon carcinogenesis...
- 3,3',4,5,5'-Pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress
Haitao Li
School of Biological Sciences, The University of Hong Kong, Hong Kong, China
Eur J Pharmacol 637:55-61. 2010
..Further mechanistic analysis revealed that PHS-induced apoptosis was caspase-dependent and mediated by its pro-oxidative action through up-regulation of reactive oxidative species generation and depletion of intracellular glutathione...
- Multifocal electroretinographic changes in patients receiving hydroxychloroquine therapy
Timothy Y Y Lai
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong, People s Republic of China
Am J Ophthalmol 140:794-807. 2005
..To evaluate the longitudinal changes in multifocal electroretinography (mfERG) in patients receiving hydroxychloroquine and to assess the effects of cumulative hydroxychloroquine dose on mfERG...
- 2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, is a potent inducer of apoptosis in colon cancer cells via targeting microtubules
Haitao Li
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Biochem Pharmacol 78:1224-32. 2009
..Collectively, these data suggest that PMS is a potent inducer of apoptosis via targeting microtubules and may merit investigation as a potential chemoprophylactic and therapeutic agent for colon cancer...
