Christian Lehmann

Summary

Publications

  1. doi request reprint Microcirculation diagnostics and applied studies in circulatory shock - research from the bench to the bedside
    Christian Lehmann
    Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 52:131-9. 2012
  2. doi request reprint Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia
    Mandana Kianian
    Department of Pharmacology, Dalhousie University, Halifax, NS, Canada Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 58:333-42. 2014
  3. doi request reprint Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia
    Juan Zhou
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 56:273-84. 2014
  4. doi request reprint Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut
    Mandana Kianian
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Basic Clin Physiol Pharmacol 24:27-33. 2013
  5. pmc Oxidized LDL and LOX-1 in experimental sepsis
    Nadia Al-Banna
    Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University Halifax, Nova Scotia, Canada B3H 2Y9
    Mediators Inflamm 2013:761789. 2013
  6. pmc Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
    Christian Lehmann
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 2Y9
    Crit Care 16:R47. 2012
  7. doi request reprint Effect of deletion of cIAP2 on intestinal microcirculation in mouse endotoxemia and polybacterial sepsis
    Christian Lehmann
    Departments of Anesthesia, Pharmacology, and Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada Department of Anesthesia and Intensive Care Medicine, Ernst Moritz Arndt University, Greifswald, Germany Department of Anesthesiology and Intensive Care Medicine, Charles University Prague, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic and Departments of Surgery, and Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Shock 41:454-7. 2014
  8. doi request reprint Adenosine receptor activation improves microcirculation in experimental intestinal ischemia/reperfusion
    Juan Zhou
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 59:257-65. 2015
  9. doi request reprint Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis
    Nadia Al-Banna
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Microvasc Res 95:82-7. 2014
  10. doi request reprint Impact of methylene blue in addition to norepinephrine on the intestinal microcirculation in experimental septic shock
    Jordan Nantais
    Department of General Surgery, Dalhousie University, Halifax, Canada
    Clin Hemorheol Microcirc 58:97-105. 2014

Collaborators

  • Dragan Pavlovic
  • Brent Johnston
  • Michael Sander
  • Juan Zhou
  • Vladimir Cerny
  • Mandana Kianian
  • Nadia Al-Banna
  • Orlando Hung
  • Jordan Nantais
  • Melanie E M Kelly
  • Romesh Shukla
  • Sara Whynot
  • Thomas Krieg
  • Marieke Soltow
  • Katrin Zimmermann
  • Stefan Weber
  • Stefan Masur
  • Alexander Maxan
  • Claudius Balzer
  • Mathis Jaskulski
  • Vo Hoai Bac
  • Tristan C Dumbarton
  • Hartmut Kern
  • Nivin Sharawi
  • Islam Saleh Abdo
  • Johanna Rüb
  • Vladimir Nedeljkov
  • Samuel Minor
  • Geoffrey Rowden
  • Alexander Spassov
  • Nizam Farah
  • Nadia A Al-Banna
  • Julia Willecke
  • Michael Wendt
  • Claudius Friedel
  • Henry Schroeder

Detail Information

Publications12

  1. doi request reprint Microcirculation diagnostics and applied studies in circulatory shock - research from the bench to the bedside
    Christian Lehmann
    Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 52:131-9. 2012
    ..Therefore, microcirculatory targets may represent the most important endpoints to optimize therapy of circulatory shock...
  2. doi request reprint Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia
    Mandana Kianian
    Department of Pharmacology, Dalhousie University, Halifax, NS, Canada Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 58:333-42. 2014
    ....
  3. doi request reprint Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia
    Juan Zhou
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 56:273-84. 2014
    ..In conclusion, physostigmine treatment significantly improved the intestinal microcirculation in experimental endotoxemia by reducing leukocyte adhesion and increasing FCD. ..
  4. doi request reprint Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut
    Mandana Kianian
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Basic Clin Physiol Pharmacol 24:27-33. 2013
    ..Our study aimed to examine intestinal leukocyte adhesion and capillary perfusion following selective inhibition of the endocannabinoid degradation enzyme, fatty acid amide hydrolase (FAAH), in experimental sepsis (endotoxemia)...
  5. pmc Oxidized LDL and LOX-1 in experimental sepsis
    Nadia Al-Banna
    Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University Halifax, Nova Scotia, Canada B3H 2Y9
    Mediators Inflamm 2013:761789. 2013
    ..Modulation of LOX-1 response could be utilized for the treatment of local and systemic inflammation, but the successful use of this target requires further understanding of its broad effects. ..
  6. pmc Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
    Christian Lehmann
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 2Y9
    Crit Care 16:R47. 2012
    ..The aim of this study was therefore to investigate the effects of CB2R manipulation on leukocyte activation within the intestinal microcirculation in two acute experimental sepsis models...
  7. doi request reprint Effect of deletion of cIAP2 on intestinal microcirculation in mouse endotoxemia and polybacterial sepsis
    Christian Lehmann
    Departments of Anesthesia, Pharmacology, and Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada Department of Anesthesia and Intensive Care Medicine, Ernst Moritz Arndt University, Greifswald, Germany Department of Anesthesiology and Intensive Care Medicine, Charles University Prague, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic and Departments of Surgery, and Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Shock 41:454-7. 2014
    ..Deletion of cIAP2 resulted in reduced microvascular leukocyte recruitment within the intestinal microcirculation in endotoxemia but not in polybacterial sepsis. ..
  8. doi request reprint Adenosine receptor activation improves microcirculation in experimental intestinal ischemia/reperfusion
    Juan Zhou
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Clin Hemorheol Microcirc 59:257-65. 2015
    ..A2BAR may be more important than A1AR because A2BAR inhibition by MRS1754 completely reversed the effect of the adenosine receptor agonist NECA. ..
  9. doi request reprint Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis
    Nadia Al-Banna
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Microvasc Res 95:82-7. 2014
    ....
  10. doi request reprint Impact of methylene blue in addition to norepinephrine on the intestinal microcirculation in experimental septic shock
    Jordan Nantais
    Department of General Surgery, Dalhousie University, Halifax, Canada
    Clin Hemorheol Microcirc 58:97-105. 2014
    ..This study suggests that methylene blue may be able to improve hemodynamics while preserving microvascular function in septic shock. ..
  11. doi request reprint Novel approaches to the development of anti-sepsis drugs
    Christian Lehmann
    Dalhousie University, Department of Anaesthesia, 10 West Victoria, 1276 South Park St, Halifax, Nova Scotia, B3H 2Y9, Canada 1 902 473 2331 1 902 423 9454
    Expert Opin Drug Discov 9:523-31. 2014
    ..Increasing incidence and high mortality of sepsis require novel approaches for the development of anti-sepsis drugs...
  12. doi request reprint Activated protein C improves pial microcirculation in experimental endotoxemia in rats
    Juan Zhou
    Department of Anesthesia, Dalhousie University, Halifax, NS, Canada
    Microvasc Res 83:276-80. 2012
    ..Our hypothesis is rhAPC protects pial microcirculation in endotoxemia...