Vernon J Lee

Summary

Publications

  1. pmc Respiratory viral pathogens among Singapore military servicemen 2009-2012: epidemiology and clinical characteristics
    Xin Quan Tan
    Biodefence Centre, Ministry of Defence, Singapore, Singapore
    BMC Infect Dis 14:204. 2014
  2. pmc Effectiveness of pandemic H1N1-2009 vaccination in reducing laboratory confirmed influenza infections among military recruits in tropical Singapore
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Singapore, Singapore
    PLoS ONE 6:e26572. 2011
  3. pmc Simple clinical and laboratory predictors of Chikungunya versus dengue infections in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    PLoS Negl Trop Dis 6:e1786. 2012
  4. ncbi request reprint Twentieth century influenza pandemics in Singapore
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 37:470-6. 2008
  5. pmc Influenza excess mortality from 1950-2000 in tropical Singapore
    Vernon J Lee
    Biodefence Center, Ministry of Defence, Singapore, Singapore
    PLoS ONE 4:e8096. 2009
  6. pmc Combination strategies for pandemic influenza response - a systematic review of mathematical modeling studies
    Vernon J Lee
    Center for Health Services Research, National University of Singapore, Singapore
    BMC Med 7:76. 2009
  7. pmc Elimination of malaria risk through integrated combination strategies in a tropical military training island
    Vernon J Lee
    Biodefence Center, Singapore Armed Forces, Singapore Headquarters Army Medical Services, Singapore Armed Forces, Singapore
    Am J Trop Med Hyg 82:1024-9. 2010
  8. pmc Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Transit Road, Singapore 778910, Singapore
    BMC Infect Dis 10:164. 2010
  9. ncbi request reprint Oseltamivir ring prophylaxis for containment of 2009 H1N1 influenza outbreaks
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Department of Epidemiology and Public Health, National University of Singapore
    N Engl J Med 362:2166-74. 2010
  10. doi request reprint Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains
    Vernon J Lee
    Biodefence Center, Singapore Armed Forces, 701 Transit Road 04 01, Singapore 778910, Singapore
    Vaccine 28:6852-7. 2010

Collaborators

Detail Information

Publications50

  1. pmc Respiratory viral pathogens among Singapore military servicemen 2009-2012: epidemiology and clinical characteristics
    Xin Quan Tan
    Biodefence Centre, Ministry of Defence, Singapore, Singapore
    BMC Infect Dis 14:204. 2014
    ..There is also a lack of studies comparing clinical characteristics of the non-influenza pathogens with influenza and amongst themselves...
  2. pmc Effectiveness of pandemic H1N1-2009 vaccination in reducing laboratory confirmed influenza infections among military recruits in tropical Singapore
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Singapore, Singapore
    PLoS ONE 6:e26572. 2011
    ..Limited information is available about pandemic H1N1-2009 influenza vaccine effectiveness in tropical communities. We studied the effectiveness of a pandemic H1N1 vaccination program in reducing influenza cases in Singapore...
  3. pmc Simple clinical and laboratory predictors of Chikungunya versus dengue infections in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    PLoS Negl Trop Dis 6:e1786. 2012
    ..This study compares their clinical presentation in Singapore adults to derive predictors to assist doctors in diagnostic decision-making...
  4. ncbi request reprint Twentieth century influenza pandemics in Singapore
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 37:470-6. 2008
    ..Singapore was substantially affected by three 20th Century pandemics. This study describes the course of the pandemics, and the preventive measures adopted...
  5. pmc Influenza excess mortality from 1950-2000 in tropical Singapore
    Vernon J Lee
    Biodefence Center, Ministry of Defence, Singapore, Singapore
    PLoS ONE 4:e8096. 2009
    ..However, there is little information about the burden of annual tropical influenza epidemics across time, and the relationship between tropical influenza epidemics compared with other regions...
