Lajeunesse D, Martel Pelletier J, Fernandes J, Laufer S, Pelletier J. Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis. Ann Rheum Dis. 2004;63:78-83 pubmed
..Licofelone reduced PGE(2) levels after long term Ob, suggesting that the reduction in uPA and IGF-I levels is linked, at least in part, to this reduction. ..