Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypesGuillaume Lettre
Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
Pediatr Nephrol 28:557-62. 2013
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- Genetic regulation of adult stature
Guillaume Lettre
Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
Curr Opin Pediatr 21:515-22. 2009
..The identification of genes that regulate human height would greatly enhance our understanding of human growth and height-associated human syndromes...
- Recent progress in the study of the genetics of height
Guillaume Lettre
Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, Canada
Hum Genet 129:465-72. 2011
..In this review, I highlight the progress made in the last 2 years in understanding how genetic variation controls height variation in humans, including non-Caucasian populations and children...
Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regionsAndrew Mk Brown
Universite de Montreal, Montreal, Quebec, Canada
BMC Res Notes 3:185. 2010
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- Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
Melissa Beaudoin
Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
Circ Cardiovasc Genet 5:547-54. 2012
..Except for a few examples (eg, PCSK9), the role of low-frequency genetic variation (minor allele frequency [MAF]) ≈0.1%-5% on MI/coronary artery disease predisposition has not been extensively investigated...
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry
Amidou N'Diaye
Montreal Heart Institute, Montreal, Canada
PLoS Genet 7:e1002298. 2011
..01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits...
- Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
Guillaume Lettre
Montreal Heart Institute, Montreal, Canada
PLoS Genet 7:e1001300. 2011
..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
- Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation
Geneviève Galarneau
Montreal Heart Institute, Montreal, Quebec, Canada
Nat Genet 42:1049-51. 2010
..6% to 49.5%. We also identified rare missense variants that causally implicate MYB in HbF production...
- Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
Zari Dastani
Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
PLoS Genet 8:e1002607. 2012
..4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance...
- Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
Ken Sin Lo
Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada
Hum Genet 129:307-17. 2011
..Our results show similarities but also differences in the genetic regulation of hematological traits in European- and African-derived populations, and highlight the role of natural selection in shaping these differences...
