L A Leiter

Summary

Publications

  1. doi request reprint Lipid-altering efficacy and safety profile of combination therapy with ezetimibe/statin vs. statin monotherapy in patients with and without diabetes: an analysis of pooled data from 27 clinical trials
    L A Leiter
    Division of Endocrinology, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, Canada
    Diabetes Obes Metab 13:615-28. 2011
  2. pmc Patient age, ethnicity, medical history, and risk factor profile, but not drug insurance coverage, predict successful attainment of glycemic targets: Time 2 Do More Quality Enhancement Research Initiative (T2DM QUERI)
    Hwee Teoh
    Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 33:2558-60. 2010
  3. ncbi request reprint Dosing irregularities and self-treated hypoglycemia in type 2 diabetes: results from the Canadian cohort of an international survey of patients and healthcare professionals
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada, and Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Diabetes 38:38-44. 2014
  4. ncbi request reprint Type 2 diabetes mellitus management in Canada: is it improving?
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Diabetes 37:82-9. 2013
  5. pmc Determinants of lifestyle behavior in type 2 diabetes: results of the 2011 cross-sectional survey on living with chronic diseases in Canada
    Calypse B Agborsangaya
    Department of Public Health Sciences, 2 040 Li Ka Shing Center for Health Research and Innovation, University of Alberta, Edmonton, AB T6G 2E1, Canada
    BMC Public Health 13:451. 2013
  6. doi request reprint Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
  7. doi request reprint Attainment of Canadian and European guidelines' lipid targets with atorvastatin plus ezetimibe vs. doubling the dose of atorvastatin
    L A Leiter
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Int J Clin Pract 64:1765-72. 2010
  8. ncbi request reprint Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial
    V Vuksan
    Department of Nutritional Sciences, St Michael s Hospital, Faculty of Medicine, University of Toronto, Ontario, Canada
    Diabetes Care 22:913-9. 1999
  9. ncbi request reprint American ginseng (Panax quinquefolius L.) attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto
    Am J Clin Nutr 73:753-8. 2001
  10. ncbi request reprint American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Ontario, Canada
    J Am Coll Nutr 19:738-44. 2000

