Joseph Lachance

Summary

Publications

  1. pmc SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it
    Joseph Lachance
    Departments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA, USA
    Bioessays 35:780-6. 2013
  2. pmc The population genetics of X-autosome synthetic lethals and steriles
    Joseph Lachance
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Genetics 189:1011-27. 2011
  3. pmc Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    BMC Med Genomics 3:57. 2010
  4. pmc Genetic background and GxE interactions modulate the penetrance of a naturally occurring wing mutation in Drosophila melanogaster
    Joseph Lachance
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6145
    G3 (Bethesda) 3:1893-901. 2013
  5. pmc A fundamental relationship between genotype frequencies and fitnesses
    Joseph Lachance
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5222, USA
    Genetics 180:1087-93. 2008
  6. pmc X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Evolution 64:3035-46. 2010
  7. pmc Detecting selection-induced departures from Hardy-Weinberg proportions
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, NY 11794 5222, USA
    Genet Sel Evol 41:15. 2009
  8. doi request reprint Long-term adaptation of epistatic genetic networks
    Roman Yukilevich
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794, USA
    Evolution 62:2215-35. 2008
  9. pmc Inbreeding, pedigree size, and the most recent common ancestor of humanity
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Theor Biol 261:238-47. 2009

Detail Information

Publications9

  1. pmc SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it
    Joseph Lachance
    Departments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA, USA
    Bioessays 35:780-6. 2013
    ..Since population genetic analyses depend on allele frequencies, it is imperative that researchers are aware of the effects of SNP ascertainment bias. With this in mind, we describe multiple ways to correct for SNP ascertainment bias...
  2. pmc The population genetics of X-autosome synthetic lethals and steriles
    Joseph Lachance
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Genetics 189:1011-27. 2011
    ..We also discuss the implications of these findings with respect to standing genetic variation and the origins of Haldane's rule...
  3. pmc Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    BMC Med Genomics 3:57. 2010
    ..derived states of disease-associated alleles differ from the rest of the genome. Characteristics of disease-associated alleles can be used to increase the yield of future studies...
  4. pmc Genetic background and GxE interactions modulate the penetrance of a naturally occurring wing mutation in Drosophila melanogaster
    Joseph Lachance
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6145
    G3 (Bethesda) 3:1893-901. 2013
    ..Taken together, these findings indicate that multiple genetic and environmental factors modulate the phenotypic effects of a naturally occurring vesiculated allele. ..
  5. pmc A fundamental relationship between genotype frequencies and fitnesses
    Joseph Lachance
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5222, USA
    Genetics 180:1087-93. 2008
    ..When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes...
  6. pmc X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Evolution 64:3035-46. 2010
    ..These findings are consistent with the view that genomes are coadapted gene complexes and that geography affects the likelihood of epistatic fitness interactions...
  7. pmc Detecting selection-induced departures from Hardy-Weinberg proportions
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, NY 11794 5222, USA
    Genet Sel Evol 41:15. 2009
    ....
  8. doi request reprint Long-term adaptation of epistatic genetic networks
    Roman Yukilevich
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794, USA
    Evolution 62:2215-35. 2008
    ..These results provide testable predictions for adaptation of traits governed by epistatic networks and the evolution of epistasis within networks...
  9. pmc Inbreeding, pedigree size, and the most recent common ancestor of humanity
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Theor Biol 261:238-47. 2009
    ..Inbreeding reduces the number of ancestors in a pedigree, pushing back global common ancestry times. These results are consistent with the remarkable findings of previous studies: all humanity shares common ancestry in the recent past...