A case series of recombinant platelet factor 4 for heparin reversal after cardiopulmonary bypassLinda Demma
Department of Anesthesiology and Critical Care Medicine, Emory University Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
Anesth Analg 115:1273-8. 2012
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- Multidisciplinary approach to the challenge of hemostasis
Jerrold H Levy
Department of Anesthesiology, Division of Cardiothoracic Anesthesiology and Critical Care, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Anesth Analg 110:354-64. 2010
..Because of the complexities of maintaining hemostatic balance, advances in hemostasis research and continuing communication across specialties are required to improve patient care and outcomes...
- The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients
Heezoo Kim
Department of Anesthesiology, Emory University School of Medicine, 3B South, 1364 Clifton Rd, Atlanta, GA 30322, USA
Anesth Analg 115:244-52. 2012
..Therefore, we evaluated the in vitro effects of this novel agent on ACT values using 3 different point-of-care instruments with kaolin or celite as an activator...
- The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients
Solomon Aronson
Department of Anesthesiology, Duke University Medical Center, Duke South, Room 102 Baker House, Durham, NC 27710, USA
Anesth Analg 107:1110-21. 2008
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- Blood coagulation: hemostasis and thrombin regulation
Kenichi A Tanaka
Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Emory University School of Medicine, Atlanta, GA 30322, USA
Anesth Analg 108:1433-46. 2009
..In this review, we focus on the regulatory mechanisms of hemostasis and thrombin generation using multiple, simplified models of coagulation...
- Recognition of heparin-induced thrombocytopenia and initiation of argatroban therapy after cardiothoracic surgery in the intensive care unit
Linda J Demma
Department of Anesthesiology, Emory University School of Medicine and Emory Healthcare, Atlanta, GA, USA
J Thorac Cardiovasc Surg 143:1213-8. 2012
..Current data regarding the safety and efficacy of argatroban in the postoperative cardiothoracic surgical patient in the intensive care setting are limited...
- Improved clot formation by combined administration of activated factor VII (NovoSeven) and fibrinogen (Haemocomplettan P)
Kenichi A Tanaka
Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA 30322, USA
Anesth Analg 106:732-8, table of contents. 2008
..However, hemostasis also depends on coagulation factors, including fibrinogen, which stabilizes platelet plugs at sites of vascular injury. We compared the hemostatic effects of rFVIIa, fibrinogen, or their combination...
Heparin anticoagulation in patients undergoing off-pump and on-pump coronary bypass surgeryKenichi A Tanaka
Division of Cardiothoracic Anesthesia, Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Road, N E, Atlanta, GA 30322, USA
J Anesth 21:297-303. 2007
..The authors analyzed the coagulation data of patients who underwent on-pump coronary artery bypass graft (CABG) or off-pump coronary artery bypass surgery (OPCAB) in a randomized prospective trial...
- In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry
Kenichi A Tanaka
Department of Anesthesiology, Emory University School of Medicine, Emory University Hospital, Atlanta, Georgia, USA
Thromb Haemost 101:827-33. 2009
..In conclusion, RB006 inhibits thrombin generation and clot formation in a concentration-dependent manner. It is feasible to monitor RB006 and its reversal with RB007 using aPTT, low range-ACT, and thrombin-activated TEG...
- In vitro comparative study of hemostatic components in warfarin-treated and fibrinogen-deficient plasma
Brady Rumph
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Cardiothorac Vasc Anesth 24:408-12. 2010
..The authors hypothesized that various hemostatic products may differently affect viscoelastic clot formation depending on their respective procoagulant activity and fibrinogen content...
- The effects of argatroban on thrombin generation and hemostatic activation in vitro
Kenichi A Tanaka
Department of Anesthesiology, Emory University Hospital, 1364 Clifton Road N E, Atlanta, GA 30322, USA
Anesth Analg 99:1283-9; table of contents. 2004
..In summary, we showed that argatroban, unlike heparin, could effectively reduce thrombin generation regardless of AT levels and could prolong ACTs in vitro at clinically used concentrations...
- A diagnosis of heparin-induced thrombocytopenia with combined clinical and laboratory methods in cardiothoracic surgical intensive care unit patients
Linda J Demma
Department of Anesthesiology, Emory University, Atlanta, GA, USA
Anesth Analg 113:697-702. 2011
..Prompt diagnosis is crucial because cessation of heparin and treatment with alternative anticoagulation can reduce the risk of thromboembolic events...
- Bleeding and management of coagulopathy
Roman M Sniecinski
Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, GA 30322, USA
J Thorac Cardiovasc Surg 142:662-7. 2011
..A general multi-modal approach is required and recommendations are made for the management of bleeding and coagulopathy in cardiac surgical patients...
- Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass
Roman Sniecinski
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA
Anesth Analg 106:713-8, table of contents. 2008
..We hypothesized that low levels of AT might lead to increased in vitro thrombin generation when procoagulant factors are added to the patient's plasma after CPB...
- The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations
Daniel Bolliger
Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Anesth Analg 111:601-8. 2010
..Protamine sulfate is the antidote for heparin, but in excess it exerts weak anticoagulation...
- Thrombin-activated thrombelastography for evaluation of thrombin interaction with thrombin inhibitors
Taro Taketomi
Division of Cardiothoracic Anesthesia, Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood Coagul Fibrinolysis 18:761-7. 2007
..The modified thrombelastography technique using nonrecalcified whole blood may be useful in evaluating the extent and reversibility of thrombin blockade with direct or indirect thrombin inhibitors...
- A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery
Satoru Ogawa
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 52:14-22. 2012
..The assessment of whole blood coagulation using rotation thromboelastometry (ROTEM) was compared to coagulation tests routinely performed during cardiac surgery...
- Fibrinogen and hemostasis: a primary hemostatic target for the management of acquired bleeding
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA
Anesth Analg 114:261-74. 2012
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- Effects of recombinant activated factor VII on thrombin-mediated feedback activation of coagulation
Taro Taketomi
Division of Cardiothoracic Anesthesia, Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA
Blood Coagul Fibrinolysis 19:135-41. 2008
..We conclude that rFVIIa therapy does not compensate for increased susceptibility to fibrinolysis due to lack of factor(s) necessary for the formation of tenase and prothrombinase...
- The effect of aprotinin on activated protein C-mediated downregulation of endogenous thrombin generation
Kenichi A Tanaka
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA
Br J Haematol 134:77-82. 2006
..Our results showed that, even though endogenous PC level is decreased after CPB, it retains its activity in the presence of thrombomodulin, and aprotinin has limited inhibitory effect on APC generation...
- Antithrombin affects hemostatic response to recombinant activated factor VII in factor VIII deficient plasma
Fania Szlam
Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA 30322, USA
Anesth Analg 106:719-24, table of contents. 2008
..We hypothesize that reduced AT concentrations would increase the procoagulant effects of rFVIIa in FVIII-deficient plasma...
- Thrombin generation assay and viscoelastic coagulation monitors demonstrate differences in the mode of thrombin inhibition between unfractionated heparin and bivalirudin
Kenichi A Tanaka
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia USA
Anesth Analg 105:933-9, table of contents. 2007
..In this study, we sought to determine if similar increases in activated partial thromboplastin time or activated clotting time due to heparin or bivalirudin would reflect the same degree of inhibition of thrombin formation...
- Heparin-induced thrombocytopenia and cardiac surgery
Jerrold H Levy
Emory University School of Medicine, Atlanta, GA 30322, USA
Curr Opin Anaesthesiol 23:74-9. 2010
..When there is clinical suspicion of HIT, heparin should be discontinued and alternative anticoagulation should be considered, as well as laboratory evaluation for HIT...
- Elevated factor VIII enhances thrombin generation in the presence of factor VIII-deficiency, factor XI-deficiency or fondaparinux
Fania Szlam
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Thromb Res 127:135-40. 2011
..The role of factor VIII in modulating hemostasis/thrombosis was investigated in plasma models of hypocoagulable and hypercoagulable state using thrombin generation (TG) assay...
- Managing clotting: a North American perspective
Roman M Sniecinski
Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA
Curr Opin Anaesthesiol 25:74-9. 2012
..An understanding of hemostasis and therapeutic approaches, especially those in our current clinical settings, is crucial in managing these patients...
- Effects of prothrombin complex concentrate and recombinant activated factor VII on vitamin K antagonist induced anticoagulation
Kenichi A Tanaka
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA
Thromb Res 122:117-23. 2008
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- Does perioperative systolic blood pressure variability predict mortality after cardiac surgery? An exploratory analysis of the ECLIPSE trials
Solomon Aronson
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Anesth Analg 113:19-30. 2011
..We tested the hypothesis that systolic blood pressure (SBP) variability in patients undergoing cardiac surgery is associated with 30-day mortality...
- Perioperative hemostatic management of patients treated with vitamin K antagonists
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322 1061, USA
Anesthesiology 109:918-26. 2008
..Although many patients who require rapid reversal of warfarin are currently treated with fresh frozen plasma, PCCs should be considered as an alternative therapy...
- A novel method to assess platelet inhibition by eptifibatide with thrombelastograph
Nobuyuki Katori
Department of Anesthesiology, Emory University Hospital, 1364 Clifton Rd, N.E, Atlanta, GA 30322, USA
Anesth Analg 99:1794-9, table of contents. 2004
..Additionally, the time to achieve maximum MA was much shorter for batroxobin TEG than for kaolin TEG. We conclude that the batroxobin-modified TEG is a sensitive method that detects platelet inhibition induced by eptifibatide...
- Reducing thrombotic complications in the perioperative setting: an update on heparin-induced thrombocytopenia
Jerrold H Levy
Emory University School of Medicine, Atlanta, Georgia 30322, USA
Anesth Analg 105:570-82. 2007
..If the surgery cannot be delayed until HIT antibodies have disappeared, intraoperative alternative anticoagulation is recommended...
- Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa
Roman M Sniecinski
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA
Anesth Analg 104:763-5. 2007
..Changes in the Jehovah's Witness (JW) blood refusal policy now give members the personal choice to accept certain processed fractions of blood, such as factor concentrates and cryoprecipitate...
- The effects of platelet count on clot retraction and tissue plasminogen activator-induced fibrinolysis on thrombelastography
Nobuyuki Katori
Department of Anesthesiology, Emory University School of Medcine, 1364 Clifton Rd, N.E, Atlanta, GA 30322, USA
Anesth Analg 100:1781-5. 2005
..In conclusion, we have shown that the decrease in amplitude at 30 and 60 min can be due to platelet-mediated clot retraction and can be attenuated by sample pretreatment with abciximab, which interrupts platelet-fibrin(ogen) binding...
- Effects of antithrombin and heparin cofactor II levels on anticoagulation with Intimatan
Kenichi A Tanaka
Department of Anesthesiology, The Emory Healthcare, Atlanta, Georgia, USA
Thromb Haemost 94:808-13. 2005
..With the absence of both cofactors, neither agent alone or in combination had any effect on thrombin generation. We conclude that Intimatan may be an effective adjunct to heparin therapy under low AT conditions...
- Management of surgical hemostasis: systemic agents
Jerrold H Levy
Department of Anesthesiology, Emory University Hospital, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Vascular 16:S14-21. 2008
..This article discusses systemic pharmacologic prohemostatic agents (aprotinin, lysine analogues, protamine, desmopressin, and recombinant factor VIIa)...
- A double-blind, placebo-controlled trial of epsilon-aminocaproic acid for reducing blood loss in coronary artery bypass grafting surgery
Mutsuhito Kikura
Department of Anesthesiology, Emory University School of Medicine, Emory University Hospital, The Emory Clinic, Atlanta, GA, USA
J Am Coll Surg 202:216-22; quiz A44-5. 2006
..This information is useful for deciding on a therapy for hemostasis in cardiac surgery...
Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathwaysRong Jiang
Cardiothoracic Research Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, Georgia, USA
J Surg Res 169:319-27. 2011
..This study tested the hypothesis that FXa can up-regulate TF on vascular endothelial cells by a mitogen-activated protein kinase (MAPK)- and NF-κB-dependent pathway...
- Pharmacologic methods to reduce perioperative bleeding
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia 30322, USA
Transfusion 48:31S-38S. 2008
- Massive transfusion coagulopathy
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, GA 30322, USA
Semin Hematol 43:S59-63. 2006
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- Prohemostatic treatment in cardiac surgery
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA
Semin Thromb Hemost 38:237-43. 2012
..This article will discuss pharmacological agents including antifibrinolytics, protamine, desmopressin, fibrinogen, purified protein concentrates, recombinant factor VIIa, factor XIII, and topical agents used in cardiac surgery...
- Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1
Jerrold H Levy
Cardiothoracic Anesthesiology and Critical Care, Emory University Hospital, Atlanta, Georgia 30322, USA
Anesth Analg 105:918-25, table of contents. 2007
..In this randomized, double-blind, placebo-controlled multicenter trial we evaluated the efficacy and tolerability of clevidipine in treating preoperative hypertension...
- Evaluation of a novel kallikrein inhibitor on hemostatic activation in vitro
Kenichi A Tanaka
Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Emory University School of Medicine, Emory University Hospital, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Thromb Res 113:333-9. 2004
..For evaluation of coagulation during DX-88 therapy, the use of PT or tissue factor-activated TEG may be preferable...
- Safety of aprotinin in heparinized and nonheparinized patients
Jerrold H Levy
Department of Anesthesiology, Emory Healthcare, Atlanta, GA 30322, USA
J Cardiothorac Vasc Anesth 18:38S-42S. 2004
- Overview of clinical efficacy and safety of pharmacologic strategies for blood conservation
Jerrold H Levy
Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Am J Health Syst Pharm 62:S15-9. 2005
..The pharmacologic management of hemostasis in patients undergoing surgery with cardiopulmonary bypass is discussed...
- Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin
Fania Szlam
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Thromb Res 125:432-7. 2010
..Recently, a novel agent, anti-IXa aptamer, RB006, has been developed. Therefore, we have evaluated the in vitro effects of this agent in warfarin plasma...
- Recombinant factor VIIa in patients with coagulopathy secondary to anticoagulant therapy, cirrhosis, or severe traumatic injury: review of safety profile
Jerrold H Levy
Department of Anesthesiology, Emory University Hospital, Atlanta, Georgia, USA
Transfusion 46:919-33. 2006
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- Repletion of factor XIII following cardiopulmonary bypass using a recombinant A-subunit homodimer. A preliminary report
Jerrold H Levy
Department of Cardiothoracic Anesthesiology and Critical Care, Emory University School of Medicine, Emory Healthcare, Atlanta, Georgia, USA
Thromb Haemost 102:765-71. 2009
..rFXIII-A(2), in doses from 11.9 IU/kg up to 50 IU/kg, was well tolerated. For post-operative FXIII replenishment, 35 IU/kg of rFXIII-A(2) may be the most appropriate dose...
- The anticoagulated patient: strategies for effective blood loss management
Jerrold H Levy
Emory University School of Medicine, Atlanta, GA 30322, USA
Surgery 142:S71-7. 2007
..Agents used to manage bleeding, including aprotinin, lysine analogs, desmopressin, and recombinant factor VIIa, are discussed...
- Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding
Kenichi A Tanaka
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Platelets 15:325-32. 2004
..For monitoring clopidogrel, it is necessary to perform more specific platelet function tests (aggregometry or platelet count ratio) using ADP as an activator...
- A phase III, double-blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass
Michael S Avidan
Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
Anesthesiology 102:276-84. 2005
..The study evaluated the efficacy of recombinant human antithrombin (rhAT) for restoring heparin responsiveness in heparin resistant patients undergoing cardiac surgery...
