Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findingsLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168 Rome, Italy
Alcohol Alcohol 44:341-52. 2009
..These possible interactions could lead to future intriguing research aimed at understanding and treating alcohol craving and dependence...
- Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Clin Exp Res 32:2047-53. 2008
..Investigating this association in alcohol-dependent (AD) patients was the aim of this preliminary and exploratory study...
- Is cortisol involved in the alcohol-related fat mass impairment? A longitudinal clinical study
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Alcohol 44:211-5. 2009
..The goal of this study was to investigate if there is any relationship between HP-hormones and metabolic and nutritional parameters in alcoholic subjects...
- Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Addict Biol 17:452-64. 2012
..This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD...
- Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol 42:375-81. 2008
..In conclusion, the renin-aldosterone axis could play a role in craving in medium-term abstinent patients and thereby leading to the hypothesis that alcohol craving could be influenced by the fluid volume intake...
- Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal study
Cristina D'Angelo
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Neurosurgery 67:265-71. 2010
..To evaluate anxiety and depression as prognostic factors for radicular and back pain after surgery in patients with lumbar disc herniation in a 1-year follow-up study...
- Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
Alcohol Alcohol 46:312-7. 2011
..To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence...
Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled studyGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Lancet 370:1915-22. 2007
..We aimed to investigate the effectiveness and safety of baclofen in achieving and maintaining alcohol abstinence in patients with liver cirrhosis...
- Affective and psychiatric disorders in celiac disease
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Dig Dis 26:140-8. 2008
..The available data suggest that screening for CD in patients with affective and/or psychiatric symptoms may be useful since these disorders could be the expression of an organic disease rather than primary psychiatric illnesses...
- Metabolic and nutritional features in adult celiac patients
Noemi Malandrino
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Dig Dis 26:128-33. 2008
..Thus, an early and accurate evaluation of nutritional status and energy metabolism represents a fundamental tool in the management of CD patients...
- Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patients
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Clin Exp Res 32:450-8. 2008
..The aim of this clinical study was to evaluate the relationships between insulin and IGF-1 plasma concentrations and alcohol craving...
- Social phobia in coeliac disease
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Scand J Gastroenterol 43:410-5. 2008
..Although social phobia is included among the anxiety disorders, its presence in CD has never been investigated. The aim of the present study was to evaluate social phobia in CD patients...
- State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal study
Cristina D'Angelo
Institute of Internal Medicine, Catholic University of Rome, and Department of Cardiac Surgery, St Andrea Hospital, Rome, Italy
J Neurosurg 108:281-6. 2008
..The relationships between these affective disorders and the patient's sex, tumor histology, and laterality of the tumor were also evaluated...
Psychosocial findings in alcohol-dependent patients before and after three months of total alcohol abstinenceAnna Ferrulli
Institute of Internal Medicine, Catholic University of Rome Rome, Italy
Front Psychiatry 1:17. 2010
..Larger controlled studies are needed to confirm these findings...
- Acute alcohol intoxication
Luisa Vonghia
Institute of Internal Medicine, Catholic University of Rome, Italy
Eur J Intern Med 19:561-7. 2008
..In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established...
- Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Am J Med 119:276.e13-8. 2006
..Accordingly, the present study was designed to compare efficacy, tolerability and safety of baclofen versus diazepam in the treatment of AWS...
- Role of the GABA(B) receptor system in alcoholism and stress: focus on clinical studies and treatment perspectives
Giovanni Addolorato
Institute of Internal Medicine, Agostino Gemelli Hospital, Catholic University of Rome, Rome, Italy
Alcohol 43:559-63. 2009
..e., cirrhosis). Future studies should investigate which alcoholic subtype may better benefit of the administration of baclofen in the treatment of alcohol dependence...
- Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy males
Giovanni Addolorato
Institutes of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168, Rome, Italy
Appetite 50:50-6. 2008
..Finally, short-term moderate ethanol intake appeared to influence the FM, although it was not able to significantly affect nutritional or body composition...
- Fecal calprotectin concentrations in alcoholic patients: a longitudinal study
Massimo Montalto
Institute of Internal Medicine, Catholic University of Rome, Italy
Eur J Gastroenterol Hepatol 23:76-80. 2011
..Moreover, FCCs in the alcoholics were compared with the FCCs in healthy controls...
- Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, Rome, Italy
Drug Alcohol Rev 28:160-5. 2009
..Accordingly, research on this topic could lead to possible development of new therapeutic approaches in the treatment of patients with alcohol problems...
- The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data
Giovanni Addolorato
Catholic University of Rome, Institute of Internal Medicine, L o A Gemelli 8, I 00168 Rome, Italy
Expert Opin Investig Drugs 18:675-86. 2009
..Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations...
- Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease
Lorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
Hum Psychopharmacol 26:554-9. 2011
..Metadoxine is approved in Europe for alcohol intoxication and is also indicated for alcoholic liver disease (ALD). This study aims to investigate the use of metadoxine as a potential pharmacotherapy for alcohol dependence (AD)...
- Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
Alcohol Clin Exp Res 30:1933-7. 2006
..Alcohol-craving and food-seeking behavior could share common neural circuits. Ghrelin is related to nutritional status, but few data are available in alcoholic patients on the relationship between ghrelin and nutritional disorders...
- Analysis of the T1288R mutation of the Wilson disease ATP7B gene in four generations of a family: possible genotype-phenotype correlation with hepatic onset
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, L go Gemelli 8, 00168, Rome, Italy
Dig Dis Sci 52:2570-5. 2007
..Consequently, a genotype-phenotype correlation could be hypothesized, although further studies are necessary to clarify this topic...
- How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a review
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Neuropsychobiology 51:59-66. 2005
..In this review, the main drugs currently used in the treatment of patients with alcohol problems are described. A hypothesis of pharmacological treatment of the different types of craving is also discussed...
- Superior vena cava thrombosis treated by angioplasty and stenting in a cirrhotic patient with peritoneovenous shunt
Lorenzo Leggio
Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
Ann Thorac Cardiovasc Surg 14:60-2. 2008
..The patient died in June 2006 due to severe liver function impairment and hepato-renal syndrome. The present case shows that percutaneous transluminal angioplasty represents a good choice for primary intervention...
- Role of the tumor necrosis factor antagonists in the treatment of inflammatory bowel disease: an update
Veruscka Leso
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Eur J Gastroenterol Hepatol 22:779-86. 2010
..The goal of this review is to provide an update and analyze the pros and cons of using anti-TNF therapies in the treatment of IBD...
- Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Urol Oncol 24:307-12. 2006
..A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported. The present case represents further evidence of a rare malignancy...
- Neurobiochemical and clinical aspects of craving in alcohol addiction: a review
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, Italy
Addict Behav 30:1209-24. 2005
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- Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, Italy
Ludovico Abenavoli
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Fitoterapia 79:142-7. 2008
- Coeliac disease and hearing loss: preliminary data on a new possible association
Lorenzo Leggio
Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
Scand J Gastroenterol 42:1209-13. 2007
..At present, no data are available on the presence of hearing loss disorder in coeliac patients. The aim of the present study was to investigate the prevalence of hearing loss in coeliac patients compared with that in healthy controls...
- Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Neuropsychopharmacology 37:163-77. 2012
..Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism...
- Understanding and treating patients with alcoholic cirrhosis: an update
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome GA, LL, Rome, Italy
Alcohol Clin Exp Res 33:1136-44. 2009
..All together the information available suggests the need of a multimodal approach in the clinical management of these patients...
- Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studies
Lorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Alcohol 43:148-50. 2008
..New developments in the neurobiological understanding of subtypes of alcoholic patients, could led to get the basis for a more personalized pharmacological therapy...
- Suppression of alcohol delirium tremens by baclofen administration: a case report
Giovanni Addolorato
Institute of Internal Medicine, Catholic University of the Sacred Heart, Gemelli Hospital, Largo A Gemelli 8, 00168 Rome, Italy
Clin Neuropharmacol 26:258-62. 2003
..Here, we report a case of DT successfully treated with baclofen. This result indicates that the efficacy of baclofen in the treatment of DT should be examined in future clinical trials...
- Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases
L Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Drug News Perspect 23:157-66. 2010
..e., GHS-R1a antagonists and/or inverse agonists) might affect alcohol-seeking behavior, thus having therapeutic potential in alcohol use disorders. Future laboratory and clinical studies testing this hypothesis are warranted...
