Michael D LaFleur

Summary

Publications

  1. pmc Potentiation of azole antifungals by 2-adamantanamine
    Michael D LaFleur
    Arietis Corporation, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 57:3585-92. 2013
  2. pmc Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms
    Michael D LaFleur
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02118, USA
    J Antimicrob Chemother 66:820-6. 2011
  3. pmc Patients with long-term oral carriage harbor high-persister mutants of Candida albicans
    Michael D LaFleur
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, 360 Huntington Avenue, 134 Mugar Hall, Boston, MA 02115, USA
    Antimicrob Agents Chemother 54:39-44. 2010
  4. pmc Candida albicans biofilms produce antifungal-tolerant persister cells
    Michael D LaFleur
    Department of Biology, Northeastern University, 360 Huntington Ave, 134 Mugar Hall, Boston, MA 02115, USA
    Antimicrob Agents Chemother 50:3839-46. 2006
  5. pmc In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori
    Ekaterina Gavrish
    Arietis Pharma, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 58:3255-60. 2014

Collaborators

  • Kim Lewis
  • Andre Nantel
  • Ekaterina Gavrish
  • Richard E Lee
  • Ida Lister
  • David Charnuska
  • Bronwyn Williams
  • Angel Han
  • Lei Yang
  • Binu Shrestha
  • E Jeffrey North
  • Chao Chen
  • Ken Coleman

Detail Information

Publications5

  1. pmc Potentiation of azole antifungals by 2-adamantanamine
    Michael D LaFleur
    Arietis Corporation, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 57:3585-92. 2013
    ..018) compared to fluconazole alone when fungal lesions were evaluated. AC17 is a promising lead in the search for more effective antifungal therapeutics. ..
  2. pmc Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms
    Michael D LaFleur
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02118, USA
    J Antimicrob Chemother 66:820-6. 2011
    ..The screen was performed against C. albicans biofilms grown in microtitre plates in order to target the most resilient forms of the pathogen...
  3. pmc Patients with long-term oral carriage harbor high-persister mutants of Candida albicans
    Michael D LaFleur
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, 360 Huntington Avenue, 134 Mugar Hall, Boston, MA 02115, USA
    Antimicrob Agents Chemother 54:39-44. 2010
    ..The drug tolerance of persisters may be a critical but overlooked component responsible for antimicrobial drug failure and relapsing infections...
  4. pmc Candida albicans biofilms produce antifungal-tolerant persister cells
    Michael D LaFleur
    Department of Biology, Northeastern University, 360 Huntington Ave, 134 Mugar Hall, Boston, MA 02115, USA
    Antimicrob Agents Chemother 50:3839-46. 2006
    ..It remains to be seen whether attachment initiates dormancy that leads to the formation of fungal persisters. This study suggests that persisters may be largely responsible for the multidrug tolerance of fungal biofilms...
  5. pmc In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori
    Ekaterina Gavrish
    Arietis Pharma, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 58:3255-60. 2014
    ..pylori infection, reducing colony counts to below the limit of detection after oral dosing of 25 mg/kg/day for 3 days. HPi1 is a promising lead in the search for more effective and specific H. pylori therapeutics. ..