Dominique Legros

Summary

Publications

  1. ncbi request reprint Treatment of human African trypanosomiasis--present situation and needs for research and development
    Dominique Legros
    Epicentre, Paris, France
    Lancet Infect Dis 2:437-40. 2002
  2. ncbi request reprint Adherence to the combination of sulphadoxine-pyrimethamine and artesunate in the Maheba refugee settlement, Zambia
    Evelyn Depoortere
    Epicentre, Paris, France
    Trop Med Int Health 9:62-7. 2004
  3. pmc Research in complex humanitarian emergencies: the Médecins Sans Frontières/Epicentre experience
    Vincent Brown
    Epicentre, Paris, France
    PLoS Med 5:e89. 2008
  4. ncbi request reprint Outbreak of beriberi in a prison in Côte d'Ivoire
    Laurence Ahoua
    Epicentre, 42 boulevard Richard Lenoir, Paris 75011, France
    Food Nutr Bull 28:283-90. 2007
  5. pmc Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004
    Jean Paul Guthmann
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Antimicrob Agents Chemother 50:3734-9. 2006
  6. ncbi request reprint Feasibility of a mass vaccination campaign using a two-dose oral cholera vaccine in an urban cholera-endemic setting in Mozambique
    Philippe Cavailler
    Epicentre, Paris, France
    Vaccine 24:4890-5. 2006
  7. ncbi request reprint Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola
    Jean Paul Guthmann
    Epicentre, 42 bis, Boulevard Richard Lenoir, 75011 Paris, France
    Trans R Soc Trop Med Hyg 99:485-92. 2005
  8. ncbi request reprint Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia
    Evelyn Depoortere
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Trop Med Int Health 10:139-45. 2005
  9. ncbi request reprint Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial
    Gerardo Priotto
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Trans R Soc Trop Med Hyg 97:325-30. 2003
  10. pmc Mortality among displaced former UNITA members and their families in Angola: a retrospective cluster survey
    Thomas Grein
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    BMJ 327:650. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Treatment of human African trypanosomiasis--present situation and needs for research and development
    Dominique Legros
    Epicentre, Paris, France
    Lancet Infect Dis 2:437-40. 2002
    ..At the same time, on a long term basis, ambitious research programmes for new compounds must be supported to ensure the sustainable development of new drugs...
  2. ncbi request reprint Adherence to the combination of sulphadoxine-pyrimethamine and artesunate in the Maheba refugee settlement, Zambia
    Evelyn Depoortere
    Epicentre, Paris, France
    Trop Med Int Health 9:62-7. 2004
    ..For these treatment regimens to remain efficacious on a long-term basis, specific and locally adapted strategies need to be implemented to ensure completion of the treatment...
  3. pmc Research in complex humanitarian emergencies: the Médecins Sans Frontières/Epicentre experience
    Vincent Brown
    Epicentre, Paris, France
    PLoS Med 5:e89. 2008
  4. ncbi request reprint Outbreak of beriberi in a prison in Côte d'Ivoire
    Laurence Ahoua
    Epicentre, 42 boulevard Richard Lenoir, Paris 75011, France
    Food Nutr Bull 28:283-90. 2007
    ..A beriberi outbreak occurred in the Maison d'Arrêt et de Correction d'Abidjan (MACA), a detention center in Abidjan, Côte d'Ivoire, between October 2002 and April 2003...
  5. pmc Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004
    Jean Paul Guthmann
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Antimicrob Agents Chemother 50:3734-9. 2006
    ..Results support the implementation of the current WHO protocol and favor analyzing PCR-corrected outcomes by Kaplan-Meier analysis (which allows for dropouts) and retaining new infections (which minimizes losses)...
  6. ncbi request reprint Feasibility of a mass vaccination campaign using a two-dose oral cholera vaccine in an urban cholera-endemic setting in Mozambique
    Philippe Cavailler
    Epicentre, Paris, France
    Vaccine 24:4890-5. 2006
    ..09 dollars, which is relatively high. However, in endemic settings where outbreaks are likely to occur, integrating cholera vaccination into the routine activities of the public health system could reduce such costs...
  7. ncbi request reprint Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola
    Jean Paul Guthmann
    Epicentre, 42 bis, Boulevard Richard Lenoir, 75011 Paris, France
    Trans R Soc Trop Med Hyg 99:485-92. 2005
    ..We recommend the use of AQ with AS, though this combination might not have a long useful therapeutic life because of AQ resistance...
  8. ncbi request reprint Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia
    Evelyn Depoortere
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Trop Med Int Health 10:139-45. 2005
    ..When implementing new malaria treatment policies, serious investment in ensuring patient adherence is essential to ascertain the effectiveness of the new treatment schedules...
  9. ncbi request reprint Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial
    Gerardo Priotto
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Trans R Soc Trop Med Hyg 97:325-30. 2003
