A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteinsB T Lahn
Howard Hughes Medical Institute, Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Hum Mol Genet 9:311-9. 2000
..The revelation that CRI-S232 contains VCX offers a more precise description of the genetic etiology of X-linked ichthyosis: it results from aberrant recombination between VCX gene arrays that flank the STS locus...
Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosomeB T Lahn
Howard Hughes Medical Institute, Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
Nat Genet 21:429-33. 1999
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Four evolutionary strata on the human X chromosomeB T Lahn
Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 286:964-7. 1999
..The first event, which marked the beginnings of X-Y differentiation, occurred about 240 to 320 million years ago, shortly after divergence of the mammalian and avian lineages...
The human Y chromosome, in the light of evolutionB T Lahn
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
Nat Rev Genet 2:207-16. 2001
..Far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles. Their relative functional conformity reflects evolutionary factors inherent to sex-specific chromosomes...
Functional coherence of the human Y chromosomeB T Lahn
Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 278:675-80. 1997
..The coherence of the NRY's gene content contrasts with the apparently haphazard content of most eukaryotic chromosomes...