Jehee Lee

Summary

Publications

  1. Omeka W, Liyanage D, Priyathilaka T, Godahewa G, Lee S, Lee S, et al. Glutaredoxin 1 from big-belly seahorse (Hippocampus abdominalis): Molecular, transcriptional, and functional evidence in teleost immune responses. Fish Shellfish Immunol. 2019;: pubmed publisher
    ..Altogether, our results suggested a vital role of HaGrx1 in redox homeostasis as well as the host innate immune defense system. ..
  2. Sandamalika W, Priyathilaka T, Nam B, Lee J. Two phospholipid scramblase 1-related proteins (PLSCR1like-a & -b) from Liza haematocheila: Molecular and transcriptional features and expression analysis after immune stimulation. Fish Shellfish Immunol. 2018;87:32-42 pubmed publisher
    ..Overall, this study provides the first experimental insight into the characteristics and immune-system relevance of PLSCR1-related genes in red lip mullets. ..
  3. Tharuka M, Priyathilaka T, Yang H, Pavithiran A, Lee J. Molecular and transcriptional insights into viperin protein from Big-belly seahorse (Hippocampus abdominalis), and its potential antiviral role. Fish Shellfish Immunol. 2019;86:599-607 pubmed publisher
    ..The obtained results suggest that HaVip is involved in the immune system of the seahorse, triggering antiviral and antibacterial responses, upon viral and bacterial pathogenic infections. ..
  4. Liyanage D, Omeka W, Yang H, Godahewa G, Kwon H, Nam B, et al. Identification of thioredoxin domain-containing protein 17 from big-belly seahorse Hippocampus abdominalis: Molecular insights, immune responses, and functional characterization. Fish Shellfish Immunol. 2019;86:301-310 pubmed publisher
    ..Together, these results show that HaTXNDC17 function is important for maintaining cellular redox homeostasis and that it is also involved in the immune mechanism in seahorses. ..
  5. Tharuka M, Priyathilaka T, Kim J, Lim C, Lee J. Molecular characterization of big-belly seahorse (Hippocamus abdominalis) arachidonate 5-lipoxygenase (HaALOX5): First evidence of an immune defensive role by induced immunological stress in teleost. Fish Shellfish Immunol. 2019;86:230-238 pubmed publisher
  6. Priyathilaka T, Bathige S, Lee S, Nam B, Lee J. Transcriptome-wide identification, functional characterization, and expression analysis of two novel invertebrate-type Toll-like receptors from disk abalone (Haliotis discus discus). Fish Shellfish Immunol. 2019;84:802-815 pubmed publisher
    ..Co-expression of AbTLR-A and AbTLR-B with AbMyD88-2 and AbMyD88-X activated NF-κB-responsive reporters in a synergetic manner. These findings demonstrate the involvement of AbTLR-A and AbTLR-B in abalone innate immunity. ..
  7. Neranjan Tharuka M, Bathige S, Oh M, Lee S, Kim M, Priyathilaka T, et al. Molecular characterization and expression analysis of big-belly seahorse (Hippocampus abdominalis) interleukin-10 and analysis of its potent anti-inflammatory properties in LPS-induced murine macrophage RAW 264.7 cells. Gene. 2019;685:1-11 pubmed publisher
    ..To summarize, our findings help in the improved understanding of the biological functions of HaIL-10 and modulation of HaIL-10 mRNA expression in response to immune stress. ..
  8. Omeka W, Liyanage D, Priyathilaka T, Kwon H, Lee S, Lee J. Characterization of four C1q/TNF-related proteins (CTRPs) from red-lip mullet (Liza haematocheila) and their transcriptional modulation in response to bacterial and pathogen-associated molecular pattern stimuli. Fish Shellfish Immunol. 2019;84:158-168 pubmed publisher
    ..garvieae). MuCTRP4-like, MuCTRP5, and MuCTRP6 showed significant upregulation in response to lipopolysaccharides (LPS). The results of this study suggest the potential involvement of Mullet CTRPs in post-immune responses. ..
  9. Perera N, Godahewa G, Jung S, Kim M, Nam B, Lee J. Identification and characterization of a carboxypeptidase N1 from red lip mullet (Liza haematocheila); revealing its immune relevance. Fish Shellfish Immunol. 2019;84:223-232 pubmed publisher
    ..These results have driven certain way towards enhancing the understanding of immune role of MuCPN1 in the complement defense mechanism of red lip mullet. ..

More Information

Publications83

  1. Sirisena D, Perera N, Godahewa G, Kwon H, Yang H, Nam B, et al. A manganese superoxide dismutase (MnSOD) from red lip mullet, Liza haematocheila: Evaluation of molecular structure, immune response, and antioxidant function. Fish Shellfish Immunol. 2019;84:73-82 pubmed publisher
    ..Results of the current study suggest that MuMnSOD acts as an antioxidant enzyme and participates in the immune response in mullet. ..
