G Lallement

Summary

Publications

  1. ncbi Protective effects of S+ ketamine and atropine against lethality and brain damage during soman-induced status epilepticus in guinea-pigs
    Frederic Dorandeu
    Département de Toxicologie CRSSA, 24 Avenue des Maquis du Gresivaudan, La Tronche, France
    Toxicology 234:185-93. 2007
  2. ncbi Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity
    Guy Lallement
    Unite de Neuropharmacologie, CRSSA, BP 87, 38702 La Tronche, France
    Drug Chem Toxicol 25:309-20. 2002
  3. ncbi Review of the value of huperzine as pretreatment of organophosphate poisoning
    Guy Lallement
    Unite de Neuropharmacologie, CRSSA, La Tronche, France
    Neurotoxicology 23:1-5. 2002
  4. ncbi Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics
    G Lallement
    Unite de Neuropharmacologie, CRSSA, La Tronche, France
    Arch Toxicol 74:480-6. 2000
  5. ncbi Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support
    G Lallement
    Unite de Neuropharmacologie, CRSSA BP, La Tronche, France
    Arch Toxicol 73:115-22. 1999
  6. ncbi Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity
    G Lallement
    Unite de Neuropharmacologie, CRSSA 24, avenue des Maquis du Grésivaudan, BP 87, 38702 La Tronche, France
    Drug Chem Toxicol 24:165-80. 2001
  7. ncbi Effects of atropine sulphate on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neuropathology
    P Carpentier
    Centre de Recherches du Service de Sante des Armees, Unite de Neuropharmacologie, La Tronche, France
    Neurotoxicology 21:521-40. 2000
  8. ncbi Memory impairment after soman intoxication in rat: correlation with central neuropathology. Improvement with anticholinergic and antiglutamatergic therapeutics
    P Filliat
    Unite de Neuropharmacologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France
    Neurotoxicology 20:535-49. 1999
  9. ncbi Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data
    L S Tonduli
    Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 58:464-73. 1999
  10. ncbi Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability
    G Lallement
    Unite de Neuropharmacologie, CRSSA 24, avenue des Maquis du Grésivaudan, B P 87, 38702 La Tronche, France
    Drug Chem Toxicol 24:151-64. 2001

