Guillaume Lettre

Summary

Publications

  1. doi request reprint Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes
    Guillaume Lettre
    Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
    Pediatr Nephrol 28:557-62. 2013
  2. doi request reprint Genetic regulation of adult stature
    Guillaume Lettre
    Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Curr Opin Pediatr 21:515-22. 2009
  3. pmc Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
    Andrew Mk Brown
    Universite de Montreal, Montreal, Quebec, Canada
    BMC Res Notes 3:185. 2010
  4. doi request reprint Recent progress in the study of the genetics of height
    Guillaume Lettre
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, Canada
    Hum Genet 129:465-72. 2011
  5. doi request reprint Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
    Melissa Beaudoin
    Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 5:547-54. 2012
  6. pmc Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry
    Amidou N'Diaye
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1002298. 2011
  7. pmc Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
    Melissa Beaudoin
    Montreal Heart Institute, Research Center, Montreal, Quebec, Canada
    PLoS Genet 9:e1003723. 2013
  8. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
  9. pmc Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients
    Geneviève Galarneau
    Montreal Heart Institute, Montreal, Quebec, Canada
    Blood 122:434-42. 2013
  10. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012

Detail Information

Publications12

  1. doi request reprint Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes
    Guillaume Lettre
    Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
    Pediatr Nephrol 28:557-62. 2013
    ....
  2. doi request reprint Genetic regulation of adult stature
    Guillaume Lettre
    Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Curr Opin Pediatr 21:515-22. 2009
    ..The identification of genes that regulate human height would greatly enhance our understanding of human growth and height-associated human syndromes...
  3. pmc Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
    Andrew Mk Brown
    Universite de Montreal, Montreal, Quebec, Canada
    BMC Res Notes 3:185. 2010
    ....
  4. doi request reprint Recent progress in the study of the genetics of height
    Guillaume Lettre
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, Canada
    Hum Genet 129:465-72. 2011
    ..In this review, I highlight the progress made in the last 2 years in understanding how genetic variation controls height variation in humans, including non-Caucasian populations and children...
  5. doi request reprint Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
    Melissa Beaudoin
    Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 5:547-54. 2012
    ..Except for a few examples (eg, PCSK9), the role of low-frequency genetic variation (minor allele frequency [MAF]) ≈0.1%-5% on MI/coronary artery disease predisposition has not been extensively investigated...
  6. pmc Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry
    Amidou N'Diaye
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1002298. 2011
    ..01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits...
  7. pmc Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
    Melissa Beaudoin
    Montreal Heart Institute, Research Center, Montreal, Quebec, Canada
    PLoS Genet 9:e1003723. 2013
    ..Rather, these are expected to help focus functional studies of the corresponding disease loci...
  8. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    ..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
  9. pmc Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients
    Geneviève Galarneau
    Montreal Heart Institute, Montreal, Quebec, Canada
    Blood 122:434-42. 2013
    ..Our results provide new leads to gaining a better understanding of clinical variability in SCD, a "simple" monogenic disease. ..
  10. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012
    ..4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance...
  11. pmc Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation
    Geneviève Galarneau
    Montreal Heart Institute, Montreal, Quebec, Canada
    Nat Genet 42:1049-51. 2010
    ..6% to 49.5%. We also identified rare missense variants that causally implicate MYB in HbF production...
  12. pmc Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
    Ken Sin Lo
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada
    Hum Genet 129:307-17. 2011
    ..Our results show similarities but also differences in the genetic regulation of hematological traits in European- and African-derived populations, and highlight the role of natural selection in shaping these differences...