R P Lanza

Summary

Publications

  1. pmc GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, MA 01605, USA
    Genome Biol 8:R240. 2007
  2. ncbi request reprint Human therapeutic cloning
    R P Lanza
    Tissue Engineering and Transplant Medicine, Advanced Cell Technology, One Innovation Drive, Worcester, Massachusetts 01605, USA
    Nat Med 5:975-7. 1999
  3. doi request reprint Reprogramming of human somatic cells using human and animal oocytes
    Young Chung
    Advanced Cell Technology, Worcester, MA 01605, USA
    Cloning Stem Cells 11:213-23. 2009
  4. ncbi request reprint Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer
    R P Lanza
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Cloning 2:79-90. 2000
  5. ncbi request reprint Prospects for the use of nuclear transfer in human transplantation
    R P Lanza
    Advanced Cell Technology, Worcester, MA 01605, USA
    Nat Biotechnol 17:1171-4. 1999
  6. ncbi request reprint Extension of cell life-span and telomere length in animals cloned from senescent somatic cells
    R P Lanza
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Science 288:665-9. 2000
  7. ncbi request reprint Comment on "Molecular correlates of primate nuclear transfer failures"
    Robert Lanza
    Advanced Cell Technology, One Innovation DriveWorcester, MA 01605, USA
    Science 301:1482; author reply 1482. 2003
  8. ncbi request reprint Regeneration of the infarcted heart with stem cells derived by nuclear transplantation
    Robert Lanza
    Advanced Cell Technology, Worcester, Mass, USA
    Circ Res 94:820-7. 2004
  9. ncbi request reprint Derivation of human embryonic stem cells from single blastomeres
    Irina Klimanskaya
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nat Protoc 2:1963-72. 2007
  10. ncbi request reprint Derive and conquer: sourcing and differentiating stem cells for therapeutic applications
    Irina Klimanskaya
    Advanced Cell Technology, 381 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Drug Discov 7:131-42. 2008

