Shaul Lev

Summary

Publications

  1. doi request reprint Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity
    Nirit Lev
    The Neuroscience Laboratory, Felsenstein Medical Research Center, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Mol Neurosci 50:542-50. 2013
  2. doi request reprint DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging
    Nirit Lev
    Department of Neurology and Laboratory of Neuroscience, Felsenstein Medical Research Centre, Tel Aviv University, Rabin Medical Centre, Campus Beilinson, Petah Tikva, 49100, Israel
    J Gerontol A Biol Sci Med Sci 68:215-25. 2013
  3. doi request reprint Computerized lung acoustic monitoring can help to differentiate between various chest radiographic densities in critically ill patients
    Shaul Lev
    Department of General Intensive Care, Rabin Medical Center, Petah Tikva, Israel
    Respiration 80:509-16. 2010
  4. pmc Changes in regional distribution of lung sounds as a function of positive end-expiratory pressure
    Shaul Lev
    Department of General Intensive Care, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
    Crit Care 13:R66. 2009
  5. doi request reprint DJ-1 protects against dopamine toxicity
    Nirit Lev
    Department of Neurology, Felsenstein Medical Research Centre, Rabin Medical Centre, Tel Aviv University, Petah Tikva, Israel
    J Neural Transm 116:151-60. 2009
  6. doi request reprint DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS
    Nirit Lev
    Laboratory of Neurosciences, Felsenstein Medical Research Center and Department of Neurology, Rabin Medical Center Beilinson Campus, The Sackler School of Medicine, Tel Aviv University, Petah Tikva, 49100, Israel
    J Mol Neurosci 38:94-102. 2009
  7. doi request reprint Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection
    Nirit Lev
    Laboratory of Neuroscience and Department of Neurology, Rabin Medical Center, FMRC, Tel Aviv University, Petah Tikva, Israel
    Neurotoxicology 29:397-405. 2008
  8. ncbi request reprint Role of DJ-1 in Parkinson's disease
    Nirit Lev
    Laboratory of Neuroscience, Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Israel
    J Mol Neurosci 29:215-25. 2006
  9. ncbi request reprint Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis
    Nirit Lev
    Laboratory of Neuroscience and Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Petah Tikva, Israel
    Antioxid Redox Signal 8:1987-95. 2006
  10. doi request reprint The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients
    Pierre Singer
    Department of General Intensive Care, Rabin Medical Center, Campus Beilinson, 49100, Petah Tikva, Israel
    Intensive Care Med 37:601-9. 2011

