Francisco Leyva-Cobian

Summary

Affiliation: Dept. of Immunology, Hospital Universitario "Marques de Valdecilla"
Location: Santander, Spain
Summary:
Head, Dept of Immunology in a university Hospital.
Clinical duties: Responsible of a general immunodiagnostic lab, HLA typing and immunodeficiencies
Main research activity: antigen presentation, Listeria-macrophage biology and HLA genetics
Publications:
1: Leyva Covián F.Eosinófilos. I. Morfología y estructura [Eosinophils: I. Morphology and structure]. Rev Clin Esp. 1975 Aug 31;138(4):293-300.
PMID: 1178978
2: Leyva Covián F. Eosinófilos. II. Quimiotaxis [Eosinophils. II. Chemotaxis]. Rev Clin Esp. 1976 Jun 15;141(5):403-410.
PMID: 948664
5: Leyva Covián F. Eosinófilos. III. Fagocitosis [Eosinophils. III. Phagocytosis]. Rev Clin Esp. 1977 Feb 15;144(3):167-171.
PMID: 320634
6: Toupin J, Leyva F, Lamoureux G. Transformation blastique par la PHA des coelomocytes de Lumbricus terrestris [PHA transformation of coelomocytes of Lubricus terrestris]. Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):29-32.
PMID: 848888
7: Lamoureux G, Toupin J, Leyva F. Un modèle de maladie à déficiences immunes spécifiques multiples: la sclérose en plaques [Multiple sclerosis: a multi-specific immune deficiency disease]. Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):531-536.
PMID: 848902
9: Leyva-Cobián F, Lamoureux G, Rojo-Ortega JM. Evolution and characterization of renal immune complexes deposition in mice bearing a syngeneic tumor. Ren Physiol. 1981;4(2-3):79-84.
PMID: 7029688
10: Arnáiz-Villena A, López-Larrea C, Leyva-Cobián F, Gil AB. Genetic independence between HLA and first component (C1q) of complement. Transplantation. 1981 Feb;31(2):139-140.
PMID: 7256826
11: Leyva-Cobián F, Moneo I, Mampaso F, Sánchez-Bayle M, Ecija JL, Bootello A. Familial C1q deficiency associated with renal and cutaneous disease. Clin Exp Immunol. 1981 Apr;44(1):173-180.
PMID: 6790209
12: Mampaso F, Ecija J, Fogué L, Moneo I, Gallego N, Leyva-Cobián F. Familial C1q deficiency in 3 siblings with glomerulonephritis and Rothmund-Thomson syndrome. Nephron. 1981;28(4):179-185.
PMID: 7029321
15: Mampaso F, Leyva-Cobián F, Martínez-Montero JC, Gonzalo A, Bellas C, Moneo I, Junquera E. Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits. Clin Nephrol. 1983 Feb;19(2):92-98.
PMID: 6188567
16: Leyva-Cobián F, Clerici N. Analysis of chemotactic factor generation in C1q-deficient sera. Int Arch Allergy Appl Immunol. 1983;71(2):151-155.
PMID: 6601627
19: Leyva-Cobián F, Clemente J. Phenotypic characterization and functional activity of human milk macrophages. Immunol Lett. 1984;8(5):249-256.
PMID: 6596292
20: Clerici N, Reboiras S, Fierro C, Leyva-Cobián F. Expression of Ia like (HLA-DR) antigens on human alveolar macrophages. Clin Exp Immunol. 1984 Nov;58(2):388-394.
PMID: 6209043
27: Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F. Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis. Proc Natl Acad Sci USA. 1986 Mar;83(5):1472-1475.
PMID: 2419908
28: Ibañez MD, Leyva Cobián F, Díaz Gómez ML. Generación del factor quimiotáctico de los eosinófilos de la anafilaxia en pacientes con urticaria a frigore y estudio de la desactivación quimiotáctica in vitro [Generation of eosinophil chemotactic factor of anaphylaxis in patients with cold urticaria and study of its in vitro chemotactic deactivation]. Med Clin (Barc). 1986 May 17;86(19):794-797.
PMID: 3736185
29: Clemente J, Clerici N, Espinosa MA, Leyva-Cobián F. Defective chemotactic response of human alveolar and colostral macrophages. Immunol Lett. 1986 Jun;12(5-6):271-276.