Research Grants

  1. Defining Critical Parameters of Mouse Cloning
    Robert Lanza; Fiscal Year: 2001

Collaborators

Detail Information

Publications22

  1. pmc GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, MA 01605, USA
    Genome Biol 8:R240. 2007
    ..Blast cells are multipotent and can differentiate into multiple lineages of hematopoeitic cells (erythroid, granulocyte and macrophage), endothelial and smooth muscle cells...
  2. ncbi request reprint Human therapeutic cloning
    R P Lanza
    Tissue Engineering and Transplant Medicine, Advanced Cell Technology, One Innovation Drive, Worcester, Massachusetts 01605, USA
    Nat Med 5:975-7. 1999
    ....
  3. doi request reprint Reprogramming of human somatic cells using human and animal oocytes
    Young Chung
    Advanced Cell Technology, Worcester, MA 01605, USA
    Cloning Stem Cells 11:213-23. 2009
    ..Without appropriate reprogramming, these data call into question the potential use of these discordant animal oocyte sources to generate patient-specific stem cells...
  4. ncbi request reprint Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer
    R P Lanza
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Cloning 2:79-90. 2000
    ..These results suggest that somatic cell cloning methods could be used to restore endangered, or even extinct, species and populations...
  5. ncbi request reprint Prospects for the use of nuclear transfer in human transplantation
    R P Lanza
    Advanced Cell Technology, Worcester, MA 01605, USA
    Nat Biotechnol 17:1171-4. 1999
    ....
  6. ncbi request reprint Extension of cell life-span and telomere length in animals cloned from senescent somatic cells
    R P Lanza
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Science 288:665-9. 2000
    ..The ability to regenerate animals and cells may have important implications for medicine and the study of mammalian aging...
  7. ncbi request reprint Comment on "Molecular correlates of primate nuclear transfer failures"
    Robert Lanza
    Advanced Cell Technology, One Innovation DriveWorcester, MA 01605, USA
    Science 301:1482; author reply 1482. 2003
  8. ncbi request reprint Regeneration of the infarcted heart with stem cells derived by nuclear transplantation
    Robert Lanza
    Advanced Cell Technology, Worcester, Mass, USA
    Circ Res 94:820-7. 2004
    ..Importantly, the magnitude of myocardial regeneration obtained in this study is significantly superior to that achieved with adult bone marrow cells...
  9. ncbi request reprint Derivation of human embryonic stem cells from single blastomeres
    Irina Klimanskaya
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nat Protoc 2:1963-72. 2007
    ..The resulting blastomere-derived outgrowths are cultured in the same manner as blastocyst-derived hES cells. The whole process takes about 3-4 months...
  10. ncbi request reprint Derive and conquer: sourcing and differentiating stem cells for therapeutic applications
    Irina Klimanskaya
    Advanced Cell Technology, 381 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Drug Discov 7:131-42. 2008
    ..Here, we address some of the problems associated with the sourcing of human ESCs and discuss the current status of stem-cell differentiation technology...
  11. ncbi request reprint Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres
    Young Chung
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nature 439:216-9. 2006
    ..The ability to generate human ES cells without the destruction of ex utero embryos would reduce or eliminate the ethical concerns of many...
  12. ncbi request reprint Long-term bovine hematopoietic engraftment with clone-derived stem cells
    Robert Lanza
    Advanced Cell Technology, Worcester, Massachusetts, USA
    Cloning Stem Cells 7:95-106. 2005
    ..The fetal HSC showed a 10-fold competition advantage over adult HSC. Cloning generated histocompatible HSC capable of long-term multilineage engraftment in a large animal model...
  13. ncbi request reprint Recombinant HoxB4 fusion proteins enhance hematopoietic differentiation of human embryonic stem cells
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, MA 01605, USA
    Stem Cells Dev 16:547-59. 2007
    ..In summary, our study demonstrates that the tPTD-HoxB4 protein can be used with other recombinant proteins to efficiently generate transplantable HSCs from human ES cells...
  14. doi request reprint Efficient differentiation of functional hepatocytes from human embryonic stem cells
    Sadhana Agarwal
    Advanced Cell Technology, 381 Plantation Street, Worcester, Massachusetts 01605, USA
    Stem Cells 26:1117-27. 2008
    ..The methodology described here represents a significant step toward the efficient generation of hepatocytes for use in regenerative medicine and drug discovery...
  15. doi request reprint Human embryonic stem cell lines generated without embryo destruction
    Young Chung
    Cell Stem Cell 2:113-7. 2008
  16. doi request reprint Robust generation of hemangioblastic progenitors from human embryonic stem cells
    Shi Jiang Lu
    Advanced Cell Technology, 381 Plantation Street, Worcester, MA 01605, USA
    Regen Med 3:693-704. 2008
    ..However, successful preclinical and clinical progress requires efficient and controlled differentiation towards the specific differentiated cell fate...
  17. pmc Generation of functional hemangioblasts from human embryonic stem cells
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nat Methods 4:501-9. 2007
    ..Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair...
  18. ncbi request reprint Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats
    Raymond D Lund
    Moran Eye Center, University of Utah Health Science Center, Salt Lake City, Utah, USA
    Cloning Stem Cells 8:189-99. 2006
    ....
  19. ncbi request reprint Human embryonic stem cells derived without feeder cells
    Irina Klimanskaya
    Advanced Cell Technology, Worcester, MA 01605, USA
    Lancet 365:1636-41. 2005
    ..We aimed to derive an embryonic stem-cell line without exposure to cells or serum...
  20. ncbi request reprint Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics
    Irina Klimanskaya
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Cloning Stem Cells 6:217-45. 2004
    ....
  21. ncbi request reprint The stem cell challenge
    Robert Lanza
    Institute of Regenerative Medicine, Wake Forest University School of Medicine, USA
    Sci Am 290:92-9. 2004
  22. ncbi request reprint Human embryonic stem cell lines derived from single blastomeres
    Irina Klimanskaya
    Advanced Cell Technology, 381 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 444:481-5. 2006
    ..The ability to create new stem cell lines and therapies without destroying embryos would address the ethical concerns of many, and allow the generation of matched tissue for children and siblings born from transferred PGD embryos...

Research Grants1

  1. Defining Critical Parameters of Mouse Cloning
    Robert Lanza; Fiscal Year: 2001
    ..They should also validate the choice of the mouse as a model system. The proposed research is expected to improve the efficiency of this technique, although this is not the primary objective. ..