Shaul Lev

Summary

Publications

  1. Lev S, Glickman Y, Kagan I, Dahan D, Cohen J, Grinev M, et al. Changes in regional distribution of lung sounds as a function of positive end-expiratory pressure. Crit Care. 2009;13:R66 pubmed publisher
    ..Further studies are needed in order to fully appreciate the contribution of PEEP increase to diaphragmatic sound redistribution. ..
  2. Lev N, Barhum Y, Pilosof N, Ickowicz D, Cohen H, Melamed E, et al. DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging. J Gerontol A Biol Sci Med Sci. 2013;68:215-25 pubmed publisher
    ..Our experimental data point to a novel potential protective function of DJ-1, which could be used as a therapeutic tool. ..
  3. Lev N, Barhum Y, Ben Zur T, Melamed E, Steiner I, Offen D. Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity. J Mol Neurosci. 2013;50:542-50 pubmed publisher
    ..These experiments demonstrated that lack of DJ-1 impairs astrocyte-mediated neuroprotection. ..
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    Lev N, Ickowicz D, Barhum Y, Blondheim N, Melamed E, Offen D. Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis. Antioxid Redox Signal. 2006;8:1987-95 pubmed
    ..In view of the accumulating evidence on the central role of oxidative stress in MS, and the importance of DJ-1 in oxidative stress management by the CNS, we believe that DJ-1 will be found to have a central role in MS. ..
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    Lev N, Roncevic D, Roncevich D, Ickowicz D, Melamed E, Offen D. Role of DJ-1 in Parkinson's disease. J Mol Neurosci. 2006;29:215-25 pubmed
    ..This article reviews the current knowledge on DJ-1, focusing on its importance in the pathogenesis of PD. ..
  6. Lev N, Ickowicz D, Melamed E, Offen D. Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection. Neurotoxicology. 2008;29:397-405 pubmed publisher
    ..These results may imply that DJ-1 plays an important role in the neuronal defense mechanism against oxidative insults. ..
  7. Lev N, Ickowicz D, Barhum Y, Melamed E, Offen D. DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS. J Mol Neurosci. 2009;38:94-102 pubmed publisher
    ..This is the first report of possible involvement of DJ-1 in ALS. Since DJ-1 has a protective role against oxidative stress, it may suggest a possible therapeutic target in ALS. ..
  8. Lev N, Ickowicz D, Barhum Y, Lev S, Melamed E, Offen D. DJ-1 protects against dopamine toxicity. J Neural Transm (Vienna). 2009;116:151-60 pubmed publisher
    ..This mechanism elucidates how mutations in DJ-1 prompt PD and imply that modulation of DJ-1 may serve as a novel neuroprotective modality. ..