PMID: 3733158
30: Clerici N, Leyva-Cobián F, Reboiras S, Lázaro de Mercado P. Functional characteristics of human alveolar macrophages in lung cancer. Lung. 1986;164(6):355-364.
PMID: 3100876
31: Clemente J, Leyva-Cobián F, Hernández M, García-Alonso A. Intracellular immunoglobulins in human milk macrophages. Ultrastructural localization and factors affecting the kinetics of immunoglobulin release. Int Arch Allergy Appl Immunol. 1986;80(3):291-299.
PMID: 3522436
34: Fierro C, Valverde D, Leyva-Cobián F, Mampaso F. A simple method for detecting anti-tubular membrane antibodies in rat lymphoid cell cultures. J Clin Lab Immunol. 1987 Apr;22(4):201-203.
PMID: 3612756
35: Roy G, Rojo N, Leyva-Cobián F. Phenotypic changes in monocytes and alveolar macrophages in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). J Clin Lab Immunol. 1987 Jul;23(3):135-141.
PMID: 3118038
36: Giménez A, Leyva-Cobián F, Fierro C, Rio M, Bricio T, Mampaso F. Effect of cyclosporin A on autoimmune tubulointerstitial nephritis in the brown Norway rat. Clin Exp Immunol. 1987 Sep;69(3):550-556.
PMID: 3311496
40: Leyva-Cobián F, Flores R. A double staining method for the detection of a macrophage surface marker and nonspecific esterase activity. J Immunol Methods. 1988 Jun 28;111(1):147-151.
PMID: 2455751
41: Roy G, Pardo A, Leyva-Cobián F. Phenotypic and functional abnormalities in monocytes from patients with haemophilia A treated with factor VIII concentrates. Acta Haematol. 1988;79(1):26-32.
PMID: 2829491
42: Fernández-Luna JL, Leyva-Cobián F, Mollinedo F. Identification of the protein HC receptor. FEBS Lett. 1988 Aug 29;236(2):471-474.
PMID: 2457516
43: Leyva-Cobián F, Unanue ER. Intracellular interference with antigen presentation. J Immunol. 1988 Sep 1;141(5):1445-1450.
PMID: 3137257
44: Fernández-Luna JL, Leyva-Cobián F, Méndez E. Measurement of protein HC (alpha 1 microglobulin) and protein HC-IgA complex in different body fluids. J Clin Pathol. 1988 Nov;41(11):1176-1179.
PMID: 2463270
45: Harding CV, Leyva-Cobián F, Unanue ER. Mechanisms of antigen processing. Immunol Rev. 1988 Dec;106:77-92.
PMID: 3075593
46: Fernández-Luna JL, Méndez E, Leyva-Cobián F. Serum levels of protein HC and its IgA complex in malignant melanoma. Am J Clin Pathol. 1989 Jan;91(1):88-91.
PMID: 2462787
49: Del Pozo V, De Andrés B, Martín E, Cárdaba B, Fernández JC, Gallardo S, Tramón P, Leyva-Cobián F, Palomino P, Lahoz C. Eosinophil as antigen-presenting cell: activation of T cell clones and T cell hybridoma by eosinophils after antigen processing. Eur J Immunol. 1992 Jul;22(7):1919-1925
PMID: 1623930
50: Álvarez-Domínguez C, Carrasco-Marín E, Leyva-Cobián F. Role of complement component C1q in phagocytosis of Listeria monocytogenes by murine macrophage-like cell lines. Infect Immun. 1993 Sep;61(9):3664-3672.
PMID: 8359889
51: Leyva-Cobián F, Álvarez-Domínguez C, Carrasco-Marín E, López-Hoyos M, López-Mato MP. Los macrófagos como células efectoras de los parásitos intracelulares. En: Parasitología Molecular (L. Rivas López, M.C. López López, ed.) C.S.I.C., Madrid, p. 217-246, 1993.
ISBN:
52: Carrasco-Marín E, Álvarez-Domínguez C, Leyva-Cobián F. Wortmannin, an inhibitor of phospholipase D activation, selectively blocks major histocompatibility complex class II-restricted antigen presentation. Eur J Immunol. 1994 Sep;24(9):2031-2039.
PMID: 8088323
53: Leyva-Cobián F, Carrasco-Marín E. Participation of intracellular oxidative pathways in antigen processing by dendritic cells, B cells and macrophages. Immunol Lett. 1994 Dec;43(1-2):29-37.
