Myosin-II puts the squeeze on asymmetric cell divisionRong Li
Stowers Institute for Medical Research 1000 E 50 th Street, Kansas City, MO 64112, USA
Dev Cell 19:639-40. 2010
..Ou et al. (2010) now report in Science a mechanism of asymmetric midzone positioning driven by a polarized cortical distribution of the contractile motor myosin-II...
The road to maturation: somatic cell interaction and self-organization of the mammalian oocyteRong Li
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
Nat Rev Mol Cell Biol 14:141-52. 2013
..Meiotic chromatin provides key instructive signals while being 'chauffeured' by both cytoskeletal systems...
- Symmetry breaking in biology
Rong Li
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
Cold Spring Harb Perspect Biol 2:a003475. 2010
..Symmetry breaking is essential for cell movement, polarity, and developmental patterning. Amplification of initial asymmetry is key to the conserved mechanisms involved...
- Symmetry breaking in the life cycle of the budding yeast
Brian D Slaughter
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
Cold Spring Harb Perspect Biol 1:a003384. 2009
..Spatial cues, such as bud scars and pheromone gradients, orient cell polarity by modulating the regulation of the Cdc42 GTPase cycle, thereby biasing the site of asymmetry amplification...
- Toward quantitative "in vivo biochemistry" with fluorescence fluctuation spectroscopy
Brian D Slaughter
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Mol Biol Cell 21:4306-11. 2010
..Along the way, we describe briefly a few recent examples where these analyses have helped address important biological questions...
- Beyond polymer polarity: how the cytoskeleton builds a polarized cell
Rong Li
The Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
Nat Rev Mol Cell Biol 9:860-73. 2008
..Crosstalk coordinates the functions of the two cytoskeletal systems...
Toward a molecular interpretation of the surface stress theory for yeast morphogenesisBrian Slaughter
The Stowers Institute for Medical Research, 1000 E. 50th St. Kansas City, Missouri 64110, USA
Curr Opin Cell Biol 18:47-53. 2006
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- Dual modes of cdc42 recycling fine-tune polarized morphogenesis
Brian D Slaughter
Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA
Dev Cell 17:823-35. 2009
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- Actin-driven chromosomal motility leads to symmetry breaking in mammalian meiotic oocytes
Hongbin Li
Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
Nat Cell Biol 10:1301-8. 2008
..Symmetry breaking of the actin cloud relative to chromosomes, and net chromosome translocation toward the cortex require actin turnover...
- Multisite phosphorylation of the guanine nucleotide exchange factor Cdc24 during yeast cell polarization
Stephanie C Wai
Stowers Institute for Medical Research, Kansas City, MO, USA
PLoS ONE 4:e6563. 2009
..Previous studies have suggested an important role for phosphorylation of Cdc24, which may regulate activity or function of the protein, representing a key step in the symmetry breaking process...
- Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
Norman Pavelka
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
Nature 468:321-5. 2010
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- The Ran GTPase mediates chromatin signaling to control cortical polarity during polar body extrusion in mouse oocytes
Manqi Deng
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Dev Cell 12:301-8. 2007
..We hypothesize that a Ran(GTP) gradient serves as a molecular ruler to interpret the asymmetric position of the meiotic chromatin...