  2. Jayasinghe J, Elvitigala D, Whang I, Nam B, Lee J. Molecular characterization of two immunity-related acute-phase proteins: Haptoglobin and serum amyloid A from black rockfish (Sebastes schlegeli). Fish Shellfish Immunol. 2015;45:680-8 pubmed publisher
  3. Godahewa G, Bathige S, Herath H, Noh J, Lee J. Characterization of rock bream (Oplegnathus fasciatus) complement components C1r and C1s in terms of molecular aspects, genomic modulation, and immune responsive transcriptional profiles following bacterial and viral pathogen exposure. Fish Shellfish Immunol. 2015;46:656-68 pubmed publisher
    ..Overall findings of the present study demonstrate the potential immune responses of OfC1r and OfC1s against invading microbial pathogens and the activation of classical signaling cascade in rock bream. ..
  4. Saranya Revathy K, Umasuthan N, Whang I, Jung H, Lim B, Nam B, et al. A potential antioxidant enzyme belonging to the atypical 2-Cys peroxiredoxin subfamily characterized from rock bream, Oplegnathus fasciatus. Comp Biochem Physiol B Biochem Mol Biol. 2015;187:1-13 pubmed publisher
    ..These findings provide an overall insight into the structural, expressional and functional aspects of RbPrx5. ..
  5. Bathige S, Umasuthan N, Godahewa G, Whang I, Kim C, Park H, et al. Three novel clade B serine protease inhibitors from disk abalone, Haliotis discus discus: Molecular perspectives and responses to immune challenges and tissue injury. Fish Shellfish Immunol. 2015;45:334-41 pubmed publisher
    ..These results suggest a potential role of AbSERPINs in response to pathogen invasion and tissue injury in disk abalone. ..
  6. Umasuthan N, Bathige S, Whang I, Lim B, Choi C, Lee J. Insights into molecular profiles and genomic evolution of an IRAK4 homolog from rock bream (Oplegnathus fasciatus): immunogen- and pathogen-induced transcriptional expression. Fish Shellfish Immunol. 2015;43:436-48 pubmed publisher
    ..Taken together, these data implicate that OfIRAK4 might be engaged in antibacterial and antiviral immunity in rock bream. ..
  7. Liyanage D, Omeka W, Godahewa G, Lee S, Nam B, Lee J. Membrane attack complex-associated molecules from redlip mullet (Liza haematocheila): Molecular characterization and transcriptional evidence of C6, C7, C8β, and C9 in innate immunity. Fish Shellfish Immunol. 2018;81:1-9 pubmed publisher
    ..These findings may help to elucidate the mechanisms behind the complement system of the teleosts innate immunity. ..
  8. Bathige S, Umasuthan N, Godahewa G, Jayasinghe J, Whang I, Noh J, et al. A homolog of Kunitz-type serine protease inhibitor from rock bream, Oplegnathus fasciatus: Molecular insights and transcriptional modulation in response to microbial and PAMP stimulation, and tissue injury. Fish Shellfish Immunol. 2015;46:285-91 pubmed publisher
    ..Collectively, these results suggest that the RbKSPI may be involved in essential immune defense against microbial pathogens and in the wound-healing process. ..
  9. Elvitigala D, Whang I, Lee J. Molecular profiling and functional insights of rock bream (Oplegnathus fasciatus) thioredoxin reductase 3-like molecule: investigation of its transcriptional modulation in response to live pathogen stress. Gene. 2015;570:122-31 pubmed publisher
    ..Taken together, these results suggest that RbTrxR-3 plays a role in the host Trx system under conditions of oxidative and pathogenic stress. ..
  10. Elvitigala D, Whang I, Nam B, Park H, Lee J. Identification of a myeloperoxidase-like ortholog from rock bream (Oplegnathus fasciatus), deciphering its transcriptional responses to induced pathogen stress. Fish Shellfish Immunol. 2015;45:477-85 pubmed publisher
    ..Together, these data suggest the potential involvement of RbMPO in the innate immune response in rock bream. ..
  11. Elvitigala D, Premachandra H, Whang I, Yeo S, Choi C, Noh J, et al. Molecular cloning, expression and functional characterization of a teleostan cytokine-induced apoptosis inhibitor from rock bream (Oplegnathus fasciatus). Dev Comp Immunol. 2015;52:48-57 pubmed publisher
    ..Therefore, RbCIAPI potentially plays an important role in host immunity by regulating the apoptosis process under pathogenic stress. ..