Detail Information

Publications26

  1. doi request reprint Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity
    Nirit Lev
    The Neuroscience Laboratory, Felsenstein Medical Research Center, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Mol Neurosci 50:542-50. 2013
    ..These experiments demonstrated that lack of DJ-1 impairs astrocyte-mediated neuroprotection...
  2. doi request reprint DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging
    Nirit Lev
    Department of Neurology and Laboratory of Neuroscience, Felsenstein Medical Research Centre, Tel Aviv University, Rabin Medical Centre, Campus Beilinson, Petah Tikva, 49100, Israel
    J Gerontol A Biol Sci Med Sci 68:215-25. 2013
    ..Our experimental data point to a novel potential protective function of DJ-1, which could be used as a therapeutic tool...
  3. doi request reprint Computerized lung acoustic monitoring can help to differentiate between various chest radiographic densities in critically ill patients
    Shaul Lev
    Department of General Intensive Care, Rabin Medical Center, Petah Tikva, Israel
    Respiration 80:509-16. 2010
    ..Complementary bedside lung monitoring modalities are often sought in order to assist in the differentiation between several lung opacities in the intensive care unit (ICU)...
  4. pmc Changes in regional distribution of lung sounds as a function of positive end-expiratory pressure
    Shaul Lev
    Department of General Intensive Care, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
    Crit Care 13:R66. 2009
    ..The objective of the present study was to assess changes in thoracic sound distribution resulting from changes in positive end-expiratory pressure (PEEP). Repeatability of automated lung sound measurements was also evaluated...
  5. doi request reprint DJ-1 protects against dopamine toxicity
    Nirit Lev
    Department of Neurology, Felsenstein Medical Research Centre, Rabin Medical Centre, Tel Aviv University, Petah Tikva, Israel
    J Neural Transm 116:151-60. 2009
    ..This mechanism elucidates how mutations in DJ-1 prompt PD and imply that modulation of DJ-1 may serve as a novel neuroprotective modality...
  6. doi request reprint DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS
    Nirit Lev
    Laboratory of Neurosciences, Felsenstein Medical Research Center and Department of Neurology, Rabin Medical Center Beilinson Campus, The Sackler School of Medicine, Tel Aviv University, Petah Tikva, 49100, Israel
    J Mol Neurosci 38:94-102. 2009
    ..This is the first report of possible involvement of DJ-1 in ALS. Since DJ-1 has a protective role against oxidative stress, it may suggest a possible therapeutic target in ALS...
  7. doi request reprint Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection
    Nirit Lev
    Laboratory of Neuroscience and Department of Neurology, Rabin Medical Center, FMRC, Tel Aviv University, Petah Tikva, Israel
    Neurotoxicology 29:397-405. 2008
    ..These results may imply that DJ-1 plays an important role in the neuronal defense mechanism against oxidative insults...
  8. ncbi request reprint Role of DJ-1 in Parkinson's disease
    Nirit Lev
    Laboratory of Neuroscience, Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Israel
    J Mol Neurosci 29:215-25. 2006
    ..This article reviews the current knowledge on DJ-1, focusing on its importance in the pathogenesis of PD...
  9. ncbi request reprint Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis
    Nirit Lev
    Laboratory of Neuroscience and Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Petah Tikva, Israel
    Antioxid Redox Signal 8:1987-95. 2006
    ..In view of the accumulating evidence on the central role of oxidative stress in MS, and the importance of DJ-1 in oxidative stress management by the CNS, we believe that DJ-1 will be found to have a central role in MS...
  10. doi request reprint The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients
    Pierre Singer
    Department of General Intensive Care, Rabin Medical Center, Campus Beilinson, 49100, Petah Tikva, Israel
    Intensive Care Med 37:601-9. 2011
    ..To determine whether nutritional support guided by repeated measurements of resting energy requirements improves the outcome of critically ill patients...
  11. ncbi request reprint Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage
    Nirit Lev
    Laboratory of Neuroscience, Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Tel Aviv, Petah Tiqva 49100, Israel
    Neurosci Lett 399:27-32. 2006
    ....
  12. pmc Prediction of extubation outcome: a randomised, controlled trial with automatic tube compensation vs. pressure support ventilation
    Jonathan Cohen
    General Intensive Care Unit, Rabin Medical Center, Petah Tikva, Israel
    Crit Care 13:R21. 2009
    ..Automatic tube compensation (ATC), specifically developed to overcome the imposed work of breathing because of artificial airways, appears ideally suited for the weaning process. We further evaluated the use of ATC in this setting...
  13. ncbi request reprint Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice
    Nirit Lev
    Felsenstein Medical Research Center, Beilinson Campus, Tel Aviv University, Sackler School of Medicine, Petah Tikva, Israel
    Neurosci Lett 359:139-42. 2004
    ..In conclusion, ablation of the bax gene attenuates the severity of MOG-induced EAE and emphasizes the importance of apoptosis in the pathogenesis of EAE and MS...
