Darius J R Lane
Lane D, Bae D, Merlot A, Sahni S, Richardson D. Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation. Nutrients. 2015;7:2274-96 pubmed publisher
..This review discusses the emerging relationship between cellular iron homeostasis; the emergent "IRP1-HIF2Î± axis"; DCYTB and ascorbate in relation to iron metabolism. ..
Lane D, Chikhani S, Richardson V, Richardson D. Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism. Biochim Biophys Acta. 2013;1833:1527-41 pubmed publisher
..Therefore, ascorbate is a novel modulator of the classical transferrin Fe uptake pathway, acting via an intracellular reductive mechanism. ..
Paluncic J, Kovacevic Z, Jansson P, Kalinowski D, Merlot A, Huang M, et al
. Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochim Biophys Acta. 2016;1863:770-84 pubmed publisher
..In addition, we discuss the roles of emerging molecular players that are involved in melanoma pathogenesis, including the functional role of the melanoma tumor antigen, p97/MFI2 (melanotransferrin). ..
Lane D, Lawen A. The glutamate aspartate transporter (GLAST) mediates L-glutamate-stimulated ascorbate-release via swelling-activated anion channels in cultured neonatal rodent astrocytes. Cell Biochem Biophys. 2013;65:107-19 pubmed publisher
..These results suggest that an impairment of astrocytic ascorbate-release may exacerbate neuronal dysfunction in neurodegenerative disorders and acute brain injury in which excitotoxicity and/or GLAST deregulation have been implicated. ..
Lane D, Saletta F, Suryo Rahmanto Y, Kovacevic Z, Richardson D. N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion. PLoS ONE. 2013;8:e57273 pubmed publisher
..Additionally, eIF3a positively regulated proliferation, but negatively regulated cell motility and invasion, which may be due to the eIF3a-dependent changes in expression of NDRG1 and p27(kip1) observed under these conditions. ..
Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al
. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
Merlot A, Sahni S, Lane D, Richardson V, Huang M, Kalinowski D, et al
. Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques". Int J Mol Sci. 2016;17: pubmed