    ..Treatment efficacy improved with SPAS3 but the cure rate at day 28 was modest. The combinations were well tolerated and safe. In areas where SP resistance is prevalent other combinations should be considered...
  10. pmc Mortality among displaced former UNITA members and their families in Angola: a retrospective cluster survey
    Thomas Grein
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    BMJ 327:650. 2003
    ..To measure retrospectively mortality among a previously inaccessible population of former UNITA members and their families displaced within Angola, before and after their arrival in resettlement camps after ceasefire of 4 April 2002...
  11. ncbi request reprint Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone
    Philippe J Guerin
    Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
    Lancet 362:705-6. 2003
    ..9%. A 5-day ciprofloxacin regimen, targeted to the most severe cases of bloody diarrhoea, was highly effective. This is the first time a large outbreak caused by Sd1 has been reported in west Africa...
  12. ncbi request reprint Consequences of armed conflict for an ethnic Karen population
    Francesco Checchi
    Epicentre, 8 rue Saint Sabin, 75011, Paris, France
    Lancet 362:74-5. 2003
  13. pmc Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series
    Francesco Checchi
    Epicentre, Paris, France
    PLoS Negl Trop Dis 1:e64. 2007
    ....
  14. pmc A look back at an ongoing problem: Shigella dysenteriae type 1 epidemics in refugee settings in Central Africa (1993-1995)
    Solen Kerneis
    Epicentre, Paris, France
    PLoS ONE 4:e4494. 2009
    ..We also explored the links between the different types of the camps and the magnitude of the outbreaks...
  15. ncbi request reprint Outbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002
    Evelyn Depoortere
    Epicentre, Paris, France
    Trop Med Int Health 9:730-6. 2004
    ..The spread of such a virus to other countries or continents cannot be excluded...
  16. doi request reprint Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin
    Christine Dubray
    Epicentre, Paris, France
    Ann Trop Paediatr 28:13-22. 2008
    ....
  17. pmc Meningitis serogroup W135 outbreak, Burkina Faso, 2002
    Nicolas Nathan
    Epicentre, Paris, France
    Emerg Infect Dis 13:920-3. 2007
    ..The highest attack rate was in children <5 years of age. We describe cases from 1 district and evaluate the performance of the Pastorex test, which had good sensitivity (84%) and specificity (89%) compared with culture or PCR...
  18. ncbi request reprint Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine
    Veerle Lejon
    Department of Parasitology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Neuroimmunol 144:132-8. 2003
    ..b. gambiense positive CSF, were associated with treatment failure. Detection of intrathecal IgM synthesis is valuable for assessment of brain involvement and treatment decision...
  19. pmc Death rates from malaria epidemics, Burundi and Ethiopia
    Jean Paul Guthmann
    Institut de Veille Sanitaire, Saint Maurice, France
    Emerg Infect Dis 13:140-3. 2007
    ..Deaths likely from malaria ranged from 1,000 to 8,900, depending on site, and accounted for 52% to 78% of total deaths. Earlier detection of malaria and better case management are needed...
  20. ncbi request reprint Laboratory diagnosis of Ebola hemorrhagic fever during an outbreak in Yambio, Sudan, 2004
    Clayton O Onyango
    World Health Organization Collaborating Center for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Nairobi, Kenya
    J Infect Dis 196:S193-8. 2007
    ..In response, case management, social mobilization, and follow-up of contacts were set up as means of surveillance. The outbreak was declared to be over on 7 August 2004...
  21. ncbi request reprint Intrathecal immune response pattern for improved diagnosis of central nervous system involvement in trypanosomiasis
    Veerle Lejon
    Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    J Infect Dis 187:1475-83. 2003
    ..We also show that trypanosomiasis-related immunoglobulin patterns are of value in differential diagnosis...
  22. doi request reprint Nosocomial transmission of severe acute respiratory syndrome: better quality of evidence is needed
    Stephane Hugonnet
    Clin Infect Dis 45:1651; author reply 1652. 2007
  23. pmc Conflict and emerging infectious diseases
    Michelle Gayer
    Disease Control in Humanitarian Emerfencies, Health Security and Environmental Cluster, World Health Organization, Geneva, Switzerland
    Emerg Infect Dis 13:1625-31. 2007
    ..This article outlines factors that potentiate emergence and transmission of infectious diseases in conflict situations and highlights several priority actions for their containment and control...
  24. ncbi request reprint Trypanosoma brucei gambiense trypanosomiasis in Terego county, northern Uganda, 1996: a lot quality assurance sampling survey
    Yvan J F Hutin
    Epicentre Office in Uganda, Kampala, Uganda
    Am J Trop Med Hyg 70:390-4. 2004
    ....
  25. ncbi request reprint Rapid assessment of mortality and malnutrition in Afghanistan
    Patrice Piola
    JAMA 288:1233-4. 2002
  26. ncbi request reprint Indirect markers to initiate highly active antiretroviral therapy in a rural African setting
    Jean Michel Tassie
    AIDS 18:1226-8. 2004