  12. Kim M, Lee S, Godahewa G, Hwang J, Seo J, Hwang S, et al. Complete genome sequence and phylogenetic analysis of spring viremia of carp virus isolated from leather carp (Cyprinus carpio nudus) in Korea in 2016. Arch Virol. 2018;163:2917-2919 pubmed publisher
    ..This report provides additional information for studying the molecular epidemiology and evolution of spring viremia of carp virus. ..
  13. Sandamalika W, Priyathilaka T, Liyanage D, Lee S, Lim H, Lee J. Molecular characterization of kappa class glutathione S-transferase from the disk abalone (Haliotis discus discus) and changes in expression following immune and stress challenges. Fish Shellfish Immunol. 2018;77:252-263 pubmed publisher
    ..Altogether, this current study suggests that AbGST? is involved in detoxification and immunological host defense mechanisms and allows abalones to overcome stresses in order for them to have an increased chance of survival. ..
  14. Elvitigala D, Wan Q, Kim H, Lee J. Identification of a C-reactive protein like homologue from black rockfish (Sebastes schlegelii) evidencing its potent anti-microbial properties at molecular level. Dev Comp Immunol. 2015;53:169-78 pubmed publisher
    ..Collectively, our results suggest that RfCRP may be important in host anti-bacterial defense, and it might potentially participate in the acute phase of infection. ..
  15. Bathige S, Umasuthan N, Godahewa G, Thulasitha W, Whang I, Won S, et al. Two variants of selenium-dependent glutathione peroxidase from the disk abalone Haliotis discus discus: Molecular characterization and immune responses to bacterial and viral stresses. Fish Shellfish Immunol. 2015;45:648-55 pubmed publisher
    ..Consequently, these findings indicate that AbSeGPx-a and AbSeGPx-b might be involved in the embryonic development of disk abalone and the regulation of immune defense system of adult animals. ..
  16. Godahewa G, Kim Y, Dananjaya S, Jayasooriya R, Noh J, Lee J, et al. Mitochondrial peroxiredoxin 3 (Prx3) from rock bream (Oplegnathus fasciatus): immune responses and role of recombinant Prx3 in protecting cells from hydrogen peroxide induced oxidative stress. Fish Shellfish Immunol. 2015;43:131-41 pubmed publisher
    ..Overall results from our study suggest that RbPrx3 may be involved in broader functions such as regulating oxidative stresses by scavenging ROS and activating immune responses in rock bream. ..
  17. Godahewa G, Lee S, Kim J, Perera N, Kim M, Kwon M, et al. Analysis of complete genome and pathogenicity studies of the spring viremia of carp virus isolated from common carp (Cyprinus carpio carpio) and largemouth bass (Micropterus salmoides): An indication of SVC disease threat in Korea. Virus Res. 2018;255:105-116 pubmed publisher
    ..This is the first study to document that Korean SVCV isolates may be epizootic in wild common carp and other susceptible animal populations in South Korea. ..
  18. Perera N, Godahewa G, Nam B, Park J, Lee J. Two metalloenzymes from rockfish (Sebastes schligellii): Deciphering their potential involvement in redox homeostasis against oxidative stress. Fish Shellfish Immunol. 2018;80:31-45 pubmed publisher
    ..Collectively, these results strengthen the general understanding of the structural and functional characteristics of SODs within the host defense system. ..
  19. Thulasitha W, Umasuthan N, Whang I, Lim B, Jung H, Noh J, et al. A CXC chemokine gene, CXCL12, from rock bream, Oplegnathus fasciatus: Molecular characterization and transcriptional profile. Fish Shellfish Immunol. 2015;45:560-6 pubmed publisher
    ..Results from the present study suggest an important role for OfCXCL12 in immune defense against bacterial and viral infection in rock bream. ..
  20. Godahewa G, Wickramaarachchi W, Whang I, Bathige S, Lim B, Choi C, et al. Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): molecular characterization, genomic arrangement and immune responses upon pathogenic stresses. Vet Immunol Immunopathol. 2014;162:180-91 pubmed publisher
    ..Taken together, our findings suggest that Rb-CPA and Rb-CPN1 have immune-related functions in rock bream. ..
  21. Umasuthan N, Bathige S, Revathy K, Nam B, Choi C, Lee J. Molecular genomic- and transcriptional-aspects of a teleost TRAF6 homolog: Possible involvement in immune responses of Oplegnathus fasciatus against pathogens. Fish Shellfish Immunol. 2015;42:66-78 pubmed publisher
    ..Altogether, these findings implicate that OfTRAF6 is not only involved in flagellin-induced signaling cascade, but also contributes to the antibacterial- and antiviral-responses. ..
