Peter LaPan

Summary

Publications

  1. pmc Single cell cytometry of protein function in RNAi treated cells and in native populations
    Peter LaPan
    Department of Biological Technologies, Oncology Research, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    BMC Cell Biol 9:43. 2008
  2. doi request reprint A Kinome-Wide siRNA Screen Identifies Multiple Roles for Protein Kinases in Hypoxic Stress Adaptation, Including Roles for IRAK4 and GAK in Protection against Apoptosis in VHL-/- Renal Carcinoma Cells, Despite Activation of the NF-κB Pathway
    Jing Pan
    1Applied Genomics, Department of Biological Technologies, Wyeth Research, Cambridge, MA, USA
    J Biomol Screen 18:782-96. 2013
  3. doi request reprint Quantitative optimization of reverse transfection conditions for 384-well siRNA library screening
    Peter LaPan
    Section of Biologic Research, Department of Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Assay Drug Dev Technol 6:683-91. 2008
  4. ncbi request reprint High-content screening moves to the front of the line
    Steven A Haney
    Department of Biological Technologies, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Drug Discov Today 11:889-94. 2006
  5. pmc Image-based assessment of growth and signaling changes in cancer cells mediated by direct cell-cell contact
    Peter LaPan
    Department of Biological Technologies, Wyeth Research, Cambridge, Massachusetts, USA
    PLoS ONE 4:e6822. 2009
  6. pmc Impact of image segmentation on high-content screening data quality for SK-BR-3 cells
    Andrew A Hill
    Department of Biological Technologies, Wyeth Research, 35 CambridgePark Drive, Cambridge, MA 02140, USA
    BMC Bioinformatics 8:340. 2007

Collaborators

Detail Information

Publications6

  1. pmc Single cell cytometry of protein function in RNAi treated cells and in native populations
    Peter LaPan
    Department of Biological Technologies, Oncology Research, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    BMC Cell Biol 9:43. 2008
    ..Such approaches are important for immune cells analyzed by flow cytometry, but have not been broadly available for adherent cells that are critical to the study of solid-tumor cancers and other disease models...
  2. doi request reprint A Kinome-Wide siRNA Screen Identifies Multiple Roles for Protein Kinases in Hypoxic Stress Adaptation, Including Roles for IRAK4 and GAK in Protection against Apoptosis in VHL-/- Renal Carcinoma Cells, Despite Activation of the NF-κB Pathway
    Jing Pan
    1Applied Genomics, Department of Biological Technologies, Wyeth Research, Cambridge, MA, USA
    J Biomol Screen 18:782-96. 2013
    ....
  3. doi request reprint Quantitative optimization of reverse transfection conditions for 384-well siRNA library screening
    Peter LaPan
    Section of Biologic Research, Department of Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Assay Drug Dev Technol 6:683-91. 2008
    ..The assay is fast, inexpensive, and quantitative. Conditions identified as optimal using this technique have been employed successfully in library screens...
  4. ncbi request reprint High-content screening moves to the front of the line
    Steven A Haney
    Department of Biological Technologies, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Drug Discov Today 11:889-94. 2006
    ..The use of HCS in target validation is expanding the work that can be done at this stage, especially the range of targets that can be characterized, and putting it into a more biological context...
  5. pmc Image-based assessment of growth and signaling changes in cancer cells mediated by direct cell-cell contact
    Peter LaPan
    Department of Biological Technologies, Wyeth Research, Cambridge, Massachusetts, USA
    PLoS ONE 4:e6822. 2009
    ..Despite the crucial importance of the cellular environment in regulating cellular signaling, in vitro methods for the study of such interactions are difficult and/or indirect...
  6. pmc Impact of image segmentation on high-content screening data quality for SK-BR-3 cells
    Andrew A Hill
    Department of Biological Technologies, Wyeth Research, 35 CambridgePark Drive, Cambridge, MA 02140, USA
    BMC Bioinformatics 8:340. 2007
    ..We asked if segmentation errors were common for a clinically relevant cell line, if such errors had measurable effects on the data, and if HCS data could be improved by automated identification of well-segmented cells...