Collaborators

Detail Information

Publications41

  1. ncbi Protective effects of S+ ketamine and atropine against lethality and brain damage during soman-induced status epilepticus in guinea-pigs
    Frederic Dorandeu
    Département de Toxicologie CRSSA, 24 Avenue des Maquis du Gresivaudan, La Tronche, France
    Toxicology 234:185-93. 2007
    ..In summary, these observations confirm that ketamine, either racemic or S-KET, in association with AS and possibly other drugs, could be highly effective in the delayed treatment of severe soman intoxication...
  2. ncbi Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity
    Guy Lallement
    Unite de Neuropharmacologie, CRSSA, BP 87, 38702 La Tronche, France
    Drug Chem Toxicol 25:309-20. 2002
    ..Thus, replacing PYR by HUP for a subchronic pre-treatment of primates gives them better tolerance to the epileptic effects of soman...
  3. ncbi Review of the value of huperzine as pretreatment of organophosphate poisoning
    Guy Lallement
    Unite de Neuropharmacologie, CRSSA, La Tronche, France
    Neurotoxicology 23:1-5. 2002
    ..Finally, recent data, showing that HUP seems to be devoid of deleterious effects in healthy subjects, are also presented. Globally, this review reinforces the therapeutical value of HUP for the optimal pretreatment of OP poisoning...
  4. ncbi Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics
    G Lallement
    Unite de Neuropharmacologie, CRSSA, La Tronche, France
    Arch Toxicol 74:480-6. 2000
    ..7 micromol diazepam/kg. Reflections on the possible incorporation of avizafone in three-drug emergency treatment are presented...
  5. ncbi Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support
    G Lallement
    Unite de Neuropharmacologie, CRSSA BP, La Tronche, France
    Arch Toxicol 73:115-22. 1999
    ..However, it should always be kept in mind that, in the case of severe OP-poisoning, medical intervention must be conducted as early as possible...
  6. ncbi Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity
    G Lallement
    Unite de Neuropharmacologie, CRSSA 24, avenue des Maquis du Grésivaudan, BP 87, 38702 La Tronche, France
    Drug Chem Toxicol 24:165-80. 2001
    ..Considerations about huperzine or physostigmine + scopolamine as the most appropriate candidate for the pretreatment of OP poisoning are given...
  7. ncbi Effects of atropine sulphate on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neuropathology
    P Carpentier
    Centre de Recherches du Service de Sante des Armees, Unite de Neuropharmacologie, La Tronche, France
    Neurotoxicology 21:521-40. 2000
    ....
  8. ncbi Memory impairment after soman intoxication in rat: correlation with central neuropathology. Improvement with anticholinergic and antiglutamatergic therapeutics
    P Filliat
    Unite de Neuropharmacologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France
    Neurotoxicology 20:535-49. 1999
    ..Only treatment with tritherapy (atropine + TCP + NBQX) was able to improve the different parameters of spatial learning, despite no effect on the convulsions of the animals...
  9. ncbi Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data
    L S Tonduli
    Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 58:464-73. 1999
    ..So we can hypothesize, that the variation of energy in gamma band after intoxication, which might be related to stress adaptation strategy, may determine whether or not the animal will exhibit an epileptic fit...
  10. ncbi Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability
    G Lallement
    Unite de Neuropharmacologie, CRSSA 24, avenue des Maquis du Grésivaudan, B P 87, 38702 La Tronche, France
    Drug Chem Toxicol 24:151-64. 2001
    ..Finally, at the light of its particular inhibitory effects on blood and central cholinesterases, HUP, compared to the other drugs, seems to be the optimal candidate to be used as pretreatment against OP poisoning...
  11. ncbi Effects of Huperzine used as pre-treatment against soman-induced seizures
    L S Tonduli
    Centre de Recherches du Service Sante des Armees, La Tronche, France
    Neurotoxicology 22:29-37. 2001
    ..This dose of HUP reduced AChE inhibition to 54% and increase of ACh level to 230 times baseline value. HUP thus appears as a promising compound to protect subjects against organophosphorus intoxication...
  12. ncbi Effects of thienylphencyclidine (TCP) on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neurotoxicity
    P Carpentier
    Centre de Recherches du Service de Sante des Armees, Unite de Neurotoxicologie, La Tronche, France
    Neurotoxicology 22:13-28. 2001
    ....
  13. ncbi Effects of paraldehyde on the convulsions induced by administration of soman in rats
    P Carpentier
    Centre de Recherches du Service de Sante des Armees, Unite de Neurotoxicologie, La Tronche, France
    Fundam Clin Pharmacol 6:309-18. 1992
    ..However, supplementary pre-medication, in addition to paraldehyde and atropine sulfate, remains necessary to improve the antilethal capacity of the pre-treatment...
  14. ncbi Venom phospholipase A2-induced impairment of glutamate uptake: an indirect and nonselective effect related to phospholipid hydrolysis
    F Dorandeu
    Department of Pharmacology, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 51:349-59. 1998
    ..Altogether, PDX-induced uptake impairment may thus be related to the direct action of AA and other PUFAs on the glutamate transporter, as well as through less selective actions...
