Eric C Lai

Summary

Publications

  1. ncbi request reprint Developmental signaling: shrimp and strawberries help flies make cones
    Eric C Lai
    545 Life Sciences Addition, University of California, Department of Molecular and Cell Biology, Berkeley, CA 947200 3200, USA
    Curr Biol 12:R722-4. 2002
  2. pmc Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs
    Eric C Lai
    Department of Molecular and Cell Biology Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Genes Dev 19:1067-80. 2005
  3. ncbi request reprint A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Dev Biol 269:1-17. 2004
  4. ncbi request reprint The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
  5. ncbi request reprint Notch signaling: control of cell communication and cell fate
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Development 131:965-73. 2004
  6. pmc The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings
    Matthew Ronshaugen
    Department of Molecular and Cell Biology, Division of Genetics, Center for Integrative Genomics, University of California, Berkeley, 94720, USA
    Genes Dev 19:2947-52. 2005
  7. pmc Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems
    Pelin Cayirlioglu
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 319:1256-60. 2008
  8. ncbi request reprint miRNAs: whys and wherefores of miRNA-mediated regulation
    Eric C Lai
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Curr Biol 15:R458-60. 2005
  9. pmc Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development
    A Aziz Aboobaker
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    Proc Natl Acad Sci U S A 102:18017-22. 2005
  10. pmc Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes
    Eric C Lai
    Howard Hughes Medical Institute, University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, California 94720 3200, USA
    RNA 10:171-5. 2004

Collaborators

  • Gerald M Rubin
  • Katsutomo Okamura
  • Robert W Williams
  • A Aziz Aboobaker
  • Xiaoli Qin
  • Mike Levine
  • Ming Li
  • Virginie Orgogozo
  • FABRICE J ROEGIERS
  • S Zipursky
  • GREG BASHAW
  • Matthew W Hahn
  • Andrew G Clark
  • Norbert Perrimon
  • Wei Jen Chung
  • Qingfa Wu
  • David M Tyler
  • Pelin Cayirlioglu
  • Joshua W Hagen
  • Gregory J Hannon
  • Serena J Silver
  • Alexander Stark
  • Matthew Ronshaugen
  • Hailan Hu
  • Shou Wei Ding
  • Yingjun Luo
  • Wan Xiang Li
  • Nelson Lau
  • Rui Lu
  • Eugene Berezikov
  • Ilona Grunwald Kadow
  • Xiaoli Zhan
  • Greg S B Suh
  • Raquel Martin
  • Dorian Gunning
  • Bryanne E Robson
  • Thomas C Kaufman
  • Lior Pachter
  • Yongkyu Park
  • David P Bartel
  • Douglas Smith
  • Michael Weir
  • Jakob S Pedersen
  • Ameya N Deoras
  • Michael Rice
  • W James Kent
  • J Graham Ruby
  • Leopold Parts
  • DEBORAH A EASTMAN
  • David Haussler
  • Pouya Kheradpour
  • Jacques van Helden
  • Sushmita Roy
  • Anat Caspi
  • Benedict Paten
  • Stein Aerts
  • Donald G Gilbert
  • Emily Hodges
  • Michael B Eisen
  • Colin N Dewey
  • Susan E Celniker
  • William M Gelbart
  • Mira V Han
  • Joseph W Carlson
  • Julius Brennecke
  • Michael F Lin
  • Benjamin J Polansky
  • Madeline A Crosby
  • Matthew D Rasmussen
  • Manolis Kellis
  • Seung Won Park
  • Bassem Hassan
  • Morgan L Maeder
  • Angie S Hinrichs
  • Frederic Biemar
  • Jason McEwen
  • Jessica Piel
  • Corey S Goodman
  • Juan Pablo Labrador

