Donald Y M Leung

Summary

Publications

  1. pmc Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 131:2213-22. 2011
  2. pmc Epidermal barrier in atopic dermatitis
    Byung Eui Kim
    Department of Pediatrics, National Jewish Health, Denver, CO, USA
    Allergy Asthma Immunol Res 4:12-6. 2012
  3. doi request reprint New insights into atopic dermatitis: role of skin barrier and immune dysregulation
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Allergol Int 62:151-61. 2013
  4. pmc Why is eczema herpeticum unexpectedly rare?
    Donald Y M Leung
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Antiviral Res 98:153-7. 2013
  5. pmc Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response
    Donald Y M Leung
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 127:965-73.e1-5. 2011
  6. doi request reprint Effects of pimecrolimus cream 1% in the treatment of patients with atopic dermatitis who demonstrate a clinical insensitivity to topical corticosteroids: a randomized, multicentre vehicle-controlled trial
    D Y M Leung
    Department of Pediatrics, University of Colorado Denver, and Division of Pediatric Allergy Immunology, National Jewish Health, Denver, CO 80206, USA
    Br J Dermatol 161:435-43. 2009
  7. pmc IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance
    Elena Goleva
    National Jewish Health, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 40:223-30. 2009
  8. doi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
  9. ncbi request reprint Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
  10. ncbi request reprint Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 24:341-8. 2006

Detail Information

Publications91

  1. pmc Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 131:2213-22. 2011
    ..These results indicate that Sp1 expression deficiency leads to abnormally increased KLK protease activity in keratinocytes and may contribute to T(H)2 immune responses in the skin by inducing TSLP...
  2. pmc Epidermal barrier in atopic dermatitis
    Byung Eui Kim
    Department of Pediatrics, National Jewish Health, Denver, CO, USA
    Allergy Asthma Immunol Res 4:12-6. 2012
    ..The basic skin care including repair and protection of the skin barrier with proper hydration and topical anti-inflammatory therapy is important to control the severity of skin disease in patients with AD...
  3. doi request reprint New insights into atopic dermatitis: role of skin barrier and immune dysregulation
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Allergol Int 62:151-61. 2013
    ..Early intervention may improve outcomes for AD as well as reduce the systemic allergen sensitization that may lead to associated allergic diseases in other organs...
  4. pmc Why is eczema herpeticum unexpectedly rare?
    Donald Y M Leung
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Antiviral Res 98:153-7. 2013
    ..ADEH+ subjects are also more likely to have a history of food allergy or asthma, early onset of AD and a history of other cutaneous infections with Staphylococcus aureus or molluscum contagiosum...
  5. pmc Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response
    Donald Y M Leung
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 127:965-73.e1-5. 2011
    ..The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood...
  6. doi request reprint Effects of pimecrolimus cream 1% in the treatment of patients with atopic dermatitis who demonstrate a clinical insensitivity to topical corticosteroids: a randomized, multicentre vehicle-controlled trial
    D Y M Leung
    Department of Pediatrics, University of Colorado Denver, and Division of Pediatric Allergy Immunology, National Jewish Health, Denver, CO 80206, USA
    Br J Dermatol 161:435-43. 2009
    ..Staphylococcus aureus produces superantigens that contribute to cutaneous inflammation and corticosteroid (CS) resistance...
  7. pmc IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance
    Elena Goleva
    National Jewish Health, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 40:223-30. 2009
    ..These data indicate that combination IL-2/IL-4 inhibits GCRalpha nuclear translocation in human T cells, and this effect is reversed by IFN-gamma via inhibition of p38 MAPK activation...
  8. doi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
    ..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...
  9. ncbi request reprint Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
    ..CLINICAL IMPLICATIONS: The atopic immune response contributes to the skin barrier defect in AD; therefore, neutralization of IL-4 and IL-13 could improve skin barrier integrity...
  10. ncbi request reprint Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 24:341-8. 2006
    ..The current study demonstrates that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner...
  11. doi request reprint Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 124:270-7, 277.e1. 2009
    ..We have demonstrated that expression of S100A11, a calcium-binding protein involved in keratinocyte differentiation, is downregulated in AD...
  12. pmc IL-25 enhances HSV-1 replication by inhibiting filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication
    Byung Eui Kim
    Department of Pediatrics, National Jewish Health, Denver, Colorado, USA
    J Invest Dermatol 133:2678-85. 2013
    ..Filaggrin breakdown products, however, inhibited HSV-1 replication in vitro. ..
