Hui Hua Li

Summary

Publications

  1. pmc Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms
    Yue Hong Zheng
    Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China
    PLoS ONE 8:e83310. 2013
  2. pmc Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    Hui Hua Li
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Clin Invest 117:3211-23. 2007
  3. pmc Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex
    Hui Hua Li
    Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, NC 27599 7126, USA
    J Clin Invest 114:1058-71. 2004
  4. pmc Transcriptional effects of E3 ligase atrogin-1/MAFbx on apoptosis, hypertrophy and inflammation in neonatal rat cardiomyocytes
    Yong Zeng
    Department of Cardiology, Peking Union Medical Hospital, Beijing, China
    PLoS ONE 8:e53831. 2013
  5. doi request reprint Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice
    Hui Min Jiang
    Key Laboratory of Remodeling Related Cardiovascular Diseases, Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Ministry of Education, Beijing, China
    Am J Hypertens 26:1224-33. 2013
  6. pmc CHIP activates HSF1 and confers protection against apoptosis and cellular stress
    Qian Dai
    Carolina Cardiovascular Biology Center, and Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    EMBO J 22:5446-58. 2003
  7. pmc Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
    Ranjana Arya
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 167:1147-59. 2004
  8. doi request reprint Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells
    Jun Jie Li
    Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, No 10 Xitoutiao, You An Men, Beijing, China
    Cell Physiol Biochem 27:463-70. 2011
  9. pmc The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun
    Hui Hua Li
    Department of Pathology, School of Basic Medical Sciences, The Key Laboratory of Remodeling related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, China
    Am J Pathol 178:1043-58. 2011
  10. pmc Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I
    Vishram Kedar
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Proc Natl Acad Sci U S A 101:18135-40. 2004

