Dual renin-angiotensin system blockade at optimal doses for proteinuriaGozewijn D Laverman
Division of Nephrology, Faculty of Medical Sciences, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Kidney Int 62:1020-5. 2002
..The antiproteinuric effect of combining the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the angiotensin II (Ang II) antagonist losartan was compared to that of the optimal antiproteinuric doses of monotherapy...
- Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes
Gozewijn D Laverman
Department of Medicine, Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
Kidney Int 63:64-71. 2003
..Therefore, in contrast with ACEI, VPI may be effective during high sodium intake...
- Between-patient differences in the renal response to renin-angiotensin system intervention: clue to optimising renoprotective therapy?
Gozewijn D Laverman
Division of Nephrology, University Hospital Groningen, Groningen, 9713, The Netherlands
J Renin Angiotensin Aldosterone Syst 3:205-13. 2002
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Effects of antiproteinuric intervention on elevated connective tissue growth factor (CTGF/CCN-2) plasma and urine levels in nondiabetic nephropathyMaartje C J Slagman
University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Clin J Am Soc Nephrol 6:1845-50. 2011
..Few data are available on CTGF in nondiabetic CKD. We investigated CTGF levels and effects of antiproteinuric interventions in nondiabetic proteinuric CKD...
Elevated N-terminal pro-brain natriuretic peptide levels predict an enhanced anti-hypertensive and anti-proteinuric benefit of dietary sodium restriction and diuretics, but not angiotensin receptor blockade, in proteinuric renal patientsMaartje C J Slagman
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 27:983-90. 2012
..We evaluated whether N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker of volume expansion, predicts the benefits of sodium targeting in CKD patients...
- Benefits of dietary sodium restriction in the management of chronic kidney disease
Jan A Krikken
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
Curr Opin Nephrol Hypertens 18:531-8. 2009
..To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications...
- An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
Paul A Smink
Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Hypertens 30:1022-8. 2012
..Treatment with the angiotensin receptor blocker (ARB) losartan lowers SUA in contrast to other ARBs. Whether reductions in SUA during ARB therapy are associated with cardiovascular protection is unclear. We aimed to investigate this...
- Erythropoietin is reduced by combination of diuretic therapy and RAAS blockade in proteinuric renal patients with preserved renal function
Maartje C J Slagman
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 25:3256-60. 2010
..RAAS blockade can decrease erythropoietin (EPO) and/or haemoglobin (Hb) levels. Diuretics decrease EPO in rodents, but their effect on EPO and Hb in humans is unknown...
- Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
Hendrik Bos
Department of Nephrology, Groningen University, Groningen, The Netherlands
J Renin Angiotensin Aldosterone Syst 4:106-12. 2003
..Renal ACE activity is a consistent marker of individual differences in proteinuria-associated renal damage: further studies are needed to investigate a possible pathogenetic role in renal damage...
- Inter-individual differences in anti-proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage
Andrea B Kramer
Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
J Pathol 201:160-7. 2003
..Further studies into the mechanisms of individual resistance to the anti-proteinuric action of ACEi are needed to develop additive intervention strategies...
- ACE inhibition versus angiotensin receptor blockade: which is better for renal and cardiovascular protection?
Gozewijn D Laverman
Department of Medicine, Division of Nephrology, University of Groningen, The Netherlands
J Am Soc Nephrol 15:S64-70. 2004
..Within this approach, full dose titration of either RAS blocker followed by add-on with the second drug is more important than the choice of the initial drug...
- Cellular cholesterol efflux to plasma from proteinuric patients is elevated and remains unaffected by antiproteinuric treatment
Liffert Vogt
Department of Internal Medicine, Division of Nephrology, room 4 045, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9718 NX Groningen, The Netherlands
Nephrol Dial Transplant 21:101-6. 2006
..The first step in RCT, cellular cholesterol efflux to plasma, may be altered in proteinuria, consequent to changes in pre-beta high-density lipoprotein (HDL) formation and plasma phospholipid transfer protein (PLTP) activity...
- Proprotein convertase subtilisin-kexin type 9 is elevated in proteinuric subjects: Relationship with lipoprotein response to antiproteinuric treatment
Arjan J Kwakernaak
Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands Electronic address
Atherosclerosis 226:459-65. 2013
..We tested whether plasma PCSK9 is elevated in proteinuric states, and determined relationships of PCSK9 with lipoprotein responses to proteinuria reduction...
- Indomethacin reduces glomerular and tubular damage markers but not renal inflammation in chronic kidney disease patients: a post-hoc analysis
Martin H de Borst
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
PLoS ONE 7:e37957. 2012
..Future studies should address whether the short term glomerulo- and tubulo-protective effects as observed outweigh the possible side-effects of NSAID treatment on the long term...
- Vascular endothelial growth factor C levels are modulated by dietary salt intake in proteinuric chronic kidney disease patients and in healthy subjects
Maartje C J Slagman
Department of Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 27:978-82. 2012
..Therefore, we investigated circulating VEGF-C levels and blood pressure during different well-controlled salt intake in chronic kidney disease (CKD) patients and in healthy subjects...
- Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials
Frank A Holtkamp
Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
Eur Heart J 32:1493-9. 2011
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- Dual blockade of the renin-angiotensin-aldosterone system in cardiac and renal disease
Maartje C J Slagman
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
Curr Opin Nephrol Hypertens 19:140-52. 2010
..This review discusses the place of dual RAAS blockade in improving these outcomes...
- Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage
Femke Waanders
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, The Netherlands
Curr Vasc Pharmacol 9:594-605. 2011
..It is obligatory that future clinical studies on the effects of MR blockade on end-organ damage take into account the sodium status...
- Improvement of sodium status to optimize the efficacy of Renin-Angiotensin system blockade
Gozewijn D Laverman
Department of Internal Medicine, Division of Nephrology, ZGT Hospital Almelo, Almelo, The Netherlands
Curr Hypertens Rep 13:397-9. 2011
..Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets...
- Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients
Paul Y Boxma
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
PLoS ONE 7:e47991. 2012
..The high dp-ucMGP levels may result in an increased risk for arterial calcification. Whether increasing vitamin K intake may have health benefits for kidney transplant recipients should be addressed by future studies...
- Lipid management in the proteinuric patient: do not overlook the importance of proteinuria reduction
Liffert Vogt
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 GX Groningen, The Netherlands
Nephrol Dial Transplant 19:5-8. 2004
- The COOPERATE trial
Liffert Vogt
Lancet 361:1055-6. 2003
- Antihypertensive therapy in chronic renal disease: a place for sympathicolytic agents?
Gozewijn D Laverman
J Hypertens 21:1625-6. 2003
