C J Lees

Summary

Publications

  1. ncbi request reprint Effects of pregnancy and lactation on bone in cynomolgus macaques: histomorphometric analysis of iliac biopsies
    C J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Bone 22:545-9. 1998
  2. ncbi request reprint Histomorphometry and bone biomarkers in cynomolgus females: a study in young, mature, and old monkeys
    C J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Bone 24:25-8. 1999
  3. ncbi request reprint Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys
    R Brommage
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 84:3757-63. 1999
  4. pmc Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet
    J R Kaplan
    Wake Forest University Primate Center, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Hum Reprod 25:3083-94. 2010
  5. ncbi request reprint Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolgus monkeys
    C E Hotchkiss
    Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 29:7-15. 2001

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Effects of pregnancy and lactation on bone in cynomolgus macaques: histomorphometric analysis of iliac biopsies
    C J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Bone 22:545-9. 1998
    ..These results suggest that, during the third trimester, the rate of bone turnover was not altered, but lactational demands for calcium were met in part by increased bone turnover...
  2. ncbi request reprint Histomorphometry and bone biomarkers in cynomolgus females: a study in young, mature, and old monkeys
    C J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Bone 24:25-8. 1999
    ..The biomarker and histomorphometric indices in the young animals reflect the growth that was occurring in this group. The older monkeys do not appear to differ significantly between 10 and 22 years of age...
  3. ncbi request reprint Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys
    R Brommage
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 84:3757-63. 1999
    ..Similar, but less dramatic, effects on BMD were observed with the lower dose of rhPTH-(1-34). Daily s.c. rhPTH-(1-34) treatment for 1 yr increases BMD in ovariectomized monkeys without inducing sustained hypercalcemia or hypercalciuria...
  4. pmc Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet
    J R Kaplan
    Wake Forest University Primate Center, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Hum Reprod 25:3083-94. 2010
    ..We hypothesized that reproductive compromise and adverse health outcomes would be induced in subordinate when compared with dominant monkeys and be mitigated by exposure to soy...
  5. ncbi request reprint Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolgus monkeys
    C E Hotchkiss
    Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 29:7-15. 2001
    ..6%; sham -1.9%, est -2.9%; L1 -6.2%, L2 -6.1%, L3 -6.7%). Bone loss at each site was correlated with bone turnover as measured by serum and urine biomarkers. There was no dose effect of levormeloxifene...