  22. Elvitigala D, Priyathilaka T, Whang I, Nam B, Lee J. A teleostan homolog of catalase from black rockfish (Sebastes schlegelii): insights into functional roles in host antioxidant defense and expressional responses to septic conditions. Fish Shellfish Immunol. 2015;44:321-31 pubmed publisher
    ..Collectively, our findings indicate that RfCat may play an indispensable role in host response to oxidative stress and maintain a correct redox balance after a pathogen invasion. ..
  23. Priyathilaka T, Elvitigala D, Whang I, Lim B, Jeong H, Yeo S, et al. Molecular characterization and transcriptional analysis of non-mammalian type Toll like receptor (TLR21) from rock bream (Oplegnathus fasciatus). Gene. 2014;553:105-16 pubmed publisher
    ..Collectively, our findings suggest that RbTLR21 is indeed an ortholog of the TLR21 family and may be important in mounting host immune responses against pathogenic infections. ..
  24. Elvitigala D, Whang I, Jung H, Lim B, Nam B, Lee J. Molecular delineation of a caspase 10 homolog from black rockfish (Sebastes schlegelii) and its transcriptional regulation in response to pathogenic stress. Gene. 2015;570:288-94 pubmed publisher
    ..Collectively, our study suggests the plausible elicitation of RfCasp10 mediated apoptosis in immune relevant tissues of black rockfish as a host immune response to a bacterial or viral infection. ..
  25. Herath H, Elvitigala D, Godahewa G, Whang I, Lee J. Molecular insights into a molluscan transferrin homolog identified from disk abalone (Haliotis discus discus) evidencing its detectable role in host antibacterial defense. Dev Comp Immunol. 2015;53:222-33 pubmed publisher
    ..plantarum) even at its highest concentration. Collectively, our results suggest that AbTrf might play a significant role in the host innate immunity, possibly by withholding iron from pathogens. ..
  26. Thulasitha W, Umasuthan N, Revathy K, Whang I, Lee J. Molecular characterization, genomic structure and expressional profiles of a CXC chemokine receptor 4 (CXCR4) from rock bream Oplegnathus fasciatus. Fish Shellfish Immunol. 2015;44:471-7 pubmed publisher
    ..Evidence of various transcription factor binding sites present in the 5'-flanking region of OfCXCR4 coupled with its observed regulated mRNA expression suggest that it may have an important role in immune surveillance in rock bream. ..
  27. Perera N, Godahewa G, Nam B, Lee J. Molecular structure and immune-stimulated transcriptional modulation of the first teleostean IFP35 counterpart from rockfish (Sebastes schlegelii). Fish Shellfish Immunol. 2016;56:496-505 pubmed publisher
    ..Therefore, the modulation patterns of both RfIFP35 and RfIFN-? suggest that RfIFP35 may be induced by RfIFN-?. ..
  28. Kwon H, Yang H, Lee S, Nilojan J, Bathige S, Nam B, et al. Characterization of a Kazal-type serine protease inhibitor from black rockfish Sebastes schlegelii and its possible role in hepatic immune response. Fish Shellfish Immunol. 2018;74:485-490 pubmed publisher
    ..Overall, we propose that SsKSPI is potentially involved in the hepatic immune response against bacterial and viral infections in black rockfish. ..
  29. Godahewa G, Perera N, Nam B, Lee J. Antioxidative properties and structural features of atypical 2-Cys peroxiredoxin from Sebastes schlegelii. Dev Comp Immunol. 2018;82:152-164 pubmed publisher
    ..Taken together, present results suggest the indispensable role of SsPrx5 in the rockfish antioxidant defense system against oxidative stresses and its role in maintaining redox balance upon pathogen invasion. ..
  30. Liyanage D, Omeka W, Godahewa G, Lee J. Molecular characterization of thioredoxin-like protein 1 (TXNL1) from big-belly seahorse Hippocampus abdominalis in response to immune stimulation. Fish Shellfish Immunol. 2018;75:181-189 pubmed publisher
    ..Moreover, significant temporal expression of ShTXNL1 was observed in gill and blood tissues after bacterial stimuli. Thus, the ShTXNL1 gene may be identified as an immunologically important gene in seahorse. ..
  31. Nikapitiya C, Dananjaya S, De Silva B, Heo G, Oh C, De Zoysa M, et al. Chitosan nanoparticles: A positive immune response modulator as display in zebrafish larvae against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2018;76:240-246 pubmed publisher
    ..hydrophila, which could be attributed to its strong immune modulatory properties. ..
  32. Oh M, Umasuthan N, Elvitigala D, Wan Q, Jo E, Ko J, et al. First comparative characterization of three distinct ferritin subunits from a teleost: Evidence for immune-responsive mRNA expression and iron depriving activity of seahorse (Hippocampus abdominalis) ferritins. Fish Shellfish Immunol. 2016;49:450-60 pubmed publisher
    ..Collectively, our findings suggest that the three HaFer subunits may be involved in iron (II) homeostasis in big belly seahorse and that they are important in its host defense mechanisms. ..
