Wang Q, Li F, Shi W, Zhang Q, Wang J, Yan X, et al
. Overexpression of DJ-1 correlates with aggressive clinicopathological characteristics and poor prognosis in malignant tumors: a meta-analysis. Onco Targets Ther. 2018;11:3931-3942 pubmed publisher
..The diagnostic OR was 34.87, and the area under the summary receiver operating characteristic curve was 0.88. This meta-analysis demonstrated that DJ-1 was an important biomarker in tumor assessment and prognosis prediction. ..
Feng W, Wang J, Yan X, Zhai C, Shi W, Wang Q, et al
. Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy. Naunyn Schmiedebergs Arch Pharmacol. 2019;: pubmed publisher
..Taken together, paclitaxel inhibits pulmonary vascular remodeling by FoxO1-mediated autophagy suppression, suggesting that paclitaxel might be a novel therapeutic agent for the prevention and treatment of PAH. ..
Shi W, Zhai C, Feng W, Wang J, Zhu Y, Li S, et al
. Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation. Life Sci. 2018;210:140-149 pubmed publisher
..Resveratrol inhibits the MCT-induced PAH by targeting on SphK1 and reverses the downstream changes of SphK1, indicating that resveratrol might be a therapeutic agent for the prevention of PAH. ..
Zhai C, Shi W, Feng W, Zhu Y, Wang J, Li S, et al
. Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-?B-mediated autophagy activation. Life Sci. 2018;208:87-95 pubmed publisher
..Activation of AMPK prevents the development of PAH by targeting on NF-?B to suppress autophagy and vascular remodeling. ..
Li M, Dong X, Liu Y, Sun X, Li Z, He J. Inhibition of ubiquitin proteasome function suppresses proliferation of pulmonary artery smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:517-23 pubmed publisher
Xie X, Zhu Y, Zhang J, Zhai C, Feng W, Pan Y, et al
. Association between Val66Met polymorphisms in brain-derived neurotrophic factor gene and asthma risk: a meta-analysis. Inflamm Res. 2015;64:875-83 pubmed publisher
..Further well-designed case-control studies with larger sample size and more ethnic groups are needed to confirm these conclusions. ..
Li M, Liu Y, Jin F, Sun X, Li Z, Liu Y, et al
. Endothelin-1 induces hypoxia inducible factor 1? expression in pulmonary artery smooth muscle cells. FEBS Lett. 2012;586:3888-93 pubmed publisher
..Cells lacking RACK1 exhibited significant elevation of HIF1? protein level. Taken together, our study suggests that ET-1 suppressed proteasome-dependent HIF1? degradation by calcineurin-dependent RACK1 de-phosphorylation. ..
Xie X, Ke R, Zhang Y, Wang G, Zhu Y, Hussian T, et al
. Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis. Genet Mol Res. 2015;14:8516-25 pubmed publisher
..03-1.70). This meta-analysis suggests that the C allele of the IL-6 -174G>C might act as a COPD risk factor in Caucasians. Further well-designed case-control studies with larger sample sizes are needed to confirm these conclusions. ..
Liu L, Pan Y, Song Y, Su X, Ke R, Yang L, et al
. Activation of AMPK ?2 inhibits airway smooth muscle cells proliferation. Eur J Pharmacol. 2016;791:235-243 pubmed publisher