Hala Gali-Muhtasib

Summary

Affiliation: American University of Beirut
Country: Lebanon

Publications

  1. ncbi request reprint Targeting hypoxia for sensitization of tumors to radio- and chemotherapy
    Khaled Ghattass
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Curr Cancer Drug Targets 13:670-85. 2013
  2. doi request reprint Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development
    Nadine Darwiche
    American University of Beirut Department of Biology, Beirut, Lebanon
    Expert Opin Drug Discov 2:361-79. 2007
  3. ncbi request reprint Inhibitory effects of plant tannins on ultraviolet light-induced epidermal DNA synthesis in hairless mice
    H U Gali-Muhtasib
    American University of Beirut, Division of Biology, Lebanon
    Photochem Photobiol 67:663-8. 1998
  4. ncbi request reprint Thymoquinone: a promising anti-cancer drug from natural sources
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Biochem Cell Biol 38:1249-53. 2006
  5. ncbi request reprint Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells
    Hala U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Cancer Chemother Pharmacol 55:369-78. 2005
  6. ncbi request reprint Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Oncol 25:857-66. 2004
  7. ncbi request reprint Hypoxic cells in tumors as a target for cancer therapy
    Hala U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    J Med Liban 50:175-9. 2002
  8. ncbi request reprint Quinoxaline 1,4-dioxides are novel angiogenesis inhibitors that potentiate antitumor effects of ionizing radiation
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Oncol 24:1121-31. 2004
  9. ncbi request reprint Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
    Hala U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Anticancer Drugs 15:389-99. 2004
  10. ncbi request reprint Modulating cell cycle: current applications and prospects for future drug development
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Curr Cancer Drug Targets 2:309-36. 2002