  6. pmc Combination strategies for pandemic influenza response - a systematic review of mathematical modeling studies
    Vernon J Lee
    Center for Health Services Research, National University of Singapore, Singapore
    BMC Med 7:76. 2009
    ..Individual strategies in pandemic preparedness plans may not reduce the impact of an influenza pandemic...
  7. pmc Elimination of malaria risk through integrated combination strategies in a tropical military training island
    Vernon J Lee
    Biodefence Center, Singapore Armed Forces, Singapore Headquarters Army Medical Services, Singapore Armed Forces, Singapore
    Am J Trop Med Hyg 82:1024-9. 2010
    ..001). There were no malaria cases on the island despite chemoprophylaxis termination, showing that comprehensive combination vector-control strategies were effective in reducing the risk of malaria...
  8. pmc Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Transit Road, Singapore 778910, Singapore
    BMC Infect Dis 10:164. 2010
    ..Anti-viral prophylaxis is used to prevent the transmission of influenza. We studied serological confirmation of 2009 Influenza A (H1N1) infections during oseltamivir prophylaxis and after cessation of prophylaxis...
  9. ncbi request reprint Oseltamivir ring prophylaxis for containment of 2009 H1N1 influenza outbreaks
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Department of Epidemiology and Public Health, National University of Singapore
    N Engl J Med 362:2166-74. 2010
    ..We report the efficacy of ring chemoprophylaxis (geographically targeted containment by means of prophylaxis) with oseltamivir to control outbreaks of 2009 H1N1 influenza in semiclosed environments...
  10. doi request reprint Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains
    Vernon J Lee
    Biodefence Center, Singapore Armed Forces, 701 Transit Road 04 01, Singapore 778910, Singapore
    Vaccine 28:6852-7. 2010
    ..In June 2009, we conducted a prospective study in Singapore on 51 individuals to determine their serologic responses before and following receipt of the 2009 Southern Hemisphere seasonal influenza vaccine...
  11. doi request reprint Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Singapore
    J Clin Virol 50:104-8. 2011
    ..Antiviral post-exposure prophylaxis with oseltamivir has been used as a strategy in mitigating the Influenza A (H1N1-2009) pandemic. There have been few reports of well-documented prophylaxis failures and the reasons for failure...
  12. pmc A clinical diagnostic model for predicting influenza among young adult military personnel with febrile respiratory illness in Singapore
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Singapore, Singapore
    PLoS ONE 6:e17468. 2011
    ..We aim to compare the differences in presentation between influenza and non-influenza cases among those with febrile respiratory illness (FRI) to determine predictors of influenza infection...
  13. pmc Cost-effectiveness of different human papillomavirus vaccines in Singapore
    Vernon J Lee
    Center for Health Services Research, National University of Singapore, Singapore
    BMC Public Health 11:203. 2011
    ..We explore the cost-effectiveness of these two HPV vaccines in tropical Singapore...
  14. pmc Comparability of different methods for estimating influenza infection rates over a single epidemic wave
    Vernon J Lee
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Epidemiol 174:468-78. 2011
    ..The various types of estimates will provide comparable findings if accurate input parameters can be obtained...
  15. pmc Economic analysis of pandemic influenza vaccination strategies in Singapore
    Vernon J Lee
    Center for Health Services Research, National University of Singapore, Singapore, Singapore
    PLoS ONE 4:e7108. 2009
    ..However, few studies have evaluated the cost-effectiveness of different vaccination strategies. This paper compares the economic outcomes of vaccination compared with treatment with antiviral agents alone, in Singapore...
  16. doi request reprint Decision tree algorithm in deciding hospitalization for adult patients with dengue haemorrhagic fever in Singapore
    V J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    Trop Med Int Health 14:1154-9. 2009
    ..To develop a simple decision tree for clinicians to decide between hospitalization and outpatient monitoring of adult dengue patients...
  17. ncbi request reprint An outbreak of Salmonella gastrointestinal illness in a military camp
    Vernon J Lee
    Army Medical Services, Singapore Armed Forces, Singapore
    Ann Acad Med Singapore 38:207-11. 2009
    ..An outbreak of gastrointestinal infection occurred in a military camp in January 2007, and an epidemiological outbreak investigation was conducted...
