Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot studyMostafa Amr
Department of Psychiatry, Mansoura University, Mansoura, Egypt
Nutr J 12:31. 2013
..The purpose of this study was to assess the efficacy of vitamin C as an adjuvant agent in the treatment of pediatric major depressive disorder in a six-month, double-blind, placebo-controlled pilot trial...
- Development of a cost-effective high-throughput process of microsatellite analysis involving miniaturized multiplexed PCR amplification and automated allele identification
Truc T M Nguyen
Department of Pediatrics, Vermont Cancer Center, University of Vermont, Burlington, VT 05401, USA
Hum Genomics 7:6. 2013
..Such analyses may involve the parallel evaluation of many microsatellite loci, which are often limited by sample DNA, are labor intensive, and require large data processing...
- Tumefactive perivascular spaces mimicking cerebral edema in a patient with diabetic hyperglycemic hyperosmolar syndrome: a case report
Seby John
Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, S100A, 44195, Cleveland, OH, USA
J Med Case Rep 7:51. 2013
..Acute cerebral edema is a significant cause of death in patients treated for diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome...
- 3T MRI induced post-traumatic stress disorder: a case report
Shaheen E Lakhan
Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S100A, Cleveland, OH, 44106, USA
Int Arch Med 5:27. 2012
..abstract:..
- Difficult diagnosis of brainstem glioblastoma multiforme in a woman: a case report and review of the literature
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Med Case Reports 3:87. 2009
..These symptoms do, however, overlap with a variety of other central nervous system disorders. Magnetic resonance imaging is the radiographic modality of choice, but can still be misleading...
- Statins and clinical outcome of acute ischemic stroke: a systematic review
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Int Arch Med 3:22. 2010
..The purpose of the present review is to systematically evaluate the effectiveness of statin pretreatment on functional outcome of acute ischemic stroke and to assess potential adverse events associated with statin use...
- Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Nutr J 9:42. 2010
..It is not surprising that there is universal interest in finding effective natural anxiolytic (anti-anxiety) treatments with a lower risk of adverse effects or withdrawal...
- Gut inflammation in chronic fatigue syndrome
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Nutr Metab (Lond) 7:79. 2010
..Probiotics also have the potential to improve gut motility, which is dysfunctional in many CFS patients...
- Anti-inflammatory effects of nicotine in obesity and ulcerative colitis
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Transl Med 9:129. 2011
..Nevertheless, we should keep in mind that the anti-inflammatory effects of nicotine could be mediated via the expression of several nAChRs on a particular target cell...
- Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Transl Med 9:202. 2011
..The potential contribution of sirtuins in protecting or regulating the circuitry of the ENS under inflamed states is also considered...
- Neuroinflammation in inflammatory bowel disease
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Neuroinflammation 7:37. 2010
..This review will discuss the effects of inflammation on enteric neural activity and potential therapeutic strategies that target neuroinflammation in the enteric nervous system...
- Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
BMC Res Notes 3:60. 2010
..This study suggests stimulation sites and prognostic indicators for DBS. We also briefly review tractography, a relatively new procedure that holds great promise for the further development of DBS...
- Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
BMC Neurol 9:59. 2009
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- Nutritional therapies for mental disorders
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Nutr J 7:2. 2008
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- Aggressive juvenile fibromatosis of the paranasal sinuses: case report and brief review
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Hematol Oncol 1:3. 2008
..We discuss the clinicopathologic features of this lesion, including structural and ultrastructural characteristics, and we review the literature regarding treatment and outcome...
- Schizophrenia genomics and proteomics: are we any closer to biomarker discovery?
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Behav Brain Funct 5:2. 2009
..While none of the recent developments described here in qualifies as biomarker discovery, many are likely to be stepping stones towards that goal...
- Addressing the primary care physician shortage in an evolving medical workforce
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, California, USA
Int Arch Med 2:14. 2009
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- Schizophrenia pathophysiology: are we any closer to a complete model?
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, California, USA
Ann Gen Psychiatry 8:12. 2009
..Consequently, it makes us question whether we are any closer to an adequate understanding of the pathophysiology of schizophrenia...
- Time for a unified approach to medical ethics
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Philos Ethics Humanit Med 4:13. 2009
..This would provide a consistent framework of knowledge for practitioners, creating a basis for clear judgment of complex issues...
- Endocytosis of glycosylphosphatidylinositol-anchored proteins
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Biomed Sci 16:93. 2009
..Ultimately, a thorough elucidation of GPI-AP mediated signaling pathways and their regulatory elements will enhance our understanding of essential biological processes and benefit as components of disease intervention strategies...
- Inflammatory mechanisms in ischemic stroke: therapeutic approaches
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Transl Med 7:97. 2009
..However, recent studies showing that regulatory T cells are major cerebroprotective immunomodulators after stroke suggest that targeting the endogenous adaptive immune response may offer novel promising neuroprotectant therapies...
- The impact of prescribed psychotropics on youth
Shaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Clin Pract Epidemiol Ment Health 3:21. 2007
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