  33. Elvitigala D, Jayasooriya R, Whang I, Lee J. First report on the gastropod proapoptotic AIF3 counterpart from disk abalone (Haliotis discus discus) deciphering its transcriptional modulation by induced pathogenic stress. Fish Shellfish Immunol. 2015;47:697-705 pubmed publisher
    ..Collectively, our study illustrates the indispensable role of AbAIF3 in inducing apoptosis in disk abalones, which in turn might be involved in hosts' immune defense mechanisms against microbial infections. ..
  34. Godahewa G, Perera N, Umasuthan N, Wan Q, Whang I, Lee J. Molecular characterization and expression analysis of B cell activating factor from rock bream (Oplegnathus fasciatus). Dev Comp Immunol. 2016;55:1-11 pubmed publisher
    ..Transcription of IL-10 and NFκB-1 was significantly stimulated by RbBAFF. Our findings provide further information regarding fish BAFF gene and its role in adaptive immunity. ..
  35. Herath H, Elvitigala D, Godahewa G, Umasuthan N, Whang I, Noh J, et al. Molecular characterization and comparative expression analysis of two teleostean pro-inflammatory cytokines, IL-1β and IL-8, from Sebastes schlegeli. Gene. 2016;575:732-42 pubmed publisher
    ..Significantly increased RfIL-1β and RfIL8 transcript levels were detected with almost similar profile patterns, further suggesting a putative involvement of these pro-inflammatory cytokines in the rockfish immunity. ..
  36. Godahewa G, Perera N, Elvitigala D, Jayasooriya R, Kim G, Lee J. Characterization of a 1-cysteine peroxiredoxin from big-belly seahorse (Hippocampus abdominalis); insights into host antioxidant defense, molecular profiling and its expressional response to septic conditions. Fish Shellfish Immunol. 2016;57:186-197 pubmed publisher
    ..These results suggest that HaPrx6 may play an important role in the immune response of the big-belly seahorse against microbial infection. Collectively, these findings provide structural and functional insights into HaPrx6. ..
  37. Umasuthan N, Bathige S, Noh J, Lee J. Gene structure, molecular characterization and transcriptional expression of two p38 isoforms (MAPK11 and MAPK14) from rock bream (Oplegnathus fasciatus). Fish Shellfish Immunol. 2015;47:331-43 pubmed publisher
    ..Collectively, these results suggest that OfMAPKs are true members of p38 subfamily, which might be induced by different immune stimuli. ..
  38. Pavithiran A, Bathige S, Kugapreethan R, Priyathilaka T, Yang H, Kim M, et al. A comparative study of three akirin genes from big belly seahorse Hippocampus abdominalis: Molecular, transcriptional and functional characterization. Fish Shellfish Immunol. 2018;74:584-592 pubmed publisher
    ..These results suggest that HaAkirin genes might play a role in regulating NF-?B dependent immune gene expression and their expression could be induced by bacterial and viral pathogen recognition molecular patterns. ..
  39. Udayantha H, Godahewa G, Bathige S, Wickramaarachchi W, Umasuthan N, De Zoysa M, et al. A molluscan calreticulin ortholog from Haliotis discus discus: Molecular characterization and transcriptional evidence for its role in host immunity. Biochem Biophys Res Commun. 2016;474:43-50 pubmed publisher
    ..These results collectively implied that AbCALR is able to be stimulated by pathogenic signals and might play a potential role in host immunity. ..
  40. Godahewa G, Perera N, Bathige S, Nam B, Noh J, Lee J. Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): Molecular and functional characterization and immune responsive mRNA expression analysis. Fish Shellfish Immunol. 2016;55:423-33 pubmed publisher
    ..Together, our findings suggest that OfCfD might be involved in immune responses in rock bream. ..
  41. Ko J, Wan Q, Bathige S, Lee J. Molecular characterization, transcriptional profiling, and antibacterial potential of G-type lysozyme from seahorse (Hippocampus abdominalis). Fish Shellfish Immunol. 2016;58:622-630 pubmed publisher
    ..Taken together, these results suggest that ShLysG might possess a potential immune defensive role against invading microbial pathogens in seahorse. ..
  42. Bathige S, Umasuthan N, Jayasinghe J, Godahewa G, Park H, Lee J. Three novel C1q domain containing proteins from the disk abalone Haliotis discus discus: Genomic organization and analysis of the transcriptional changes in response to bacterial pathogens. Fish Shellfish Immunol. 2016;56:181-187 pubmed publisher
    ..The results of this study suggest that AbC1qDCs are involved in immune responses against invading bacterial pathogens. ..