  13. doi request reprint Identification of glucocorticoid-induced TNF receptor-related protein ligand on keratinocytes: ligation by GITR induces keratinocyte chemokine production and augments T-cell proliferation
    Aideen M Byrne
    Department of Pediatrics, National Jewish Health, Denver, Colorado, USA
    J Invest Dermatol 129:2784-94. 2009
    ....
  14. doi request reprint Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages
    Elena Goleva
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:550-9.e3. 2008
    ..The cause of corticosteroid-resistant (CR) asthma is unknown...
  15. ncbi request reprint Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
    ..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens...
  16. pmc Cathelicidin deficiency predisposes to eczema herpeticum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 117:836-41. 2006
    ..Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV)...
  17. pmc Specificity protein 1 is pivotal in the skin's antiviral response
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colo, USA
    J Allergy Clin Immunol 127:430-438.e1-2. 2011
    ..Previous studies have found specificity protein (Sp) 1 transcription factor in the viral replication machinery and postulated that Sp1 was required for viral replication in host cells...
  18. ncbi request reprint Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3262-9. 2003
    ..These observations could explain the increased susceptibility of AD skin to microorganisms, and suggest a new fundamental rule that may explain the mechanism for frequent infection in other Th2 cytokine-mediated diseases...
  19. pmc ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells
    Ling Bo Li
    Divisions of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Blood 110:1570-7. 2007
    ..The data indicate refractory steroid-induced transactivation but similar steroid-induced transrepression of CD8(+) cells compared with CD4(+) cells caused by decreased levels of the histone acetyltransferase ATF2...
  20. doi request reprint Obesity impairs apoptotic cell clearance in asthma
    Ruby Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Allergy Clin Immunol 131:1041-7, 1047.e1-3. 2013
    ..Asthma in obese adults is typically more severe and less responsive to glucocorticoids than asthma in nonobese adults...
  21. pmc Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use
    Daniel A Searing
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:995-1000. 2010
    ..There is little knowledge about clinical variables associated with vitamin D (VitD) insufficiency in asthmatic children...
  22. pmc IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
    Sarita Sehra
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 184:3186-90. 2010
    ..These data suggest that IL-4 plays an important role in regulating epidermal homeostasis and innate barrier function...
  23. pmc The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections
    Michael D Howell
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 128:1006-14. 2011
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with increased susceptibility to recurrent skin infections...
  24. pmc Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Immunol Rev 242:233-46. 2011
    ....
  25. ncbi request reprint Divergent expression and function of glucocorticoid receptor beta in human monocytes and T cells
    Ling Bo Li
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    J Leukoc Biol 79:818-27. 2006
    ..Our data suggest that GCRbeta contributes to variation in the GC responses of monocytes versus T cells...
  26. pmc Cluster analysis of obesity and asthma phenotypes
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e36631. 2012
    ..We utilized an hypothesis-free cluster analytical approach to define the contribution of obesity and related variables to asthma phenotype...
  27. pmc Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:457-63. 2007
    ..Macrophage inflammatory protein 3alpha (MIP-3alpha) is a C-C chemokine expressed by keratinocytes that exhibits antimicrobial activity against bacteria and fungi; however, its role in antiviral innate immunity is unknown...
  28. pmc Staphylococcus aureus α-toxin modulates skin host response to viral infection
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 130:683-691.e2. 2012
    ..Patients with atopic dermatitis (AD) with a history of eczema herpeticum have increased staphylococcal colonization and infections. However, whether Staphylococcus aureus alters the outcome of skin viral infection has not been determined...
  29. ncbi request reprint Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 125:738-45. 2005
    ..Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP...
  30. ncbi request reprint The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3
    Kevin O Kisich
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 127:2368-80. 2007
    ..aureus were exposed to human skin explants. Blocking peptide binding of HBD3 inhibited killing of the bacteria, indicating an essential role for beta-defensin 3 in the constitutive killing of bacteria by normal keratinocytes...
  31. doi request reprint Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3
    Kevin O Kisich
    Division of Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 122:62-8. 2008
    ..Individuals with atopic dermatitis (AD) have frequent colonization and infection with Staphylococcus aureus. Rapid elimination of S. aureus depends on constitutive synthesis and mobilization of human beta-defensin-3 (HBD-3)...
