Manxiang Li

Summary

Publications

  1. Wang Q, Li F, Shi W, Zhang Q, Wang J, Yan X, et al. Overexpression of DJ-1 correlates with aggressive clinicopathological characteristics and poor prognosis in malignant tumors: a meta-analysis. Onco Targets Ther. 2018;11:3931-3942 pubmed publisher
    ..The diagnostic OR was 34.87, and the area under the summary receiver operating characteristic curve was 0.88. This meta-analysis demonstrated that DJ-1 was an important biomarker in tumor assessment and prognosis prediction. ..
  2. Feng W, Wang J, Yan X, Zhai C, Shi W, Wang Q, et al. Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy. Naunyn Schmiedebergs Arch Pharmacol. 2019;: pubmed publisher
    ..Taken together, paclitaxel inhibits pulmonary vascular remodeling by FoxO1-mediated autophagy suppression, suggesting that paclitaxel might be a novel therapeutic agent for the prevention and treatment of PAH. ..
  3. Shi W, Zhai C, Feng W, Wang J, Zhu Y, Li S, et al. Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation. Life Sci. 2018;210:140-149 pubmed publisher
    ..Resveratrol inhibits the MCT-induced PAH by targeting on SphK1 and reverses the downstream changes of SphK1, indicating that resveratrol might be a therapeutic agent for the prevention of PAH. ..
  4. Zhai C, Shi W, Feng W, Zhu Y, Wang J, Li S, et al. Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-?B-mediated autophagy activation. Life Sci. 2018;208:87-95 pubmed publisher
    ..Activation of AMPK prevents the development of PAH by targeting on NF-?B to suppress autophagy and vascular remodeling. ..
  5. Li M, Dong X, Liu Y, Sun X, Li Z, He J. Inhibition of ubiquitin proteasome function suppresses proliferation of pulmonary artery smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:517-23 pubmed publisher
  6. Xie X, Zhu Y, Zhang J, Zhai C, Feng W, Pan Y, et al. Association between Val66Met polymorphisms in brain-derived neurotrophic factor gene and asthma risk: a meta-analysis. Inflamm Res. 2015;64:875-83 pubmed publisher
    ..Further well-designed case-control studies with larger sample size and more ethnic groups are needed to confirm these conclusions. ..
  7. Li M, Liu Y, Jin F, Sun X, Li Z, Liu Y, et al. Endothelin-1 induces hypoxia inducible factor 1? expression in pulmonary artery smooth muscle cells. FEBS Lett. 2012;586:3888-93 pubmed publisher
    ..Cells lacking RACK1 exhibited significant elevation of HIF1? protein level. Taken together, our study suggests that ET-1 suppressed proteasome-dependent HIF1? degradation by calcineurin-dependent RACK1 de-phosphorylation. ..
  8. Xie X, Ke R, Zhang Y, Wang G, Zhu Y, Hussian T, et al. Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis. Genet Mol Res. 2015;14:8516-25 pubmed publisher
    ..03-1.70). This meta-analysis suggests that the C allele of the IL-6 -174G>C might act as a COPD risk factor in Caucasians. Further well-designed case-control studies with larger sample sizes are needed to confirm these conclusions. ..
  9. Liu L, Pan Y, Song Y, Su X, Ke R, Yang L, et al. Activation of AMPK ?2 inhibits airway smooth muscle cells proliferation. Eur J Pharmacol. 2016;791:235-243 pubmed publisher

More Information

Publications21

  1. Pan Y, Liu L, Li S, Wang K, Ke R, Shi W, et al. Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms. Sci Rep. 2018;8:3624 pubmed publisher
  2. Ke R, Liu L, Zhu Y, Li S, Xie X, Li F, et al. Knockdown of AMPK?2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway. Int J Mol Sci. 2016;17: pubmed publisher
  3. Song Y, Wu Y, Su X, Zhu Y, Liu L, Pan Y, et al. Activation of AMPK inhibits PDGF-induced pulmonary arterial smooth muscle cells proliferation and its potential mechanisms. Pharmacol Res. 2016;107:117-124 pubmed publisher
  4. Li M, Zacharia J, Sun X, Wier W. Effects of siRNA knock-down of TRPC6 and InsP(3)R1 in vasopressin-induced Ca(2+) oscillations of A7r5 vascular smooth muscle cells. Pharmacol Res. 2008;58:308-15 pubmed publisher
  5. Xie X, Li S, Zhu Y, Liu L, Pan Y, Wang J, et al. MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells. Cell Tissue Res. 2017;369:527-539 pubmed publisher
    ..Taken together, our study demonstrates that ET-1 stimulates miR-27a/b expression by activation of the NF-κB pathway, which in turn results in PPARγ reduction and contributes to ET-1-induced PASMC proliferation. ..
  6. Li S, Pan Y, Ke R, Xie X, Zhai C, Shi W, et al. Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells. Sci Rep. 2017;7:6088 pubmed publisher
  7. Li F, Zhu Y, Wan Y, Xie X, Ke R, Zhai C, et al. Activation of PPAR? inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms. Eur J Pharmacol. 2017;814:324-334 pubmed publisher
    ..Our study indicates that HDAC1/miR-124/CDK4 axis plays an important role in PDGF-induced PASMC proliferation, and activation of PPAR? inhibits PASMC proliferation by acting on HDAC1 pathway. ..
  8. Xie X, Li S, Zhu Y, Liu L, Ke R, Wang J, et al. Egr-1 mediates leptin-induced PPAR? reduction and proliferation of pulmonary artery smooth muscle cells. Mol Biol Cell. 2018;29:356-362 pubmed publisher
  9. Zhu Y, Yan X, Zhai C, Yang L, Li M. Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis. BMC Pulm Med. 2017;17:193 pubmed publisher
    ..019; T vs. C: OR?=?1.320, 95% CI?=?1.016-1.713, P?=?0.037). The G allele of CHI3L1 rs4950928 might be a protective factor against the development of asthma. However, the rs10494132 polymorphism of CHIA might be a risk factor for asthma. ..
  10. Zhang D, Wang G, Han D, Zhang Y, Xu J, Lu J, et al. Activation of PPAR-? ameliorates pulmonary arterial hypertension via inducing heme oxygenase-1 and p21(WAF1): an in vivo study in rats. Life Sci. 2014;98:39-43 pubmed publisher
    ..In the present study, we intended to determine whether similar mechanisms have been involved in activation of PPAR-? inhibition of development of rat PAH model...
  11. Li M, Liu Y, Shi H, Zhang Y, Wang G, Xu J, et al. Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:961-8 pubmed publisher
    ..Taken together, our study suggests that simvastatin inhibits PASMCs proliferation by sequential upregulation of HO-1 and p21(WAF1) to benefit pulmonary hypertension...
  12. Li M, Li Z, Sun X, Yang L, Fang P, Liu Y, et al. Heme oxygenase-1/p21WAF1 mediates peroxisome proliferator-activated receptor-gamma signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells. FEBS J. 2010;277:1543-50 pubmed publisher
    ..Our study also indicates that rosiglitazone, a medicine widely used in the treatment of type 2 diabetes mellitus, has potential benefits for patients with pulmonary hypertension...