  18. ncbi request reprint User acceptability and feasibility of self-testing with HIV rapid tests
    Vernon J Lee
    Department of Clinical Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital, 802 Moulmein Road, Singapore
    J Acquir Immune Defic Syndr 45:449-53. 2007
    ..Because HIV rapid tests are considered for self-testing, this study aims to determine the user acceptability and feasibility of self-testing...
  19. ncbi request reprint Influenza and the pandemic threat
    V J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Singapore Med J 47:463-70. 2006
    ..To develop effective preparedness plans, it is important for healthcare workers to understand the disease's epidemiology, outcomes, and treatment and prevention strategies available...
  20. ncbi request reprint Hookworm infections in Singaporean soldiers after jungle training in Brunei Darussalam
    Vernon J Lee
    Army Medical Services, Singapore Armed Forces, 701 Transit Road, Level 3, Singapore 778910, Republic of Singapore
    Trans R Soc Trop Med Hyg 101:1214-8. 2007
    ..Helminth infections are common in visitors to rural Asia. As preventing exposure is often difficult, empirical treatment with anthelminthics should be considered in travellers to high risk areas...
  21. pmc Influenza pandemics in Singapore, a tropical, globally connected city
    Vernon J Lee
    Tan Tock Seng Hospital, Singapore
    Emerg Infect Dis 13:1052-7. 2007
    ..With the increase in travel and trade, a future pandemic may reach a globally connected city early and spread worldwide. Preparedness and surveillance plans must be developed to include the megacities of the tropical world...
  22. doi request reprint Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
    ..Singapore experienced its worst dengue outbreak in 30 years in 2004, with 9459 notified cases, of which 83% were hospitalized...
  23. ncbi request reprint Coordination and resource maximization during disaster relief efforts
    Vernon J Lee
    Headquarters Medical Corps, Singapore Armed Forces
    Prehosp Disaster Med 21:s8-12. 2006
    ..In the aftermath of the Earthquake and Tsunami in Southeast Asia, many relief organizations sent medical aid to affected areas...
  24. pmc Economics of neuraminidase inhibitor stock piling for pandemic influenza, Singapore
    Vernon J Lee
    Tan Tock Seng Hospital, Singapore
    Emerg Infect Dis 12:95-102. 2006
    ..6%. Prophylaxis for pandemics with a 5% case-fatality rate would save 50,000 lives and 81 billion dollars. These models can help policymakers weigh the options for pandemic planning...
  25. ncbi request reprint Disaster relief and initial response to the earthquake and tsunami in Meulaboh, Indonesia
    V J Lee
    Headquarters Medical Crops, Singapore Armed Forces, Singapore
    Ann Acad Med Singapore 34:586-90. 2005
    ..Water, sanitation, hygiene, and vector control were some of the problems faced, with the goal to provide the most effective public health for the greatest number of people given the limited resources available...
  26. pmc Effectiveness of neuraminidase inhibitors for preventing staff absenteeism during pandemic influenza
    Vernon J Lee
    Tan Tock Seng Hospital, Singapore
    Emerg Infect Dis 13:449-57. 2007
    ..Small investments in treatment and prophylaxis, if adequate and timely, can reduce absenteeism among essential staff...
  27. doi request reprint Effectiveness of public health measures in mitigating pandemic influenza spread: a prospective sero-epidemiological cohort study
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Department of Epidemiology and Public Health, National University of Singapore, Singapore Armed Forces, Singapore
    J Infect Dis 202:1319-26. 2010
    ..Few studies have validated the effectiveness of public health interventions in reducing influenza spread in realā€life settings. We aim to validate these measures used during the 2009 pandemic...
  28. ncbi request reprint Factors influencing infection by pandemic influenza A(H1N1)pdm09 over three epidemic waves in Singapore
    Mark I C Chen
    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore
    Influenza Other Respir Viruses 7:1380-9. 2013
    ..Previous influenza pandemics had second and on occasion third waves in many countries that were at times more severe than the initial pandemic waves...
