F Markus Leweke

Summary

Publications

  1. ncbi request reprint Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Res 94:29-36. 2007
  2. doi request reprint Cannabis and psychiatric disorders: it is not only addiction
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Addict Biol 13:264-75. 2008
  3. doi request reprint Schizophrenia
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Curr Top Behav Neurosci 1:387-96. 2009
  4. doi request reprint Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia
    Dagmar Koethe
    Dept of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    Eur Arch Psychiatry Clin Neurosci 259:195-202. 2009
  5. doi request reprint Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Br J Psychiatry 194:371-2. 2009
  6. pmc Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
    J Neural Transm 116:301-5. 2009
  7. ncbi request reprint Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Schizophr Res 88:142-50. 2006
  8. ncbi request reprint The initial prodrome of schizophrenia: different duration, different underlying deficits?
    Frauke Schultze-Lutter
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Compr Psychiatry 48:479-88. 2007
  9. ncbi request reprint Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse
    Daniela Muhl
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
    Naunyn Schmiedebergs Arch Pharmacol 387:691-5. 2014
  10. ncbi request reprint Cannabis-associated psychosis: current status of research
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    CNS Drugs 18:895-910. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Res 94:29-36. 2007
    ..In the present study we examined whether cannabis use may alter such a mechanism...
  2. doi request reprint Cannabis and psychiatric disorders: it is not only addiction
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Addict Biol 13:264-75. 2008
    ..With numerous open questions and controversial results, further research is required to specify and extend the findings in this area, which provides a promising target for novel pharmacotherapeutic interventions...
  3. doi request reprint Schizophrenia
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Curr Top Behav Neurosci 1:387-96. 2009
    ..A possible neurobiological mechanism for the deleterious influence of cannabis use in schizophrenia is discussed, involving the disruption of endogenous cannabinoid signalling and function...
  4. doi request reprint Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia
    Dagmar Koethe
    Dept of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    Eur Arch Psychiatry Clin Neurosci 259:195-202. 2009
    ..70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia...
  5. doi request reprint Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Br J Psychiatry 194:371-2. 2009
    ..Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia...
  6. pmc Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
    J Neural Transm 116:301-5. 2009
    ..Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation...
  7. ncbi request reprint Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Schizophr Res 88:142-50. 2006
    ....
  8. ncbi request reprint The initial prodrome of schizophrenia: different duration, different underlying deficits?
    Frauke Schultze-Lutter
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Compr Psychiatry 48:479-88. 2007
    ....
  9. ncbi request reprint Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse
    Daniela Muhl
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
    Naunyn Schmiedebergs Arch Pharmacol 387:691-5. 2014
    ..These alterations resemble those obtained for marijuana smokers that had stopped cannabis use only few days before testing and may be implicated in the pathogenesis of disorders associated with long-term cannabis use. ..
  10. ncbi request reprint Cannabis-associated psychosis: current status of research
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    CNS Drugs 18:895-910. 2004
    ..Long-term psychotherapeutic treatment options involve case management strategies and are mainly based on specialised psychotherapeutic programmes to encourage cannabis users to stop their use of the drug...
  11. doi request reprint Cerebrospinal fluid diagnostics in first-episode schizophrenia
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 261:529-30. 2011
    ..3%) cases of mild to moderate headache or local pain at the puncture site. Our results underline the value of lumbar puncture in the clinical workup of first-episode patients with suspected schizophrenia...
  12. ncbi request reprint Source-reconstruction of event-related fields reveals hyperfunction and hypofunction of cortical circuits in antipsychotic-naive, first-episode schizophrenia patients during Mooney face processing
    Davide Rivolta
    Department of Neurophysiology, Max Planck Institute for Brain Research and Ernst Strüngmann Institute ESI for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main 60528, Germany, School of Psychology, University of East London, London E15 4LZ, United Kingdom, Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Politecnica de Madrid, Madrid 28223, Spain, MEG Unit, Brain Imaging Centre, Johann Wolfgang Goethe University, Frankfurt am Main 60529, Germany, Institute for Medical Psychology, Johann Wolfgang Goethe University, Frankfurt am Main 60054, Germany, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne 50924, Germany, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany, Department of General Psychiatry, Medical Faculty Heidelberg, Heidelberg University, Heidelberg 69115, Germany, Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, Frankfurt am Main 60438, Germany, and Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, United Kingdom
    J Neurosci 34:5909-17. 2014
    ....
  13. doi request reprint Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapine
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Neuropsychopharmacol 14:43-51. 2011
    ..Furthermore, the present data give further support and validity for the suitability of chronic pubertal cannabinoid administration as an animal model for aspects of schizophrenia...
  14. ncbi request reprint Antibodies to infectious agents in individuals with recent onset schizophrenia
    F Markus Leweke
    Dept of Psychiatry and Psychotherapy, University of Cologne, Cologne, France
    Eur Arch Psychiatry Clin Neurosci 254:4-8. 2004
    ..These findings indicate that infectious agents may play a role in the etiopathogenesis of some cases of schizophrenia...
  15. ncbi request reprint Oxcarbazepine as an adjunct for schizophrenia
    F Markus Leweke
    Am J Psychiatry 161:1130-1. 2004
  16. ncbi request reprint Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
    Andrea Giuffrida
    Department of Pharmacology, University of California, Irvine, CA, USA
    Neuropsychopharmacology 29:2108-14. 2004
    ..452, P = 0.001). The results suggest that anandamide elevation in acute paranoid schizophrenia may reflect a compensatory adaptation to the disease state...
  17. ncbi request reprint Peptide correlation: a means to identify high quality quantitative information in large-scale proteomic studies
    Emanuel Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    J Sep Sci 30:2190-7. 2007
    ..The peptide correlation analysis we present here provides an intuitive and simple procedure to obtain a high quality quantitative information from proteomics data...
  18. ncbi request reprint Clozapine alone versus clozapine and risperidone for refractory schizophrenia
    Guido Grass
    N Engl J Med 354:1846-8; author reply 1846-8. 2006
  19. pmc Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia
    Elaine Holmes
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    PLoS Med 3:e327. 2006
    ....
  20. pmc Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis
    Jeffrey T J Huang
    Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 3:e428. 2006
    ..The identification of biological markers (so-called biomarkers) of psychosis is a fundamental step towards a better understanding of the pathogenesis of psychosis and holds the potential for more objective testing methods...
  21. ncbi request reprint Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal
    Udo Bonnet
    Rheinische Kliniken Essen, Klinik für Psychiatrie und Psychotherapie und Klinik für abhängiges Verhalten und Suchtmedizin, Universitat Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:434-8. 2007
    ..Delayed beneficial effects of gabapentin on mood were frequently reported in various patient populations. This is the first controlled study which addressed acute effects of gabapentin on mood...
  22. ncbi request reprint 2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia
    Sudhakaran Prabakaran
    Institute of Biotechnology and Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, United Kingdom
    J Proteome Res 6:141-9. 2007
    ..If peripheral cells can be used as a disease surrogate, promising new investigative avenues could be explored...
  23. ncbi request reprint CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspects
    Jeffrey T J Huang
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    J Sep Sci 30:214-25. 2007
    ..Our strategy provides a simple and controlled method for CSF biomarker discovery...
  24. ncbi request reprint Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples
    Yishai Levin
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    J Sep Sci 30:2198-203. 2007
    ..Using this approach, we identified 1709 serum proteins covering a dynamic range of over three orders of magnitude. We believe that label-free quantitative proteomics is especially suited for biomarker discovery in large sample sets...