Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis useF Markus Leweke
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Res 94:29-36. 2007
..In the present study we examined whether cannabis use may alter such a mechanism...
Cannabis and psychiatric disorders: it is not only addictionF Markus Leweke
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Addict Biol 13:264-75. 2008
..With numerous open questions and controversial results, further research is required to specify and extend the findings in this area, which provides a promising target for novel pharmacotherapeutic interventions...
- Schizophrenia
F Markus Leweke
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Curr Top Behav Neurosci 1:387-96. 2009
..A possible neurobiological mechanism for the deleterious influence of cannabis use in schizophrenia is discussed, involving the disruption of endogenous cannabinoid signalling and function...
- Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia
Dagmar Koethe
Dept of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 259:195-202. 2009
..70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia...
- Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis
Dagmar Koethe
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Br J Psychiatry 194:371-2. 2009
..Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia...
Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluidDagmar Koethe
Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
J Neural Transm 116:301-5. 2009
..Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation...
- Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness
Dagmar Koethe
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Schizophr Res 88:142-50. 2006
....
- The initial prodrome of schizophrenia: different duration, different underlying deficits?
Frauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Compr Psychiatry 48:479-88. 2007
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- Cerebrospinal fluid diagnostics in first-episode schizophrenia
Laura Kranaster
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, J5, 68159, Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 261:529-30. 2011
..3%) cases of mild to moderate headache or local pain at the puncture site. Our results underline the value of lumbar puncture in the clinical workup of first-episode patients with suspected schizophrenia...
- Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapine
F Markus Leweke
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Int J Neuropsychopharmacol 14:43-51. 2011
..Furthermore, the present data give further support and validity for the suitability of chronic pubertal cannabinoid administration as an animal model for aspects of schizophrenia...
- Cannabis-associated psychosis: current status of research
F Markus Leweke
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
CNS Drugs 18:895-910. 2004
..Long-term psychotherapeutic treatment options involve case management strategies and are mainly based on specialised psychotherapeutic programmes to encourage cannabis users to stop their use of the drug...
- Antibodies to infectious agents in individuals with recent onset schizophrenia
F Markus Leweke
Dept. of Psychiatry and Psychotherapy, University of Cologne, Cologne, France
Eur Arch Psychiatry Clin Neurosci 254:4-8. 2004
..These findings indicate that infectious agents may play a role in the etiopathogenesis of some cases of schizophrenia...
- Oxcarbazepine as an adjunct for schizophrenia
F Markus Leweke
Am J Psychiatry 161:1130-1. 2004
- Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
Andrea Giuffrida
Department of Pharmacology, University of California, Irvine, CA, USA
Neuropsychopharmacology 29:2108-14. 2004
..452, P = 0.001). The results suggest that anandamide elevation in acute paranoid schizophrenia may reflect a compensatory adaptation to the disease state...
- Clozapine alone versus clozapine and risperidone for refractory schizophrenia
Guido Grass
N Engl J Med 354:1846-8; author reply 1846-8. 2006
- Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia
Elaine Holmes
Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
PLoS Med 3:e327. 2006
..Furthermore, our results suggest that the initiation of antipsychotic treatment during a first psychotic episode may influence treatment response and/or outcome...
- Peptide correlation: a means to identify high quality quantitative information in large-scale proteomic studies
Emanuel Schwarz
Institute of Biotechnology, University of Cambridge, Cambridge, UK
J Sep Sci 30:2190-7. 2007
..The peptide correlation analysis we present here provides an intuitive and simple procedure to obtain a high quality quantitative information from proteomics data...
- Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples
Yishai Levin
Institute of Biotechnology, University of Cambridge, Cambridge, UK
J Sep Sci 30:2198-203. 2007
..Using this approach, we identified 1709 serum proteins covering a dynamic range of over three orders of magnitude. We believe that label-free quantitative proteomics is especially suited for biomarker discovery in large sample sets...
- Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis
Jeffrey T-J Huang
Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom
PLoS Med 3:e428. 2006
..Further studies are required to validate the clinical effectiveness and disease specificity of the identified biomarkers...
- CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspects
Jeffrey T J Huang
Institute of Biotechnology, University of Cambridge, Cambridge, UK
J Sep Sci 30:214-25. 2007
..Our strategy provides a simple and controlled method for CSF biomarker discovery...
- 2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia
Sudhakaran Prabakaran
Institute of Biotechnology and Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, United Kingdom
J Proteome Res 6:141-9. 2007
..If peripheral cells can be used as a disease surrogate, promising new investigative avenues could be explored...
- Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal
Udo Bonnet
Rheinische Kliniken Essen, Klinik für Psychiatrie und Psychotherapie und Klinik für abhängiges Verhalten und Suchtmedizin, Universitat Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
Prog Neuropsychopharmacol Biol Psychiatry 31:434-8. 2007
..Delayed beneficial effects of gabapentin on mood were frequently reported in various patient populations. This is the first controlled study which addressed acute effects of gabapentin on mood...
