Valerio Leoni

Summary

Publications

  1. doi request reprint Oxysterols as markers of neurological disease--a review
    Valerio Leoni
    Division of Biochemistry and Genetics, National Institute of Neurology C Besta, Milan, Italy
    Scand J Clin Lab Invest 69:22-5. 2009
  2. pmc Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics IRCCS Foundation Neurological Institute C Besta, Milan, Italy
    Mol Genet Metab 105:463-71. 2012
  3. doi request reprint Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, chole
    Valerio Leoni
    Laboratory of Clinical Chemistry, Hospital of Varese, ASST Settelaghi, Varese, Italy Laboratory of Clinical Pathology, Foundation IRCCS Istituto Neurologico Carlo Besta, Milan, Italy Electronic address
    J Steroid Biochem Mol Biol . 2016
  4. doi request reprint The impairment of cholesterol metabolism in Huntington disease
    Valerio Leoni
    Laboratory of Clinical Chemistry, Ospedale Causa Pia Luvini, Cittiglio, AO Ospedale di Circolo e Fondazione Macchi, Varese, Italy Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milano, Italy Electronic address
    Biochim Biophys Acta 1851:1095-105. 2015
  5. doi request reprint Study of cholesterol metabolism in Huntington's disease
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milano, Italy Electronic address
    Biochem Biophys Res Commun 446:697-701. 2014
  6. doi request reprint Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, AmadeoLab R17, Foundation IRCCS Institute of Neurology Carlo Besta, Via Celoria 11, Milan, Italy
    J Alzheimers Dis 36:739-47. 2013
  7. doi request reprint Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milano, Italy
    Biochem Pharmacol 86:26-36. 2013
  8. doi request reprint 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milan, Italy
    Biochimie 95:595-612. 2013
  9. doi request reprint Whole body cholesterol metabolism is impaired in Huntington's disease
    V Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, MI, Italy
    Neurosci Lett 494:245-9. 2011
  10. doi request reprint The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease
    Valerio Leoni
    Genetics of Neurodegenerative and Metabolic Diseases Unit, IRCCS National Institute of Neurology C Besta, Milan, Italy
    Clin Chem Lab Med 49:375-83. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint Oxysterols as markers of neurological disease--a review
    Valerio Leoni
    Division of Biochemistry and Genetics, National Institute of Neurology C Besta, Milan, Italy
    Scand J Clin Lab Invest 69:22-5. 2009
    ..Compared with other available biomarkers in CSF, such as Total Tau, Phospo-Tau and beta(42) amyloid, the 24S-hydroxycholesterol appears to be the most sensitive biomarker in the evaluation of patients with cognitive impairment disease...
  2. pmc Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics IRCCS Foundation Neurological Institute C Besta, Milan, Italy
    Mol Genet Metab 105:463-71. 2012
    ..Our study illustrates the value of metabolic profiling as a tool for systematically exploring the biochemical basis of inherited metabolic diseases...
  3. doi request reprint Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, chole
    Valerio Leoni
    Laboratory of Clinical Chemistry, Hospital of Varese, ASST Settelaghi, Varese, Italy Laboratory of Clinical Pathology, Foundation IRCCS Istituto Neurologico Carlo Besta, Milan, Italy Electronic address
    J Steroid Biochem Mol Biol . 2016
    ..A better knowledge of mitochondrial associated dysfunctions triggered by 7KC will contribute to bring new information on the demyelination processes which are linked with oxidative stress and lipid peroxidation, especially in MS...
  4. doi request reprint The impairment of cholesterol metabolism in Huntington disease
    Valerio Leoni
    Laboratory of Clinical Chemistry, Ospedale Causa Pia Luvini, Cittiglio, AO Ospedale di Circolo e Fondazione Macchi, Varese, Italy Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milano, Italy Electronic address
    Biochim Biophys Acta 1851:1095-105. 2015
    ..This article is part of a Special Issue entitled Brain Lipids. ..
  5. doi request reprint Study of cholesterol metabolism in Huntington's disease
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milano, Italy Electronic address
    Biochem Biophys Res Commun 446:697-701. 2014
    ..Dysregulation of PGC1α and mitochondrial dysfunction may reduce synthesis of Acetyl-CoA and ATP contributing to the cerebral and whole body impairment of cholesterol metabolism. ..
  6. doi request reprint Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, AmadeoLab R17, Foundation IRCCS Institute of Neurology Carlo Besta, Via Celoria 11, Milan, Italy
