Kui Li

Summary

Publications

  1. pmc Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates
    Kui Li
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hepatology 55:666-75. 2012
  2. pmc Thermal stability and inactivation of hepatitis C virus grown in cell culture
    Hongshuo Song
    Department of Microbiology, Peking University Health Science Center, Beijing 100191, China
    Virol J 7:40. 2010
  3. pmc Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
    Eileen Foy
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:2986-91. 2005
  4. pmc Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I
    Rhea Sumpter
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
    J Virol 79:2689-99. 2005
  5. pmc Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent
    Nan Wang
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 285:6080-90. 2010
  6. pmc TRIM56 is an essential component of the TLR3 antiviral signaling pathway
    Yang Shen
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:36404-13. 2012
  7. pmc Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection
    Yueh Ming Loo
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:6001-6. 2006
  8. pmc Innate immune responses in hepatitis C virus infection
    Kui Li
    Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA
    Semin Immunopathol 35:53-72. 2013
  9. pmc TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
    Jie Wang
    Department of Microbiology, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    J Virol 85:3733-45. 2011
  10. pmc Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity
    W Shannon Orr
    University of Tennessee Health Science Center, Department of Surgery, Memphis, Tennessee, USA
    PLoS ONE 8:e51309. 2013

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates
    Kui Li
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hepatology 55:666-75. 2012
    ..Moreover, robust production of chemokines and inflammatory cytokines was also observed in primary human hepatocytes after stimulation with extracellular poly-I:C, a TLR3 ligand...
  2. pmc Thermal stability and inactivation of hepatitis C virus grown in cell culture
    Hongshuo Song
    Department of Microbiology, Peking University Health Science Center, Beijing 100191, China
    Virol J 7:40. 2010
    ..Hepatitis C virus (HCV) is a blood-borne flavivirus that infects many millions of people worldwide. Relatively little is known, however, concerning the stability of HCV and reliable procedures for inactivating this virus...
  3. pmc Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
    Eileen Foy
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:2986-91. 2005
    ..Our results demonstrate that these processes are amenable to restoration through pharmacologic inhibition of viral protease function...
  4. pmc Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I
    Rhea Sumpter
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
    J Virol 79:2689-99. 2005
    ..RIG-I is thus a pathogen receptor that regulates cellular permissiveness to HCV replication and, as an interferon-responsive gene, may play a key role in interferon-based therapies for the treatment of HCV infection...
  5. pmc Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent
    Nan Wang
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 285:6080-90. 2010
    ..Collectively, these data suggest that ZAP is a direct target gene of IRF3 action in cellular antiviral responses...
  6. pmc TRIM56 is an essential component of the TLR3 antiviral signaling pathway
    Yang Shen
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:36404-13. 2012
    ..Together, our data demonstrate TRIM56 is an essential component of the TLR3 antiviral signaling pathway and reveal a novel role for TRIM56 in innate antiviral immunity...
  7. pmc Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection
    Yueh Ming Loo
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:6001-6. 2006
    ..HCV protease inhibitors effectively prevent IPS-1 proteolysis, suggesting they may be capable of restoring this innate host response in clinical practice...
  8. pmc Innate immune responses in hepatitis C virus infection
    Kui Li
    Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA
    Semin Immunopathol 35:53-72. 2013
    ..In this review, we summarize recent advances in understanding innate immune responses to HCV infection, focusing on induction and effector mechanisms of the interferon antiviral response as well as the evasion strategies of HCV...
  9. pmc TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
    Jie Wang
    Department of Microbiology, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    J Virol 85:3733-45. 2011
    ..Together, our data demonstrate that TRIM56 is a novel antiviral host factor that restricts pestivirus infection...
  10. pmc Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity
    W Shannon Orr
    University of Tennessee Health Science Center, Department of Surgery, Memphis, Tennessee, USA
    PLoS ONE 8:e51309. 2013
    ..These data suggest that preventing the radiation-induced activation of the NF-κΒ pathway is a promising way to improve the antitumor efficacy of ionizing radiation and warrants clinical trials...
  11. ncbi request reprint Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    Eileen Foy
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Science 300:1145-8. 2003
    ..Thus, the NS3/4A protease represents a dual therapeutic target, the inhibition of which may both block viral replication and restore IRF-3 control of HCV infection...

Research Grants3

  1. Role of TLR3 Signaling in Control of HCV
    Kui Li; Fiscal Year: 2009
    ..abstract_text> ..
  2. Role of TLR3 Signaling in Control of HCV
    Kui Li; Fiscal Year: 2010
    ..abstract_text> ..