  29. pmc Safety and cost savings of reducing adult dengue hospitalization in a tertiary care hospital in Singapore
    Linda K Lee
    Tan Tock Seng Hospital, Communicable Disease Centre, 11 Jalan Tan Tock Seng, 308433 Singapore
    Trans R Soc Trop Med Hyg 107:37-42. 2013
    ..To minimize hospitalization, the Communicable Disease Centre at Tan Tock Seng Hospital (TTSH) in Singapore implemented new admission criteria which included clinical, laboratory, and DHF predictive parameters in 2007...
  30. pmc Higher risk of infection with dengue at the weekend among male Singaporeans
    Alex R Cook
    Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore
    Am J Trop Med Hyg 87:1116-8. 2012
    ..The study motivates further research identifying locales frequented in the week leading up to onset to improve the effective targeting of vector control efforts...
  31. pmc Serological response in RT-PCR confirmed H1N1-2009 influenza a by hemagglutination inhibition and virus neutralization assays: an observational study
    Mark I Chen
    Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    PLoS ONE 5:e12474. 2010
    ..We describe the serological response following H1N1-2009 influenza A infections confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR)...
  32. doi request reprint Comparison of neutralizing antibody and cell-mediated immune responses to pandemic H1N1 2009 influenza virus before and after H1N1 2009 influenza vaccination of elderly subjects and healthcare workers
    J P Hsu
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore 117597
    Int J Infect Dis 16:e621-7. 2012
    ..We investigated both humoral and cellular immune responses against the pandemic H1N1 2009 virus before and after immunization with inactivated H1N1 2009 vaccine...
  33. pmc Differing clinical characteristics between influenza strains among young healthy adults in the tropics
    Jonathan Yap
    Biodefence Centre, Ministry of Defence, Singapore
    BMC Infect Dis 12:12. 2012
    ..Influenza infections may result in different clinical presentations. This study aims to determine the clinical differences between circulating influenza strains in a young healthy adult population in the tropics...
  34. pmc Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic fever in adult dengue inpatients in Singapore
    Tun L Thein
    Communicable Disease Center, Tan Tock Seng Hospital, Singapore
    Am J Trop Med Hyg 85:942-5. 2011
    ..The decision tree predicted DHF with a Sn of 99%, Sp 12%, PPV 16%, and NPV 99%. Both tools performed well despite a switch in predominant dengue serotypes...
  35. pmc Teacher led school-based surveillance can allow accurate tracking of emerging infectious diseases - evidence from serial cross-sectional surveys of febrile respiratory illness during the H1N1 2009 influenza pandemic in Singapore
    Shu E Soh
    National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore
    BMC Infect Dis 12:336. 2012
    ..We compared several school-based influenza monitoring systems with clinic-based influenza-like illness (ILI) surveillance, and assessed the variation in illness rates between and within schools...
  36. pmc Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore
    Luis R Carrasco
    Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore
    PLoS Negl Trop Dis 5:e1426. 2011
    ..5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines in such settings...
  37. ncbi request reprint Outbreak of acute norovirus gastroenteritis in a military facility in Singapore: a public health perspective
    Jonathan Yap
    Biodefence Centre, Ministry of Defence, Singapore
    Singapore Med J 53:249-54. 2012
    ..This study describes the epidemiological investigations conducted to determine the cause of outbreak and the efficacy of the public health measures implemented...
  38. pmc Clinical relevance and discriminatory value of elevated liver aminotransferase levels for dengue severity
    Linda K Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    PLoS Negl Trop Dis 6:e1676. 2012
    ..We aimed to assess the clinical relevance and discriminatory value of AST or ALT for dengue hemorrhagic fever (DHF) and severe dengue...
  39. ncbi request reprint Travel characteristics and health practices among travellers at the travellers' health and vaccination clinic in Singapore
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 35:667-73. 2006
    ..This study describes the profile and healthseeking behaviour of travellers attending a travel health clinic in Singapore...
