Mitchell K P Lai

Summary

Publications

  1. doi request reprint Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology
    Mitchell K P Lai
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    J Neural Transm (Vienna) 115:1165-72. 2008
  2. doi request reprint Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Kent Ridge, Singapore
    Psychopharmacology (Berl) 213:431-9. 2011
  3. doi request reprint Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neuroreport 21:1111-5. 2010
  4. pmc Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 29:1524-32. 2008
  5. doi request reprint Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias
    Yuan Sheng
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    J Neurol Sci 315:110-4. 2012
  6. doi request reprint Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease
    Nur Ezan Mohamed
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    J Alzheimers Dis 44:431-7. 2015
  7. doi request reprint Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden
    Michelle G K Tan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Clinical Research, Singapore General Hospital, Singapore
    Neurochem Int 64:29-36. 2014
  8. ncbi request reprint Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 28:1381-7. 2007
  9. doi request reprint Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease
    Nur Ezan Mohamed
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neurochem Int 58:820-5. 2011
  10. doi request reprint Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex
    Jasinda H Lee
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neurochem Int 57:985-9. 2010

Collaborators

Detail Information

Publications14

  1. doi request reprint Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology
    Mitchell K P Lai
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    J Neural Transm (Vienna) 115:1165-72. 2008
    ....
  2. doi request reprint Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Kent Ridge, Singapore
    Psychopharmacology (Berl) 213:431-9. 2011
    ..However, it is unclear whether such deficits play a role in non-cognitive, neuropsychiatric behaviors that occur frequently in AD and cause significant caregiver distress...
  3. doi request reprint Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neuroreport 21:1111-5. 2010
    ..This study suggests a pathogenic link between neurofibrillary tangle load and aggressive behaviours in the hippocampus of dementia patients...
  4. pmc Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 29:1524-32. 2008
    ..We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD...
  5. doi request reprint Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias
    Yuan Sheng
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    J Neurol Sci 315:110-4. 2012
    ..In this study, we measured cortical H(3) receptors in patients with subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MIX)...
  6. doi request reprint Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease
    Nur Ezan Mohamed
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    J Alzheimers Dis 44:431-7. 2015
    ..However, it is unclear whether subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MixD) manifest similar changes in the glutamatergic system...
  7. doi request reprint Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden
    Michelle G K Tan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Clinical Research, Singapore General Hospital, Singapore
    Neurochem Int 64:29-36. 2014
    ..Furthermore, RPH3A expression is selectively downregulated in cultured neurons treated with Aβ25-35 peptides. Our data suggest that presynaptic SNARE dysfunction forms part of the synaptopathology of AD. ..
  8. ncbi request reprint Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 28:1381-7. 2007
    ....
  9. doi request reprint Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease
    Nur Ezan Mohamed
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neurochem Int 58:820-5. 2011
    ..Our study suggests that GluR2 up-regulation may be an adaptive process in SIVD, and that this process is repressed in the presence of concomitant AD in mixed dementia...
  10. doi request reprint Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex
    Jasinda H Lee
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neurochem Int 57:985-9. 2010
    ..Our study suggests that CB1 receptors are intact in AD and may play a role in preserving cognitive function. Therefore, CB1 receptors should be further assessed as a potential therapeutic target in AD...
  11. ncbi request reprint Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease
    Mitchell K P Lai
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurobiol Dis 22:555-61. 2006
    ..This study suggests that APOE epsilon4 selectively affects presynaptic cholinergic function which may contribute to the clinical and neuropathological features of AD...
  12. ncbi request reprint Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease
    Mitchell K P Lai
    Department of Clinical Research, Singapore General Hospital, Singapore
    Brain Res 974:82-7. 2003
    ..Our data indicate further study of 5-HT(1A) receptors as a pharmacological target for the treatment of behavioral symptoms in AD...
  13. doi request reprint Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias
    Nur Ezan Mohamed
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore, 117597, Singapore
    J Neural Transm (Vienna) 121:71-8. 2014
    ..Our study suggests that GluA2/3/4 losses may be a neurochemical marker of motor disability in Lewy body dementias. ..
  14. doi request reprint Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes
    Siew Ying Wong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Neuroreport 25:881-6. 2014
    ..These data suggest that andrographolide should be evaluated further as a therapeutic for central nervous system diseases characterized by astrocyte-mediated neuroinflammatory processes. ..