  14. doi request reprint The utilization of solid organs for transplantation in the setting of infection with multidrug-resistant organisms: an expert opinion
    Jihad Bishara
    Unit of Infectious Diseases, Rabin Medical Center, Petah Tikva, Israel
    Clin Transplant 26:811-5. 2012
    ..In this viewpoint article, we present an algorithm based on expert opinion and our clinical experience with a donor who was found to be an asymptomatic carrier of CR-KP...
  15. pmc Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
    Ewa Kozela
    The Dr Miriam and Sheldon G Adelson Center for Biology of Addictive Diseases, Physiology and Pharmacology Department, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Br J Pharmacol 163:1507-19. 2011
    ..However, phytocannabinoids like cannabidiol (CBD), devoid of psychoactive activity, are, potentially, safe and effective alternatives for alleviating neuroinflammation and neurodegeneration...
  16. doi request reprint Polyphenols in the prevention and treatment of sepsis syndromes: rationale and pre-clinical evidence
    Haim Shapiro
    Institute for Nutrition Research, Rabin Medical Center, Petah Tikva, Israel
    Nutrition 25:981-97. 2009
    ..Whether delivered alone or in combination with nutritional formulas, polyphenols may help to prevent and treat sepsis...
  17. ncbi request reprint Extubation outcome following a spontaneous breathing trial with automatic tube compensation versus continuous positive airway pressure
    Jonathan D Cohen
    Department of General Intensive Care, Rabin Medical Center, Campus Beilinson, Petah Tikva, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Crit Care Med 34:682-6. 2006
    ....
  18. doi request reprint Indirect calorimetry measurements in the ventilated critically ill patient: facts and controversies--the heat is on
    Shaul Lev
    General Intensive Care Department, Rabin Medical Center, Institute for Nutrition Research, Campus Beilinson, Petah Tikva 49100, Israel
    Crit Care Clin 26:e1-9. 2010
    ..The aim of this review was to describe the advantages of measuring indirect calorimetry within the concept of energy-protein goal-oriented therapy...
  19. doi request reprint Lesions outside the CNS in Parkinson's disease
    Ruth Djaldetti
    Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Mov Disord 24:793-800. 2009
    ..It establishes this illness as a systemic CNS and peripheral disorder that warrants new hypotheses regarding its causation and progression...
  20. doi request reprint Outcome of lung transplant recipients requiring readmission to the intensive care unit
    Jonathan Cohen
    Department of General Intensive Care, Tel Aviv University, Tel Aviv, Israel
    J Heart Lung Transplant 30:54-8. 2011
    ..Many serious medical complications have been described occurring from months to years after lung transplantation, often necessitating admission to an intensive care unit (ICU). We examined the factors associated with death...
  21. doi request reprint Cell replacement therapy for Parkinson's disease: how close are we to the clinic?
    Javier Ganz
    Laboratory of Neuroscience, Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University, Israel
    Expert Rev Neurother 11:1325-39. 2011
    ..In this article, we present an update on CRT for PD, reviewing the research milestones, various stem cells used and tailored differentiation methods, and analyze the information gained from the clinical trials...
  22. ncbi request reprint Neuroprotection in progressive brain disorders
    Ruth Djaldetti
    Department of Neurology, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Isr Med Assoc J 5:576-80. 2003
    ..At present there is limited clinical evidence for direct neuroprotective effects against these diseases, but much effort is being invested in research on novel technologies and compounds...
  23. ncbi request reprint Apoptosis and Parkinson's disease
    Nirit Lev
    Neurosciences Laboratory, Department of Neurology, Felsenstein Medical Research Center, Sackler School of Medicine, Rabin Medical Center, Beilinson Campus, 49100, Petach Tikva, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 27:245-50. 2003
    ....
  24. doi request reprint n-3 fatty acids and γ-linolenic acid supplementation in the nutritional support of ventilated patients with acute lung injury or acute respiratory distress syndrome
    Shaul Lev
    Department of Intensive Care, Beilinson Hospital, Rabin Medical Center, in affiliation with the Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel
    World Rev Nutr Diet 105:136-43. 2013
    ..More recent findings have taught us that too much of these supplements are detrimental and that the bolus administration may not be as efficient as continuous administration...
  25. doi request reprint Effectiveness and safety of colistin: prospective comparative cohort study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Antimicrob Chemother 65:1019-27. 2010
    ..Colistin has re-entered clinical use by necessity. We aimed to assess its effectiveness and safety compared with newer antibiotics...
  26. ncbi request reprint Hypophosphatemia following open heart surgery: incidence and consequences
    Jonathan Cohen
    Department of General Intensive Care, Rabin Medical Center, Petah Tikva, Israel
    Eur J Cardiothorac Surg 26:306-10. 2004
    ..The contribution of SH to these complications after cardiac surgery is not well defined...