Detail Information

Publications33

  1. doi request reprint Lipid-altering efficacy and safety profile of combination therapy with ezetimibe/statin vs. statin monotherapy in patients with and without diabetes: an analysis of pooled data from 27 clinical trials
    L A Leiter
    Division of Endocrinology, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, Canada
    Diabetes Obes Metab 13:615-28. 2011
    ..This post hoc analysis compared the lipid-altering efficacy and safety of ezetimibe 10 mg plus statin (EZE/statin) vs. statin monotherapy in hypercholesterolaemic patients with and without diabetes...
  2. pmc Patient age, ethnicity, medical history, and risk factor profile, but not drug insurance coverage, predict successful attainment of glycemic targets: Time 2 Do More Quality Enhancement Research Initiative (T2DM QUERI)
    Hwee Teoh
    Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 33:2558-60. 2010
    ..To identify factors in patients with type 2 diabetes and A1C >7.0% associated with attainment of A1C ≤ 7.0%...
  3. ncbi request reprint Dosing irregularities and self-treated hypoglycemia in type 2 diabetes: results from the Canadian cohort of an international survey of patients and healthcare professionals
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada, and Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Diabetes 38:38-44. 2014
    ..The multinational, online Global Attitude of Patients and Physicians (GAPP2) survey was conducted to address this situation...
  4. ncbi request reprint Type 2 diabetes mellitus management in Canada: is it improving?
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Diabetes 37:82-9. 2013
    ..To gain insight into the current management of patients with type 2 diabetes mellitus by Canadian primary care physicians...
  5. pmc Determinants of lifestyle behavior in type 2 diabetes: results of the 2011 cross-sectional survey on living with chronic diseases in Canada
    Calypse B Agborsangaya
    Department of Public Health Sciences, 2 040 Li Ka Shing Center for Health Research and Innovation, University of Alberta, Edmonton, AB T6G 2E1, Canada
    BMC Public Health 13:451. 2013
    ..We evaluated the prevalence of engagement in lifestyle behaviors for management of the disease, as well as the impact of healthcare professional support on these behaviors...
  6. doi request reprint Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
    ..Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations...
  7. doi request reprint Attainment of Canadian and European guidelines' lipid targets with atorvastatin plus ezetimibe vs. doubling the dose of atorvastatin
    L A Leiter
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Int J Clin Pract 64:1765-72. 2010
    ..Canadian and European treatment guidelines identify low-density lipoprotein cholesterol (LDL-C) as a primary treatment target for hypercholesterolaemia...
  8. ncbi request reprint Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial
    V Vuksan
    Department of Nutritional Sciences, St Michael s Hospital, Faculty of Medicine, University of Toronto, Ontario, Canada
    Diabetes Care 22:913-9. 1999
    ..To examine whether Konjac-mannan (KJM) fiber improves metabolic control as measured by glycemia, lipidemia, and blood pressure in high-risk type 2 diabetic patients...
  9. ncbi request reprint American ginseng (Panax quinquefolius L.) attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto
    Am J Clin Nutr 73:753-8. 2001
    ..Whether this effect can be replicated with doses <3 g and administration times closer to the oral glucose challenge is unclear...
  10. ncbi request reprint American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Ontario, Canada
    J Am Coll Nutr 19:738-44. 2000
    ..in nondiabetic individuals to achieve further improvements in glucose tolerance seen previously when 3 g of AG was taken 40 minutes before a 25 g glucose challenge...
  11. doi request reprint Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD)
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:227-34. 2013
    ..We aimed to explore whether long-term changes in postprandial responses on low-glycemic-index (GI) or low-CHO diets were due to acute or chronic effects in T2DM...
  12. ncbi request reprint Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Diabetes Care 23:1221-6. 2000
    ..We previously demonstrated that 3 g American ginseng (AG) reduced postprandial glycemia (PPG) in type 2 diabetic individuals. We investigated whether further reductions can be achieved with escalation of dose and time of AG administration...
  13. ncbi request reprint Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial
    V Vuksan
    Department of Nutritional Sciences, St Michael s Hospital, University of Toronto, Canada
    Diabetes Care 23:9-14. 2000
    ..To test this hypothesis, we investigated the effect of supplementing a high-carbohydrate diet with fiber from Konjac-mannan (KJM) on metabolic control in subjects with the insulin resistance syndrome...
  14. ncbi request reprint Konjac-Mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitus
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, and Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Ontario, Canada
    J Am Coll Nutr 20:370S-380S; discussion 381S-383S. 2001
    ..A determination of the active ingredients in AG, and the rheology-biology relationship of KJM are also warranted...
  15. ncbi request reprint The effect of acarbose on insulin sensitivity in subjects with impaired glucose tolerance
    J L Chiasson
    Research Center, Hotel Dieu de Montreal, Toronto, Canada
    Diabetes Care 19:1190-3. 1996
    ..To study the effect of acarbose, an alpha-glucosidase inhibitor, on postprandial plasma glucose and insulin and insulin sensitivity in subjects with impaired glucose tolerance (IGT)...
  16. ncbi request reprint Simple skinfold-thickness measurements complement conventional anthropometric assessments in predicting glucose tolerance
    J L Sievenpiper
