B L Langdahl

Summary

Publications

  1. doi request reprint Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study
    Bente Langdahl
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 27:2251-8. 2012
  2. pmc Diagnosis and management of primary hyperparathyroidism in Europe
    B L Langdahl
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    QJM 105:519-25. 2012
  3. pmc Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy
    Thomas A Rasmussen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    BMC Infect Dis 11:267. 2011
  4. pmc Reduction in fracture rate and back pain and increased quality of life in postmenopausal women treated with teriparatide: 18-month data from the European Forsteo Observational Study (EFOS)
    Bente L Langdahl
    Department of Endocrinology, Arhus University Hospital, Tage Hansens Gade 2, Arhus, 8000, Denmark
    Calcif Tissue Int 85:484-93. 2009
  5. doi request reprint Teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: an analysis by gender and menopausal status
    B L Langdahl
    Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000 Aarhus, Denmark
    Osteoporos Int 20:2095-104. 2009
  6. ncbi request reprint Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis
    T Harsløf
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 87:25-35. 2010
  7. doi request reprint Haplotypes of promoter and intron 1 polymorphisms in the COLIA1 gene are associated with increased risk of osteoporosis
    L B Husted
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Calcif Tissue Int 84:85-96. 2009
  8. doi request reprint Effects of COLIA1 polymorphisms and haplotypes on perimenopausal bone mass, postmenopausal bone loss and fracture risk
    N González-Bofill
    Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 22:1145-56. 2011
  9. doi request reprint Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis
    T Harsløf
    Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, 8000, Arhus C, Denmark
    Osteoporos Int 22:2655-66. 2011
  10. ncbi request reprint Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis
    L B Husted
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Osteoporos Int 24:949-59. 2013