  32. pmc Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:1077-1083.e8. 2010
    ..Immune features of infants with food allergy have not been delineated...
  33. pmc Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death
    Anne M Brauweiler
    Division of Pediatric Allergy and Immunology, National Jewish Health, Denver, Colo, USA
    J Allergy Clin Immunol 131:421-7.e1-2. 2013
    ..AD skin lesions are often exacerbated by Staphylococcus aureus-mediated secretion of the virulence factor α-toxin. It is unknown whether lack of keratinocyte differentiation predisposes to enhanced lethality from staphylococcal toxins...
  34. pmc Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1
    Yong Zhang
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 188:2127-35. 2012
    ..In conclusion, this study identified the upregulation of MKP-1 by vitamin D as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages...
  35. ncbi request reprint Adrenomedullin is highly expressed in blood monocytes associated with acute Kawasaki disease: a microarray gene expression study
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Pediatr Res 57:49-55. 2005
    ..Our current study suggests that ADM-expressing monocytes that infiltrate the coronary vascular wall may be the cause of coronary dilation in the acute phase of KD...
  36. pmc Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation
    Yong Zhang
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 284:24542-52. 2009
    ..This study demonstrates cross-talk between estrogen-induced PP5 and GR action. It also reveals that PP5 inhibition may antagonize estrogen-promoted events in response to corticosteroid therapy...
  37. doi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2008
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 123:319-27. 2009
    ..New therapeutic approaches to AD, urticaria, and angioedema have been reported including use of probiotics, biologics, vitamin D, and skin barrier creams...
  38. pmc Inhibition of histone deacetylase 2 expression by elevated glucocorticoid receptor beta in steroid-resistant asthma
    Ling Bo Li
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Crit Care Med 182:877-83. 2010
    ..Cross-talk between glucocorticoid receptors and histone deacetylases (HDACs) under steroid-insensitive conditions has not been explored...
  39. pmc Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
    ..Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma...
  40. ncbi request reprint Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes
    Ivan D Cardona
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:688-95. 2006
    ..Superantigens inhibit naturally occurring CD4+CD25+ regulatory T-cell (nTreg) activity, yet the mechanism for this is unknown...
  41. ncbi request reprint Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis
    Ichiro Nomura
    Department Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:1195-202. 2003
    ..DNA microarray studies allow the simultaneous comparison of thousands of messenger RNAs that may identify the disease-specific pattern of tissue inflammatory responses...
  42. ncbi request reprint Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway
    Ling Bo Li
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:1059-69. 2004
    ..Microbial superantigens induce human T-cell resistance to corticosteroids...
  43. ncbi request reprint Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:1763-7. 2004
    ..01). These data support a role for cathelicidins in the inhibition of orthopox virus (vaccinia) replication both in vitro and in vivo. Susceptibility of patients with AD to eczema vaccinatum may be due to a deficiency of cathelicidin...
  44. pmc Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma
    Elena Goleva
    Department of Pediatrics, National Jewish Medical Research Center, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:607-16. 2006
    ..Glucocorticoids (GCs) are highly effective in the treatment of asthma. However, some individuals have GC-insensitive asthma...
  45. doi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2011
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 129:76-85. 2012
    ..The role of skin barrier abnormalities, as well as the modulatory effects of the innate and adaptive immune responses, are major areas of investigation...
  46. pmc Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma
    Elena Goleva
    Division of Pediatric Allergy and Immunology, National Jewish Health, Denver, CO, USA
    J Allergy Clin Immunol 129:1243-51. 2012
    ..The effects of serum vitamin D status on atopy, steroid requirement, and functional responsiveness to corticosteroids in children versus adults with asthma have not been studied systematically...
  47. ncbi request reprint Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 93:S1-21. 2004
  48. pmc Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 126:332-7. 2008
    ..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism...
  49. pmc Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:150-5. 2007
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD...
  50. ncbi request reprint Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    ..We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis...
  51. pmc Recent insights into atopic dermatitis and implications for management of infectious complications
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:4-13; quiz 14-5. 2010
    ..A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes...
  52. pmc Usefulness of PBMCs to predict clinical response to corticosteroids in asthmatic patients
    Elena Goleva
    Division of Pediatric Allergy and Immunology, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 129:687-693.e1. 2012
    ..Blood tests are needed to identify steroid-resistant (SR) asthmatic patients early so that they can be managed with alternative anti-inflammatory therapy...