  15. doi An unexpected plasma cholinesterase activity rebound after challenge with a high dose of the nerve agent VX
    F Dorandeu
    Departement de Toxicologie, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, BP 87, F 38702 La Tronche Cedex, France
    Toxicology 248:151-7. 2008
    ..Nature of the organ(s) and mechanisms involved in enzyme release will need further investigations as it may represent a mechanism of defence, i.e. VX scavenging, that could advantageously be exploited...
  16. ncbi Secreted phospholipase A2-induced neurotoxicity and epileptic seizures after intracerebral administration: an unexplained heterogeneity as emphasized with paradoxin and crotoxin
    F Dorandeu
    Department of Toxicology, Unit of Neuropharmacology, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 54:848-62. 1998
    ..Further studies are strongly required...
  17. ncbi Delta activity as an early indicator for soman-induced brain damage: a review
    P Carpentier
    Unite de Neuropharmacologie, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    Neurotoxicology 22:299-315. 2001
    ....
  18. doi Cutaneous challenge with chemical warfare agents in the SKH-1 hairless mouse. (I) Development of a model for screening studies in skin decontamination and protection
    F Dorandeu
    Département de toxicologie et risque chimique, Institut de Recherche Biomédicale des Armées, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    Hum Exp Toxicol 30:470-90. 2011
    ..Long-term effects of SM burn were also evaluated. The model was then used in the companion paper (Taysse et al.(1))...
  19. ncbi Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman
    G Lallement
    Unite de Neuropharmacologie, Centre de Recherches du Service de Santé des Armées La Tronche France
    Neurotoxicology 20:675-84. 1999
    ..Globally, the current lack of any other NMDA receptor antagonist suitable for human use reinforces the therapeutic value of gacyclidine as a central nervous system protective agent for the treatment of OP poisoning...
  20. ncbi [Overview on neurogenesis induced by organophosphate poisoning: results and perspectives]
    G Lallement
    Departement de Toxicologie, Centre de Recherches du Service de Santé des Armées CRSSA, 24, avenue des Maquis du Grésivaudan, BP 87, F 38702, La Tronche Cedex, France
    Ann Pharm Fr 65:415-21. 2007
    ....
  21. ncbi Swine models in the design of more effective medical countermeasures against organophosphorus poisoning
    F Dorandeu
    Departement de Toxicologie, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, BP 87, F 38702 La Tronche Cedex, France
    Toxicology 233:128-44. 2007
    ..However, there exists a large amount of data in the model on anaesthesia and different types of shock favouring their use for evaluation of complex situations such as the anaesthesia of OP poisoned patients and combined injuries...
  22. ncbi Long-term behavioral consequences of soman poisoning in mice
    Pierre Filliat
    Departement de Toxicologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, 24 Avenue des Maquis du Gresivaudan, B P 87, 38702 La Tronche Cedex, France
    Neurotoxicology 28:508-19. 2007
    ..At the same time, learning skills slightly recovered in the HWL group. Mnemonic cognitive data are discussed in relation to the neuropathology, neurogenesis and sprouting occurring in the hippocampus of soman-intoxicated animals...
  23. doi Long-term consequences of soman poisoning in mice: part 2. Emotional behavior
    Stéphanie Coubard
    Département de Physiologie Intégrée, IMASSA, B P 73, 91223 BRETIGNY SUR ORGE cedex, France
    Behav Brain Res 191:95-103. 2008
    ..This latter behavioral result is in accordance with the delayed neuronal regeneration patterns described in the companion paper (part 1)...
  24. ncbi Soman-induced convulsions: the neuropathology revisited
    Valerie Baille
    Centre de Recherches du Service de Sante des Armees, Departement de Toxicologie, BP87, 38702 La Tronche Cedex, France
    Toxicology 215:1-24. 2005
    ..In soman poisoning as well as in other cerebral pathologies, premature conclusions on this question can potentially be misleading and might even lead to detrimental therapies...
  25. ncbi Efficacy of the ketamine-atropine combination in the delayed treatment of soman-induced status epilepticus
    Frederic Dorandeu
    Departement de Toxicologie, CRSSA, 24 Avenue des Maquis du Gresivaudan, F 38 702 La Tronche, France
    Brain Res 1051:164-75. 2005
    ..e., when KET efficacy is dramatically reduced. All in all, these observations suggest that KET, in association with atropine sulfate and possibly other drugs, may be highly effective in the delayed treatment of severe soman intoxication...
  26. ncbi Prolonged inflammatory gene response following soman-induced seizures in mice
    Franck Dhote
    Département de Toxicologie CRSSA, 24 Avenue des Maquis du Gresivaudan, F 38 702 La Tronche, France
    Toxicology 238:166-76. 2007
    ..In conclusion, the present study indicates a quick neuro-inflammatory gene response that does not subside over 7 days suggesting a potential role in the neurological consequences of soman-induced status epilepticus...
  27. ncbi Effects of chronic administration of huperzine A on memory in guinea pigs
    Pierre Filliat
    Unite de Neuropharmacologie, CRSSA, 24, avenue des Maquis du Grésivaudan, BP 87, 38702, La Tronche Cedex, France
    Drug Chem Toxicol 25:9-24. 2002
