Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthmaJoseph M Parker
MedImmune LLC, Gaithersburg, MD, USA
BMC Pulm Med 11:14. 2011
..Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics...
Efficacy and safety of dry powder fluticasone propionate in children with persistent asthmaC F LaForce
North Carolina Clinical Research, Raleigh 27607, USA
Ann Allergy Asthma Immunol 85:407-15. 2000
..Flovent Diskus is a powder formulation of the inhaled corticosteroid fluticasone propionate (FP) delivered via a breath-actuated, multidose inhaler...
Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochlorideCraig La Force
Carolina Allergy and Asthma Consultants, 4301 Lake Boon Trail, Suite 309A, Raleigh, NC 27607, USA
Expert Rev Clin Immunol 1:191-201. 2005
..Azelastine hydrochloride has demonstrated a favorable safety profile during approximately 20 years of clinical use...
Evaluation of olopatadine hydrochloride nasal spray, 0.6%, used in combination with an intranasal corticosteroid in seasonal allergic rhinitisCraig F LaForce
North Carolina Clinical Research, Raleigh, North Carolina 27607, USA
Allergy Asthma Proc 31:132-40. 2010
..Overall, 19 AEs were reported in the OLO + FNS group and 29 AEs were reported in the AZE + FNS group. OLO, when administered adjunctively with FNS, is effective, safe, and well-tolerated in patients with SAR...
Efficacy and safety of ciclesonide hydrofluoroalkane nasal aerosol once daily for the treatment of seasonal allergic rhinitisCraig LaForce
North Carolina Clinical Research, Raleigh, North Carolina 27607, USA
Ann Allergy Asthma Immunol 103:166-73. 2009
..Aerosol-based corticosteroid nasal formulations may be preferred over current aqueous nasal sprays by some patients because they traditionally cause less pharyngeal and anterior nose runoff...
Patient satisfaction with a pressurized metered-dose inhaler with an integrated dose counter containing a fixed-dose mometasone furoate/formoterol combinationCraig LaForce
Department of Pediatrics, University of North Carolina School of Medicine, North Carolina Clinical Research, Raleigh, NC, USA
J Asthma 48:625-31. 2011
....
Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadineCraig F LaForce
Carolina Allergy and Asthma Consultants, Raleigh, North Carolina 27607, USA
Ann Allergy Asthma Immunol 93:154-9. 2004
..Currently available oral second-generation antihistamines do not provide adequate symptom relief for many allergy patients...
Montelukast effectively treats the nighttime impact of seasonal allergic rhinitisEli O Meltzer
Allergy and Asthma Medical Group and Research Center, San Diego, CA 92109, USA
Am J Rhinol 19:591-8. 2005
..In these studies, montelukast significantly improved the NSS, a clinically relevant and valid measure in patients with SAR...
Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthmaBrian J Lipworth
Allergy Research Group, Department of Medicine and Therapeutics, University of Dundee, Dundee, Scotland
Ann Allergy Asthma Immunol 94:465-72. 2005
..Ciclesonide (hydrofluoroalkane propellant) is a novel inhaled corticosteroid with few, if any, clinical adverse events...
Randomized controlled trial evaluating the clinical benefit of montelukast for treating spring seasonal allergic rhinitisJanet van Adelsberg
Merck and Co Inc Rahway, New Jersey, USA
Ann Allergy Asthma Immunol 90:214-22. 2003
..Symptoms of allergic rhinitis are mediated in part by cysteinyl leukotrienes...
Fluticasone propionate hydrofluoroalkane inhalation aerosol in patients receiving inhaled corticosteroidsWilliam R Lumry
AARA Research Center, Dallas, TX 75231, USA
Ann Allergy Asthma Immunol 96:51-9. 2006
..Therefore, some metered-dose inhaler products are being reformulated with "ozone-friendly" hydrofluoroalkane propellants...