Lorenzo Leggio

Summary

Publications

  1. doi request reprint Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168 Rome, Italy
    Alcohol Alcohol 44:341-52. 2009
  2. doi request reprint Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:2047-53. 2008
  3. doi request reprint Is cortisol involved in the alcohol-related fat mass impairment? A longitudinal clinical study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Alcohol 44:211-5. 2009
  4. doi request reprint Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Addict Biol 17:452-64. 2012
  5. doi request reprint Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol 42:375-81. 2008
  6. doi request reprint Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal study
    Cristina D'Angelo
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neurosurgery 67:265-71. 2010
  7. doi request reprint Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
    Alcohol Alcohol 46:312-7. 2011
  8. ncbi request reprint Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Lancet 370:1915-22. 2007
  9. doi request reprint Affective and psychiatric disorders in celiac disease
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Dig Dis 26:140-8. 2008
  10. doi request reprint Metabolic and nutritional features in adult celiac patients
    Noemi Malandrino
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Dig Dis 26:128-33. 2008

Collaborators

Detail Information

Publications38

  1. doi request reprint Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168 Rome, Italy
    Alcohol Alcohol 44:341-52. 2009
    ..These possible interactions could lead to future intriguing research aimed at understanding and treating alcohol craving and dependence...
  2. doi request reprint Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:2047-53. 2008
    ..Investigating this association in alcohol-dependent (AD) patients was the aim of this preliminary and exploratory study...
  3. doi request reprint Is cortisol involved in the alcohol-related fat mass impairment? A longitudinal clinical study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Alcohol 44:211-5. 2009
    ..The goal of this study was to investigate if there is any relationship between HP-hormones and metabolic and nutritional parameters in alcoholic subjects...
  4. doi request reprint Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Addict Biol 17:452-64. 2012
    ..This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD...
  5. doi request reprint Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol 42:375-81. 2008
    ..In conclusion, the renin-aldosterone axis could play a role in craving in medium-term abstinent patients and thereby leading to the hypothesis that alcohol craving could be influenced by the fluid volume intake...
  6. doi request reprint Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal study
    Cristina D'Angelo
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neurosurgery 67:265-71. 2010
    ..To evaluate anxiety and depression as prognostic factors for radicular and back pain after surgery in patients with lumbar disc herniation in a 1-year follow-up study...
  7. doi request reprint Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
    Alcohol Alcohol 46:312-7. 2011
    ..To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence...
  8. ncbi request reprint Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Lancet 370:1915-22. 2007
    ..We aimed to investigate the effectiveness and safety of baclofen in achieving and maintaining alcohol abstinence in patients with liver cirrhosis...
  9. doi request reprint Affective and psychiatric disorders in celiac disease
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Dig Dis 26:140-8. 2008
    ..The available data suggest that screening for CD in patients with affective and/or psychiatric symptoms may be useful since these disorders could be the expression of an organic disease rather than primary psychiatric illnesses...
  10. doi request reprint Metabolic and nutritional features in adult celiac patients
    Noemi Malandrino
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Dig Dis 26:128-33. 2008
    ..Thus, an early and accurate evaluation of nutritional status and energy metabolism represents a fundamental tool in the management of CD patients...
  11. doi request reprint Social phobia in coeliac disease
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Scand J Gastroenterol 43:410-5. 2008
    ..Although social phobia is included among the anxiety disorders, its presence in CD has never been investigated. The aim of the present study was to evaluate social phobia in CD patients...
  12. doi request reprint Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patients
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:450-8. 2008
    ..The aim of this clinical study was to evaluate the relationships between insulin and IGF-1 plasma concentrations and alcohol craving...
  13. doi request reprint State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal study
    Cristina D'Angelo
    Institute of Internal Medicine, Catholic University of Rome, and Department of Cardiac Surgery, St Andrea Hospital, Rome, Italy
    J Neurosurg 108:281-6. 2008
    ..The relationships between these affective disorders and the patient's sex, tumor histology, and laterality of the tumor were also evaluated...
  14. pmc Psychosocial findings in alcohol-dependent patients before and after three months of total alcohol abstinence
    Anna Ferrulli
    Institute of Internal Medicine, Catholic University of Rome Rome, Italy
    Front Psychiatry 1:17. 2010
    ..Larger controlled studies are needed to confirm these findings...
  15. doi request reprint Management of alcohol dependence in patients with liver disease
    Giovanni Addolorato
    Department of Internal Medicine, Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo Gemelli 8, 00168 Rome, Italy
    CNS Drugs 27:287-99. 2013
    ..To date, baclofen represents the only anti-craving medication formally tested in a randomized clinical trial in alcoholic patients affected by liver cirrhosis, although additional confirmatory studies are warranted...
  16. ncbi request reprint Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
    Alcohol Clin Exp Res 30:1933-7. 2006
    ..Alcohol-craving and food-seeking behavior could share common neural circuits. Ghrelin is related to nutritional status, but few data are available in alcoholic patients on the relationship between ghrelin and nutritional disorders...
  17. doi request reprint Acute alcohol intoxication
    Luisa Vonghia
    Institute of Internal Medicine, Catholic University of Rome, Italy
    Eur J Intern Med 19:561-7. 2008
    ..In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established...
  18. ncbi request reprint Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Med 119:276.e13-8. 2006
    ..Accordingly, the present study was designed to compare efficacy, tolerability and safety of baclofen versus diazepam in the treatment of AWS...