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Centre, and the Division of Metabolism and Endocrinology, St Michael's Hospital, Toronto, ON, Canada
    Am J Clin Nutr 73:567-73. 2001
    ..59, P < 0.001) and the insulin sensitivity index (partial R(2) = 0.49, P < 0.001). CONCLUSION: Skinfold-thickness measurements may complement other established measurements for predicting abnormal glucose and insulin regulation...
  17. ncbi request reprint A comparison of the assessment and management of cardiometabolic risk in patients with and without type 2 diabetes mellitus in Canadian primary care
    H Teoh
    Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 15:1093-100. 2013
    ..To investigate the cardiometabolic risk (CMR) assessment and management patterns for individuals with and without type 2 diabetes mellitus (T2DM) in Canadian primary care practices...
  18. doi request reprint Viscosity of fiber preloads affects food intake in adolescents
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 19:498-503. 2009
    ....
  19. ncbi request reprint Diabetes Screening in Canada (DIASCAN) Study: prevalence of undiagnosed diabetes and glucose intolerance in family physician offices
    L A Leiter
    St Michael s Hospital and University of Toronto, 61 Queen St E, M4V 2L5 Toronto, Ontario, Canada
    Diabetes Care 24:1038-43. 2001
    ..To assess the prevalence of undiagnosed diabetes and glucose intolerance in individuals > or =40 years of age who contacted their family physician for routine care...
  20. pmc The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes
    D J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, ON, Canada M5C 2T2
    Diabetologia 54:271-9. 2011
    ..We therefore assessed the effect of fruit with special emphasis on low GI fruit intake in type 2 diabetes...
  21. doi request reprint Poor achievement of guidelines-recommended targets in type 2 diabetes: findings from a contemporary prospective cohort study
    M F B Braga
    Department of Medicine, Division of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada
    Int J Clin Pract 66:457-64. 2012
    ..5 mmol/l]...
  22. doi request reprint Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian trial of carbohydrates in diabetes): a randomised controlled trial
    T M S Wolever
    Department of Nutritional Sciences, 150 College St, Toronto, ON, Canada, M5S 3E2
    Diabetologia 51:1607-15. 2008
    ..Since this is a report of secondary analysis on a previously published trial, the results should be considered as hypothesis-generating...
  23. ncbi request reprint Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials
    S Chiu
    1 Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada 2 Department of Human Biology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Eur J Clin Nutr 68:416-23. 2014
    ..To determine the effect of fructose on markers of NAFLD, we conducted a systematic review and meta-analysis of controlled feeding trials...
  24. doi request reprint Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study
    L A Leiter
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Diabet Med 28:1343-51. 2011
    ..To assess the prevalence of persistent lipid abnormalities in statin-treated patients with diabetes with and without the metabolic syndrome...
  25. ncbi request reprint Efficacy and safety of cerivastatin in primary hypercholesterolemia: a long term comparative titration study with simvastatin
    L A Leiter
    University of Toronto, Toronto, Canada
    Can J Cardiol 15:545-55. 1999
    ..To compare cerivastatin with simvastatin in their long term safety and efficacy in reducing low density lipoprotein cholesterol (LDL-C)...
  26. ncbi request reprint Beta-cell preservation: a potential role for thiazolidinediones to improve clinical care in Type 2 diabetes
    L A Leiter
    Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Diabet Med 22:963-72. 2005
    ..Data are accumulating to show that this therapeutic group offers a number of advantages over traditionally employed oral agents, and these data demonstrate the growing importance of thiazolidinediones in Type 2 diabetes management...
  27. ncbi request reprint High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center and the Department of Medicine, The Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Canada
    Am J Clin Nutr 74:57-63. 2001
    ..Further studies are required to assess the longer-term effects on renal function...
  28. ncbi request reprint Low density lipoprotein cholesterol: is lower better?
    L A Leiter
    St Michael s Hospital, Toronto, Canada
    Can J Cardiol 16:20A-2A. 2000
    ..The greatest clinical benefits have been associated with the greatest LDL-C reductions, although the incremental benefit is less at lower levels. Ongoing studies will help determine optimal new treatment targets for LDL-C...
  29. ncbi request reprint Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia
    J L Sievenpiper
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Eur J Clin Nutr 57:243-8. 2003
    ..Whether this effect is reproducible using AG with a different profile is unknown. We therefore investigated the effect of a different batch of AG on glycemia following a 75 g oral glucose tolerance test (OGTT)...
  30. ncbi request reprint Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure
    D J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, ON, Canada
    Eur J Clin Nutr 62:781-8. 2008
    ..To determine the effect on blood pressure of dietary advice to consume a combination of plant-based cholesterol-lowering foods (dietary portfolio)...
  31. ncbi request reprint Aspartame: effects on learning, behavior, and mood
    S Saravis
    Department of Medicine, University of Toronto, Ontario, Canada
    Pediatrics 86:75-83. 1990
    ..Thus, the effect of aspartame on the short-term behavior of healthy 9- to 10-year-old children appears to be related to its absence of metabolic consequences rather than to its amino acid composition and putative neurochemical impact...