Gozewijn D Laverman

Summary

Publications

  1. ncbi request reprint Dual renin-angiotensin system blockade at optimal doses for proteinuria
    Gozewijn D Laverman
    Division of Nephrology, Faculty of Medical Sciences, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Kidney Int 62:1020-5. 2002
  2. ncbi request reprint Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes
    Gozewijn D Laverman
    Department of Medicine, Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Kidney Int 63:64-71. 2003
  3. ncbi request reprint Between-patient differences in the renal response to renin-angiotensin system intervention: clue to optimising renoprotective therapy?
    Gozewijn D Laverman
    Division of Nephrology, University Hospital Groningen, Groningen, 9713, The Netherlands
    J Renin Angiotensin Aldosterone Syst 3:205-13. 2002
  4. pmc Effects of antiproteinuric intervention on elevated connective tissue growth factor (CTGF/CCN-2) plasma and urine levels in nondiabetic nephropathy
    Maartje C J Slagman
    University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:1845-50. 2011
  5. doi request reprint Elevated N-terminal pro-brain natriuretic peptide levels predict an enhanced anti-hypertensive and anti-proteinuric benefit of dietary sodium restriction and diuretics, but not angiotensin receptor blockade, in proteinuric renal patients
    Maartje C J Slagman
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:983-90. 2012
  6. doi request reprint Proprotein convertase subtilisin-kexin type 9 is elevated in proteinuric subjects: relationship with lipoprotein response to antiproteinuric treatment
    Arjan J Kwakernaak
    Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
    Atherosclerosis 226:459-65. 2013
  7. doi request reprint Benefits of dietary sodium restriction in the management of chronic kidney disease
    Jan A Krikken
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 18:531-8. 2009
  8. doi request reprint An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 30:1022-8. 2012
  9. doi request reprint Erythropoietin is reduced by combination of diuretic therapy and RAAS blockade in proteinuric renal patients with preserved renal function
    Maartje C J Slagman
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:3256-60. 2010
  10. ncbi request reprint Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
    Hendrik Bos
    Department of Nephrology, Groningen University, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:106-12. 2003