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Targeting hypoxia for sensitization of tumors to radio- and chemotherapy
    Khaled Ghattass
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Curr Cancer Drug Targets 13:670-85. 2013
    ..Such multi-faceted targeted therapies ultimately enhance treatment outcomes and reduce normal tissue toxicity by the selective targeting of solid tumors. ..
  2. doi request reprint Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development
    Nadine Darwiche
    American University of Beirut Department of Biology, Beirut, Lebanon
    Expert Opin Drug Discov 2:361-79. 2007
    ..This review presents the discovery of plant-derived anticancer agents, their biologic activities, with emphasis on cell cycle and apoptotic effects and combination strategies for treatment optimization...
  3. ncbi request reprint Inhibitory effects of plant tannins on ultraviolet light-induced epidermal DNA synthesis in hairless mice
    H U Gali-Muhtasib
    American University of Beirut, Division of Biology, Lebanon
    Photochem Photobiol 67:663-8. 1998
    ..These results suggest that various oligomeric HT and CT may be useful against tumor-promoting responses associated with the exposure of skin to physical carcinogens...
  4. ncbi request reprint Thymoquinone: a promising anti-cancer drug from natural sources
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Biochem Cell Biol 38:1249-53. 2006
    ..The combination of TQ with clinically used anti-cancer drugs has led to improvements in their therapeutic index and prevents non-tumor tissues from sustaining chemotherapy-induced damage...
  5. ncbi request reprint Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells
    Hala U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Cancer Chemother Pharmacol 55:369-78. 2005
    ..Taken together, these findings provide insights into possible molecular mechanisms of growth inhibition by QdNOs that could aid in their evaluation for anticancer therapy...
  6. ncbi request reprint Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Oncol 25:857-66. 2004
    ..The apoptotic effects of TQ are modulated by Bcl-2 protein and are linked to and dependent on p53. Our data support the potential for using the agent TQ for the treatment of colon cancer...
  7. ncbi request reprint Hypoxic cells in tumors as a target for cancer therapy
    Hala U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    J Med Liban 50:175-9. 2002
    ..The deciphering of the mechanism of action of QdNOs may allow us to ultimately recommend their use as therapeutic agents against human tumors...
  8. ncbi request reprint Quinoxaline 1,4-dioxides are novel angiogenesis inhibitors that potentiate antitumor effects of ionizing radiation
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Oncol 24:1121-31. 2004
    ..These findings should stimulate further research in other tumor models as these compounds could have potential clinical applications in cancer therapy...
  9. ncbi request reprint Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
    Hala U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Anticancer Drugs 15:389-99. 2004
    ..The apoptotic effects of TQ were more pronounced in SP-1 than in I7 cells. Collectively, these findings support a potential role for TQ as a chemopreventive agent, particularly at the early stages of skin tumorigenesis...
  10. ncbi request reprint Modulating cell cycle: current applications and prospects for future drug development
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Curr Cancer Drug Targets 2:309-36. 2002
    ..Examples of novel cell cycle-targeting agents that are in, or are close to being in clinical trials will be provided...
  11. ncbi request reprint Plant tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethylhydrazine in mice
    H U Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Nutr Cancer 39:108-16. 2001
    ..Interestingly, at 10 micrograms/ml, GT induced apoptosis in T-84 cells as determined by the Hoechst DNA staining technique. Collectively, these findings support a potential role for tannins as chemopreventive agents against colon cancer...
  12. ncbi request reprint Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs
    H U Gali-Muhtasib
    Department of Biology, American University of Beirut, Lebanon
    Oncol Rep 8:679-84. 2001
    ..Because of their selective toxicity to hypoxic cells (cells found in human tumors), these drugs may provide useful therapeutic agents against solid tumors...
  13. ncbi request reprint Traditional uses of Salvia libanotica (East Mediterranean sage) and the effects of its essential oils
    H Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    J Ethnopharmacol 71:513-20. 2000
    ..The paper also discusses the therapeutic value of the individual components present in the essential oil extract of this plant, and the complications that could arise from the irrational use of this extract by man...
  14. ncbi request reprint Chemopreventive effects of sage oil on skin papillomas in mice
    H U Gali-Muhtasib
    Department of Biology, American University of Beirut, Lebanon
    Phytomedicine 7:129-36. 2000
    ..Our results suggest that the oil extract of the sage plant has potent suppressive activities against tumor promotion in mouse skin and thus could be an effective chemopreventive agent against skin cancer...
  15. ncbi request reprint Photoprotective effects of some quinoxaline 1,4-dioxides in hairless mice
    H U Gali-Muhtasib
    Department of Biology, American University of Beirut, Lebanon
    Med Oncol 15:262-9. 1998
    ..These results suggest that QdO, in particular BPQ and certain derivatives of it, may be useful in protecting the skin against UVB-induced skin damage...
  16. pdf Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    J Cell Mol Med 12:330-42. 2008
    ..These data should encourage further in vivo testing and support the potential use of TQ as a therapeutic agent in human colorectal cancer...
  17. pmc The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells
    Joelle Haykal
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Radiat Oncol 4:25. 2009
    ..We sought to clarify whether increased radiation-induced DNA damage, decreased rate of damage repair, and the generation of reactive oxygen species (ROS) contribute to DCQ enhancement of IR...
  18. pmc Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells
    Wafica Itani
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Radiat Oncol 2:1. 2007