Collaborators

Detail Information

Publications24

  1. pmc Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms
    Yue Hong Zheng
    Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China
    PLoS ONE 8:e83310. 2013
    ..In conclusion, these findings provide new insight into the multiple mechanisms of Notch signaling involved in AAA formation and suggest that γ-secretase inhibitor DBZ might be a novel therapeutic drug for treating AAAS. ..
  2. pmc Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    Hui Hua Li
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Clin Invest 117:3211-23. 2007
    ....
  3. pmc Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex
    Hui Hua Li
    Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, NC 27599 7126, USA
    J Clin Invest 114:1058-71. 2004
    ....
  4. pmc Transcriptional effects of E3 ligase atrogin-1/MAFbx on apoptosis, hypertrophy and inflammation in neonatal rat cardiomyocytes
    Yong Zeng
    Department of Cardiology, Peking Union Medical Hospital, Beijing, China
    PLoS ONE 8:e53831. 2013
    ....
  5. doi request reprint Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice
    Hui Min Jiang
    Key Laboratory of Remodeling Related Cardiovascular Diseases, Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Ministry of Education, Beijing, China
    Am J Hypertens 26:1224-33. 2013
    ..Thus, we sought to investigate the causal relation of G-CSF to neutrophil recruitment and cardiac fibrosis in C57BL/6J mice...
  6. pmc CHIP activates HSF1 and confers protection against apoptosis and cellular stress
    Qian Dai
    Carolina Cardiovascular Biology Center, and Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    EMBO J 22:5446-58. 2003
    ..CHIP exerts a central and unique role in tuning the response to stress at multiple levels by regulation of protein quality control and transcriptional activation of stress response signaling...
  7. pmc Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
    Ranjana Arya
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 167:1147-59. 2004
    ..These findings establish that MURF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy...
  8. doi request reprint Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells
    Jun Jie Li
    Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, No 10 Xitoutiao, You An Men, Beijing, China
    Cell Physiol Biochem 27:463-70. 2011
    ..The mRNA expression of atrogin-1 is induced by oxidative stress via p38 mitogen-activated protein kinase (p38 MAPK). However, the molecular mechanisms that regulate the stability of atrogin-1 protein remain unclear...
  9. pmc The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun
    Hui Hua Li
    Department of Pathology, School of Basic Medical Sciences, The Key Laboratory of Remodeling related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, China
    Am J Pathol 178:1043-58. 2011
    ..MuRF1's cardioprotection in I/R injury is attenuated in the presence of pharmacologic JNK inhibition in vivo, suggesting a prominent role of MuRF1's regulation of c-Jun in the intact heart...
  10. pmc Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I
    Vishram Kedar
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Proc Natl Acad Sci U S A 101:18135-40. 2004
    ..In cardiomyocytes, these processes may determine the balance between hypertrophic and antihypertrophic signals and the regulation of myocyte contractile responses in the setting of heart failure...
  11. doi request reprint Carboxyl terminus of heat shock protein 70-interacting protein inhibits angiotensin II-induced cardiac remodeling
    Kun Yang
    Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Am J Hypertens 25:994-1001. 2012
    ....
  12. doi request reprint Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor
    Hui Yang
    The Key Laboratory of Remodeling related Cardiovascular Diseases, Department of Pathology School of Basic Medical Sciences, Capital Medical University, Beijing, China
    Peptides 32:2108-15. 2011
    ..These findings suggest that Ang IV may have a protective effect on Ang II-induced cardiac injury and dysfunction and may be a novel therapeutic target for hypertensive heart disease...
  13. pmc Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways
    Chen Chen
    Beijing Anzhen Hospital, Affiliated to Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, The Key Laboratory of Remodelling related Cardiovascular Diseases, Ministry of Education, Beijing, China
    Immunology 142:307-19. 2014
    ..Taken together, our results demonstrate a novel role of E1 in Ang II-induced activation of DCs, and inhibition of E1 activity might be a potential therapeutic target for DC-mediated autoimmune diseases...
  14. pmc Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice
    Yuan Zhang
    Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e21104. 2011
    ..However, the role of Nrdp1 in DOX-induced cardiac injury remains to be determined...
  15. ncbi request reprint AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis
    Yu Liu
    Department of Pathology, Physiology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, No 10 Xitoutiao, You An Men, Beijing, 100069, China
    Apoptosis 19:1254-68. 2014
    ..These results may provide a novel therapeutic approach for ischemic heart diseases. ..
  16. doi request reprint Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
    Lina Song
    Department of Pathology, Physiology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, Ministry of Education, No 10 Xitoutiao You An Men, Beijing, 100069, China
    Apoptosis 19:567-80. 2014
    ..Our data indicated that 12/15-LOX inhibitor baicalein can prevent myocardial I/R injury by modulation of multiple mechanisms, and suggest that baicalein could represent a novel therapeutic drug for acute myocardial infarction. ..
  17. pmc Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction
    Fuli Zhu
    Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling related Cardiovascular Diseases, Ministry of Education, Beijing, China
    PLoS ONE 8:e74535. 2013
    ....
  18. doi request reprint Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells
    Yue Hong Zheng
    Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China
    J Cell Physiol 227:127-35. 2012
    ..Thus, inhibition of OPN-induced autophagy might be a potential therapeutic target in the treatment of AAA disease. J. Cell. Physiol. 227: 127-135, 2012. © 2011 Wiley Periodicals, Inc...
  19. ncbi request reprint Toll-like receptor-2 ligand peptidoglycan upregulates expression and ubiquitin ligase activity of CHIP through JNK pathway
    Yan Meng
    Department of Pathology, Physiology and Pathophysiology, AnZhen Hospital the Key Laboratory of Remodeling Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, Beijing, China
    Cell Physiol Biochem 32:1097-105. 2013
    ..However, it is unclear whether TLR2 agonist PGN regulates the expression and activation of CHIP...
  20. doi request reprint Epigallocatechin gallate inhibits angiotensin II-induced endothelial barrier dysfunction via inhibition of the p38 MAPK/HSP27 pathway
    Dan Yang
    Department of Pathology, Capital Medical University, Beijing, China
    Acta Pharmacol Sin 31:1401-6. 2010
    ..To investigate the effect of epigallocatechin gallate (EGCG) on angiotensin II (Ang II)-induced stress fiber formation and hyperpermeability in endothelial cells...
  21. ncbi request reprint Regulation of the cytoplasmic quality control protein degradation pathway by BAG2
    Qian Dai
    Carolina Cardiovascular Biology Center and the Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Biol Chem 280:38673-81. 2005
    ..The association of BAG2 with CHIP provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP...
  22. ncbi request reprint Comparative effects of paclitaxel and rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling
    Cam Patterson
    Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
    Arterioscler Thromb Vasc Biol 26:1473-80. 2006
    ..However, the optimal payloads for stents are not clear, and the appropriate stent-based therapies for high-risk patients, such as diabetics, have not been clearly established...
  23. pmc NIPBL mutational analysis in 120 individuals with Cornelia de Lange syndrome and evaluation of genotype-phenotype correlations
    Lynette A Gillis
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Am J Hum Genet 75:610-23. 2004
    ..Analysis also suggested a trend toward a milder phenotype in individuals with missense mutations than in those with other types of mutations...
  24. ncbi request reprint Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
    Hui Zeng
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang Ya School of Medicine, Hunan, P R China
    Clin Chem Lab Med 45:1199-206. 2007
    ..The aim of the present study was to investigate whether histamine induces up-regulated expression of uncoupling protein 2 (UCP2) and fat acid-binding protein (aP2) in white adipocytes (differentiated 3T3-L1 cells)...