Shaheen E Lakhan

Summary

Publications

  1. pmc Application of mild therapeutic hypothermia on stroke: a systematic review and meta-analysis
    Shaheen E Lakhan
    Department of Biosciences, Global Neuroscience Initiative Foundation, Los Angeles, Panorama City, P O Box 4832 CA 91412, USA
    Stroke Res Treat 2012:295906. 2012
  2. pmc Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA 90210, USA
    Pain Res Treat 2012:952906. 2012
  3. pmc Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation Los Angeles, California
    Brain Behav 2:661-77. 2012
  4. pmc Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
    Shaheen E Lakhan
    Biosciences Department, Global Neuroscience Initiative Foundation Beverly Hills, CA, USA Neurological Institute, Cleveland Clinic Cleveland, OH, USA
    Front Neurol 4:32. 2013
  5. pmc NMDA Receptor Activity in Neuropsychiatric Disorders
    Shaheen E Lakhan
    Biosciences Department, Global Neuroscience Initiative Foundation, Beverly Hills, CA, USA Neurological Institute, Cleveland Clinic, Cleveland, OH, USA
    Front Psychiatry 4:52. 2013
  6. pmc Mindfulness-based therapies in the treatment of somatization disorders: a systematic review and meta-analysis
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, California, United States of America
    PLoS ONE 8:e71834. 2013
  7. pmc The emerging role of dietary fructose in obesity and cognitive decline
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Nutr J 12:114. 2013
  8. pmc Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study
    Mostafa Amr
    Department of Psychiatry, Mansoura University, Mansoura, Egypt
    Nutr J 12:31. 2013
  9. pmc Development of a cost-effective high-throughput process of microsatellite analysis involving miniaturized multiplexed PCR amplification and automated allele identification
    Truc T M Nguyen
    Department of Pediatrics, Vermont Cancer Center, University of Vermont, Burlington, VT 05401, USA
    Hum Genomics 7:6. 2013
  10. pmc Tumefactive perivascular spaces mimicking cerebral edema in a patient with diabetic hyperglycemic hyperosmolar syndrome: a case report
    Seby John
    Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, S100A, 44195, Cleveland, OH, USA
    J Med Case Rep 7:51. 2013