    ..The sensitizing effects of 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide (DCQ) and ionizing radiation (IR) were determined in four colon cancer cells and in FHs74Int normal intestinal cells...
  19. ncbi request reprint Purified salograviolide A isolated from centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells
    Akram Ghantous
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Oncol 32:841-9. 2008
    ..These studies suggest the potential therapeutic effects of Centaurea ainetensis, and its component, Salograviolide A, against epidermal squamous cell carcinogenesis...
  20. doi request reprint Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Cancer Res 68:5609-18. 2008
    ..9-fold risk, univariate Cox regression; Kaplan-Meier, P = 0.04). We suggest that the inhibition of the stress response sensor CHEK1 might contribute to the antineoplastic activity of specific DNA-damaging drugs...
  21. pmc Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21
    Mona El-Khatib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Radiat Oncol 5:107. 2010
    ..In this study, we used HCT116 that are either wildtype for p53 and p21, null for p53 or null for p21 to understand the role of these genes in DCQ toxicity...
  22. ncbi request reprint Radiosensitization of EMT6 mammary carcinoma cells by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide
    Joelle Haykal
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Radiother Oncol 86:412-8. 2008
    ..Previously, we have reported that 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide (DCQ) is a radiosensitizer. Here, we investigate the mechanism of radiosensitization...
  23. doi request reprint Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
    Nahed El-Najjar
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Apoptosis 15:183-95. 2010
    ..These data present evidence linking the pro-oxidant effects of TQ with its apoptotic effects in colon cancer and prove a protective role of MAPK...
  24. ncbi request reprint Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells
    Steve Harakeh
    Biology Department, American University of Beirut, Lebanon
    Chem Biol Interact 148:101-13. 2004
    ..The present findings suggest that DCQ merits further investigation as a potential therapeutic agent for this incurable disease...
  25. ncbi request reprint Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer
    Nahed El-Najjar
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Oncol Rep 17:1517-23. 2007
    ..0001) and decreased the mean size of aberrant crypt foci in the DMH model of colon cancer. These data collectively suggest that O. cynarocephalum has potential anti-colon cancer effects...
  26. doi request reprint What made sesquiterpene lactones reach cancer clinical trials?
    Akram Ghantous
    Biology Department, American University of Beirut, Beirut, Lebanon
    Drug Discov Today 15:668-78. 2010
    ..These drugs are selective toward tumor and cancer stem cells by targeting specific signaling pathways, which make them lead compounds in cancer clinical trials...
  27. ncbi request reprint Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes
    Nadine Darwiche
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Radiat Res 163:296-306. 2005
    ..Our findings indicate that the inhibition of AP1 activity by retinoids explains, at least in part, the chemopreventive potential of retinoids in UV-radiation-associated epidermal damage...
  28. ncbi request reprint Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis
    Nahed El-Najjar
    Department of Biology, American University of Beirut, Beirut 1107 2020, Lebanon
    Oncol Rep 19:897-904. 2008
    ..These data support the testing of the C. ainetensis extract and its bioactive molecule, Salograviolide A, in colon cancer treatment...
  29. ncbi request reprint Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes
    Samar Maalouf
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Mol Carcinog 34:121-30. 2002
    ..Thus, these antioxidant vitamins are potential drugs for the protection from or the reduction of UVB-associated epidermal damage...
  30. doi request reprint Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21
    Akram Ghantous
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Cancer Prev Res (Phila) 5:1298-309. 2012
    ..These results show that low doses of parthenolide inhibit tumor promotion and epigenetically modulate p21 expression, highlighting the potential role of this drug as a chemopreventive agent and in epigenetic cancer therapy...
  31. ncbi request reprint Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status
    Sahar Al-Ayyoubi
    Department of Biology, The American University of Beirut, Beirut, Lebanon
    Mol Carcinog 46:176-86. 2007
    ..Our results demonstrate that GT inhibits the growth of HCT-116 colon cancer cells in a p53-independent manner but exhibits differential sensitivity to apoptosis induction in HCT-116 cells with distinct p53 status...
  32. doi request reprint Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts
    Racha Al-Halabi
    American University of Beirut, Lebanon
    Cancer Biol Ther 12:59-68. 2011
    ..Overall, our results indicate that the anti-inflammatory and antitumor activities of GT may be mediated in part through the suppression of NF-ĸB activation...
  33. doi request reprint A journey under the sea: the quest for marine anti-cancer alkaloids
    Rita Tohme
    Department of Biology, American University of Beirut, Beirut, P O Box 11 0236, Lebanon
    Molecules 16:9665-96. 2011
    ..This review sheds light on the rich array of anti-cancer alkaloids in the marine ecosystem and introduces the most investigated compounds and their mechanisms of action...
  34. doi request reprint Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells
    Rita Tohme
    AUB Nature Conservation Center, American University of Beirut, Beirut, P O Box 11 0236, Lebanon
    Molecules 18:8275-88. 2013
    ..Further structure-activity relationship studies related the bioactivity of the tested compounds to their skeleton, their lipophilicity, and to the type of functional groups neighboring the main alkylating center of the molecule...
  35. doi request reprint Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide
    Mohamed Salla
    Department of Biology, American University of Beirut, Riad El Solh, Beirut, Lebanon
    J Nat Med 67:468-79. 2013
    ..Taken together, our data suggest that the combination of Sal A and TNP may be of therapeutic interest against colon cancer...