Conference scene: progress with promising human antibodiesJames W Larrick
Panorama Research Institute, Sunnyvale, CA 94089, USA
Immunotherapy 4:257-61. 2012
..The conference was sponsored by the international journal Human Antibodies, in association with the Integrative Medical Sciences Association (IMSA). The Program Chairman was Professor Mark Glassy, IMSA, San Diego, CA, USA...
Applied Healthspan engineeringJames W Larrick
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California 94089, USA
Rejuvenation Res 13:265-80. 2010
..AHE supports the study of cell, tissue, and organ homeostatic mechanisms to derive new regenerative and tissue replacement therapies to extend the period of human health...
Dissecting mammalian target of rapamycin to promote longevityAndrew R Mendelsohn
Panorama Research Institute and Regenerative Sciences Institute, 1230 Bordeaux Drive, Sunnyvale, California 94089, USA
Rejuvenation Res 15:334-7. 2012
..The search for inhibitors of the mTORC1 component Raptor may prove a productive approach to create a better mTOR inhibitor...
Fibroblast growth factor-21 is a promising dietary restriction mimeticAndrew R Mendelsohn
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California
Rejuvenation Res 15:624-8. 2012
..More in-depth studies of the effects of FGF21 and its inducers on longevity and health span are warranted...
The DNA methylome as a biomarker for epigenetic instability and human agingAndrew R Mendelsohn
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California, USA
Rejuvenation Res 16:74-7. 2013
..The model may eventually lead to experiments to differentiate the contributions of biomolecular damage and noise/incomplete structural replication during aging...
Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic?Andrew R Mendelsohn
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California
Rejuvenation Res 16:152-7. 2013
..If true, rejuvenation of at least some aged cells may be simpler than generally appreciated...
Dietary restriction: critical co-factors to separate health span from life span benefitsAndrew R Mendelsohn
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California
Rejuvenation Res 15:523-9. 2012
..Optimized health span engineering will require a much deeper understanding of DR...
Ectopic expression of telomerase safely increases health span and life spanAndrew R Mendelsohn
Panorama Research Institute, Sunnyvale, California 94089, USA
Rejuvenation Res 15:435-8. 2012
..Such a positive feedback loop implies that safety must be carefully considered in the development of drugs that stimulate telomerase activity...
Epigenetic-mediated decline in synaptic plasticity during agingAndrew R Mendelsohn
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, CA 94089, USA
Rejuvenation Res 15:98-101. 2012
..Such dysfunctional epigenetic pathways may provide novel targets for cognitive enhancing therapeutics...