Ramon C J Langen

Summary

Publications

  1. ncbi request reprint Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, PO Box 5800, 6202, AZ Maastricht, The Netherlands
    Respir Res 14:117. 2013
  2. ncbi request reprint Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease
    R C J Langen
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Biochem Cell Biol 45:2245-56. 2013
  3. ncbi request reprint NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy
    Ramon C J Langen
    Department of Respiratory Medicine, NUTRIM School of Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 47:288-97. 2012
  4. ncbi request reprint Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Cell Physiol 292:C1636-44. 2007
  5. doi request reprint Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-κB activation
    Pascal P H Hommelberg
    Department of Human Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mol Nutr Food Res 54:1763-72. 2010
  6. ncbi request reprint Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 35:689-96. 2006
  7. doi request reprint Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 301:C995-C1007. 2011
  8. ncbi request reprint Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6202 AZ Maastricht, The Netherlands
    J Biol Chem 283:358-66. 2008
  9. ncbi request reprint Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 290:C453-62. 2006
  10. doi request reprint Inflammatory signaling in skeletal muscle insulin resistance: green signal for nutritional intervention?
    Pascal P H Hommelberg
    Department of Human Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 13:647-55. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, PO Box 5800, 6202, AZ Maastricht, The Netherlands
    Respir Res 14:117. 2013
    ..In the present study we investigated the effect of the selective GSK-3 inhibitor SB216763 on muscle mass in a guinea pig model of lipopolysaccharide (LPS)-induced pulmonary inflammation-associated muscle atrophy...
  2. ncbi request reprint Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease
    R C J Langen
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Biochem Cell Biol 45:2245-56. 2013
    ..This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  3. ncbi request reprint NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy
    Ramon C J Langen
    Department of Respiratory Medicine, NUTRIM School of Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 47:288-97. 2012
    ....
  4. ncbi request reprint Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Cell Physiol 292:C1636-44. 2007
    ....
  5. doi request reprint Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-κB activation
    Pascal P H Hommelberg
    Department of Human Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mol Nutr Food Res 54:1763-72. 2010
    ..The aims of this study were to evaluate whether CLAs inhibit myogenic differentiation and lower GLUT4 mRNA expression and to address the involvement of NF-kB activation in potential effects of CLA on these processes...
  6. ncbi request reprint Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 35:689-96. 2006
    ....
  7. doi request reprint Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 301:C995-C1007. 2011
    ....
  8. ncbi request reprint Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6202 AZ Maastricht, The Netherlands
    J Biol Chem 283:358-66. 2008
    ..Inhibition of GSK-3beta may be a potential strategy in prevention or treatment of muscle atrophy...
  9. ncbi request reprint Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 290:C453-62. 2006
    ..Therefore, this study identifies GSK-3beta as a potential target for pharmacological stimulation of muscle growth...
  10. doi request reprint Inflammatory signaling in skeletal muscle insulin resistance: green signal for nutritional intervention?
    Pascal P H Hommelberg
    Department of Human Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 13:647-55. 2010
    ....
  11. ncbi request reprint Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    FASEB J 18:227-37. 2004
    ..These results implicate that TNFalpha inhibits myogenic differentiation through destabilizing MyoD protein in a NF-kappaB-dependent manner, which interferes with skeletal muscle regeneration and may contribute to muscle wasting...
  12. ncbi request reprint Regulation of skeletal muscle plasticity by glycogen synthase kinase-3β: a potential target for the treatment of muscle wasting
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Curr Pharm Des 19:3276-98. 2013
    ....
  13. pmc Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation
    Pascal P H Hommelberg
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Cell Mol Life Sci 68:1215-25. 2011
    ..In conclusion, we have demonstrated that activation of the NF-κB pathway is not required for palmitate-induced insulin resistance in skeletal muscle cells...
  14. doi request reprint Trans fatty acid-induced NF-kappaB activation does not induce insulin resistance in cultured murine skeletal muscle cells
    Pascal P H Hommelberg
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Lipids 45:285-90. 2010
    ..We therefore conclude that FA-induced NF-kappaB activation is not sufficient for the induction of insulin resistance in skeletal muscle cells...
  15. doi request reprint Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 40:710-6. 2009
    ..In this mouse model, chronic cigarette smoke exposure resulted in systemic features that closely resemble the early signs of the extrapulmonary manifestations observed in patients with COPD...
  16. doi request reprint Distinct responses of protein turnover regulatory pathways in hypoxia- and semistarvation-induced muscle atrophy
    Chiel C de Theije
    NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 305:L82-91. 2013
    ....
  17. doi request reprint Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent
    Pascal P H Hommelberg
    Maastricht University, Dept of Human Biology, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 296:E114-20. 2009
    ..Collectively, these results demonstrate that SFA-induced NF-kappaB activation coincides with insulin resistance and depends on FA chain length...
  18. ncbi request reprint Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    In Vitro Cell Dev Biol Anim 39:163-9. 2003
    ..This protocol may aid studies aimed at elucidating mechanisms of myogenic differentiation, where a homogeneous population of myotubes is preferred...