S I Kreydiyyeh

Summary

Affiliation: American University of Beirut
Country: Lebanon

Publications

  1. pmc Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK
    Ola El-Zein
    Department of Biology, American University of Beirut, Beirut, Lebanon
    PLoS ONE 8:e83360. 2013
  2. ncbi request reprint PGE2 exerts dose-dependent opposite effects on net water and chloride absorption from the rat colon
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Prostaglandins Other Lipid Mediat 79:43-52. 2006
  3. ncbi request reprint Tumor necrosis factor alpha down-regulates the Na+-K+ ATPase and the Na+-K+2Cl- cotransporter in the kidney cortex and medulla
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Cytokine 33:138-44. 2006
  4. ncbi request reprint Interleukin-1 beta inhibits Na+-K+ ATPase activity and protein expression in cardiac myocytes
    Sawsan I Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Cytokine 26:1-8. 2004
  5. ncbi request reprint The signal transduction pathway that mediates the effect of interleukin-1 beta on the Na+-K+-ATPase in LLC-PK1 cells
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Pflugers Arch 448:231-8. 2004
  6. ncbi request reprint Aniseed oil increases glucose absorption and reduces urine output in the rat
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Life Sci 74:663-73. 2003
  7. ncbi request reprint TNF-alpha modulates hepatic Na+-K+ ATPase activity via PGE2 and EP2 receptors
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Prostaglandins Other Lipid Mediat 83:295-303. 2007
  8. ncbi request reprint Interleukin-1beta increases urine flow rate and inhibits protein expression of Na(+)/K(+)-ATPase in the rat jejunum and kidney
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    J Interferon Cytokine Res 22:1041-8. 2002
  9. ncbi request reprint The mechanism by which interleukin-1 beta reduces net fluid absorption from the rat colon
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Eur Cytokine Netw 13:358-63. 2002
  10. ncbi request reprint Diuretic effect and mechanism of action of parsley
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    J Ethnopharmacol 79:353-7. 2002

Collaborators

  • J Usta
  • J J Haddad
  • Danielle Jacques
  • Ola El-Zein
  • Maya F Serhan
  • N F Ramia
  • Antoine T Chalfoun
  • Ari Kassardjian
  • Rawad F Hodeify
  • Yester Skayian
  • Sarine Markossian
  • Anwar B Bikhazi
  • Rana Mahmoud Al-Sadi
  • David E Smith
  • Darine S Zwainy
  • Karine Audette
  • May M Skoury
  • Abdo R Jurjus