  53. pmc Vitamin D in atopic dermatitis, asthma and allergic diseases
    Daniel A Searing
    Division of Pediatric Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, K731a, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 30:397-409. 2010
    ....
  54. doi request reprint Ceragenins: a class of antiviral compounds to treat orthopox infections
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 129:2668-75. 2009
    ..This suggests that treatment with CSA-13 may be an intervention for individuals with a disseminated VV skin infection...
  55. doi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2010
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 127:326-35. 2011
    ..New therapeutic approaches to control chronic urticaria have also been identified during the past year...
  56. ncbi request reprint Role of bacterial superantigens in atopic dermatitis : implications for future therapeutic strategies
    Ivan D Cardona
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Clin Dermatol 7:273-9. 2006
    ....
  57. pmc Body mass and glucocorticoid response in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:682-7. 2008
    ..Obesity may alter glucocorticoid response in asthma...
  58. ncbi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects
    Scott H Sicherer
    The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 118:170-7. 2006
    ..Progress in our understanding of the immunology of atopic dermatitis and autoimmune urticaria has also been made. These observations will likely contribute toward optimizing management of these common allergic disorders...
  59. pmc Airway remodeling and lack of bronchodilator response in steroid-resistant asthma
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 802060, USA
    J Allergy Clin Immunol 120:1065-72. 2007
    ..Steroid-resistant (SR) asthma is characterized by airway inflammation that fails to resolve despite treatment with corticosteroids, raising concerns that resistance to steroid therapy in asthma could lead to airway remodeling...
  60. doi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 125:85-97. 2010
    ..These exciting advances reported in the Journal can improve patient care today and provide insights on how we can improve the diagnosis and treatment of these allergic diseases in the future...
  61. doi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 131:55-66. 2013
    ..Augmentation of the skin barrier with reduction in skin inflammatory responses will likely lead to the most effective intervention in patients with this common skin disease...
  62. doi request reprint TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier
    Byung Eui Kim
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 131:1272-9. 2011
    ..Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression...
  63. ncbi request reprint T regulatory cells in atopic dermatitis and subversion of their activity by superantigens
    Liang Shiou Ou
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:756-63. 2004
    ..CD4+CD25+ T regulatory (Treg) cells are thought to play an important role in controlling inflammatory responses...
  64. doi request reprint Disease severity, scratching, and sleep quality in patients with atopic dermatitis
    Bruce G Bender
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Am Acad Dermatol 58:415-20. 2008
    ..The relationship between sleep quality and disease severity in patients with atopic dermatitis has not been clearly defined...
  65. doi request reprint Neutrophilic airway inflammation and association with bacterial lipopolysaccharide in children with asthma and wheezing
    Pia J Hauk
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Pediatr Pulmonol 43:916-23. 2008
    ....
  66. ncbi request reprint Immune dysregulation in atopic dermatitis
    Peck Y Ong
    National Jewish Medical and Research Center, Department of Pediatrics, Room K926i, 1400 Jackson Street, Denver, Colorado 80206, USA
    Curr Allergy Asthma Rep 6:384-9. 2006
    ..Understanding these pathomechanisms may improve our current therapies for atopic dermatitis...
  67. ncbi request reprint 10. Atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:S475-80. 2006
    ..New treatment approaches include use of topical steroids as maintenance therapy and use of topical calcineurin inhibitors for early intervention with topical steroids used as rescue therapy...
  68. ncbi request reprint Advances in allergic skin diseases
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:S805-12. 2003
    ..The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to a rethinking of potential management approaches in atopic dermatitis...
  69. doi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2007
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 121:1351-8. 2008
    ..New therapeutic approaches to AD, urticaria, and angioedema have been reported, including use of sublingual immunotherapy, anti-IgE, and a kallikrein inhibitor...
  70. ncbi request reprint Factors that regulate naturally occurring T regulatory cell-mediated suppression
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:1094-100. 2005
    ..Understanding the events that control suppressive function of nTreg cells will allow manipulation of these cells to inhibit or enhance their functions in the development of novel therapies for autoimmune and allergic diseases...
  71. ncbi request reprint A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 169:5934-40. 2002
    ..This study demonstrates a novel role for STAT5 in IL-2-induced steroid insensitivity...
