Daniel Lajeunesse

Summary

Publications

  1. pmc Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
    Arthritis Res Ther 9:R117. 2007
  2. pmc Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis
    D Lajeunesse
    Unité de recherche en arthrose, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Ann Rheum Dis 63:78-83. 2004
  3. ncbi The role of bone in the treatment of osteoarthritis
    Daniel Lajeunesse
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 12:S34-8. 2004
  4. ncbi Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts
    Daniel Lajeunesse
    Unité de recherche en arthrose, Centre de recherche du Centre hospitalier de I Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    Bone 33:703-10. 2003
  5. pmc The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 7:R1091-102. 2005
  6. doi Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Bone 44:1143-50. 2009
  7. pmc The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein
    Kelitha Maxis
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec, Canada, H2L 4M1
    Arthritis Res Ther 8:R181. 2006
  8. doi Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Bone 43:284-91. 2008
  9. ncbi Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 38:333-41. 2006
  10. pmc Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Res Ther 8:R177. 2006

Collaborators

Detail Information

Publications32

  1. pmc Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
    Arthritis Res Ther 9:R117. 2007
    ..This was confirmed by the decreased resorptive activity for the combination of CS and GS. These data are of major significance and may help to explain how these two drugs exert a positive effect on OA pathophysiology...
  2. pmc Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis
    D Lajeunesse
    Unité de recherche en arthrose, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Ann Rheum Dis 63:78-83. 2004
    ..To determine if treatment with licofelone, a combined 5-lipoxygenase and cyclo-oxygenase inhibitor, in vivo in experimental dog osteoarthritis can modify bone cell metabolism in long term in vitro subchondral osteoblast cell cultures (Ob)...
  3. ncbi The role of bone in the treatment of osteoarthritis
    Daniel Lajeunesse
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 12:S34-8. 2004
    ..However, restraining collagen deposition and mineral removal, and/or improving mineral deposition, could provide a better, more mineralized, bone matrix in OA patients...
  4. ncbi Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts
    Daniel Lajeunesse
    Unité de recherche en arthrose, Centre de recherche du Centre hospitalier de I Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    Bone 33:703-10. 2003
    ..Taken together, these results could suggest that HA of increasing MW has positive effects on OA Ob by modifying their biological synthetic capacities...
  5. pmc The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 7:R1091-102. 2005
    ..Moreover, our findings also indicate the possible auto-regulation of 5-LOX gene expression by licofelone in OA cartilage...
  6. doi Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Bone 44:1143-50. 2009
    ..In this study, we investigated the expression, production, modulation, and role of PAR-2 in human OA subchondral bone osteoblasts...
  7. pmc The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein
    Kelitha Maxis
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec, Canada, H2L 4M1
    Arthritis Res Ther 8:R181. 2006
    ..The expression of FLAP in OA osteoblasts is also modulated differently by 1,25(OH)2D3 and TGF-beta depending on their endogenous low and high PGE2 levels...
  8. doi Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Bone 43:284-91. 2008
    ..The impact of the modulation of RANKL1 and 3 on the membranous RANKL level was also studied...
  9. ncbi Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 38:333-41. 2006
    ..These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA...
  10. pmc Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Res Ther 8:R177. 2006
    ..The altered response of OA Obs to IGF-1 may be due to abnormal IGF-1 signaling in these cells. This is mostly linked with abnormal IRS-1/Syp and IRS-1/Grb2 interaction in these cells...
  11. doi Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production
    Denis Couchourel
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 60:1438-50. 2009
    ..Bone tissue in osteoarthritis (OA) is composed of abundant undermineralized osteoid matrix. The aim of this study was to investigate the mechanisms responsible for this abnormal matrix, using in vitro OA subchondral osteoblasts...
  12. doi Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Rheumatology (Oxford) 48:1482-90. 2009
    ..Furthermore, the role of OPG and RANKL on the production of catabolic/anabolic factors was assessed...
  13. ncbi Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition
    Yosabeth Paredes
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 46:1804-12. 2002
    ....
  14. pmc Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
    Marie Solange Mutabaruka
    Unité de recherche en Arthose, Centre de recherche du Centre Hospitalier de l Université de Montréal CR CHUM, Hopital Notre Dame, 1560 rue Sherbrooke Est, Montreal, QC H2L 4 M1, Canada
    Arthritis Res Ther 12:R20. 2010
    ..Here we determined if endogenous leptin produced by OA Ob could be responsible for the expression of the abnormal phenotypic biomarkers observed in OA Ob...
  15. ncbi New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Curr Rheumatol Rep 8:30-6. 2006
    ..This paper should help the reader better understand the most recent advances regarding the roles of these factors in this disease process, and how new therapeutic targets may be identified...
  16. ncbi The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 34:527-38. 2004