    ..It thus appears that subchronic administration of huperzine A did not induce deleterious effects on spatial memory...
  28. ncbi Early changes in MAP2 protein in the rat hippocampus following soman intoxication
    Guy Lallement
    Centre de Recherches du Service de Santé des Armés, Unite de Neuropharmacologie, La Tronche, France
    Drug Chem Toxicol 26:219-29. 2003
    ....
  29. ncbi Flunarizine: a possible adjuvant medication against soman poisoning?
    Pierre Carpentier
    Centre de Recherches du Service de Sante des Armees, Unite de Neuropharmacologie, La Tronche Cedex, France
    Drug Chem Toxicol 27:213-31. 2004
    ..In the light of these findings, it seems premature to definitely reject (or recommend) Flu as a possible adjuvant medication against soman poisoning. Further studies are required to determine its real potential interest...
  30. ncbi Disruption of mice sleep stages induced by low doses of organophosphorus compound soman
    David Crouzier
    Centre de Recherches du Service Sante des Armees, 24, avenue des Maquis du Grésivaudan, BP 87 n38, 702 La Tronche Cedex, France
    Toxicology 199:59-71. 2004
    ..We observed an increase of energy in the EEG theta band during 3 days after soman injection and an increase of slow wave sleep during the second to the fifth day after soman injection...
  31. doi Long-term consequences of soman poisoning in mice Part 1. Neuropathology and neuronal regeneration in the amygdala
    Jean Marc Collombet
    Departement de Toxicologie, CRSSA 24, avenue des Maquis du Grésivaudan, B P 87, 38702 La Tronche Cedex, France
    Behav Brain Res 191:88-94. 2008
    ..In the companion paper (see part 2), the possible effects of both long-term neuropathology and delayed neuronal regeneration were evaluated on amygdala-driven emotional processes...
  32. ncbi Inhibition of crotoxin phospholipase A(2) activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex
    Frederic Dorandeu
    Departement de Toxicologie, Unite de Neuropharmacologie, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    Biochem Pharmacol 63:755-61. 2002
    ..Other approaches would be required to resolve this question...
  33. ncbi Chemical toxicants and low-level radiation exposure
    Eric T Multon
    Departement de Radiobiologie et Radiopathologie, Centre de Recherches du Service de Sante des Armees, BP 87, 38702 La Tronche, France
    Mil Med 167:98-100. 2002
  34. ncbi Neuroprotective and antiepileptic activities of ketamine in nerve agent poisoning
    Georges Mion
    Anesthesiology 98:1517; author reply 1517-8. 2003
  35. ncbi Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice
    Jean Marc Collombet
    Departement de Toxicologie, CRSSA B P 87 38702 LA Tronche, France
    Toxicology 210:9-23. 2005
    ..Interestingly, the administration of cytokines resulted in the differentiation of BrdU-positive cells into new neurons in the CA1 hippocampal layer, whereas astrocytic differentiation was preferentially observed in the amygdala...
  36. ncbi Soman poisoning induces delayed astrogliotic scar and angiogenesis in damaged mouse brain areas
    Jean Marc Collombet
    Departement de Toxicologie, CRSSA, 24 Avenue des Maquis du Gresivaudan, B P 87, 38702 La Tronche Cedex, France
    Neurotoxicology 28:38-48. 2007
    ..e. CA1 field and amygdala) evidencing the formation of a glial scar. In this study, we discuss the key role of VEGF in the angiogenic process and in the glial or neuronal response induced by soman poisoning...
  37. ncbi Early reduction of NeuN antigenicity induced by soman poisoning in mice can be used to predict delayed neuronal degeneration in the hippocampus
    Jean Marc Collombet
    Centre de Recherches du Service de Santé des Armées CRSSA, Departement de Toxicologie, 24 Avenue des Maquis du Gresivaudan, B P 87, 38702 La Tronche Cedex, France
    Neurosci Lett 398:337-42. 2006
    ..In this study, we discuss the potential use of NeuN immunohistochemistry as a good biomarker to predict delayed neuronal degeneration in the rodent hippocampus after various brain injuries...
  38. ncbi Neuronal regeneration partially compensates the delayed neuronal cell death observed in the hippocampal CA1 field of soman-poisoned mice
    Jean Marc Collombet
    Departement de Toxicologie, Centre de Recherches du Service de Santé des Armées CRSSA, 24, avenue des Maquis du Grésivaudan, B P 87, 38702 La Tronche Cedex, France
    Neurotoxicology 27:201-9. 2006
    ....
  39. ncbi Effect of soman poisoning on populations of bone marrow and peripheral blood cells in mice
    Jean Marc Collombet
    Departement de Toxicologie, CRSSA 24, avenue des Maquis du Grésivaudan, B P 87, 38702 La Tronche Cedex, France
    Neurotoxicology 26:89-98. 2005
    ....
  40. ncbi Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain
    Jean Marc Collombet
    Departement de Toxicologie, C R S S A, B P 87, 24 Avenue des Maquis du Gresivaudan, 38702 La Tronche Cedex, France
    Toxicology 208:319-34. 2005
    ..This increased proliferation rate was detected up to 1 month after poisoning...
  41. ncbi Effects of aspirin and mefenamic acid on soman poisoning-induced neuropathology in mice
    Jean Marc Collombet
    Departement de Toxicologie, CRSSA, La Tronche, France
    Drug Chem Toxicol 29:167-81. 2006
    ..However, this drug also diminished the proliferation of neural precursor cells. The possible neurochemical mechanisms underlying such differences in the efficacy of the two drugs are also reviewed...