Eric Lagasse

Summary

Publications

  1. ncbi Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    E Lagasse
    StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA
    Nat Med 6:1229-34. 2000
  2. ncbi Hepatic regeneration from hematopoietic stem cells
    Timothy W Austin
    StemCells, Inc, 3155 Porter Drive, Palo Alto, CA 94304, USA
    Mech Dev 120:131-5. 2003
  3. ncbi Kinetics of liver repopulation after bone marrow transplantation
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland 97201, USA
    Am J Pathol 161:565-74. 2002
  4. ncbi Cell fusion is the principal source of bone-marrow-derived hepatocytes
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 422:897-901. 2003
  5. ncbi The origin and liver repopulating capacity of murine oval cells
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 100:11881-8. 2003
  6. ncbi Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias
    Siddhartha Jaiswal
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:10002-7. 2003
  7. ncbi Over-expression of Bcl-2 provides protection in septic mice by a trans effect
    Akiko Iwata
    Department of Surgery and Medicine, University of Washington, Seattle, WA 98104, USA
    J Immunol 171:3136-41. 2003
  8. ncbi BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia
    Nader Omidvar
    Institut National de la Sante et de la Recherche Medicale U718 and 728, Universite Paris 7 Denis Diderot, Faculte de Medicine, Institut Universitaire d Hématologie IFR105, Paris, France
    Cancer Res 67:11657-67. 2007
  9. ncbi A stochastic model for cancer stem cell origin in metastatic colon cancer
    Christine Odoux
    McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh Medical School, 100 Technology Drive, Suite 200, Pittsburgh PA, 15219 3130, USA
    Cancer Res 68:6932-41. 2008

Collaborators

  • Akiko Iwata
  • MARKUS C GROMPE
  • IRVING LERNER WEISSMAN
  • Xiaoying Wang
  • Holger Willenbring
  • N Shaun B Thomas
  • Donna Stolz
  • K Akashi
  • Christine Odoux
  • Nader Omidvar
  • Siddhartha Jaiswal
  • Timothy W Austin
  • Dale W Lewis
  • Toshitaka Hoppo
  • Susanne M Gollin
  • Helene Fohrer
  • T Clark Gamblin
  • Lynda Guzik
  • David A Geller
  • Robert West
  • Pierre Fenaux
  • Dean Felsher
  • Scott Kogan
  • Christophe Leboeuf
  • Carole le Pogam
  • Stephanie Beurlet
  • Murielle Reboul
  • Annie Soulie
  • Azim Mohamedali
  • Anne Janin
  • Rose Ann Padua
  • Ghulam J Mufti
  • Christine Chomienne
  • Marika Pla
  • Maria Elena Noguera
  • Niclas Setterblad
  • Maria-Elena Noguera
  • Michaela Fontenay
  • Toshihiro Miyamoto
  • David Traver

Detail Information

Publications9

  1. ncbi Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    E Lagasse
    StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA
    Nat Med 6:1229-34. 2000
    ....
  2. ncbi Hepatic regeneration from hematopoietic stem cells
    Timothy W Austin
    StemCells, Inc, 3155 Porter Drive, Palo Alto, CA 94304, USA
    Mech Dev 120:131-5. 2003
    ..A better understanding of the various stem or progenitor cells of the hepatic lineage may facilitate cellular transplantation approaches for the correction of hepatic function in patients with end-stage liver disease...
  3. ncbi Kinetics of liver repopulation after bone marrow transplantation
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland 97201, USA
    Am J Pathol 161:565-74. 2002
    ..We conclude that hepatocyte replacement by bone marrow cells is a slow and rare event. Significant improvements in the efficiency of this process will be needed before clinical success can be expected...
  4. ncbi Cell fusion is the principal source of bone-marrow-derived hepatocytes
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 422:897-901. 2003
    ..We conclude that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells...
  5. ncbi The origin and liver repopulating capacity of murine oval cells
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 100:11881-8. 2003
    ..We conclude that hepatic oval cells do not originate in bone marrow but in the liver itself, and that they have valuable properties for therapeutic liver repopulation...
  6. ncbi Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias
    Siddhartha Jaiswal
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:10002-7. 2003
    ....
  7. ncbi Over-expression of Bcl-2 provides protection in septic mice by a trans effect
    Akiko Iwata
    Department of Surgery and Medicine, University of Washington, Seattle, WA 98104, USA
    J Immunol 171:3136-41. 2003
    ..We propose that over-expression of Bcl-2 in T cells or myeloid cells induce release of a molecule(s) that protects against death following CLP...
  8. ncbi BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia
    Nader Omidvar
    Institut National de la Sante et de la Recherche Medicale U718 and 728, Universite Paris 7 Denis Diderot, Faculte de Medicine, Institut Universitaire d Hématologie IFR105, Paris, France
    Cancer Res 67:11657-67. 2007
    ..The colocalization of BCL-2 and RAS in the bone marrow of MDS/AML patients offers targeting either oncogene as a therapeutic strategy...
  9. ncbi A stochastic model for cancer stem cell origin in metastatic colon cancer
    Christine Odoux
    McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh Medical School, 100 Technology Drive, Suite 200, Pittsburgh PA, 15219 3130, USA
    Cancer Res 68:6932-41. 2008
    ..Thus, this new model for cancer origin and metastatic progression includes features of both the hierarchical model for cancerous stem cells and the stochastic model, driven by the observation of chromosomal instability...