    ....
  17. doi Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Ann Rheum Dis 72:250-7. 2013
    ..To explore the disease-modifying effect, under therapeutic conditions, of strontium ranelate (SrRan) on the progression of joint structural changes and on the major pathophysiological pathways in an experimental osteoarthritis dog model...
  18. doi Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts
    Thomas F Chan
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    J Bone Miner Res 26:1399-410. 2011
    ..We conclude that elevated TGF-β1 levels in OA osteoblasts can stimulate DKK2 expression, which, in turn, is responsible, at least in part, for their abnormal phenotype...
  19. ncbi Expression of ICAM-1 by osteoblasts in healthy individuals and in patients suffering from osteoarthritis and osteoporosis
    Patrick Lavigne
    Orthopaedics Research Laboratory, Department of Orthopaedics, Centre hospitalier Sacré Coeur, Montreal, Quebec, Canada
    Bone 35:463-70. 2004
    ..To relate ICAM-1 expression in OA Ob with interleukin-6 (IL-6) and prostaglandin E2 (PGE2) production...
  20. doi R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts
    Elie Abed
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 63:3865-75. 2011
    ..The purpose of this study was to investigate the potential role of Rspo-1 and Rspo-2 in OA osteoblasts...
  21. doi An active role for soluble and membrane intercellular adhesion molecule-1 in osteoclast activity in vitro
    Julio C Fernandes
    Orthopaedic Research Laboratory, Department of Orthopaedics, Centre hospitalier Sacré Coeur, 5400 Boul, Gouin Ouest, Montreal, Quebec, Canada, H4J 1C5
    J Bone Miner Metab 26:543-50. 2008
    ..These results indicate that ICAM-1 and sICAM have a dual effect on bone homeostasis, increasing osteoclast activity while lowering osteoblast anabolic activity...
  22. doi Targeting subchondral bone for treating osteoarthritis: what is the evidence?
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada
    Best Pract Res Clin Rheumatol 24:51-70. 2010
    ....
  23. ncbi Metabolic activity of osteoblasts retrieved from osteoarthritic patients after stimulation with mediators involved in periprosthetic loosening
    Patrick Lavigne
    Osteoarthritis Research Unit, Department of Orthopaedics, Centre Hospitalier de l Université de Montréal Hôpital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 34:478-86. 2004
    ..To compare the effects of polymethylmetacrylate (PMMA), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) on osteoarthritic (OA) human osteoblasts (Ob)...
  24. ncbi Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening
    Qin Shi
    Orthopedics Department, Hĵpital Notre Dame, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Rheumatol 29:1437-45. 2002
    ..This study explored whether osteoblast metabolism in trabecular bone of failed total hip replacement (fTHR) in primary osteoarthritis (OA) plays a role in differential failure...
  25. ncbi Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage
    Mélanie Guévremont
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de Université de Montréal, Montreal, Quebec, Canada
    J Bone Miner Res 18:1073-81. 2003
    ..In summary, this study raises the hypothesis that the HGF found in articular cartilage is produced by osteoblasts, diffuses into the cartilage, and may be implicated in the OA process...
  26. doi Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 58:3820-30. 2008
    ..The purpose of this study was to investigate the importance of the ephrin system in OA subchondral bone osteoblasts...
  27. ncbi Involvement of ICAM-1 in bone metabolism: a potential target in the treatment of bone diseases?
    Patrick Lavigne
    Hopital du Sacre Coeur de Montreal, Orthopedics Research Laboratory, Department of Orthopedics, 5400 Boul Gouin Ouest, Montreal, Quebec, H4J 1C5, Canada
    Expert Opin Biol Ther 5:313-20. 2005
    ..As new discoveries on the role of this adhesion molecule are being reported, ICAM-1 could become a potential target for other bone diseases as well...
  28. doi Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity
    Elie Abed
    Unité de recherche en arthrose, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hopital Notre Dame, Montreal, Quebec H2L 4M1, Canada
    Bone 59:28-36. 2014
    ..However the role of SIRT1 and SOST in OA Ob remains unknown. Herein, we explored the role played by SIRT1 and SOST on the abnormal mineralization and cWnt signaling in OA Ob...
  29. doi Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
    Mohit Kapoor
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
    Nat Rev Rheumatol 7:33-42. 2011
    ..This Review discusses the current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA and addresses the potential of anticytokine therapy in the treatment of this disease...
  30. ncbi Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling
    Daniel Lajeunesse
    Unité de recherche en arthrose, Centre Hospitalier d Université de Montréal, Hopital Notre Dame, Quebec, Canada
    Curr Opin Rheumatol 15:628-33. 2003
    ..In this review, new factors either produced by subchondral bone tissue or modifying osteoblast metabolism, yet implicated in osteoarthritis, are discussed...
  31. ncbi Osteoarthritis: a metabolic disease induced by local abnormal leptin activity?
    Daniel Lajeunesse
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC, Canada
    Curr Rheumatol Rep 7:79-81. 2005
  32. ncbi Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport
    Stéphanie G Dubois
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal H2L 4M1, Quebec, Canada H3C 3J7
    Am J Physiol Cell Physiol 283:C1414-21. 2002
    ..In conclusion, we observed a correlation between the inhibition of P(i) uptake by CM from Hyp cells and elevated NEP-like activities...