PMID: 7737687
54: Ocejo-Vinyals JG, Leyva-Cobián F, Fernández-Luna JL. A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema. Mol Med. 1995 Sep;1(6):700-705.
PMID: 8529136
56: Leyva-Cobián F. Lesiones por reacciones de hipersensibilidad retardada. En: Medicina Interna (Rozman/Farreras, Ed.), XIII edición, Editorial Doyma, Barcelona, p. 2763-2767, 1995.
ISBN:
57: Carrasco-Marín E, Alvarez-Domínguez C, López-Mato P, Martínez-Palencia R, Leyva-Cobián F. Iron salts and iron-containing porphyrins block presentation of protein antigens by macrophages to MHC class II-restricted T cells. Cell Immunol. 1996 Aug 1;171(2):173-185.
PMID: 8806786
58: Carrasco-Marín E, Leyva-Cobián F. Presentación antigénica en un modelo experimental (ratones NOD) de diabetes autoinmune tipo I. En: Autoinmunidad: algunos aspectos básicos y clínicos. (Portolés Alonso, A, ed.) Real Academia de Farmacia, Madrid, p. 331-356, 1996.
ISBN:
59: Álvarez-Domínguez C, Vázquez-Boland JA, Carrasco-Marín E, López-Mato P, Leyva-Cobián F. Host cell heparan sulfate proteoglycans mediate attachment and entry of Listeria monocytogenes, and the listerial surface protein ActA is involved in heparan sulfate receptor recognition. Infect Immun. 1997 Jan;65(1):78-88.
PMID: 8975895
60: González-Fernández M, Carrasco-Marín E, Álvarez-Domínguez C, Outschoorn IM, Leyva-Cobián F. Inhibitory effects of thymus-independent type 2 antigens on MHC class II-restricted antigen presentation: comparative analysis of carbohydrate structures and the antigen presenting cell. Cell Immunol. 1997 Feb 25;176(1):1-13.
PMID: 9070312
61: Leyva-Cobián F, Outschoorn IM, Carrasco-Marín E, Álvarez-Domínguez C. The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells. Clin Immunol Immunopathol. 1997 Oct;85(1):1-15.
PMID: 9325063
62: Sánchez-Velasco P, Leyva-Cobián F. Los interferones y su biología. En: Melanoma maligno (A.J. Moyano, Ed.), Ediciones Ergón S.A., Madrid, p. 65-84, 1997.
ISBN:
63: Combarros O, Escribano J, Sánchez-Velasco P, Leyva-Cobián F, Oterino A, Leno C, Berciano J. Association of the HLA-A2 allele with an earlier age of onset of Alzheimers disease. Acta Neurol Scand. 1998 Aug;98(2):140-141.
PMID: 9724015
64: Carrasco-Marín E, Paz-Miguel JE, López-Mato P, Álvarez-Domínguez C, Leyva-Cobián F. Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells. Immunology. 1998 Nov;95(3):314-321.
PMID: 9824492
65: Sánchez-Velasco P, Escribano-de-Diego J, Martínez-de-Pancorbo M, Leyva-Cobián F. Caucasian Spanish-Basque Normal (Province of Vizcaya, Arratia Cluster). En: HLA 1998 (P.I. Terasaki, DW Gjertson, Ed.), UCLA Tissue Typing Laboratory, Los Angeles, p. 182, 1998.
ISBN:
66: Sánchez-Velasco P, Escribano-de-Diego J, Leyva-Cobián F. Caucasian Spanish Normal (Cantabrian Community, Cabuérniga Cluster). En: HLA 1998 (P.I. Terasaki & D.W. Gjertson, Ed.), UCLA Tissue Typing Laboratory, Los Angeles, p. 183, 1998.
ISBN:
67: Escribano-de-Diego J, Sánchez-Velasco P, Leyva-Cobián F. Caucasian Spanish Normal (Cantabrian Community). En: HLA 1998 (P.I. Terasaki & D.W. Gjertson, Ed.), UCLA Tissue Typing Laboratory, Los Angeles, p. 184, 1998.
ISBN:
68: Sánchez-Velasco P, Escribano-de-Diego J, Leyva-Cobián F. Caucasian Spanish Normal (Cantabrian Community, Pasiego Cluster). En: HLA 1998 (P.I. Terasaki & D.W. Gjertson, Ed.), UCLA Tissue Typing Laboratory, Los Angeles, p. 185, 1998.