Collaborators

Detail Information

Publications20

  1. doi request reprint Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study
    Bente Langdahl
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 27:2251-8. 2012
    ..Discontinuation of ODN resulted in reversal of treatment effects. Treatment with ODN for up to 5 years was generally well-tolerated...
  2. pmc Diagnosis and management of primary hyperparathyroidism in Europe
    B L Langdahl
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    QJM 105:519-25. 2012
    ..There is continued debate as to the optimal strategy for diagnosis and management of primary hyperparathyroidism (PHPT)...
  3. pmc Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy
    Thomas A Rasmussen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    BMC Infect Dis 11:267. 2011
    ..Our objective was to evaluate and compare the effect of abacavir on levels of biomarkers associated with cardiovascular risk...
  4. pmc Reduction in fracture rate and back pain and increased quality of life in postmenopausal women treated with teriparatide: 18-month data from the European Forsteo Observational Study (EFOS)
    Bente L Langdahl
    Department of Endocrinology, Arhus University Hospital, Tage Hansens Gade 2, Arhus, 8000, Denmark
    Calcif Tissue Int 85:484-93. 2009
    ..This was associated with a clinically significant improvement in HRQoL. Safety was consistent with current prescribing information. These results should be interpreted in the context of the open-label, noncontrolled design of the study...
  5. doi request reprint Teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: an analysis by gender and menopausal status
    B L Langdahl
    Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000 Aarhus, Denmark
    Osteoporos Int 20:2095-104. 2009
    ..8% versus 3.7%, p < 0.001), premenopausal women (7.0% versus 0.7%, p < 0.001), and men (7.3% versus 3.7%, p = 0.03)...
  6. ncbi request reprint Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis
    T Harsløf
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 87:25-35. 2010
    ..We confirm that genetic variants in ESR1 and ESR2, but not RIZ1, are important in osteoporosis. We found no evidence of interaction between polymorphisms, but we found that the effects of genetic variants in ESR1 might be sex dependent...
  7. doi request reprint Haplotypes of promoter and intron 1 polymorphisms in the COLIA1 gene are associated with increased risk of osteoporosis
    L B Husted
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Calcif Tissue Int 84:85-96. 2009
    ..These findings are in agreement with functional studies showing that these polymorphisms influence gene expression...
  8. doi request reprint Effects of COLIA1 polymorphisms and haplotypes on perimenopausal bone mass, postmenopausal bone loss and fracture risk
    N González-Bofill
    Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 22:1145-56. 2011
    ..We found that the -1997T allele and a haplotype containing it were associated with reduced bone mineral density (BMD) and increased bone turnover at menopause and after 10 years of follow-up...
  9. doi request reprint Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis
    T Harsløf
    Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, 8000, Arhus C, Denmark
    Osteoporos Int 22:2655-66. 2011
    ..We investigated the effect of polymorphisms in the PPARγ gene on BMD and fracture risk in two Danish cohorts and found opposing effects of certain SNPs and haplotypes in the two cohorts probably owing to environmental factors...
  10. ncbi request reprint Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis
    L B Husted
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Osteoporos Int 24:949-59. 2013
    ....
  11. doi request reprint Polymorphisms in the ALOX12 gene and osteoporosis
    T Harsløf
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, 8000, Aarhus C, Denmark
    Osteoporos Int 22:2249-59. 2011
    ..We investigated the effect of polymorphisms in the ALOX12 gene on BMD and fracture risk in two Danish cohorts and found four polymorphisms and a haplotype thereof to be associated with BMD and fracture risk...
  12. ncbi request reprint Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures
    B L Langdahl
    Aarhus University Hospital, Aarhus Amtssygehus, Denmark
    Eur J Clin Invest 30:608-17. 2000
    ..Vitamin D is essential for normal bone metabolism. Polymorphisms in exon 2, intron 8 and exon 9 of the vitamin D receptor (VDR) gene have previously been found to be associated with bone mass and bone turnover...
  13. doi request reprint Polymorphisms of muscle genes are associated with bone mass and incident osteoporotic fractures in Caucasians
    T Harsløf
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 92:467-76. 2013
    ..08). This study is the first to demonstrate an association between a variant in MSTN and fracture risk and bone loss. Further studies are needed to confirm the findings...
  14. ncbi request reprint A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk
    S S Torekov
    Department of Biomedical Sciences and NNF Center for Basic Metabolic Research S S T, T Han, O P, J J H, Faculty of Health and Medical Sciences P E, University of Copenhagen, DK 2200 Copenhagen, Denmark Department of Endocrinology and Metabolism T Har, L R, B L L, Aarhus University Hospital, DK 8000 C Aarhus, Denmark Department of Cardiology, Nephrology, and Endocrinology P E, Hillerød Hospital, DK 3400 Hillerød, Denmark Department of Endocrinology J B J, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark and Department of Endocrinology M A P H, Odense University Hospital, DK 5000 Odense, Denmark
    J Clin Endocrinol Metab 99:E729-33. 2014
    ..Carriers of the functional variant GIPR Glu354Gln (rs1800437) have higher plasma glucose 2 hours after glucose ingestion, suggesting that the variant encoding GIPR 354Gln decreases the effect of GIP...
  15. ncbi request reprint A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures
    B L Langdahl
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Calcif Tissue Int 73:237-43. 2003
    ..In conclusion, we have demonstrated that the CAG repeat polymorphism in the first exon of the AR gene is associated with reduced bone mass and increased risk of osteoporotic fractures in women...
  16. ncbi request reprint The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures
    S Knudsen
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Calcif Tissue Int 80:21-30. 2007
    ..In conclusion, all the polymorphisms within the IL-1alpha gene are in strong linkage disequilibrium and not convincingly associated with fracture risk, BMD, or bone turnover...
  17. doi request reprint The expression and regulation of bone-acting cytokines in human peripheral adipose tissue in organ culture
    T Harsløf
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
    Horm Metab Res 43:477-82. 2011
    ..In conclusion, bone acting cytokines are produced in the adipose tissue and may affect bone through endocrine mechanisms...
  18. ncbi request reprint Bone nanostructure near titanium and porous tantalum implants studied by scanning small angle x-ray scattering
    M H Bünger
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, 2 Tage Hansens gade, DK 8000 Aarhus, Denmark
    Eur Cell Mater 12:81-91. 2006
    ..The study shows that sSAXS is a powerful tool to characterize the nanostructure of bone near implant surfaces...
  19. ncbi request reprint A TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are not
    B L Langdahl
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Denmark
    J Bone Miner Res 15:2222-30. 2000
    ..Polymorphisms in the first exon and first intron of the ER gene are not associated with osteoporotic fractures, bone mass, or bone turnover...
  20. ncbi request reprint Semiquantitative mRNA measurements of osteoinductive growth factors in human iliac-crest bone: expression of LMP splice variants in human bone
    M H Bünger
    Orthopeadic Research Laboratory, Department of Orthopedics E, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Calcif Tissue Int 73:446-54. 2003
    ..Higher variation in the expression of TGF-beta, BMP-2 and BMP-7 was found in the older age groups, but whether or not this can be correlated to age-related changes in bone turnover requires further studies...