  40. ncbi request reprint Seroepidemiology of varicella and the reliability of a self-reported history of varicella infection in Singapore military recruits
    P Dashraath
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 36:636-41. 2007
    ..The latter is a possible proxy for seroprevalence, and may be used to provide efficient identification of candidates for vaccination...
  41. ncbi request reprint Predictive tools for severe dengue conforming to world health organization 2009 criteria
    Luis R Carrasco
    Department of Biological Sciences, National University of Singapore, Singapore
    PLoS Negl Trop Dis 8:e2972. 2014
    ..For severe dengue (SD), proposed by the World Health Organization (WHO) 2009 dengue guidelines, predictive tools are lacking...
  42. pmc Strategies for antiviral stockpiling for future influenza pandemics: a global epidemic-economic perspective
    Luis R Carrasco
    Department of Statistics and Applied Probability, National University of Singapore, Singapore 117543, Republic of Singapore
    J R Soc Interface 8:1307-13. 2011
    ..Lower prices and international cooperation are necessary to make the life-saving potential of antivirals cost-effective in resource-limited countries...
  43. doi request reprint Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection
    David C Lye
    Department of Infectious Disease, Tan Tock Seng Hospital, National Healthcare Group, Singapore
    Clin Infect Dis 48:1262-5. 2009
    ..Prophylactic platelet transfusion was ineffective in preventing bleeding in adult patients with dengue infection...
  44. pmc Real-time epidemic monitoring and forecasting of H1N1-2009 using influenza-like illness from general practice and family doctor clinics in Singapore
    Jimmy Boon Som Ong
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    PLoS ONE 5:e10036. 2010
    ....
  45. pmc Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study
    Yee Sin Leo
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    BMC Infect Dis 11:123. 2011
    ..A new WHO 2009 guideline emphasized warning signs and a wider range of severe dengue manifestations. We aim to evaluate the utility of these two guidelines in confirmed adult dengue fatalities...
  46. pmc Accuracy and user-acceptability of HIV self-testing using an oral fluid-based HIV rapid test
    Oon Tek Ng
    Department of Infectious Disease, Tan Tock Seng Hospital, Singapore
    PLoS ONE 7:e45168. 2012
    ..We assessed the accuracy of self-testing by untrained participants compared to healthcare worker (HCW) testing, participants' ability to interpret sample results and user-acceptability of self-tests in Singapore...
  47. pmc Trends in parameterization, economics and host behaviour in influenza pandemic modelling: a review and reporting protocol
    Luis R Carrasco
    Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore
    Emerg Themes Epidemiol 10:3. 2013
    ..The volume of influenza pandemic modelling studies has increased dramatically in the last decade. Many models incorporate now sophisticated parameterization and validation techniques, economic analyses and the behaviour of individuals...
  48. pmc Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study
    Junxiong Pang
    Infectious Diseases, Genome Institute of Singapore, Singapore, Singapore
    PLoS Negl Trop Dis 6:e1641. 2012
    ..This study explored demographic and comorbidity risk factors for DHF in adult dengue epidemics in Singapore in year 2006 (predominantly serotype 1) and in year 2007-2008 (predominantly serotype 2)...
  49. pmc Knowledge, attitudes and practices towards pandemic influenza among cases, close contacts, and healthcare workers in tropical Singapore: a cross-sectional survey
    Jonathan Yap
    Healthcare Branch, Ministry of Defence, Singapore
    BMC Public Health 10:442. 2010
    ..We aim to determine the differences in knowledge, attitudes and practices in various different cohorts and explore the pertinent factors that influenced behavior in tropical Singapore...
  50. pmc Predictors of failed attendances in a multi-specialty outpatient centre using electronic databases
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    BMC Health Serv Res 5:51. 2005
    ..The objective of this study is to show the factors in an existing electronic database that affect failed appointments and to develop a predictive probability model to increase the effectiveness of interventions...