ISBN:
69: Sánchez-Velasco P, Escribano de Diego J, Paz-Miguel JE, Ocejo-Vinyals G, Leyva-Cobián F. HLA-DR, DQ nucleotide sequence polymorphisms in the Pasiegos (Pas valleys, Northern Spain) and comparison of the allelic and haplotypic frequencies with those of other European populations. Tissue Antigens. 1999 Jan;53(1):65-73.
PMID:
70: Segundo C, Medina F, Rodríguez C, Martínez-Palencia R, Leyva-Cobián F, Brieva JA. Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood. 1999 Aug 1;94(3):1012-1020.
PMID:
71: Escribano-de-Diego J, Sánchez-Velasco P, Luzuriaga C, Ocejo-Vinyals JG, Paz-Miguel JE, Leyva-Cobián F. HLA class II immunogenetics and incidence of insulin-dependent diabetes mellitus in the population of Cantabria (Northern Spain). Hum Immunol. 1999 Oct;60(10):990-1000.
PMID:
72: Paz-Miguel JE, Flores R, Sánchez-Velasco P, Ocejo-Vinyals G, Escribano de Diego J, López de Rego J, Leyva-Cobián F. Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Downs syndrome. J Immunol. 1999 Nov 15;163(10):5399-5410.
PMID:
73: Gómez-Román JJ, Ocejo-Vinyals JG, Sánchez-Velasco P, Leyva-Cobián F, Val-Bernal JF. Presence of human herpesvirus 8 DNA sequences in renal transplantation-associated pleural Kaposi sarcoma. Arch Pathol Lab Med. 1999 Dec;123(12):1269-1273.
PMID:
74: Sánchez-Velasco P, Mendizabal L, Antón EM, Ocejo-Vinyals G, Jerez J, Leyva-Cobián F. Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype. Hum Immunol. 2000 Mar;61(3):314-319.
PMID:
75: Gómez-Román JJ, Ocejo-Vinyals G, Sánchez-Velasco P, Nieto EH, Leyva-Cobián F, Val-Bernal JF. Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor). Lab Invest. 2000 Jul;80(7):1121-1126.
PMID:
76: Ocejo-Vinyals JG, Lozano MJ, Sánchez-Velasco P, Escribano de Diego J, Paz-Miguel JE, Leyva-Cobián F. An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly. Arch Dis Child. 2000 Aug;83(2):165-169.
PMID:
77: Álvarez-Domínguez C, Carrasco-Marín E, López-Mato P, Leyva-Cobián F. The contribution of both oxygen and nitrogen intermediates to the intracellular killing mechanisms of C1q-opsonized Listeria monocytogenes by the macrophage-like IC-21 cell line. Immunology. 2000 Sep;101(1):83-89.
PMID:
78: Leyva-Cobián F. Lesiones por reacciones de hipersensibilidad retardada. En: Medicina Interna (Rozman/Farreras, Ed.), XIV edición. Editorial Harcourt, Madrid, p. 3172-3175, 2000.
ISBN:
79: Sánchez-Velasco P, Ocejo-Vinyals JG, Flores R, Gómez-Román JJ, Lozano MJ, Leyva-Cobián F. Simultaneous multiorgan presence of human herpesvirus 8 and restricted lymphotropism of Epstein-Barr virus DNA sequences in a human immunodeficiency virus-negative immunodeficient infant. J Infect Dis. 2001 Jan 15;183(2):338-342.
PMID:
80: Paz-Miguel JE, Pardo-Manuel de Villena F, Sánchez-Velasco P, Leyva-Cobián F. H2-haplotype-dependent unequal transmission of the 1716 translocation chromosome from Ts65Dn females. Mamm Genome. 2001 Jan;12(1):83-85.
PMID:
81: Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Hernández-Nieto E, Leyva-Cobián F, Val-Bernal JF. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol. 2001 May;25(5):624-629.
PMID:
82: Sánchez-Velasco P, Karadsheh NS, García-Martín A, Ruíz de Alegria C, Leyva-Cobián F. Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations. Hum Immunol. 2001 Sep;62(9):901-909.
PMID:
83: Sánchez-Velasco P, Leyva-Cobián F. The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations. Tissue Antigens. 2001 Oct;58(4):223-233.
