D Lee

Summary

Publications

  1. ncbi Potent and selective nonpeptide inhibitors of caspases 3 and 7
    D Lee
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Med Chem 44:2015-26. 2001
  2. ncbi Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
    D Lee
    Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:16007-14. 2000
  3. ncbi Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro
    M E Nuttall
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Orthop Res 18:356-63. 2000
  4. ncbi Role of caspases in human renal proximal tubular epithelial cell apoptosis
    V Y Wong
    Department of Renal Pharmacology, GlaxoSmithKline, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939, USA
    Eur J Pharmacol 433:135-40. 2001
  5. ncbi Structure-based combinatorial library design: discovery of non-peptidic inhibitors of caspases 3 and 8
    M S Head
    Physical and Structural Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Comput Aided Mol Des 15:1105-17. 2001
  6. ncbi Apoptosis in polycystic kidney disease: involvement of caspases
    S M Ali
    Departments of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Am J Physiol Regul Integr Comp Physiol 278:R763-9. 2000

Collaborators

Detail Information

Publications6

  1. ncbi Potent and selective nonpeptide inhibitors of caspases 3 and 7
    D Lee
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Med Chem 44:2015-26. 2001
    ..These compounds inhibit apoptosis in three cell-based models: human Jurkat T cells, human chondrocytes, and mouse bone marrow neutrophils...
  2. ncbi Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
    D Lee
    Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:16007-14. 2000
    ....
  3. ncbi Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro
    M E Nuttall
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Orthop Res 18:356-63. 2000
    ....
  4. ncbi Role of caspases in human renal proximal tubular epithelial cell apoptosis
    V Y Wong
    Department of Renal Pharmacology, GlaxoSmithKline, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939, USA
    Eur J Pharmacol 433:135-40. 2001
    ....
  5. ncbi Structure-based combinatorial library design: discovery of non-peptidic inhibitors of caspases 3 and 8
    M S Head
    Physical and Structural Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Comput Aided Mol Des 15:1105-17. 2001
    ..A 2.5-A resolution co-crystal structure of caspase 3 and a thiomethylketone array member is reported. The structure-based design strategy has proved useful for identifying caspase inhibitors...
  6. ncbi Apoptosis in polycystic kidney disease: involvement of caspases
    S M Ali
    Departments of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Am J Physiol Regul Integr Comp Physiol 278:R763-9. 2000
    ..These data suggest that there is a caspase-dependent apoptosis pathway associated with PKD and support the hypothesis that apoptotic cell death contributes to cyst formation in PKD...