  72. ncbi request reprint Atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:40-3. 2006
  73. ncbi request reprint Racial differences in T-lymphocyte response to glucocorticoids
    Monica J Federico
    National Jewish Medical and Research Center, 1400 Jackson St J316, Denver, CO 80206, USA
    Chest 127:571-8. 2005
    ..Asthma morbidity and mortality is increased in blacks...
  74. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    ..This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies...
  75. ncbi request reprint Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation
    Jordan E Scott
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 120:1382-8. 2007
    ..Patients with atopic dermatitis (AD) exposed to the vaccinia virus (VV) smallpox vaccine have an increased risk of developing eczema vaccinatum...
  76. ncbi request reprint Atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Lancet 361:151-60. 2003
    ..New management approaches have evolved from advances in our understanding of the pathobiology of this common skin disorder...
  77. ncbi request reprint Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 168:505-10. 2002
    ..In addition, IL-15 was found to suppress IgE synthesis (p < 0.01) by the PBMC of AD patients. These data support the concept that reduced IL-15 expression may contribute to the pathogenesis of AD...
  78. ncbi request reprint Preface to atopic dermatitis intervention to control the atopic march
    Donald Y M Leung
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Allergy Clin Immunol 112:S117. 2003
  79. ncbi request reprint Actigraphy assessment of sleep disturbance in patients with atopic dermatitis: an objective life quality measure
    Bruce G Bender
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 111:598-602. 2003
    ....
  80. ncbi request reprint Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease
    Donald Y M Leung
    Department of Pediatrics, The National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
    J Pediatr 140:742-6. 2002
    ..To assess the prevalence of superantigen secreting bacteria in children with acute Kawasaki disease (KD) relative to control patients...
  81. ncbi request reprint Increased glucocorticoid receptor Beta expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype
    Pia J Hauk
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 27:361-7. 2002
    ..Furthermore, in such cells GCRalpha is complexed with GCRbeta. Such heterodimer formation may account for the reduced effectiveness of GC action in cells overexpressing GCRbeta...
  82. ncbi request reprint CD56+ cells induce steroid resistance in B cells exposed to IL-15
    Qing Xu
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:7110-5. 2004
    ..This study demonstrates that B cells develop steroid resistance in the presence of CD56(+) cells after IL-15 stimulation. Furthermore, IL-15 and IL-4 have the capacity to induce B cell insensitivity to steroids...
  83. ncbi request reprint Atopic dermatitis
    Peck Y Ong
    National Jewish Medical and Research Center, Denver, Colorado, USA
    Clin Allergy Immunol 16:355-79. 2002
  84. ncbi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insect stings
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 114:118-24. 2004
    ..Lastly, there are new recommendations for patients with convincing insect sting reaction histories but negative skin test responses to venom...
  85. ncbi request reprint Advances in atopic dermatitis
    Liang Shiou Ou
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chang Gung Med J 28:1-8. 2005
    ..The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to the rethinking of potential management approaches in AD...
  86. ncbi request reprint Update on glucocorticoid action and resistance
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:3-22; quiz 23. 2003
    ..The treatment of these patients requires a systematic approach to rule out underlying conditions that lead to steroid resistance or treatment failure, as well as the use of alternative strategies to inhibit tissue inflammation...
  87. ncbi request reprint New concepts in the pathogenesis of atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, CO, USA
    Curr Opin Immunol 15:634-8. 2003
    ..An increased prevalence of atopic dermatitis has generated increased interest and research into each of these areas, and new treatment strategies are being developed based upon an increased understanding of these issues...
  88. ncbi request reprint Infection in atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pediatr 15:399-404. 2003
    ..This skin disease is often triggered by bacterial, fungal, or viral skin infections. The mechanisms resulting in this increased propensity for skin infections have been an area of active investigation...
  89. doi request reprint A multidisciplinary approach to evaluation and treatment of atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA
    Semin Cutan Med Surg 27:115-27. 2008
    ..A multidisciplinary approach is needed to comprehensively evaluate triggers and response to treatment, address confounding factors including sleep disruption, and educate patients and caregivers...
  90. ncbi request reprint Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO, 80206, USA
    J Allergy Clin Immunol 114:183-91. 2004
    ..Combination treatment with steroids and long-acting beta2-agonists provides greater asthma control than simply increasing the dose of steroids...