PMID:
84: Martín M, Echevarria S, Leyva-Cobián F, Pereda I, López-Hoyos M. Limited immune reconstitution at intermediate stages of HIV-1 infection during one year of highly active antiretroviral therapy in antiretroviral-naive versus non-naive adults. Eur J Clin Microbiol Infect Dis. 2001 Dec;20(12):871-879.
PMID:
85: Ding Y, Saylors RL, Brown H, Parham DM, Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Leyva-Cobián F, Val-Bernal JF. Pulmonary inflammatory pseudotumor with HHV-8.
Am J Surg Pathol. 2002 Aug;26(8):1089-91; author reply 1091-2. Comment on: Am J Surg Pathol. 2001 May;25(5):624-629.
PMID:
87: Miñambres E, Cemborain A, Sánchez-Velasco P, Gandarillas M, Díaz-Regañón G, Sánchez-González U, Leyva-Cobián F. Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury. Crit Care Med. 2003 Mar;31(3):933-938.
PMID:
88: Sánchez-Velasco P, Gomez-Casado E, Martínez-Laso J, Moscoso J, Zamora J, Lowy E, Silvera C, Cemborain A, Leyva-Cobián F, Arnáiz-Villena A. HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians. Tissue Antigens. 2003 May;61(5):384-392.
PMID:
89: Maca-Meyer N, Sánchez-Velasco P, Flores C, Larruga JM, González AM, Oterino A, Leyva-Cobián F. Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain). Ann Hum Genet. 2003 Jul;67(Pt 4):329-339.
PMID:
90: Zarrabeitia MT, Riancho JA, Lareu MV, Leyva-Cobián F, Carracedo A. Significance of micro-geographical population structure in forensic cases: a bayesian exploration. Int J Legal Med. 2003 Oct;117(5):302-305.
PMID:
91: Oterino A, Valle N, Bravo Y, Muñoz P, Sánchez-Velasco P, Ruíz-Alegría C, Castillo J, Leyva-Cobián F, Vadillo A, Pascual J. MTHFR T677 homozygosis influences the presence of aura in migraineurs. Cephalalgia. 2004 Jun;24(6):491-494.
PMID:
93: Leyva-Cobián F. Lesiones por reacciones de hipersensibilidad retardada. En: “Medicina Interna” (Eds.: P. Farreras & C. Rozman), XV edición, Elsevier, Madrid, p. 2775-2778, 2004.
ISBN:
94: Prada-Delgado A, Carrasco-Marín E, Pena-Macarro C, Del Cerro-Vadillo E, Fresno-Escudero M, Leyva-Cobián F, Álvarez-Domínguez C. Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival. Traffic. 2005 Mar;6(3):252-265.
PMID:
95: Sánchez-Velasco P, Antón E, Muñoz D, Martínez-Quesada J, Ruíz de Alegria C, López-Hoyos M, García-Martín A, Jiménez I, Alonso ST, Duque S, Suárez A, Jerez J, Leyva-Cobián F. Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients. Hum Immunol. 2005 Jul;66(7):818-825.
PMID:
96: Oterino A, Valle N, Pascual J, Bravo Y, Muñoz P, Castillo J, Ruíz-Alegria C, Sánchez-Velasco P, Leyva-Cobián F, Cid C. Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele. Mol Brain Res. 2005 Sep 13;139(1):163-168.
PMID:
97: Carrasco-Marín E, Crespo-Facorro B, Leyva-Cobían F, Vazquez-Barquero JL. Aspectos inmunológicos en la psicosis. En: “Fases Iniciales de Enfermedades Mentales: Psicosis” (Eds: J.L. Vazquez-Barquero, B. Crespo-Facorro & A. Herranz), Editorial Masson S.A., p. 47-52, 2005.
ISBN:
98: Oterino A, Pascual J, Ruíz de Alegria C, Valle N, Castillo J, Bravo Y, González F, Sánchez-Velasco P, Cayón A, Leyva-Cobián F, Alonso-Arranz A, Muñoz P. Association of migraine and ESR1 G325C polymorphism. Neuroreport. 2006 Jan 23;17(1):61-64.
PMID:
99: del Cerro-Vadillo E, Madrazo-Toca F, Carrasco-Marín E, Fernández-Prieto L, Beck C, Leyva-Cobián F, Saftig P, Álvarez-Domínguez C. Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth. J Immunol. 2006 Feb 1;176(3):1321-1325.