Detail Information

Publications28

  1. ncbi request reprint Developmental signaling: shrimp and strawberries help flies make cones
    Eric C Lai
    545 Life Sciences Addition, University of California, Department of Molecular and Cell Biology, Berkeley, CA 947200 3200, USA
    Curr Biol 12:R722-4. 2002
    ..A new study has revealed a serial linkage between them, via Ebi and Strawberry Notch, which is important in determining the cone cell fate in the Drosophila eye...
  2. pmc Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs
    Eric C Lai
    Department of Molecular and Cell Biology Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Genes Dev 19:1067-80. 2005
    ..Collectively, these data establish insights into miRNA target recognition and demonstrate that the Notch signaling pathway is a major target of miRNA-mediated regulation in Drosophila...
  3. ncbi request reprint A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Dev Biol 269:1-17. 2004
    ..We propose that most Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this stereotyped pattern of cell divisions may have been built during evolution...
  4. ncbi request reprint The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development...
  5. ncbi request reprint Notch signaling: control of cell communication and cell fate
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Development 131:965-73. 2004
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns...
  6. pmc The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings
    Matthew Ronshaugen
    Department of Molecular and Cell Biology, Division of Genetics, Center for Integrative Genomics, University of California, Berkeley, 94720, USA
    Genes Dev 19:2947-52. 2005
    ..These findings provide the first evidence for a noncoding homeotic gene and raise the possibility that other such genes occur within the Bithorax complex. We also discuss the regulation of mir-iab-4 expression during development...
  7. pmc Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems
    Pelin Cayirlioglu
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 319:1256-60. 2008
    ..We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2...
  8. ncbi request reprint miRNAs: whys and wherefores of miRNA-mediated regulation
    Eric C Lai
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Curr Biol 15:R458-60. 2005
    ..New bioinformatic and genetic studies are setting the stage for unraveling the specific biological functions of miRNAs...
  9. pmc Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development
    A Aziz Aboobaker
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    Proc Natl Acad Sci U S A 102:18017-22. 2005
    ..Intriguingly, the expression patterns of several fly miRNAs are analogous to those of their vertebrate counterparts, suggesting that these miRNAs may have ancient roles in animal patterning...
  10. pmc Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes
    Eric C Lai
    Howard Hughes Medical Institute, University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, California 94720 3200, USA
    RNA 10:171-5. 2004
    ....
  11. pmc Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
    Hailan Hu
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:4613-8. 2005
    ..Dosage-sensitive genetic interactions among CrGAP, Robo, and Rac support a model in which CrGAP transduces signals downstream of Robo receptor to regulate Rac-dependent cytoskeletal changes...
  12. pmc Drosophila tufted is a gain-of-function allele of the proneural gene amos
    Eric C Lai
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genetics 163:1413-25. 2003
    ..This phenomenon seems instead to be related to their shared ability to activate Asense and Senseless...
  13. pmc Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs
    Qingfa Wu
    Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 107:1606-11. 2010
    ..We propose that invertebrate viruses discovered by this approach may include previously undescribed human and vertebrate viral pathogens that are transmitted by arthropod vectors...
  14. ncbi request reprint microRNAs: runts of the genome assert themselves
    Eric C Lai
    Department of Molecular and Cell Biology, University of California HHMI, 645 Life Sciences Addition, Berkeley, CA 94720 3200, USA
    Curr Biol 13:R925-36. 2003
  15. ncbi request reprint RNA sensors and riboswitches: self-regulating messages
    Eric C Lai
    545 Life Sciences Addition, University of California, Department of Molecular and Cell Biology, Berkeley, CA 94720 3200, USA
    Curr Biol 13:R285-91. 2003
    ..Remarkably, these sensors allow associated mRNAs to regulate their own transcription or translation accordingly, without the need for regulatory proteins...
  16. pmc Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
    Eric C Lai
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    EMBO Rep 3:840-5. 2002
    ..This review highlights differences in composition and similarities in function of different CSL co-repressor complexes, which actively repress Notch pathway target genes in the absence of Notch pathway activity...
  17. pmc Predicting and validating microRNA targets
    Eric C Lai
    545 Life Sciences Addition, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Genome Biol 5:115. 2004
    ..There has been considerable progress, but assessing success and biological significance requires a move into the 'wet' lab...
  18. pmc Computational identification of Drosophila microRNA genes
    Eric C Lai
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, 539 Life Sciences Addition, Berkeley, CA 94720, USA
    Genome Biol 4:R42. 2003
    ..Second, miRNAs are usually highly conserved between the genomes of related species. Third, miRNAs display a characteristic pattern of evolutionary divergence...
  19. ncbi request reprint Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation
    Eric C Lai
    University of California at Berkeley, Department of Molecular and Cell Biology, 545 Life Sciences Addition 3200, Berkeley, California 94720 3200, USA
    Nat Genet 30:363-4. 2002
    ..These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes...
  20. ncbi request reprint Protein degradation: four E3s for the notch pathway
    Eric C Lai
    University of California, Department of Molecular and Cell Biology, Berkeley, California 94720 3200, USA
    Curr Biol 12:R74-8. 2002
    ..These include Suppressor of deltex/Itch and Sel-10, which both regulate Notch, Neuralized, which regulates the Notch ligand Delta, and LNX, which regulates the Notch antagonist Numb...
  21. ncbi request reprint Notch cleavage: Nicastrin helps Presenilin make the final cut
    Eric C Lai
    University of California, Department of Molecular and Cell Biology, Berkeley 94720 3200, USA
    Curr Biol 12:R200-2. 2002
    ..Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex...
  22. pmc The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila
    Katsutomo Okamura
    Memorial Sloan Kettering Cancer Center, Department of Developmental Biology, 1275 York Ave, Box 252, New York, NY 10021, USA
    Cell 130:89-100. 2007
    ..These findings reveal that mirtrons are an alternate source of miRNA-type regulatory RNAs...
  23. pmc Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
    Alexander Stark
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
    Nature 450:219-32. 2007
    ..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies...
  24. pmc Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci
    David M Tyler
    Department of Developmental Biology, Sloan Kettering Institute, New York, New York 10021, USA
    Genes Dev 22:26-36. 2008
    ..These findings demonstrate that antisense transcription and processing contributes to the functional diversification of miRNA genes...
  25. pmc The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs
    Katsutomo Okamura
    Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
    Nature 453:803-6. 2008
    ..These novel regulatory RNAs reveal unexpected complexity in the sorting of small RNAs, and open a window onto the biological usage of endogenous RNA interference in Drosophila...
  26. pmc Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster
    Katsutomo Okamura
    Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
    Nat Struct Mol Biol 15:581-90. 2008
    ..These newly recognized siRNA pathways broaden the scope of regulatory networks mediated by small RNAs...
  27. pmc Endogenous RNA interference provides a somatic defense against Drosophila transposons
    Wei Jen Chung
    Department of Developmental Biology, Sloan Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Ave, Box 252, New York, New York 10065, USA
    Curr Biol 18:795-802. 2008
    ..The piRNA system is thought to provide primarily a germline defense against TE activity...
  28. pmc Functional screening identifies miR-315 as a potent activator of Wingless signaling
    Serena J Silver
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:18151-6. 2007
    ..In summary, activity-based screening can selectively identify miRNAs whose deregulation can lead to interpretable phenotypic consequences...