Collaborators

Detail Information

Publications40

  1. pmc Application of mild therapeutic hypothermia on stroke: a systematic review and meta-analysis
    Shaheen E Lakhan
    Department of Biosciences, Global Neuroscience Initiative Foundation, Los Angeles, Panorama City, P O Box 4832 CA 91412, USA
    Stroke Res Treat 2012:295906. 2012
    ..Discussion. Hypothermia does not significantly improve stroke severity; however, this finding should be taken with caution due to the high heterogeneity and limited number of included studies. No impact on mortality was observed...
  2. pmc Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA 90210, USA
    Pain Res Treat 2012:952906. 2012
    ..Increased MMP activity was detected in migraine patients, independent of aura, in tight association with metabolic derangements. The therapeutic implications of MMP inhibition are considered in the context of neurogenic pain regulation...
  3. pmc Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation Los Angeles, California
    Brain Behav 2:661-77. 2012
    ..As ADHD medications are prescribed for long-term treatment, there is a need for long-term safety studies and education on the health risks associated with misuse is imperative...
  4. pmc Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
    Shaheen E Lakhan
    Biosciences Department, Global Neuroscience Initiative Foundation Beverly Hills, CA, USA Neurological Institute, Cleveland Clinic Cleveland, OH, USA
    Front Neurol 4:32. 2013
    ..This review provides an overview of MMPs' role in BBB breakdown during acute ischemic stroke. The possible role of MMPs in combination treatment of acute ischemic stroke is also examined...
  5. pmc NMDA Receptor Activity in Neuropsychiatric Disorders
    Shaheen E Lakhan
    Biosciences Department, Global Neuroscience Initiative Foundation, Beverly Hills, CA, USA Neurological Institute, Cleveland Clinic, Cleveland, OH, USA
    Front Psychiatry 4:52. 2013
    ....
  6. pmc Mindfulness-based therapies in the treatment of somatization disorders: a systematic review and meta-analysis
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, California, United States of America
    PLoS ONE 8:e71834. 2013
    ..Recently, several lines of research have explored the potential for mindfulness-therapy in treating somatization disorders, including fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome...
  7. pmc The emerging role of dietary fructose in obesity and cognitive decline
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Nutr J 12:114. 2013
    ..The paper then considers the effects of omega-3 fatty acids (FAs), which have been linked to promising results in cognitive function including ameliorating the impact of a high-fructose diet. ..
  8. pmc Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study
    Mostafa Amr
    Department of Psychiatry, Mansoura University, Mansoura, Egypt
    Nutr J 12:31. 2013
    ..The purpose of this study was to assess the efficacy of vitamin C as an adjuvant agent in the treatment of pediatric major depressive disorder in a six-month, double-blind, placebo-controlled pilot trial...
  9. pmc Development of a cost-effective high-throughput process of microsatellite analysis involving miniaturized multiplexed PCR amplification and automated allele identification
    Truc T M Nguyen
    Department of Pediatrics, Vermont Cancer Center, University of Vermont, Burlington, VT 05401, USA
    Hum Genomics 7:6. 2013
    ..Such analyses may involve the parallel evaluation of many microsatellite loci, which are often limited by sample DNA, are labor intensive, and require large data processing...
  10. pmc Tumefactive perivascular spaces mimicking cerebral edema in a patient with diabetic hyperglycemic hyperosmolar syndrome: a case report
    Seby John
    Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, S100A, 44195, Cleveland, OH, USA
    J Med Case Rep 7:51. 2013
    ..Acute cerebral edema is a significant cause of death in patients treated for diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome...
  11. pmc 3T MRI induced post-traumatic stress disorder: a case report
    Shaheen E Lakhan
    Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S100A, Cleveland, OH, 44106, USA
    Int Arch Med 5:27. 2012
    ..abstract:..
  12. pmc Difficult diagnosis of brainstem glioblastoma multiforme in a woman: a case report and review of the literature
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Med Case Reports 3:87. 2009
    ..These symptoms do, however, overlap with a variety of other central nervous system disorders. Magnetic resonance imaging is the radiographic modality of choice, but can still be misleading...
  13. pmc Aggressive juvenile fibromatosis of the paranasal sinuses: case report and brief review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Hematol Oncol 1:3. 2008
    ..We discuss the clinicopathologic features of this lesion, including structural and ultrastructural characteristics, and we review the literature regarding treatment and outcome...
  14. pmc Nutritional therapies for mental disorders
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Nutr J 7:2. 2008
    ....
  15. pmc The impact of prescribed psychotropics on youth
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Clin Pract Epidemiol Ment Health 3:21. 2007
    ....
  16. pmc Endocytosis of glycosylphosphatidylinositol-anchored proteins
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Biomed Sci 16:93. 2009
    ..Ultimately, a thorough elucidation of GPI-AP mediated signaling pathways and their regulatory elements will enhance our understanding of essential biological processes and benefit as components of disease intervention strategies...
  17. pmc Schizophrenia genomics and proteomics: are we any closer to biomarker discovery?
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Behav Brain Funct 5:2. 2009
    ..While none of the recent developments described here in qualifies as biomarker discovery, many are likely to be stepping stones towards that goal...
  18. pmc Time for a unified approach to medical ethics
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Philos Ethics Humanit Med 4:13. 2009
    ..This would provide a consistent framework of knowledge for practitioners, creating a basis for clear judgment of complex issues...
  19. pmc Inflammatory mechanisms in ischemic stroke: therapeutic approaches
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Transl Med 7:97. 2009
    ..However, recent studies showing that regulatory T cells are major cerebroprotective immunomodulators after stroke suggest that targeting the endogenous adaptive immune response may offer novel promising neuroprotectant therapies...
  20. pmc Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    BMC Neurol 9:59. 2009
    ....
  21. pmc Schizophrenia pathophysiology: are we any closer to a complete model?
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, California, USA
    Ann Gen Psychiatry 8:12. 2009
    ..Consequently, it makes us question whether we are any closer to an adequate understanding of the pathophysiology of schizophrenia...
  22. pmc Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    BMC Res Notes 3:60. 2010
    ..This study suggests stimulation sites and prognostic indicators for DBS. We also briefly review tractography, a relatively new procedure that holds great promise for the further development of DBS...
  23. pmc Addressing the primary care physician shortage in an evolving medical workforce
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, California, USA
    Int Arch Med 2:14. 2009
    ....
  24. pmc Statins and clinical outcome of acute ischemic stroke: a systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Int Arch Med 3:22. 2010
    ..The purpose of the present review is to systematically evaluate the effectiveness of statin pretreatment on functional outcome of acute ischemic stroke and to assess potential adverse events associated with statin use...
  25. pmc Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Nutr J 9:42. 2010
    ..It is not surprising that there is universal interest in finding effective natural anxiolytic (anti-anxiety) treatments with a lower risk of adverse effects or withdrawal...
  26. pmc Gut inflammation in chronic fatigue syndrome
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    Nutr Metab (Lond) 7:79. 2010
    ..Probiotics also have the potential to improve gut motility, which is dysfunctional in many CFS patients...
  27. pmc Anti-inflammatory effects of nicotine in obesity and ulcerative colitis
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Transl Med 9:129. 2011
    ..Nevertheless, we should keep in mind that the anti-inflammatory effects of nicotine could be mediated via the expression of several nAChRs on a particular target cell...
  28. pmc Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Transl Med 9:202. 2011
    ..The potential contribution of sirtuins in protecting or regulating the circuitry of the ENS under inflamed states is also considered...
  29. pmc Neuroinflammation in inflammatory bowel disease
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Neuroinflammation 7:37. 2010
    ..This review will discuss the effects of inflammation on enteric neural activity and potential therapeutic strategies that target neuroinflammation in the enteric nervous system...