PMID:
100: García-Astudillo LA, Leyva-Cobián F. Human herpesvirus-8 infection and Kaposis sarcoma after liver and kidney transplantation in different geographical areas of Spain. Transpl Immunol. 2006 Dec;17(1):65-69.
PMID:
101: Mata I, Crespo-Facorro B, Pérez-Iglesias R, Carrasco-Marín E, Arranz MJ, Pelayo-Terán JM, Leyva-Cobián F, Vázquez-Barquero JL. Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141(8):939-943.
PMID:
102: Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S,Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark Å,Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BPC, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She J-X, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobián F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue Antigens 2007 Aug;70(2):110-127.
PMID:
103: Rodrigo E, Sánchez-Velasco P, Ruíz JC, Fernández-Fresnedo G, López-Hoyos M, Piñera C, Palomar R, Gómez-Alamillo C, González-Cotorruelo J, Leyba-Cobián F, Arias M. Cytokine polymorphisms and risk of infection after kidney transplantation. Transplant Proc. 2007 Sep;39(7):2219-2221.
PMID:
104: Sánchez-Velasco P, Rodrigo E, Valero R, Ruíz JC, Fernández-Fresnedo G, López-Hoyos M, Piñera C, Palomar R, Leyva-Cobián F, Arias M. Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection. Clin Transplant. 2008 Jan-Feb;22(1):55-60.
PMID:
105: Roiz-Santiáñez R, Crespo-Facorro B, Pérez-Iglesias R, Pelayo-Terán JM, Carrasco-Marín E, Mata I, Sánchez E, Leyva-Cobián F, Vázquez-Barquero JL. Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis. Psychiatry Res. 2008 Feb 28;162(2):167-171.
PMID:
106: Álvarez-Domínguez C, Madrazo-Toca F, Fernández-Prieto L, Vandekerckhove J, Pareja E, Tobes R, Gómez-López MT, Del Cerro-Vadillo E, Fresno M, Leyva-Cobián F, Carrasco-Marín E. Characterization of a Listeria monocytogenes protein interfering with Rab5a. Traffic. 2008 Mar;9(3):325-337.
PMID:
107: Crespo-Facorro B, Carrasco-Marín E, Pérez-Iglesias R, Pelayo-Terán JM, Fernández-Prieto L, Leyva-Cobián F, Vázquez-Barquero JL. Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugs. Psychiatry Res. 2008 Mar 15;158(2):206-216.
PMID:
108: Pelayo-Terán JM, Crespo-Facorro B, Carrasco-Marín E, Pérez-Iglesias R, Mata I, Arranz MJ, Leyva-Cobián F, Vázquez-Barquero JL. Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):550-556.
PMID:
109: Leyva-Cobián F, Ocejo-Vinyals J-G. Lesiones por reacciones de hipersensibilidad retardada. En: “Medicina Interna” (Eds.: C. Rozman & F. Cardellach), XVI edición, Elsevier España, S.L., Barcelona, p. 2811-2815, 2009.
ISBN:
110: Sánchez-Castañón M, Baquero IC, Sánchez-Velasco P, Fariñas M-C, Ausín F, Leyva-Cobián F, Ocejo-Vinyals J-G. Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in Northern Spain. Int J Tuberc Lung Dis 2009 Apr; 13 (4): 480-485.
PMID:
111: Sánchez-Velasco P, Rodrigo E, Fernández-Fresnedo G, Ocejo-Vinyals JG, Ruiz JC, Arnau A, Leyva-Cobián F, Arias M. Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome. Transplant Proc. 2010 Oct;42(8):2854-2855.
