Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteinsHui Hua Li
Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
J Clin Invest 117:3211-23. 2007
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- Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex
Hui Hua Li
Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, NC 27599 7126, USA
J Clin Invest 114:1058-71. 2004
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- CHIP activates HSF1 and confers protection against apoptosis and cellular stress
Qian Dai
Carolina Cardiovascular Biology Center, and Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
EMBO J 22:5446-58. 2003
..CHIP exerts a central and unique role in tuning the response to stress at multiple levels by regulation of protein quality control and transcriptional activation of stress response signaling...
- Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
Ranjana Arya
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
J Cell Biol 167:1147-59. 2004
..These findings establish that MURF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy...
- Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I
Vishram Kedar
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
Proc Natl Acad Sci U S A 101:18135-40. 2004
..In cardiomyocytes, these processes may determine the balance between hypertrophic and antihypertrophic signals and the regulation of myocyte contractile responses in the setting of heart failure...
Regulation of the cytoplasmic quality control protein degradation pathway by BAG2Qian Dai
Carolina Cardiovascular Biology Center and the Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
J Biol Chem 280:38673-81. 2005
..The association of BAG2 with CHIP provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP...
- Comparative effects of paclitaxel and rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling
Cam Patterson
Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
Arterioscler Thromb Vasc Biol 26:1473-80. 2006
..However, the optimal payloads for stents are not clear, and the appropriate stent-based therapies for high-risk patients, such as diabetics, have not been clearly established...
- NIPBL mutational analysis in 120 individuals with Cornelia de Lange syndrome and evaluation of genotype-phenotype correlations
Lynette A Gillis
Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
Am J Hum Genet 75:610-23. 2004
..Analysis also suggested a trend toward a milder phenotype in individuals with missense mutations than in those with other types of mutations...
- Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
Hui Zeng
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang Ya School of Medicine, Hunan, P R China
Clin Chem Lab Med 45:1199-206. 2007
..The aim of the present study was to investigate whether histamine induces up-regulated expression of uncoupling protein 2 (UCP2) and fat acid-binding protein (aP2) in white adipocytes (differentiated 3T3-L1 cells)...
