Ren J, Sui H, Fang F, Li Q, Li B. The application of ApcMin/+ mouse model in colorectal tumor researches. J Cancer Res Clin Oncol. 2019;145:1111-1122 pubmed publisher
..This article will give a brief review on the related molecular mechanisms of the ApcMin/+ mouse model and its application in colorectal tumor researches. ..
Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, et al
. Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance. Cell Metab. 2018;28:104-117.e5 pubmed publisher
..Together, we propose an effective cancer therapy concept by combining drugs that target angiogenesis and lipid metabolism. ..
Zhou L, Hu Q, Sui H, Ci S, Wang Y, Liu X, et al
. Tanshinone II--a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer. Asian Pac J Cancer Prev. 2012;13:4453-8 pubmed
..The results indicate that Tan II-A can effectively inhibit tumor growth and angiogenesis of human colorectal cancer via inhibiting the expression level of COX-2 and VEGF. ..
Sui H, Pan S, Feng Y, Jin B, Liu X, Zhou L, et al
. Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-?B pathway. BMC Complement Altern Med. 2014;14:279 pubmed publisher
..Our study has provided the first direct evidence that ZJW reverses drug-resistance in human colorectal cancer by blocking the PI3K/Akt/NF-?B signaling pathway, and could be considered as a useful drug for cancer therapy. ..
Sui H, Cai G, Pan S, Deng W, Wang Y, Chen Z, et al
. miR200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer. Mol Cancer Ther. 2014;13:3137-51 pubmed publisher
..Restoration of miR200c expression in MDR colorectal cancer may serve as a promising therapeutic approach in MDR-induced metastasis. ..
Zhou L, Feng Y, Jin Y, Liu X, Sui H, Chai N, et al
. Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer. BMC Cancer. 2014;14:747 pubmed publisher
..HIPK2 protein modulates the phosphorylation status of p53, and levels of Bax and Bcl-2 in CRC. We also found that VB effectively activated the HIPK2-p53 signaling pathway, resulting in increased CRC cell apoptosis. ..
Ji Q, Liu X, Han Z, Zhou L, Sui H, Yan L, et al
. Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-Î²1/Smads signaling pathway mediated Snail/E-cadherin expression. BMC Cancer. 2015;15:97 pubmed publisher
Liu N, Zhou N, Chai N, Liu X, Jiang H, Wu Q, et al
. Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. BMC Cancer. 2016;16:321 pubmed publisher
..The COX-2/Wnt/beta-catenin/VEGF pathway plays an important role in H. pylori-associated gastric cancer development. The COX-2/Wnt/beta-catenin pathway is therefore a novel therapeutic target for H. pylori-associated gastric cancers. ..
Liu X, Ji Q, Zhang C, Liu X, Liu Y, Liu N, et al
. miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models. Sci Rep. 2017;7:7113 pubmed publisher
..pylori-induced gastric cancer, shedding new light on the mechanisms underlying H. pylori-associated gastric cancer. ..