PMID:

Publications

  1. ncbi request reprint Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain
    M Sánchez-Castañón
    Immunology Service, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Int J Tuberc Lung Dis 13:480-5. 2009
  2. ncbi request reprint Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype
    P Sanchez-Velasco
    Servicios de Inmunologia, Santander, Spain
    Hum Immunol 61:314-9. 2000
  3. ncbi request reprint Simultaneous multiorgan presence of human herpesvirus 8 and restricted lymphotropism of Epstein-Barr virus DNA sequences in a human immunodeficiency virus-negative immunodeficient infant
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    J Infect Dis 183:338-342. 2001
  4. pmc A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema
    J G Ocejo-Vinyals
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Mol Med 1:700-5. 1995
  5. ncbi request reprint Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor)
    J J Gómez-Roman
    Departamento de Anatomia Patologica, Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Am J Surg Pathol 25:624-9. 2001
  6. doi request reprint Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection
    Pablo Sánchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servico Cántabro de Salud, Santander, Spain
    Clin Transplant 22:55-60. 2008
  7. ncbi request reprint Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis
    G Thomson
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Tissue Antigens 70:110-27. 2007
  8. doi request reprint Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome
    P Sanchez-Velasco
    Service of Immunology, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    Transplant Proc 42:2854-5. 2010
  9. ncbi request reprint Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth
    Elida Del Cerro-Vadillo
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    J Immunol 176:1321-5. 2006
  10. ncbi request reprint Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele
    Agustin Oterino
    Services of Neurology, University Hospital Marqués de Valdecilla UC, Santander 39008, Spain
    Brain Res Mol Brain Res 139:163-8. 2005

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain
    M Sánchez-Castañón
    Immunology Service, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Int J Tuberc Lung Dis 13:480-5. 2009
    ....
  2. ncbi request reprint Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype
    P Sanchez-Velasco
    Servicios de Inmunologia, Santander, Spain
    Hum Immunol 61:314-9. 2000
    ..The data suggest that this haplotype can be considered to be a susceptibility factor for hypersensitivity to A. simplex antigens...
  3. ncbi request reprint Simultaneous multiorgan presence of human herpesvirus 8 and restricted lymphotropism of Epstein-Barr virus DNA sequences in a human immunodeficiency virus-negative immunodeficient infant
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    J Infect Dis 183:338-342. 2001
    ..This report is believed to be the first of multiorgan dissemination of HHV-8 in a primary immunodeficiency...
  4. pmc A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema
    J G Ocejo-Vinyals
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Mol Med 1:700-5. 1995
    ..Most of the dysfunctional proteins result from mutations involving the Arg-444 (the P-1 site of the reactive center) or amino acids NH2-terminal to the reactive center...
  5. ncbi request reprint Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor)
    J J Gómez-Roman
    Departamento de Anatomia Patologica, Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Am J Surg Pathol 25:624-9. 2001
    ..These differences may be related to either cell-specific or immunologic host factors...
  6. doi request reprint Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection
    Pablo Sánchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servico Cántabro de Salud, Santander, Spain
    Clin Transplant 22:55-60. 2008
    ..This assay identifies transplant patients at risk for infection or rejection, providing information which can guide immunosuppressive therapy...
  7. ncbi request reprint Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis
    G Thomson
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Tissue Antigens 70:110-27. 2007
    ..Our results show that meta-analyses and use of the P/C ratio and rankings thereof can be valuable in determining T1D risk factors at the haplotype and amino acid residue levels...
  8. doi request reprint Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome
    P Sanchez-Velasco
    Service of Immunology, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    Transplant Proc 42:2854-5. 2010
    ..The relationship between IL-6 polymorphisms and graft survival, cardiovascular events, and new-onset diabetes mellitus after kidney transplantation is controversial...
  9. ncbi request reprint Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth
    Elida Del Cerro-Vadillo
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    J Immunol 176:1321-5. 2006
    ..Based on infection experiments with mutant bacteria, in vitro degradation, and immunoprecipitation experiments, we suggest that a major target of cathepsin D is the main virulence factor listeriolysin O...
  10. ncbi request reprint Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele
    Agustin Oterino
    Services of Neurology, University Hospital Marqués de Valdecilla UC, Santander 39008, Spain
    Brain Res Mol Brain Res 139:163-8. 2005
    ..08; 95% CI = 1.3-7.4). We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1...
  11. ncbi request reprint Significance of micro-geographical population structure in forensic cases: a bayesian exploration
    Maria T Zarrabeitia
    Unit of Legal Medicine, Faculty of Medicine, University of Cantabria, 39011, Santander, Spain
    Int J Legal Med 117:302-5. 2003
    ..A bayesian analysis revealed that this had a significant impact on the estimation of the probability of identity in scenarios of low "a priori" odds of suspicion...
  12. ncbi request reprint Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury
    Eduardo Minambres
    Departamento de Medicina Intensiva, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Crit Care Med 31:933-8. 2003
    ....