Detail Information

Publications24

  1. pmc Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK
    Ola El-Zein
    Department of Biology, American University of Beirut, Beirut, Lebanon
    PLoS ONE 8:e83360. 2013
    ..The results reveal a modulatory role of leptin in nutrient absorption in addition to its known satiety inducing effect. ..
  2. ncbi request reprint PGE2 exerts dose-dependent opposite effects on net water and chloride absorption from the rat colon
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Prostaglandins Other Lipid Mediat 79:43-52. 2006
    ..The observed increase in net water and Cl- absorption was attributed in this case to an increase in absorptive processes with no effect on secretion...
  3. ncbi request reprint Tumor necrosis factor alpha down-regulates the Na+-K+ ATPase and the Na+-K+2Cl- cotransporter in the kidney cortex and medulla
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Cytokine 33:138-44. 2006
    ..It was concluded that the effect of TNF-alpha on the pump is mediated via PGE2 which is released at relatively high doses. The effect of the cytokine on the cotransporter is, however, independent of PGE2...
  4. ncbi request reprint Interleukin-1 beta inhibits Na+-K+ ATPase activity and protein expression in cardiac myocytes
    Sawsan I Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Cytokine 26:1-8. 2004
    ....
  5. ncbi request reprint The signal transduction pathway that mediates the effect of interleukin-1 beta on the Na+-K+-ATPase in LLC-PK1 cells
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Pflugers Arch 448:231-8. 2004
    ..This activates NF-kappaB, thus leading to increased COX-2 expression and PGE(2) release. PGE(2) in turn inhibits NF-kappaB and reduces the protein expression of Na(+)-K(+)-ATPase...
  6. ncbi request reprint Aniseed oil increases glucose absorption and reduces urine output in the rat
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Life Sci 74:663-73. 2003
    ..The colonic Na+-K+ ATPase was however, resistant to the oil...
  7. ncbi request reprint TNF-alpha modulates hepatic Na+-K+ ATPase activity via PGE2 and EP2 receptors
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Prostaglandins Other Lipid Mediat 83:295-303. 2007
    ..It was concluded that TNF-alpha induces in hepatocytes, PGE2 production which in turn reduces the activity and protein expression of the Na(+)-K(+) ATPase by activating EP2 receptors...
  8. ncbi request reprint Interleukin-1beta increases urine flow rate and inhibits protein expression of Na(+)/K(+)-ATPase in the rat jejunum and kidney
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    J Interferon Cytokine Res 22:1041-8. 2002
    ..The results suggest that the diuretic and natriuretic effect of IL-1beta and its inhibitory effect on glucose absorption are all due to downregulation of the Na(+)/K(+) pump in the kidney and jejunum...
  9. ncbi request reprint The mechanism by which interleukin-1 beta reduces net fluid absorption from the rat colon
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Eur Cytokine Netw 13:358-63. 2002
    ..The ultimate effect of the two processes is a net decrease in Na(+)+ and Cl(-) absorption and an increase in water retention in the colon leading to the observed diarrhea in inflammatory bowel disease...
  10. ncbi request reprint Diuretic effect and mechanism of action of parsley
    Sawsan Ibrahim Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    J Ethnopharmacol 79:353-7. 2002
    ..The mechanism of action of parsley seems to be mediated through an inhibition of the Na+-K+ pump that would lead to a reduction in Na+ and K+ reabsorption leading thus to an osmotic water flow into the lumen, and diuresis...
  11. ncbi request reprint Epinephrine stimulates the Na+-K+ ATPase in isolated rat jejunal crypt cells
    S I Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Life Sci 67:1275-83. 2000
    ..These results suggest that epinephrine stimulates the Na+-K+ ATPase in jejunal crypt cells by activating alpha2 receptors and decreasing intracellular calcium, and not by altering cAMP levels...
  12. ncbi request reprint Effect of cinnamon, clove and some of their constituents on the Na(+)-K(+)-ATPase activity and alanine absorption in the rat jejunum
    S I Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, Beirut, Lebanon
    Food Chem Toxicol 38:755-62. 2000
    ..It was concluded that the active principle(s) in clove and cinnamon can permeate the membrane of the enterocytes and inhibit the Na(+)-K(+)-ATPase that provides the driving force for many transport processes...
  13. ncbi request reprint Interleukin-1 beta inhibits the intestinal transport of [14C] 3-O-methylglucose in the rat
    S I Kreydiyyeh
    Department of Biology, American University of Beirut, Lebanon
    Life Sci 63:1913-9. 1998
    ..The effect of IL-1beta on the hexose transport across the brush border membrane may thus be attributed to its inhibitory effect on the Na+-K+ ATPase...
  14. ncbi request reprint The mechanism underlying the laxative properties of parsley extract
    S I Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Phytomedicine 8:382-8. 2001
    ..The results suggest that parsley acts by, inhibiting sodium and consequently water absorption through an inhibition of the Na+-K+ pump, and by stimulating the NaKCl, transporter and increasing electrolyte and water secretion...
  15. ncbi request reprint Effect of diabetes mellitus and insulin on the regulation of the PepT 1 symporter in rat jejunum
    Anwar B Bikhazi
    Department of Physiology, American University of Beirut, Beirut, Lebanon
    Mol Pharm 1:300-8. 2004
    ..In addition, the results suggest a probable role of systemic insulin binding at the vascular site of the jejunal epithelium, and the role that this hormone may be playing in the regulation and probably cellular trafficking of PepT1...
  16. doi request reprint TNF-alpha modulates the Na+/ K+ ATPase and the Na+K+2Cl- symporter in LLC-PK cells
    N F Ramia
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Eur J Clin Invest 39:280-8. 2009
    ....
  17. doi request reprint Insulin down-regulates the Na+/K+ ATPase in enterocytes but increases intestinal glucose absorption
    Maya F Serhan
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Gen Comp Endocrinol 167:228-33. 2010
    ..Considering the inhibitory effect of the hormone on the Na(+)/K(+) ATPase, it was concluded that insulin acts by increasing the number of glucose transporters, a hypothesis that was confirmed by Western blot analysis...
  18. ncbi request reprint Alpha and beta adrenoceptors mediate the inhibitory effect of epinephrine on the mucosal uptake of phenylalanine in the rat jejunum
    S I Kreydiyyeh
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Can J Physiol Pharmacol 75:1312-5. 1997
    ..Epinephrine reduced, by about 30%, the mucosal transport of phenylalanine by activating alpha 1, alpha 2, and beta adrenergic receptors. The effect of the latter was not apparent however, until the alpha 2 receptors were blocked...
  19. ncbi request reprint PGE2 reduces net water and chloride absorption from the rat colon by targeting the Na+/H+ exchanger and the Na+ K+ 2Cl- cotransporter
    Rawad F Hodeify
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Prostaglandins Leukot Essent Fatty Acids 76:285-92. 2007
    ..Changes in the activity of the pump are secondary to changes in the activity of the other transporters...
  20. ncbi request reprint Tumor necrosis factor alpha alters Na+-K+ ATPase activity in rat cardiac myocytes: involvement of NF-kappaB, AP-1 and PGE2
    Yester Skayian
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Life Sci 80:173-80. 2006
    ..It was concluded that TNF-alpha activates NF-kappaB and AP-1 and induces PGE(2) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE(2)...
  21. ncbi request reprint Involvement of the cytoskeleton in the effect of PGE2 on ion transport in the rat distal colon
    Antoine T Chalfoun
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Bliss Street, Beirut, Lebanon
    Prostaglandins Other Lipid Mediat 85:58-64. 2008
    ..It was concluded that both microfilament and microtubular networks are involved in the basal and PGE2-elicited increase in colonic ion absorption...
  22. ncbi request reprint JNK modulates the effect of caspases and NF-kappaB in the TNF-alpha-induced down-regulation of Na+/K+ATPase in HepG2 cells
    Ari Kassardjian
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    J Cell Physiol 216:615-20. 2008
    ..Their activity was however modulated at 1 h by c-JNK, which stimulated the caspases and inhibited NF-kappaB, resulting in a net inhibition of the ATPase, and probably favoring the apoptotic pathway...
  23. ncbi request reprint Mediators of interleukin-1 beta action Na(+)-K(+)ATPase in Caco-2 cells
    Rana Mahmoud Al-Sadi
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut Lebanon
    Eur Cytokine Netw 14:83-90. 2003
    ..These results indicate that IL-1beta reduces the expression of ATPase independently of NFkB but, through a major pathway involving p38 and COX-2/PGE2, and another pathway involving JNK/AP1...
  24. ncbi request reprint TNF-alpha down-regulates the Na+-K+ ATPase and the Na+-K+-2Cl-cotransporter in the rat colon via PGE2
    Sarine Markossian
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Cytokine 30:319-27. 2005
    ..The inhibitory effect on absorption is more significant than the inhibitory effect on secretion resulting in a decrease in net electrolyte uptake and consequently in more water retention in the lumen...