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Dual renin-angiotensin system blockade at optimal doses for proteinuria
    Gozewijn D Laverman
    Division of Nephrology, Faculty of Medical Sciences, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Kidney Int 62:1020-5. 2002
    ..The antiproteinuric effect of combining the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the angiotensin II (Ang II) antagonist losartan was compared to that of the optimal antiproteinuric doses of monotherapy...
  2. ncbi request reprint Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes
    Gozewijn D Laverman
    Department of Medicine, Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Kidney Int 63:64-71. 2003
    ..Therefore, in contrast with ACEI, VPI may be effective during high sodium intake...
  3. ncbi request reprint Between-patient differences in the renal response to renin-angiotensin system intervention: clue to optimising renoprotective therapy?
    Gozewijn D Laverman
    Division of Nephrology, University Hospital Groningen, Groningen, 9713, The Netherlands
    J Renin Angiotensin Aldosterone Syst 3:205-13. 2002
    ....
  4. pmc Effects of antiproteinuric intervention on elevated connective tissue growth factor (CTGF/CCN-2) plasma and urine levels in nondiabetic nephropathy
    Maartje C J Slagman
    University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:1845-50. 2011
    ..Few data are available on CTGF in nondiabetic CKD. We investigated CTGF levels and effects of antiproteinuric interventions in nondiabetic proteinuric CKD...
  5. doi request reprint Elevated N-terminal pro-brain natriuretic peptide levels predict an enhanced anti-hypertensive and anti-proteinuric benefit of dietary sodium restriction and diuretics, but not angiotensin receptor blockade, in proteinuric renal patients
    Maartje C J Slagman
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:983-90. 2012
    ..We evaluated whether N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker of volume expansion, predicts the benefits of sodium targeting in CKD patients...
  6. doi request reprint Proprotein convertase subtilisin-kexin type 9 is elevated in proteinuric subjects: relationship with lipoprotein response to antiproteinuric treatment
    Arjan J Kwakernaak
    Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
    Atherosclerosis 226:459-65. 2013
    ..We tested whether plasma PCSK9 is elevated in proteinuric states, and determined relationships of PCSK9 with lipoprotein responses to proteinuria reduction...
  7. doi request reprint Benefits of dietary sodium restriction in the management of chronic kidney disease
    Jan A Krikken
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 18:531-8. 2009
    ..To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications...
  8. doi request reprint An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 30:1022-8. 2012
    ..Treatment with the angiotensin receptor blocker (ARB) losartan lowers SUA in contrast to other ARBs. Whether reductions in SUA during ARB therapy are associated with cardiovascular protection is unclear. We aimed to investigate this...
  9. doi request reprint Erythropoietin is reduced by combination of diuretic therapy and RAAS blockade in proteinuric renal patients with preserved renal function
    Maartje C J Slagman
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:3256-60. 2010
    ..RAAS blockade can decrease erythropoietin (EPO) and/or haemoglobin (Hb) levels. Diuretics decrease EPO in rodents, but their effect on EPO and Hb in humans is unknown...
  10. ncbi request reprint Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
    Hendrik Bos
    Department of Nephrology, Groningen University, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:106-12. 2003
    ..Renal ACE activity is a consistent marker of individual differences in proteinuria-associated renal damage: further studies are needed to investigate a possible pathogenetic role in renal damage...
  11. ncbi request reprint Inter-individual differences in anti-proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage
    Andrea B Kramer
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    J Pathol 201:160-7. 2003
    ..Further studies into the mechanisms of individual resistance to the anti-proteinuric action of ACEi are needed to develop additive intervention strategies...
  12. doi request reprint Performance of MDRD study and CKD-EPI equations for long-term follow-up of nondiabetic patients with chronic kidney disease
    Hilde Tent
    Department of Internal Medicine Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:iii89-95. 2012
    ....
  13. ncbi request reprint ACE inhibition versus angiotensin receptor blockade: which is better for renal and cardiovascular protection?
    Gozewijn D Laverman
    Department of Medicine, Division of Nephrology, University of Groningen, The Netherlands
    J Am Soc Nephrol 15:S64-70. 2004
    ..Within this approach, full dose titration of either RAS blocker followed by add-on with the second drug is more important than the choice of the initial drug...
  14. ncbi request reprint Cellular cholesterol efflux to plasma from proteinuric patients is elevated and remains unaffected by antiproteinuric treatment
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, room 4 045, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9718 NX Groningen, The Netherlands
    Nephrol Dial Transplant 21:101-6. 2006
    ..The first step in RCT, cellular cholesterol efflux to plasma, may be altered in proteinuria, consequent to changes in pre-beta high-density lipoprotein (HDL) formation and plasma phospholipid transfer protein (PLTP) activity...
  15. pmc Indomethacin reduces glomerular and tubular damage markers but not renal inflammation in chronic kidney disease patients: a post-hoc analysis
    Martin H de Borst
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e37957. 2012
    ..Future studies should address whether the short term glomerulo- and tubulo-protective effects as observed outweigh the possible side-effects of NSAID treatment on the long term...
  16. doi request reprint Vascular endothelial growth factor C levels are modulated by dietary salt intake in proteinuric chronic kidney disease patients and in healthy subjects
    Maartje C J Slagman
    Department of Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:978-82. 2012
    ..Therefore, we investigated circulating VEGF-C levels and blood pressure during different well-controlled salt intake in chronic kidney disease (CKD) patients and in healthy subjects...
  17. doi request reprint Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
    Eur Heart J 32:1493-9. 2011
    ....
  18. ncbi request reprint Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage
    Femke Waanders
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, The Netherlands
    Curr Vasc Pharmacol 9:594-605. 2011
    ..It is obligatory that future clinical studies on the effects of MR blockade on end-organ damage take into account the sodium status...
  19. doi request reprint Dual blockade of the renin-angiotensin-aldosterone system in cardiac and renal disease
    Maartje C J Slagman
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 19:140-52. 2010
    ..This review discusses the place of dual RAAS blockade in improving these outcomes...
  20. pmc Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients
    Paul Y Boxma
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e47991. 2012
    ..The high dp-ucMGP levels may result in an increased risk for arterial calcification. Whether increasing vitamin K intake may have health benefits for kidney transplant recipients should be addressed by future studies...
  21. pmc Improvement of sodium status to optimize the efficacy of Renin-Angiotensin system blockade
    Gozewijn D Laverman
    Department of Internal Medicine, Division of Nephrology, ZGT Hospital Almelo, Almelo, The Netherlands
    Curr Hypertens Rep 13:397-9. 2011
    ..Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets...
  22. ncbi request reprint Lipid management in the proteinuric patient: do not overlook the importance of proteinuria reduction
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 GX Groningen, The Netherlands
    Nephrol Dial Transplant 19:5-8. 2004
  23. ncbi request reprint The COOPERATE trial
    Liffert Vogt
    Lancet 361:1055-6. 2003
  24. ncbi request reprint Antihypertensive therapy in chronic renal disease: a place for sympathicolytic agents?
    Gozewijn D Laverman
    J Hypertens 21:1625-6. 2003