  13. ncbi request reprint Limited immune reconstitution at intermediate stages of HIV-1 infection during one year of highly active antiretroviral therapy in antiretroviral-naive versus non-naive adults
    M Martin
    Immunology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Eur J Clin Microbiol Infect Dis 20:871-9. 2001
    ..This finding indicates a need for longer HIV suppression in order to achieve effective recovery of the immune system...
  14. ncbi request reprint The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Tissue Antigens 58:223-33. 2001
    ..These observations suggest a mixture of alleles in Svans from geographically distinct areas, and probably do not support a common ancestor for these Caucasian inhabitants and people from Northern Spain...
  15. ncbi request reprint Phenotypic changes in monocytes and alveolar macrophages in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC)
    G Roy
    Department of Immunology, , Madrid, Spain
    J Clin Lab Immunol 23:135-41. 1987
    ..5 +/- 10.9%, p less than 0.005) patients in comparison with controls (87.4 +/- 8.7%). Only alveolar M phi from one AIDS patient could be studied for LFA-1 antigen and this was into the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi request reprint MTHFR T677 homozygosis influences the presence of aura in migraineurs
    A Oterino
    Service of Neurology, University Hospital Marques de Valdecilla, Santander, Spain
    Cephalalgia 24:491-4. 2004
    ..Overall, however, there was no association between migraine and the C677T MTHFR polymorphism...
  17. ncbi request reprint Characterization of a Listeria monocytogenes protein interfering with Rab5a
    Carmen Alvarez-Dominguez
    Servicio de Inmunología and Instituto de Formación e Investigación Marqués de Valdecilla IFIMAV, Hospital Universitario Marques de Valdecilla, 39008 Santander, Spain
    Traffic 9:325-37. 2008
    ..Listeria GAPDH might be the first intracellular gram-positive enzyme targeted to Rab proteins with ADP-ribosylating ability and a putative novel virulence factor...
  18. ncbi request reprint Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival
    Amaya Prada-Delgado
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, 39008 Santander, Spain
    Traffic 6:252-65. 2005
    ..We cotransfected functional Rab5a GEF into this dominant negative mutant and restored normal LM intraphagosomal viability, Rab5a exchange and listericidal action of cathepsin-D...
  19. pmc Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis
    E Mendez
    Proc Natl Acad Sci U S A 83:1472-5. 1986
    ..These results suggest that protein HC and its IgA complex play physiological roles in the regulation of the inflammatory response...
  20. ncbi request reprint Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients
    Pablo Sánchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Hum Immunol 66:818-25. 2005
    ..02) were significantly increased in the former. These observations emphasize the importance of the DRB1*0103-DQA1*0101-DQB1*0501 haplotype as a strong candidate for susceptibility to vbPLA2 hypersensitivity, at least in our region...
  21. ncbi request reprint Association of migraine and ESR1 G325C polymorphism
    Agustin Oterino
    Services of Neurology, Universitary Hospital Marques de Valdecilla, Santander, Spain
    Neuroreport 17:61-4. 2006
    ..Women carrying the C352C genotype were over 3 times more likely to suffer from migraine than those carrying the G325G genotype. Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population...
  22. doi request reprint Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugs
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 158:206-16. 2008
    ..Thus, patients with a first episode of psychosis have inflammatory-like immunological function during early phases of the illness that it is independent of the antipsychotic treatment used...
  23. ncbi request reprint Human herpesvirus-8 infection and Kaposi's sarcoma after liver and kidney transplantation in different geographical areas of Spain
    Luis Alfonso García-Astudillo
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Transpl Immunol 17:65-9. 2006
    ..Time of KS diagnosis after transplant is significantly higher in kidney transplant patients (33.7 months) than in liver transplant recipients (10.4 months), indicating that the latter have a higher risk of developing KS...
  24. ncbi request reprint HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians
    P Sanchez-Velasco
    Department of Immunology and Molecular Biology, Hosp 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 61:384-92. 2003
    ..These populations have been compared with neighbouring ones and other Mediterraneans by using neighbour-joining dendrograms and plane genetic distances...
  25. ncbi request reprint Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Hum Immunol 62:901-9. 2001
    ....
  26. ncbi request reprint Pulmonary inflammatory pseudotumor with HHV-8
    Yiling Ding
    Am J Surg Pathol 26:1089-91; author reply 1091-2. 2002
  27. ncbi request reprint Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Am J Med Genet B Neuropsychiatr Genet 141:939-43. 2006
    ..These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs...