G A Levy

Summary

Publications

  1. ncbi request reprint 12-month follow-up analysis of a multicenter, randomized, prospective trial in de novo liver transplant recipients (LIS2T) comparing cyclosporine microemulsion (C2 monitoring) and tacrolimus
    Gary Levy
    University Health Network, Toronto General Hospital, Toronto, ON, Canada
    Liver Transpl 12:1464-72. 2006
  2. ncbi request reprint Reduced mortality with right-lobe living donor compared to deceased-donor liver transplantation when analyzed from the time of listing
    S A Shah
    Multi Organ Transplant Unit, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 7:998-1002. 2007
  3. ncbi request reprint Neoral C2 monitoring in solid organ transplantation
    G A Levy
    Multi Organ Transplantation Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transplant Proc 36:392S-395S. 2004
  4. ncbi request reprint Targeted delivery of ribavirin improves outcome of murine viral fulminant hepatitis via enhanced anti-viral activity
    Gary A Levy
    Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Hepatology 43:581-91. 2006
  5. ncbi request reprint Safety, tolerability, and efficacy of everolimus in de novo liver transplant recipients: 12- and 36-month results
    Gary Levy
    Multiorgan Transplantation, Toronto General Hospital, Toronto, Ontario, Canada
    Liver Transpl 12:1640-8. 2006
  6. ncbi request reprint Long-term immunosuppression and drug interactions
    G A Levy
    Multi Organ Transplant Program, Toronto General Hospital, University of Toronto, Ontario, Canada
    Liver Transpl 7:S53-9. 2001
  7. doi request reprint Progress in transplantation
    Gary A Levy
    University of Toronto Transplantation Institute, Toronto General Hospital, Toronto, Ontario, Canada
    Ther Drug Monit 32:246-9. 2010
  8. doi request reprint Adult living liver donors have excellent long-term medical outcomes: the University of Toronto liver transplant experience
    L Adcock
    Liver Transplant Program, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 10:364-71. 2010
  9. ncbi request reprint Biliary strictures in 130 consecutive right lobe living donor liver transplant recipients: results of a Western center
    S A Shah
    Department of Surgery, Multi Organ Transplatation Unit, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 7:161-7. 2007
  10. ncbi request reprint A pharmacoeconomic analysis of Neoral without intravenous cyclosporine in liver transplantation in Canada
    A W Hemming
    Department of Surgery, Toronto Hospital, University of Toronto, Canada
    Clin Transplant 12:425-9. 1998

Collaborators

Detail Information

Publications45

  1. ncbi request reprint 12-month follow-up analysis of a multicenter, randomized, prospective trial in de novo liver transplant recipients (LIS2T) comparing cyclosporine microemulsion (C2 monitoring) and tacrolimus
    Gary Levy
    University Health Network, Toronto General Hospital, Toronto, ON, Canada
    Liver Transpl 12:1464-72. 2006
    ..More patients required antidiabetic therapy with tacrolimus regardless of diabetic status at baseline...
  2. ncbi request reprint Reduced mortality with right-lobe living donor compared to deceased-donor liver transplantation when analyzed from the time of listing
    S A Shah
    Multi Organ Transplant Unit, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 7:998-1002. 2007
    ..80%; p < 0.001). To our knowledge, this is the first report to document a survival advantage at time of listing for RLDLT over DDLT...
  3. ncbi request reprint Neoral C2 monitoring in solid organ transplantation
    G A Levy
    Multi Organ Transplantation Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transplant Proc 36:392S-395S. 2004
  4. ncbi request reprint Targeted delivery of ribavirin improves outcome of murine viral fulminant hepatitis via enhanced anti-viral activity
    Gary A Levy
    Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Hepatology 43:581-91. 2006
    ....
  5. ncbi request reprint Safety, tolerability, and efficacy of everolimus in de novo liver transplant recipients: 12- and 36-month results
    Gary Levy
    Multiorgan Transplantation, Toronto General Hospital, Toronto, Ontario, Canada
    Liver Transpl 12:1640-8. 2006
    ..In conclusion, this study demonstrates that everolimus in combination with oral cyclosporine had an acceptable safety and tolerability profile, paving the way for additional studies in this transplant indication...
  6. ncbi request reprint Long-term immunosuppression and drug interactions
    G A Levy
    Multi Organ Transplant Program, Toronto General Hospital, University of Toronto, Ontario, Canada
    Liver Transpl 7:S53-9. 2001
    ..4. Individual patient immunosuppressive protocols should be developed. 5. Drug interactions are common and the source of significant morbidity...
  7. doi request reprint Progress in transplantation
    Gary A Levy
    University of Toronto Transplantation Institute, Toronto General Hospital, Toronto, Ontario, Canada
    Ther Drug Monit 32:246-9. 2010
    ....
  8. doi request reprint Adult living liver donors have excellent long-term medical outcomes: the University of Toronto liver transplant experience
    L Adcock
    Liver Transplant Program, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 10:364-71. 2010
    ..This prospective study suggests that living liver donation can be performed safely without any serious late medical complications and suggests that long-term follow-up may contribute to favorable donor outcomes...
  9. ncbi request reprint Biliary strictures in 130 consecutive right lobe living donor liver transplant recipients: results of a Western center
    S A Shah
    Department of Surgery, Multi Organ Transplatation Unit, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 7:161-7. 2007
    ..D-D anastomosis is safe after RLDLT and provides access for future endoscopic therapy in cases of leak or stricture. When presented with multiple bile ducts, ductoplasty should be considered to reduce the potential chance of stricture...
  10. ncbi request reprint A pharmacoeconomic analysis of Neoral without intravenous cyclosporine in liver transplantation in Canada
    A W Hemming
    Department of Surgery, Toronto Hospital, University of Toronto, Canada
    Clin Transplant 12:425-9. 1998
    ..The savings achieved with Neoral proved robust on sensitivity analysis. The change of practice to an induction immunosuppression regimen of Neoral without i.v. CsA has achieved a cost savings in adult liver transplantation at our center...
  11. doi request reprint The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis
    M C Melnyk
    Multi Organ Transplant Program, University of Toronto and Toronto General Hospital, Toronto, ON, Canada
    Scand J Rheumatol 40:269-78. 2011
    ..We hypothesized that expression of mFGL2 in inflamed synovium contributes to the fibrin deposition and subsequent inflammation in arthritis...
  12. ncbi request reprint Selective use of older adults in right lobe living donor liver transplantation
    S A Shah
    Multi Organ Transplant Unit, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 7:142-50. 2007
    ..95). Early experience with the use of selected older adults (>44 years) for RLDLT is encouraging, but may be associated with a higher rate of biliary complications in the recipient...
  13. ncbi request reprint Pharmacokinetics and tolerability of 40-0-[2-hydroxyethyl]rapamycin in de novo liver transplant recipients
    G A Levy
    Toronto General Hospital, Ontario, Canada
    Transplantation 71:160-3. 2001
    ..CsA pharmacokinetics were not affected by single-dose RAD coadministration. RAD capsules administered in single doses of 7.5 mg were well tolerated and safe...
  14. ncbi request reprint Results of lis2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation
    Gary Levy
    University Health Network, The Toronto Hospital, Toronto, Canada
    Transplantation 77:1632-8. 2004
    ..The incidence of adverse events is comparable except for a significantly higher incidence of diabetes mellitus and diarrhea in the tacrolimus group. Both agents are effective primary immunosuppressants in liver transplant recipients...
  15. pmc Post-transplant recurrent hepatitis B viral liver disease. Viral-burden, steatoviral, and fibroviral hepatitis B
    M J Phillips
    Department of Pathology, Hospital for Sick Children, Toronto Hospital, Ontario, Canada
    Am J Pathol 140:1295-308. 1992
    ..Steatosis is not usually considered a feature of HBV liver pathology. These results suggest that more than one type of posttransfusion recurrent hepatitis B liver disease exists pathologically...
  16. doi request reprint Adult right-lobe living liver donors: quality of life, attitudes and predictors of donor outcomes
    D A Dubay
    Liver Transplant Unit, Multiorgan Transplant Program, University Health Network, Toronto, Ontario, Canada
    Am J Transplant 9:1169-78. 2009
    ..Risk factors identified in this study should be prospectively evaluated in future research...
  17. ncbi request reprint Ancrod improves survival in murine systemic lupus erythematosus
    E H Cole
    Department of Medicine, University of Toronto, Ontario, Canada
    Kidney Int 37:29-35. 1990
    ..This was associated with a decrease in plasma PCA inducing activity and with an inhibitory effect on PCA induction. These results suggest that PCA contributes to injury in murine lupus glomerulonephritis by promoting fibrin deposition...
  18. ncbi request reprint Procoagulants in fetus rejection: the role of the OX-2 (CD200) tolerance signal
    D A Clark
    Departments of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, Mucosal Immunology Group, Immunology and Inflammation Program, McMaster University, Rm 3V39, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Semin Immunol 13:255-63. 2001
    ..Similarities and differences between findings in the mouse and human, and the potential evolutionary significance of mechanisms affecting reproductive success are reviewed...
  19. ncbi request reprint Patient management by Neoral C(2) monitoring: an international consensus statement
    Gary Levy
    Multiorgan Transplant Program, Toronto General Hospital, 621 University Avenue, 10NU 116, Toronto, Ontario M5G 2C4, Canada
    Transplantation 73:S12-8. 2002
  20. doi request reprint Normothermic acellular ex vivo liver perfusion reduces liver and bile duct injury of pig livers retrieved after cardiac death
    M U Boehnert
    Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada
    Am J Transplant 13:1441-9. 2013
    ..524 ± 187 U/L, p < 0.05), with similar bile production (2.5 ± 1.2 cc/h vs. 2.8 ± 1.4 cc/h; p = 0.2). NEVLP improved HA perfusion and decreased markers of liver duct injury in DCD grafts...
  21. ncbi request reprint C2 monitoring strategy for optimising cyclosporin immunosuppression from the Neoral formulation
    G A Levy
    Multi Organ Transplantation, The Toronto Hospital, Toronto, Ontario, Canada
    BioDrugs 15:279-90. 2001
    ....
  22. ncbi request reprint New strategies to optimize clinical outcomes with cyclosporine in liver transplantation
    G A Levy
    Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Gastroenterol Hepatol 25:289-93. 2002
  23. pmc Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis
    G A Levy
    Multi Organ Transplant Program, Toronto General Hospital and the University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 156:1217-25. 2000
    ..Fibrin stained positively in these areas and was confirmed by electron microscopy. These studies define a unique prothrombinase gene (HFGL2) and implicate its importance in the pathogenesis of fulminant viral hepatitis...
  24. ncbi request reprint Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids
    Sarah E Ward
    Toronto General Research Institute and University of Toronto, ON, Canada
    Antivir Ther 10:263-75. 2005
    ....
  25. ncbi request reprint Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study
    Mona R Loutfy
    North York General Hospital, Toronto General Research Institute, Toronto, Ontario
    JAMA 290:3222-8. 2003
    ..Severe acute respiratory syndrome (SARS) is a new clinical entity for which no effective therapeutic strategy has been developed...
  26. ncbi request reprint Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia
    M Knackstedt
    Toronto General Hospital Research Institute, University of Toronto, Ontario, Canada
    Am J Reprod Immunol 46:196-210. 2001
    ..CONCLUSIONS: Activation of fg12 prothrombinase by Th1-type cytokines in pregnancy may lead to spontaneous abortion, or in ongoing pregnancy, to pre-eclampsia and/or IUGR...
  27. ncbi request reprint HDAF transgenic pig livers are protected from hyperacute rejection during ex vivo perfusion with human blood
    Yigang Luo
    Transplantation Technologies Inc, London, Ontario, Canada
    Xenotransplantation 9:36-44. 2002
    ....
  28. ncbi request reprint Living-donor right hepatectomy with or without inclusion of middle hepatic vein: comparison of morbidity and outcome in 56 patients
    Mark S Cattral
    Department of Surgery, Multiorgan Transplantation Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 4:751-7. 2004
    ..We conclude that including the MHV with living-donor right lobe grafts can be performed safely in most donors...
  29. doi request reprint The difference in the fibrosis progression of recurrent hepatitis C after live donor liver transplantation versus deceased donor liver transplantation is attributable to the difference in donor age
    Nazia Selzner
    Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, Canada
    Liver Transpl 14:1778-86. 2008
    ..In conclusion, donor age, rather than the transplant approach, determines the progression of recurrent hepatitis C after LT. LDLT, allowing for the selection of younger donors, may particularly benefit hepatitis C patients...
  30. ncbi request reprint Interactions between cytomegalovirus, human herpesvirus-6, and the recurrence of hepatitis C after liver transplantation
    Atul Humar
    Department of Medicine, Multi Organ Transplantation, Toronto General Hospital, University Health Network, Department of Microbiology, University of Toronto, Toronto, Canada
    Am J Transplant 2:461-6. 2002
    ..031). In conclusion, HHV-6 and CMV infection and viral load were not associated with increased overall rates of HCV recurrence or HCV viral load after liver transplantation but may be associated with more severe forms of recurrence...
  31. pmc Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome
    Xue Zhong Ma
    Multi Organ Transplant Program, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    J Virol 84:12419-28. 2010
    ..The results further suggest that targeting the proteasome may be an effective new treatment for severe coronavirus infections...
  32. ncbi request reprint Clinical impact of human herpesvirus 6 infection after liver transplantation
    Atul Humar
    Toronto General Hospital, Toronto, Ontario, Canada, M5G 2C4
    Transplantation 73:599-604. 2002
    ..The objective of this study was to determine the clinical impact of HHV-6 infection after liver transplantation including both direct and indirect effects...
  33. ncbi request reprint Severe Acute Respiratory Syndrome (SARS) in a liver transplant recipient and guidelines for donor SARS screening
    Deepali Kumar
    Infectious Diseases and Multi Organ Transplant, University Health Network, University of Toronto, Ontario, Canada
    Am J Transplant 3:977-81. 2003
    ..As SARS spreads throughout the world, it may become an increasingly significant problem for transplant patients and programs...
  34. ncbi request reprint Ex vivo and extracorporeal perfusion with hDAF pig kidneys
    Yigang Luo
    Department of Surgery, The University of Western Ontario, London, Ontario, Canada
    Xenotransplantation 10:410-21. 2003
    ..We conclude that hDAF transgene protects against HAR, allowing the pig kidney to function normally while perfused with human blood, and that extracorporeal perfusion using hDAF pig kidneys is a safe procedure in baboons...
  35. ncbi request reprint Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, University of Toronto, Toronto, Ontario, Canada
    Liver Transpl 12:1584-93. 2006
    ..The ROC for this risk index was 0.79. MBT in liver transplantation surgery can be accurately predicted by 7 readily available preoperative predictors...
  36. ncbi request reprint Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection
    Qin Ning
    Laboratory of Infectious Immunology, Department of Infectious Disease, Institute of Immunology, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 174:7403-11. 2005
    ..These data collectively suggest that fgl2 accounts for the fibrin deposition seen in both experimental and human allograft rejection and provide a rationale for targeting fgl2 as adjunctive therapy to treat allograft rejection...
  37. ncbi request reprint Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B
    Chuan Long Zhu
    Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 11:6936-40. 2005
    ..To evaluate the expression of fibrinogen-like protein 2 (fgl2) and its correlation with disease progression in both mice and patients with severe viral hepatitis...
  38. ncbi request reprint Comparison of cyclosporine microemulsion and tacrolimus in 39 recipients of living donor liver transplantation
    Koichi Tanaka
    Organ Transplant Unit, Kyoto University, Kyoto, Japan
    Liver Transpl 11:1395-402. 2005
    ..In conclusion, CsA-ME C2 monitoring or tacrolimus both offer effective protection against rejection in living donor liver transplants while maintaining a good safety profile...
  39. doi request reprint Cyclosporine pharmacokinetics and blood pressure responses after conversion to once-daily dosing in maintenance liver transplant patients
    John M Kovarik
    Novartis Pharmaceuticals, Basel, Switzerland
    Clin Transplant 22:68-75. 2008
    ..Conversion to once-daily dosing was associated with a decrease in nighttime mean arterial blood pressure...
  40. ncbi request reprint Clinical validation studies of Neoral C(2) monitoring: a review
    Bjorn Nashan
    Klinik für Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Transplantation 73:S3-11. 2002
  41. ncbi request reprint Identification of the receptor for FGL2 and implications for susceptibility to mouse hepatitis virus (MHV-3)-induced fulminant hepatitis
    Hao Liu
    Multi Organ Transplant Program, University Health Network, University of Toronto, Canada
    Adv Exp Med Biol 581:421-5. 2006
  42. ncbi request reprint Murine hepatitis virus strain 1 as a model for severe acute respiratory distress syndrome (SARS)
    Nadine DeAlbuquerque
    University of Toronto, Canada
    Adv Exp Med Biol 581:373-8. 2006
  43. ncbi request reprint [The study of cis-element HNF4 in the regulation of mfg12 prothrombinase/fibroleukin gene expression in response to nucleocapsid protein of MHV-3]
    Qin Ning
    Division of Clinical Immunology, Tongji Hospital, Institute of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Yi Xue Za Zhi 83:678-83. 2003
    ..To identify the transcription factor(s) that is essential for activation of mfgl2 prothrombinase/fibroleukin gene in response to nucleocapsid protein of murine hepatitis virus type 3 (MHV-3)...
  44. ncbi request reprint STAT1 and STAT3 alpha/beta splice form activation predicts host responses in mouse hepatitis virus type 3 infection
    Qin Ning
    Division of Clinical Immunology, Tongji Hospital, Institute of Immunology, Tongji Medical College and Huazhong University of Science and Technology, Wuhan, China
    J Med Virol 69:306-12. 2003
    ....
  45. ncbi request reprint STAT1 and STAT3 alpha/beta splice form activation predicts host responses in mouse hepatitis virus type 2 infection. J Med Virol 2003;69:306-312
    Gary Levy
    J Med Virol 71:474. 2003