Eric S Lander

Summary

Publications

  1. doi request reprint Initial impact of the sequencing of the human genome
    Eric S Lander
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 470:187-97. 2011
  2. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
  3. pmc The genome of the green anole lizard and a comparative analysis with birds and mammals
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 477:587-91. 2011
  4. pmc A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    Maite Huarte
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 142:409-19. 2010
  5. doi request reprint Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
  6. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
  7. pmc Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:15468-73. 2002
  8. ncbi request reprint The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
  9. ncbi request reprint A molecular signature of metastasis in primary solid tumors
    Sridhar Ramaswamy
    Whitehead Institute MIT Center for Genome Research, One Kendall Square, Building 300, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:49-54. 2003
  10. pmc Highly parallel identification of essential genes in cancer cells
    Biao Luo
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:20380-5. 2008

Collaborators

  • Levi Garraway
  • Joshua Z Levin
  • Rameen Beroukhim
  • Robert Weinberg
  • Kai Tao
  • Cath Brooksbank
  • Elaine R Mardis
  • Charlotte Kuperwasser
  • Justin Lamb
  • Jing Yang
  • Scott L Carter
  • Reinhard Dummer
  • Min Li
  • William Hahn
  • Paul Mischel
  • Tyler E Jacks
  • Mark A Rubin
  • Berthold Gottgens
  • Mitchell Guttman
  • Chad Nusbaum
  • Todd R Golub
  • Manuel Garber
  • David B Jaffe
  • Vamsi K Mootha
  • Xiaohui Xie
  • Jessica Alföldi
  • Kerstin Lindblad-Toh
  • Aravind Subramanian
  • John L Rinn
  • Maite Huarte
  • Aviv Regev
  • Ahmad M Khalil
  • Matthew Meyerson
  • Piyush B Gupta
  • Bradley E Bernstein
  • Tamer T Onder
  • Sarah Young
  • Craig B Lowe
  • Evan Mauceli
  • David Haussler
  • Marcia Lara
  • Federica Di Palma
  • Or Zuk
  • Andreas Gnirke
  • James Robinson
  • Michael F Berger
  • Xian Adiconis
  • Aviva Presser Aiden
  • Magdalena J Koziol
  • Gad Getz
  • Derek Y Chiang
  • Manching Ku
  • Biao Luo
  • Carsten Russ
  • Aviva Presser
  • Manolis Kellis
  • Tarjei S Mikkelsen
  • Michael Kamal
  • Rudolf Jaenisch
  • Pablo Tamayo
  • Jill P Mesirov
  • Christopher T Harbison
  • Smita Sihag
  • Nick Patterson
  • David Altshuler
  • Pere Puigserver
  • Sridhar Ramaswamy
  • Chang Zheng Chen
  • David Humpherys
  • Brian J Parker
  • Elliott H Margulies
  • CHRISTOPHER BOTKA
  • Lucas D Ward
  • Brian J Raney
  • Shalili Jhangiani
  • Wesley C Warren
  • Richard K Wilson
  • Catrina Fronik
  • Lynne V Nazareth
  • Donna M Muzny
  • Erica Sodergren
  • David A Ray
  • Michele Clamp
  • George M Weinstock
  • Jakob S Pedersen
  • Jean Chang
  • Toby Bloom
  • Huyen H Dihn
  • Jiayu Wen
  • David Heiman

Detail Information

Publications23

  1. doi request reprint Initial impact of the sequencing of the human genome
    Eric S Lander
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 470:187-97. 2011
    ..I also discuss the road ahead in fulfilling the promise of genomics for medicine...
  2. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
    ..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
  3. pmc The genome of the green anole lizard and a comparative analysis with birds and mammals
    Jessica Alföldi
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 477:587-91. 2011
    ..Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins. An anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations...
  4. pmc A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    Maite Huarte
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 142:409-19. 2010
    ..We propose a model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes...
  5. doi request reprint Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
    ..This study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs...
  6. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  7. pmc Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:15468-73. 2002
    ..Our overall strategy may be applicable for the identification of markers for other tissue-specific stem cells...
  8. ncbi request reprint The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
    ..These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project...
  9. ncbi request reprint A molecular signature of metastasis in primary solid tumors
    Sridhar Ramaswamy
    Whitehead Institute MIT Center for Genome Research, One Kendall Square, Building 300, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:49-54. 2003
    ..These results suggest that the metastatic potential of human tumors is encoded in the bulk of a primary tumor, thus challenging the notion that metastases arise from rare cells within a primary tumor that have the ability to metastasize...
  10. pmc Highly parallel identification of essential genes in cancer cells
    Biao Luo
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:20380-5. 2008
    ....
  11. pmc Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    Aravind Subramanian
    Broad Institute of Massachusetts Institute of Technology and Harvard, 320 Charles Street, Cambridge, MA 02141, USA
    Proc Natl Acad Sci U S A 102:15545-50. 2005
    ..The GSEA method is embodied in a freely available software package, together with an initial database of 1,325 biologically defined gene sets...
  12. ncbi request reprint PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
    ..Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments...
  13. pmc Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network
    Aviva Presser Aiden
    Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Cell Stem Cell 6:591-602. 2010
    ..We suggest that Wilms cells share a transcriptional and epigenetic landscape with a normal renal stem cell, which is inherently susceptible to transformation and may represent a cell of origin for this disease...
  14. pmc Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs
    Mitchell Guttman
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:503-10. 2010
    ..Our results open the way to direct experimental manipulation of thousands of noncoding RNAs and demonstrate the power of ab initio reconstruction to render a comprehensive picture of mammalian transcriptomes...
  15. pmc Integrative analysis of the melanoma transcriptome
    Michael F Berger
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 20:413-27. 2010
    ..Taken together, these results may indicate new avenues for target discovery in melanoma, while also providing a template for large-scale transcriptome studies across many tumor types...
  16. pmc Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    Vamsi K Mootha
    The Eli and Edythe L Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139 1561, USA
    Proc Natl Acad Sci U S A 101:6570-5. 2004
    ....
  17. pmc Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    Ahmad M Khalil
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:11667-72. 2009
    ..We propose a model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression...
  18. pmc High-resolution mapping of copy-number alterations with massively parallel sequencing
    Derek Y Chiang
    Broad Institute, Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA 02142, USA
    Nat Methods 6:99-103. 2009
    ....
  19. pmc Transcriptional regulatory code of a eukaryotic genome
    Christopher T Harbison
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 431:99-104. 2004
    ..We find that environment-specific use of regulatory elements predicts mechanistic models for the function of a large population of yeast's transcriptional regulators...
  20. pmc Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
    Rameen Beroukhim
    Broad Institute, Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:20007-12. 2007
    ..Our results support the feasibility and utility of systematic characterization of the cancer genome...
  21. pmc Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    Tarjei S Mikkelsen
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Nature 448:553-60. 2007
    ..This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations...
  22. pmc A large family of ancient repeat elements in the human genome is under strong selection
    Michael Kamal
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:2740-5. 2006
    ..Although the precise function of these elements remains unknown, the evidence suggests that this unusual family may play a cis-regulatory or structural role in mammalian genomes...
  23. pmc Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei
    David Humpherys
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:12889-94. 2002
    ..Our results demonstrate frequent abnormal gene expression in clones, in which most expression abnormalities appear common to the NT procedure whereas others appear to reflect the particular donor nucleus...