  19. doi request reprint Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center
    Giovanni Addolorato
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy Alcohol Addiction Unit, Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 37:1601-8. 2013
    ..We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well...
  20. doi request reprint Role of the GABA(B) receptor system in alcoholism and stress: focus on clinical studies and treatment perspectives
    Giovanni Addolorato
    Institute of Internal Medicine, Agostino Gemelli Hospital, Catholic University of Rome, Rome, Italy
    Alcohol 43:559-63. 2009
    ..e., cirrhosis). Future studies should investigate which alcoholic subtype may better benefit of the administration of baclofen in the treatment of alcohol dependence...
  21. doi request reprint Fecal calprotectin concentrations in alcoholic patients: a longitudinal study
    Massimo Montalto
    Institute of Internal Medicine, Catholic University of Rome, Italy
    Eur J Gastroenterol Hepatol 23:76-80. 2011
    ..Moreover, FCCs in the alcoholics were compared with the FCCs in healthy controls...
  22. ncbi request reprint Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy males
    Giovanni Addolorato
    Institutes of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168, Rome, Italy
    Appetite 50:50-6. 2008
    ..Finally, short-term moderate ethanol intake appeared to influence the FM, although it was not able to significantly affect nutritional or body composition...
  23. ncbi request reprint Analysis of the T1288R mutation of the Wilson disease ATP7B gene in four generations of a family: possible genotype-phenotype correlation with hepatic onset
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, L go Gemelli 8, 00168, Rome, Italy
    Dig Dis Sci 52:2570-5. 2007
    ..Consequently, a genotype-phenotype correlation could be hypothesized, although further studies are necessary to clarify this topic...
  24. ncbi request reprint How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a review
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neuropsychobiology 51:59-66. 2005
    ..In this review, the main drugs currently used in the treatment of patients with alcohol problems are described. A hypothesis of pharmacological treatment of the different types of craving is also discussed...
  25. ncbi request reprint Superior vena cava thrombosis treated by angioplasty and stenting in a cirrhotic patient with peritoneovenous shunt
    Lorenzo Leggio
    Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
    Ann Thorac Cardiovasc Surg 14:60-2. 2008
    ..The patient died in June 2006 due to severe liver function impairment and hepato-renal syndrome. The present case shows that percutaneous transluminal angioplasty represents a good choice for primary intervention...
  26. doi request reprint Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Hum Psychopharmacol 26:554-9. 2011
    ..Metadoxine is approved in Europe for alcohol intoxication and is also indicated for alcoholic liver disease (ALD). This study aims to investigate the use of metadoxine as a potential pharmacotherapy for alcohol dependence (AD)...
  27. doi request reprint Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, Rome, Italy
    Drug Alcohol Rev 28:160-5. 2009
    ..Accordingly, research on this topic could lead to possible development of new therapeutic approaches in the treatment of patients with alcohol problems...
  28. ncbi request reprint The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data
    Giovanni Addolorato
    Catholic University of Rome, Institute of Internal Medicine, L o A Gemelli 8, I 00168 Rome, Italy
    Expert Opin Investig Drugs 18:675-86. 2009
    ..Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations...
  29. ncbi request reprint Coeliac disease and hearing loss: preliminary data on a new possible association
    Lorenzo Leggio
    Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
    Scand J Gastroenterol 42:1209-13. 2007
    ..At present, no data are available on the presence of hearing loss disorder in coeliac patients. The aim of the present study was to investigate the prevalence of hearing loss in coeliac patients compared with that in healthy controls...
  30. doi request reprint Role of the tumor necrosis factor antagonists in the treatment of inflammatory bowel disease: an update
    Veruscka Leso
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Eur J Gastroenterol Hepatol 22:779-86. 2010
    ..The goal of this review is to provide an update and analyze the pros and cons of using anti-TNF therapies in the treatment of IBD...
  31. ncbi request reprint Neurobiochemical and clinical aspects of craving in alcohol addiction: a review
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo A Gemelli 8, 00168 Rome, Italy
    Addict Behav 30:1209-24. 2005
    ....
  32. doi request reprint Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, Italy
    Ludovico Abenavoli
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Fitoterapia 79:142-7. 2008
  33. ncbi request reprint Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Urol Oncol 24:307-12. 2006
    ..A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported. The present case represents further evidence of a rare malignancy...
  34. pmc Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neuropsychopharmacology 37:163-77. 2012
    ..Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism...
  35. doi request reprint Understanding and treating patients with alcoholic cirrhosis: an update
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome GA, LL, Rome, Italy
    Alcohol Clin Exp Res 33:1136-44. 2009
    ..All together the information available suggests the need of a multimodal approach in the clinical management of these patients...
  36. doi request reprint Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studies
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Alcohol 43:148-50. 2008
    ..New developments in the neurobiological understanding of subtypes of alcoholic patients, could led to get the basis for a more personalized pharmacological therapy...
  37. ncbi request reprint Suppression of alcohol delirium tremens by baclofen administration: a case report
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of the Sacred Heart, Gemelli Hospital, Largo A Gemelli 8, 00168 Rome, Italy
    Clin Neuropharmacol 26:258-62. 2003
    ..Here, we report a case of DT successfully treated with baclofen. This result indicates that the efficacy of baclofen in the treatment of DT should be examined in future clinical trials...
  38. doi request reprint Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases
    L Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Drug News Perspect 23:157-66. 2010
    ..e., GHS-R1a antagonists and/or inverse agonists) might affect alcohol-seeking behavior, thus having therapeutic potential in alcohol use disorders. Future laboratory and clinical studies testing this hypothesis are warranted...