J W Larrick

Summary

Publications

  1. ncbi request reprint Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes
    J G Morgan
    Genelabs Inc, Redwood City, CA 94063
    J Immunol 147:3210-4. 1991
  2. ncbi request reprint CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases
    H A Pereira
    Dept of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322
    Life Sci 46:189-96. 1990
  3. pmc Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity
    M Hirata
    Department of Bacteriology, School of Medicine, Iwate Medical University, Morioka, Japan
    Infect Immun 62:1421-6. 1994
  4. ncbi request reprint Production of secretory IgA antibodies in plants
    J W Larrick
    Planet Biotechnology, Inc, 25571 Clawiter Road, Hayward, CA 94043, USA
    Biomol Eng 18:87-94. 2001
  5. ncbi request reprint Producing proteins in transgenic plants and animals
    J W Larrick
    Planet Biotechnology, Inc, 2438 Wyandotte Street, Mountain View, CA 94043, USA
    Curr Opin Biotechnol 12:411-8. 2001
  6. ncbi request reprint Structural, functional analysis and localization of the human CAP18 gene
    J W Larrick
    Palo Alto Institute of Molecular Medicine, Mountain View, CA 94043, USA
    FEBS Lett 398:74-80. 1996
  7. ncbi request reprint A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity
    J W Larrick
    Palo Alto Institute of Molecular Medicine, Mountain View, CA 94043
    J Immunol 152:231-40. 1994
  8. pmc Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein
    J W Larrick
    Palo Alto Institute of Molecular Medicine, Mountain View, California 94043
    Infect Immun 63:1291-7. 1995
  9. ncbi request reprint Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity
    Y Wang
    Panorama Research, Inc, 2462 Wyandotte Street, Mountain View, California 94043, USA
    J Med Chem 43:1541-9. 2000
  10. ncbi request reprint Complementary DNA sequence of rabbit CAP18--a unique lipopolysaccharide binding protein
    J W Larrick
    Genelabs Incorporated, Redwood City, CA 94063
    Biochem Biophys Res Commun 179:170-5. 1991

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes
    J G Morgan
    Genelabs Inc, Redwood City, CA 94063
    J Immunol 147:3210-4. 1991
    ..quot; Whereas CAP37 is expressed in undifferentiated HL-60 cells no message is detected in mature neutrophils...
  2. ncbi request reprint CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases
    H A Pereira
    Dept of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322
    Life Sci 46:189-96. 1990
    ..However, a critical substitution of a serine for a histidine at position 41, results in its lack of serine protease activity...
  3. pmc Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity
    M Hirata
    Department of Bacteriology, School of Medicine, Iwate Medical University, Morioka, Japan
    Infect Immun 62:1421-6. 1994
    ..In this regard, CAP may have therapeutic potential for sepsis and endotoxin shock...
  4. ncbi request reprint Production of secretory IgA antibodies in plants
    J W Larrick
    Planet Biotechnology, Inc, 25571 Clawiter Road, Hayward, CA 94043, USA
    Biomol Eng 18:87-94. 2001
    ..g. catalytic antibodies)...
  5. ncbi request reprint Producing proteins in transgenic plants and animals
    J W Larrick
    Planet Biotechnology, Inc, 2438 Wyandotte Street, Mountain View, CA 94043, USA
    Curr Opin Biotechnol 12:411-8. 2001
    ..The first commercial products to be made in this way have experienced much success, and it is predicted that in the future a plethora of protein products will be made using these 'natural' bioreactors...
  6. ncbi request reprint Structural, functional analysis and localization of the human CAP18 gene
    J W Larrick
    Palo Alto Institute of Molecular Medicine, Mountain View, CA 94043, USA
    FEBS Lett 398:74-80. 1996
    ..This work forms the groundwork for future analysis of the genetic regulation of this antimicrobial protein during PMN differentiation...
  7. ncbi request reprint A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity
    J W Larrick
    Palo Alto Institute of Molecular Medicine, Mountain View, CA 94043
    J Immunol 152:231-40. 1994
    ..CAP18(106-142) may have therapeutic utility for conditions associated with elevated concentrations of LPS...
  8. pmc Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein
    J W Larrick
    Palo Alto Institute of Molecular Medicine, Mountain View, California 94043
    Infect Immun 63:1291-7. 1995
    ..CAP18(104-140) may have therapeutic utility for conditions associated with elevated concentrations of LPS...
  9. ncbi request reprint Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity
    Y Wang
    Panorama Research, Inc, 2462 Wyandotte Street, Mountain View, California 94043, USA
    J Med Chem 43:1541-9. 2000
    ..Most importantly, 26 and 30 are not myelosuppressive at therapeutically effective doses. The mechanism of tumor cell death is through induction of apoptosis, and is accompanied by DNA fragmentation...
  10. ncbi request reprint Complementary DNA sequence of rabbit CAP18--a unique lipopolysaccharide binding protein
    J W Larrick
    Genelabs Incorporated, Redwood City, CA 94063
    Biochem Biophys Res Commun 179:170-5. 1991
    ..There are no N-linked glycosylation sites. The CAP18 sequence bears no homology with other known LPS-binding proteins including human bacterial permeability increasing protein (BPI)(1) and rabbit LPS binding protein (LBP)(2)...
  11. pmc Interaction of CAP18-derived peptides with membranes made from endotoxins or phospholipids
    T Gutsmann
    Research Center Borstel, Department of Immunochemistry and Biochemical Microbiology, D-23845 Borstel, Germany
    Biophys J 80:2935-45. 2001
    ..Thus, we propose that the physicochemical properties of both the peptides as well as of the target membranes are important for antibacterial activity...
  12. ncbi request reprint The solution structure of the active domain of CAP18--a lipopolysaccharide binding protein from rabbit leukocytes
    C Chen
    Division of Structural Biology, Academia Sinica, Nankang, Taipei, Taiwan, ROC
    FEBS Lett 370:46-52. 1995
    ....
  13. ncbi request reprint Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases
    J G Morgan
    Genelabs Inc, Redwood City, CA 94063
    Adv Exp Med Biol 305:89-96. 1991
    ..Sequencing of the cDNA reveals a protein of 225 amino acids with significant nucleotide homology to cathepsin G and human neutrophil elastase...