  43. Thulasitha W, Umasuthan N, Jayasooriya R, Noh J, Park H, Lee J. A thioredoxin domain-containing protein 12 from black rockfish Sebastes schlegelii: Responses to immune challenges and protection from apoptosis against oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2016;185-186:29-37 pubmed publisher
    ..Collectively, the present data indicate that RfTXNDC12 is a TXN superfamily member, which could function as a potential antioxidant enzyme and be involved in a defense mechanism against immune challenges. ..
  44. Perera N, Godahewa G, Lee J. Copper-zinc-superoxide dismutase (CuZnSOD), an antioxidant gene from seahorse (Hippocampus abdominalis); molecular cloning, sequence characterization, antioxidant activity and potential peroxidation function of its recombinant protein. Fish Shellfish Immunol. 2016;57:386-399 pubmed publisher
    ..Our findings demonstrated that HaCuZnSOD is an important antioxidant, which might be involved in the host antioxidant defense mechanism against oxidative stress. ..
  45. Thulasitha W, Umasuthan N, Whang I, Nam B, Lee J. Antimicrobial response of galectin-1 from rock bream Oplegnathus fasciatus: Molecular, transcriptional, and biological characterization. Fish Shellfish Immunol. 2016;50:66-78 pubmed publisher
    ..Collectively, results from the present study indicate that OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream. ..
  46. Umasuthan N, Mothishri M, Thulasitha W, Nam B, Lee J. Molecular, genomic, and expressional delineation of a piscidin from rock bream (Oplegnathus fasciatus) with evidence for the potent antimicrobial activities of Of-Pis1 peptide. Fish Shellfish Immunol. 2016;48:154-68 pubmed publisher
    ..Collectively, the data presented in the current study improve our understanding of the piscidin AMP family, and the contribution of Of-Pis1 to the rock bream immunity. ..
  47. Thulasitha W, Whang I, Umasuthan N, Kang H, Mothishri M, Lee S, et al. A galectin related protein from Oplegnathus fasciatus: Genomic, molecular, transcriptional features and biological responses against microbial pathogens. Dev Comp Immunol. 2016;56:13-24 pubmed publisher
    ..These results collectively suggest that OfGal like B is involved in pathogen recognition and plays a significant role(s) in the innate defense mechanism of rock bream. ..
  48. Bathige S, Umasuthan N, Park H, Lee J. An invertebrate signal transducer and activator of transcription 5 (STAT5) ortholog from the disk abalone, Haliotis discus discus: Genomic structure, early developmental expression, and immune responses to bacterial and viral stresses. Dev Comp Immunol. 2016;56:46-56 pubmed publisher
    ..Further, this study provides a basis for structural and functional exploration of STAT members in the invertebrate JAK/STAT signaling pathway. ..
  49. Thulasitha W, Kim Y, Umasuthan N, Jayasooriya R, Kim G, Nam B, et al. Thioredoxin domain-containing protein 12 from Oplegnathus fasciatus: Molecular characterization, expression against immune stimuli, and biological activities related to oxidative stress. Fish Shellfish Immunol. 2016;54:11-21 pubmed publisher
    ..Taken together, the results from our study suggest that OfTXNDC12 encodes for a potent antioxidant involved in redox regulation that shows significant responses to immune stimuli. ..
  50. Nilojan J, Bathige S, Thulasitha W, Kwon H, Jung S, Kim M, et al. Transcriptional profiling, molecular cloning, and functional analysis of C1 inhibitor, the main regulator of the complement system in black rockfish, Sebastes schlegelii. Fish Shellfish Immunol. 2018;75:263-273 pubmed publisher
    ..Taken together, results from the present study indicate that SsC1inh actively plays a significant role in maintaining homeostasis in the immune system of black rock fish. ..
  51. Oh M, Elvitigala D, Bathige S, Lee S, Kim M, Lee J. Molecular and functional characterization of caspase-8 from the big-belly seahorse (Hippocampus abdominalis). Fish Shellfish Immunol. 2016;58:650-662 pubmed publisher
    ..Taken together, our findings suggest that HaCasp-8 is an important component in the caspase cascade, and its expression can be significantly modulated under pathogen stress conditions in the big-belly seahorse. ..
  52. Jayasinghe J, Bathige S, Nam B, Noh J, Lee J. Comprehensive characterization of three glutathione S-transferase family proteins from black rockfish (Sebastes schlegelii). Comp Biochem Physiol C Toxicol Pharmacol. 2016;189:31-43 pubmed publisher
  53. Herath H, Wickramasinghe P, Bathige S, Jayasooriya R, Kim G, Park M, et al. Molecular identification and functional delineation of a glutathione reductase homolog from disk abalone (Haliotis discus discus): Insights as a potent player in host antioxidant defense. Fish Shellfish Immunol. 2017;60:355-367 pubmed publisher
    ..Taken together, the results of the current study suggest that AbGSR plays an important role in antioxidant-mediated host defense mechanisms and also provide insights into the immunological contribution of AbGSR. ..