    J Alzheimers Dis 36:739-47. 2013
    ..Our data suggest that 24OHC may be more sensitive than the classical biomarkers in an early phase of the neurodegenerative process and a better marker for "brain health" in old age. ..
  7. doi request reprint Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milano, Italy
    Biochem Pharmacol 86:26-36. 2013
    ..24OHC itself was cytotoxic. Analysis of side chain oxysterols in the CSF is likely to provided useful information about cholesterol metabolism and ApoE function in the pathogenesis of AD...
  8. doi request reprint 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Institute of Neurology Carlo Besta, Milan, Italy
    Biochimie 95:595-612. 2013
    ..The study of plasma 24OHC is likely to offer an insight about brain cholesterol turnover with a limited diagnostic power...
  9. doi request reprint Whole body cholesterol metabolism is impaired in Huntington's disease
    V Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, MI, Italy
    Neurosci Lett 494:245-9. 2011
    ....
  10. doi request reprint The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease
    Valerio Leoni
    Genetics of Neurodegenerative and Metabolic Diseases Unit, IRCCS National Institute of Neurology C Besta, Milan, Italy
    Clin Chem Lab Med 49:375-83. 2011
    ..In the study of cognitive impaired patients and in their follow-up, biomarkers should be interpreted in consideration of the ApoE genotype in order to better predict the progression of the disease...
  11. doi request reprint Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment
    Valerio Leoni
    Unit of Genetic of Neurodegenerative and Metabolic Diseases, IRCCS National Institute of Neurology C Besta, Via Celoria 11, 20133 Milano, Italy
    Biochem Soc Trans 38:1021-5. 2010
    ....
  12. doi request reprint Oxysterols as biomarkers in neurodegenerative diseases
    Valerio Leoni
    Genetic of neurodegenerative and metabolic diseases Unit, IRCCS National Institute of Neurology C Besta, Milano, Italy
    Chem Phys Lipids 164:515-24. 2011
    ....
  13. doi request reprint Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease
    Valerio Leoni
    Unit Biochemistry and Genetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    Brain 131:2851-9. 2008
    ..We conclude that that 24OHC levels complement MRI morphometry as a valuable tool to follow neurodegenerative changes in the early stages of Huntington disease...
  14. ncbi request reprint Diagnostic use of cerebral and extracerebral oxysterols
    Valerio Leoni
    Department of Experimental and Clinical Biomedical Science DSBSC, University of Insubria, Varese, Italy
    Clin Chem Lab Med 42:186-91. 2004
    ....
  15. ncbi request reprint Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
    Valerio Leoni
    Department of Experimental and Clinical Biomedical Science, University of Insubria, Varese, Italy
    J Lipid Res 44:793-9. 2003
    ..Results are discussed in relation to the possible use of 24-OH-cholCSF as a surrogate marker of central nervous system demyelination and/or neuronal death...
  16. pmc Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression
    Valerio Leoni
    Laboratory of Clinical Pathology and Medical Genetics, Fondazione IRCCS Institute of Neurology Carlo Besta, Milan, Italy
    Neurobiol Dis 55:37-43. 2013
    ..The results are interpreted in terms of cholesterol synthesis and neuronal degeneration. This study provides evidence that 24OHC is a relatively important marker of HD progression...
  17. pmc Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice
    Marta Valenza
    Department of Biosciences, Centre for Stem Cell Research Università degli Studi di Milano, Milan, Italy
    EMBO Mol Med 7:1547-64. 2015
    ..These results demonstrate that cholesterol supplementation to the HD brain reverses functional alterations associated with HD and highlight the potential of this new drug-administration route to the diseased brain. ..
  18. pmc MIF/CD74 axis is a target for novel therapies in colon carcinomatosis
    Fabio Bozzi
    Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, Milan, 20133, Italy
    J Exp Clin Cancer Res 36:16. 2017
    ..Strategies aimed at obtaining a complete cytoreduction are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc)...
  19. ncbi request reprint Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis
    Valerio Leoni
    Department of Experimental and Clinical Biomedical Science DSBSC, University of Insubria, Varese, Italy
    Neurosci Lett 331:163-6. 2002
    ..The possibility is discussed that plasma levels of 24S-OH-chol may add significantly to existing methods used for evaluation of the different phases of multiple sclerosis...