Olivier M Lardinois

Summary

Publications

  1. pmc Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry
    Olivier M Lardinois
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 47:10440-8. 2008
  2. pmc Spin scavenging analysis of myoglobin protein-centered radicals using stable nitroxide radicals: characterization of oxoammonium cation-induced modifications
    Olivier M Lardinois
    Laboratories of Pharmacology and Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 22:1034-49. 2009
  3. pmc Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA, and off-line tandem mass spectrometry
    Olivier M Lardinois
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 44:893-906. 2008
  4. ncbi request reprint Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization
    Charles D Detweiler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, MD F0 01, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:969-76. 2005
  5. pmc Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:98-106. 2013

Collaborators

Detail Information

Publications5

  1. pmc Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry
    Olivier M Lardinois
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 47:10440-8. 2008
    ..Together, the data support the argument that wild-type Ngb is protected from attack by H 2O 2 by the coordinated distal His...
  2. pmc Spin scavenging analysis of myoglobin protein-centered radicals using stable nitroxide radicals: characterization of oxoammonium cation-induced modifications
    Olivier M Lardinois
    Laboratories of Pharmacology and Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 22:1034-49. 2009
    ..g., by use of 2,4-dinitrophenyl hydrazine). The results reveal the pitfalls inherent in using stable nitroxide radicals such as TEMPOL to identify sites of radical formation on hemoproteins...
  3. pmc Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA, and off-line tandem mass spectrometry
    Olivier M Lardinois
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 44:893-906. 2008
    ..The results demonstrate the power of the new experimental strategy to select DMPO-labeled peptides and identify sites of DMPO covalent attachments...
  4. ncbi request reprint Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization
    Charles D Detweiler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, MD F0 01, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:969-76. 2005
    ..Interestingly, formation of the myoglobin dimer, which is known to be formed primarily by cross-linkage of tyrosine-151, was inhibited by the addition of DMPO...
  5. pmc Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:98-106. 2013
    ..Our present study demonstrates that myeloperoxidase initiates (bi)sulfite oxidation leading to MPO radical damage, possibly leading to (bi)sulfite-exacerbated allergic reactions...