  54. Kugapreethan R, Umasuthan N, Wan Q, Thulasitha W, Kim C, Lee J. Comparative analysis of two thioredoxin-like genes in black rockfish Sebastes schlegelii and their possible involvement in redox homeostasis and innate immune responses. Dev Comp Immunol. 2017;67:43-56 pubmed publisher
  55. Umasuthan N, Bathige S, Thulasitha W, Jayasooriya R, Shin Y, Lee J. Identification of a gene encoding a membrane-anchored toll-like receptor 5 (TLR5M) in Oplegnathus fasciatus that responds to flagellin challenge and activates NF-?B. Fish Shellfish Immunol. 2017;62:276-290 pubmed publisher
    ..Collectively, our study represents the genomic, evolutional, expressional and functional insights into a receptor and adaptor molecules of teleost origin that are involved in flagellin sensing. ..
  56. Nilojan J, Bathige S, Kugapreethan R, Thulasitha W, Nam B, Lee J. Molecular, transcriptional and functional insights into duplicated goose-type lysozymes from Sebastes schlegelii and their potential immunological role. Fish Shellfish Immunol. 2017;67:66-77 pubmed publisher
    ..0. The results provide evidence for the vital immunological role and bacteriolytic potential of RfLysG1 and RfLysG2. ..
  57. Oh M, Bathige S, Kim Y, Lee S, Yang H, Kim M, et al. A CXCL ortholog from Hippocampus abdominalis: Molecular features and functional delineation as a pro-inflammatory chemokine. Fish Shellfish Immunol. 2017;67:218-227 pubmed publisher
  58. Bathige S, Umasuthan N, Priyathilaka T, Thulasitha W, Jayasinghe J, Wan Q, et al. Molecular cloning, transcriptional profiling, and subcellular localization of signal transducer and activator of transcription 2 (STAT2) ortholog from rock bream, Oplegnathus fasciatus. Gene. 2017;626:95-105 pubmed publisher
    ..Altogether, these findings suggest that RbSTAT2 is involved in various biologically crucial mechanisms, and provides immune protection to the rock bream. ..
  59. Godahewa G, Perera N, Lee J. Insights into the multifunctional role of natural killer enhancing factor-A (NKEF-A/Prx1) in big-belly seahorse (Hippocampus abdominalis): DNA protection, insulin reduction, H2O2 scavenging, and immune modulation activity. Gene. 2018;642:324-334 pubmed publisher
    ..Thus, HaNKEF-A can safeguards big-belly seahorse from oxidative damage and pathogenic infections. This study provides insight into the functions of NKEF-A/Prx1 in fish species. ..
  60. Udayantha H, Bathige S, Priyathilaka T, Lee S, Kim M, Lee J. Identification and characterization of molluscan caveolin-1 ortholog from Haliotis discus discus: Possible involvement in embryogenesis and host defense mechanism against pathogenic stress. Gene Expr Patterns. 2018;27:85-92 pubmed publisher
    ..Collectively, these data suggest that CAV1 plays an important role in embryogenesis and host immune defense in disk abalone. ..
  61. Perera N, Godahewa G, Lee S, Kim M, Hwang J, Kwon M, et al. Manganese-superoxide dismutase (MnSOD), a role player in seahorse (Hippocampus abdominalis) antioxidant defense system and adaptive immune system. Fish Shellfish Immunol. 2017;68:435-442 pubmed publisher
    ..Collectively, the results obtained through the expressional analysis profiles and the functional assays provide insights into potential immune related and antioxidant roles of HaMnSOD in the big belly seahorse. ..
  62. Tharuka M, Bathige S, Lee J. Molecular cloning, biochemical characterization, and expression analysis of two glutathione S-transferase paralogs from the big-belly seahorse (Hippocampus abdominalis). Comp Biochem Physiol B Biochem Mol Biol. 2017;214:1-11 pubmed publisher
  63. Thulasitha W, Umasuthan N, Wan Q, Nam B, Kang T, Lee J. A proto-type galectin-2 from rock bream (Oplegnathus fasciatus): Molecular, genomic, and expression analysis, and recognition of microbial pathogens by recombinant protein. Dev Comp Immunol. 2017;71:70-81 pubmed publisher
    ..The results of this study indicate that the galectin-2 from rock bream has a potential role in immunity, particularly in the recognition of invading pathogens. ..
  64. Priyathilaka T, Bathige S, Herath H, Lee S, Lee J. Molecular identification of disk abalone (Haliotis discus discus) tetraspanin 33 and CD63: Insights into potent players in the disk abalone host defense system. Fish Shellfish Immunol. 2017;69:173-184 pubmed publisher
    ..Collectively, these findings suggest that AbCD63 and AbTSPAN33 are involved in innate immune responses in disk abalone during pathogenic stress. ..
  65. Perera N, Godahewa G, Lee J. Mitogen-activated protein kinase 1 from disk abalone (Haliotis discus discus): Roles in early development and immunity-related transcriptional responses. Fish Shellfish Immunol. 2016;59:57-65 pubmed publisher
    ..Significant modulation of AbMAPK1 expression under pathogenic stress suggested its putative involvement in the immune defense mechanism. ..
  66. Godahewa G, Perera N, Lee S, Kim M, Lee J. A cysteine protease (cathepsin Z) from disk abalone, Haliotis discus discus: Genomic characterization and transcriptional profiling during bacterial infections. Gene. 2017;627:500-507 pubmed publisher
    ..Collectively, these lines of evidences suggest that AbCTSZ plays an indispensable role in the innate immunity of disk abalone. ..
  67. Perera N, Godahewa G, Hwang J, Kwon M, Hwang S, Lee J. Molecular, structural, and functional comparison of N lobe and C lobe of the transferrin from rock bream, Oplegnathus fasciatus, with respect to its immune response. Fish Shellfish Immunol. 2017;68:299-309 pubmed publisher
    ..i.). These findings demonstrated that RbTf is an important antimicrobial protein that can combat bacterial pathogens. ..
  68. Bathige S, Umasuthan N, Godahewa G, Thulasitha W, Jayasinghe J, Wan Q, et al. Molecular insights of two STAT1 variants from rock bream (Oplegnathus fasciatus) and their transcriptional regulation in response to pathogenic stress, interleukin-10, and tissue injury. Fish Shellfish Immunol. 2017;69:128-141 pubmed publisher
  69. Lee S, Elvitigala D, Lee S, Kim H, Park H, Lee J. Molecular characterization of a bactericidal permeability-increasing protein/lipopolysaccharide-binding protein from black rockfish (Sebastes schlegelii): Deciphering its putative antibacterial role. Dev Comp Immunol. 2017;67:266-275 pubmed publisher
    ..Collectively, our findings suggest that RfBPI/LBP plays an essential role in host antimicrobial defense, plausibly through selective eradication of invading bacteria. ..
  70. Jo E, Elvitigala D, Wan Q, Oh M, Oh C, Lee J. Identification and molecular profiling of DC-SIGN-like from big belly seahorse (Hippocampus abdominalis) inferring its potential relevancy in host immunity. Dev Comp Immunol. 2017;77:270-279 pubmed publisher
    ..Moreover, recombinant ShDCS-like-CRD domain exhibited detectable agglutination activity against different bacteria. Collectively, these results suggest that ShDCS-like may potentially involve in immune function in big belly seahorses. ..
  71. Priyathilaka T, Bathige S, Lee S, Lee J. Molecular identification and functional analysis of two variants of myeloid differentiation factor 88 (MyD88) from disk abalone (Haliotis discus discus). Dev Comp Immunol. 2018;79:113-127 pubmed publisher
    ..Altogether, these results suggest that existence of a MyD88-dependent like signaling pathway in disk abalone and that both AbMyD88-2 and AbMyD88-X might be involved in innate immune and inflammatory responses. ..
  72. Kugapreethan R, Wan Q, Nilojan J, Lee J. Identification and characterization of a calcium-dependent lily-type lectin from black rockfish (Sebastes schlegelii): Molecular antennas are involved in host defense via pathogen recognition. Dev Comp Immunol. 2018;81:54-62 pubmed publisher
    ..Our results implied the crucial role of SsLTL as a PRR molecule in the black rockfish defense mechanism against invading microbial pathogens. ..
  73. Nilojan J, Bathige S, Kugapreethan R, Yang H, Kim M, Nam B, et al. Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii. Dev Comp Immunol. 2018;81:279-290 pubmed publisher
    ..Taken together, these results indicate that SsC1r and SsC1s have significant properties to aid in the immunity of black rockfish by activating the complement system by proteolytic cleavage. ..
  74. Priyathilaka T, Oh M, Bathige S, De Zoysa M, Lee J. Two distinct CXC chemokine receptors (CXCR3 and CXCR4) from the big-belly seahorse Hippocampus abdominalis: Molecular perspectives and immune defensive role upon pathogenic stress. Fish Shellfish Immunol. 2017;65:59-70 pubmed publisher