- The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss
Jerrold H Levy
Emory University School of Medicine, Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, GA, USA
Expert Opin Biol Ther 3:509-17. 2003
..A Biologics License Application for HBOC-201 is currently under review by the US FDA...
- Prohemostatic agents to prevent perioperative blood loss
Jerrold H Levy
Emory University Hospital, Atlanta, Georgia 30322, USA
Semin Thromb Hemost 34:439-44. 2008
..This article will discuss pharmacologic prohemostatic agents (antifibrinolytics, protamine, desmopressin, fibrinogen, purified protein concentrates, recombinant factor VIIa)...
- Case 4-2007. Aprotinin-induced cardiovascular collapse after a negative test dose in a patient scheduled for repeat mitral valve surgery
Phillip L Beaulieu
Department of Anesthesiology, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
J Cardiothorac Vasc Anesth 21:597-601. 2007
- Etiology and assessment of hypercoagulability with lessons from heparin-induced thrombocytopenia
Roman M Sniecinski
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA
Anesth Analg 112:46-58. 2011
..In this article, we review the etiology, risks, and assessment of thrombophilia, with emphasis on the clinical lessons learned from heparin-induced thrombocytopenia...
- Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant factor VIIa (NovoSeven)
Kenichi A Tanaka
Department of Anesthesiology, Emory University School of Medicine and Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia 30322, USA
Anesthesiology 98:1513-5. 2003
- Efficacy and safety of aprotinin in cardiac surgery
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, GA, USA
Orthopedics 27:s659-62. 2004
..One of the major adverse effects is anaphylaxis that occurs on re-exposure to aprotinin...
- Novel oral anticoagulants: implications in the perioperative setting
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA
Anesthesiology 113:726-45. 2010
..The impact of the new agents will be influenced by the balance between efficacy and safety, improved convenience, and potential cost-effectiveness benefits...
- Invited commentary
Jerrold H Levy
Emory Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
Ann Thorac Surg 84:986-7. 2007
- Heparin-induced thrombocytopenia, a prothrombotic disease
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Road N E, Atlanta, GA 30322, USA
Hematol Oncol Clin North Am 21:65-88. 2007
..With prompt recognition, diagnosis, and treatment of HIT, the clinical outcomes and health economic burdens of this prothrombotic disease are improved significantly...
- Evaluation and management of bleeding during cardiac surgery
Jerrold H Levy
Department of Anesthesiology, Emory University Hospital, 1364 Clifton Rd, N E, Atlanta, GA 30322, USA
Curr Hematol Rep 4:368-72. 2005
..The ability to reduce blood product transfusions and to decrease operative times and reexploration rates favorably affects patient outcomes, availability of blood products, and overall health care costs...
- Regulation of thrombin activity--pharmacologic and structural aspects
Kenichi A Tanaka
Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Emory Healthcare, 1364 Clifton Road N E, Atlanta, GA 30322, USA
Hematol Oncol Clin North Am 21:33-50. 2007
..The aim of this article is to review endogenous serine protease inhibitors and novel antithrombotic agents in relation to pharmacologic regulation of thrombin...
- A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
Elliott Bennett-Guerrero
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Anesth Analg 104:378-83. 2007
..In this study we assessed the safety of eritoran administration in patients undergoing cardiac surgery and obtained preliminary efficacy data for the prophylaxis of endotoxin-mediated surgical complications...
- Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes
Bruce D Spiess
Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, Virginia 23298 0695, USA
Transfusion 44:1143-8. 2004
..The current analysis investigates the hypothesis that PLT transfusion is associated with adverse outcomes associated with coronary artery bypass graft surgery (CABG)...
- Inflammatory response to cardiopulmonary bypass
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia, USA
Ann Thorac Surg 75:S715-20. 2003
..Novel agents are under investigation to further improve outcomes in cardiac surgical patients...
- Aprotinin: a pharmacologic overview
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, GA, USA
Orthopedics 27:s653-8. 2004
..The pharmacologic properties of aprotinin may lead clinicians to consider this therapy for use as a hemostatic and anti-inflammatory agent in surgeries beyond its established use in coronary artery bypass graft surgery...
- Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Road N E, Atlanta, GA 30322, USA
Hematol Oncol Clin North Am 21:89-101. 2007
..Strategies for cardiac surgical patients during cardiopulmonary bypass include administration of either lysine analogs, such as epsilon aminocaproic acid and tranexamic acid, or the serine protease inhibitor aprotinin...
- Novel pharmacologic approaches to reduce bleeding
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia 30322, USA
Can J Anaesth 50:S26-30. 2003
- Early experience with activated recombinant factor VII for intractable hemorrhage after cardiovascular surgery
Michael E Halkos
Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
Ann Thorac Surg 79:1303-6. 2005
..CONCLUSIONS: When used as rescue therapy for intractable hemorrhage after cardiovascular surgery, rFVIIa may be effective in promoting hemostasis, preventing reexploration, and reducing transfusion requirements...
- Anaphylaxis during cardiac surgery: implications for clinicians
Jerrold H Levy
Emory Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
Anesth Analg 106:392-403. 2008
..In this review, we focus on recent concepts in understanding the incidence and management approaches for patients at risk for anaphylaxis in the operating room setting, with an emphasis on cardiac surgical patients...
- Hemostatic agents
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia 30322, USA
Transfusion 44:58S-62S. 2004
- Tissue factor-activated thromboelastograms in children undergoing cardiac surgery: baseline values and comparisons
Bruce E Miller
Department of Anesthesiology, Emory University School of Medicine, Children s Healthcare of Atlanta at Egleston, Atlanta, Georgia 30322, USA
Anesth Analg 97:1289-93. 2003
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- The role of thrombin and protease-activated receptors in pain mechanisms
Paul S Garcia
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA
Thromb Haemost 103:1145-51. 2010
..This review highlights several pathways in the mediation of pain sensation that can be influenced by thrombin...
- Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine and Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia 30322, USA
Anesthesiology 96:1095-102. 2002
....
- Management of systemic and pulmonary hypertension
Jerrold H Levy
Department of Anesthesiology, Emory University School of Medicine, and Cardiothoracic Anesthesiology, Emory Healthcare, Atlanta, Georgia, USA
Tex Heart Inst J 32:467-71. 2005
..Treatment for vasospasm is usually empiric; pharmacologic options include nitroglycerin, but dihydropyridine calcium channel blockers and phosphodiesterase inhibitors should also be considered...
- Hereditary angioedema: current and emerging treatment options
Jerrold H Levy
FAHA, Department of Anesthesiology, Emory University Hospital, Atlanta, GA 30322, USA
Anesth Analg 110:1271-80. 2010
..Specific attention is given to the perioperative management of patients with HAE...
- Treatment of persistent tachycardia with dexmedetomidine during off-pump cardiac surgery
Sibylle Ruesch
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Anesth Analg 95:316-8, table of contents. 2002
..IMPLICATIONS: After unsuccessful treatment of intraoperative tachycardia with esmolol during off-pump revascularization, heart rate was successfully reduced with a bolus and infusion of dexmedetomidine...
- Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial
Jerrold H Levy
Emory University Hospital, Atlanta, GA, USA
J Thorac Cardiovasc Surg 124:35-42. 2002
..In a third of cases, HBOC-201 eliminated the need for red blood cell transfusion, although substantial doses were needed to produce this modest degree of blood conservation...
- Clevidipine in adult cardiac surgical patients: a dose-finding study
James M Bailey
Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Anesthesiology 96:1086-94. 2002
..The purpose of this study was to investigate the pharmacodynamics and pharmacokinetics of a short-acting calcium channel antagonist, clevidipine, in the treatment of hypertension in postoperative cardiac surgical patients...
- Intravenous milrinone in cardiac surgery
Jerrold H Levy
Division of Cardiothoracic Anesthesiology and Critical Care, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia, USA
Ann Thorac Surg 73:325-30. 2002
..Low-dose milrinone may have antiinflammatory properties and potentially can improve splanchnic perfusion...
