Viviane Labrie

Summary

Publications

  1. pmc Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Learn Mem 16:28-37. 2009
  2. doi request reprint The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Neurosci Biobehav Rev 34:351-72. 2010
  3. pmc Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice
    V Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Genes Brain Behav 9:11-25. 2010
  4. doi request reprint Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 860, 600 University Avenue, Toronto, ON, Canada, M5G 1X5
    Psychopharmacology (Berl) 200:217-30. 2008
  5. doi request reprint Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5
    Pharmacol Biochem Behav 91:610-20. 2009
  6. ncbi request reprint D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
    Steven Duffy
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Neuropsychopharmacology 33:1004-18. 2008
  7. pmc Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Hum Mol Genet 18:3227-43. 2009
  8. doi request reprint Contributions of the D-serine pathway to schizophrenia
    Viviane Labrie
    Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
    Neuropharmacology 62:1484-503. 2012
  9. ncbi request reprint Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
    Tatiana Lipina
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Psychopharmacology (Berl) 179:54-67. 2005

Detail Information

Publications9

  1. pmc Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Learn Mem 16:28-37. 2009
    ..The NMDAR glycine site and DAO may be promising therapeutic targets to improve cognitive flexibility and inhibitory learning in psychiatric disorders such as schizophrenia and anxiety syndromes...
  2. doi request reprint The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Neurosci Biobehav Rev 34:351-72. 2010
    ..Future pharmacological approaches for schizophrenia treatment may involve targeting enzymes that affect D-serine synthesis and metabolism...
  3. pmc Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice
    V Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Genes Brain Behav 9:11-25. 2010
    ..Diminished DAO activity and elevations in D-serine may serve as an effective therapeutic intervention for the treatment of psychiatric symptoms...
  4. doi request reprint Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 860, 600 University Avenue, Toronto, ON, Canada, M5G 1X5
    Psychopharmacology (Berl) 200:217-30. 2008
    ..Abnormal glutamatergic neurotransmission may contribute to these pathophysiological dimensions of schizophrenia...
  5. doi request reprint Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5
    Pharmacol Biochem Behav 91:610-20. 2009
    ..Consequently, application of these treatments for amelioration of schizophrenic symptoms necessitates caution as an enhancement of comorbid anxiety disorders may result...
  6. ncbi request reprint D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
    Steven Duffy
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Neuropsychopharmacology 33:1004-18. 2008
    ..By enhancing this form of synaptic plasticity, D-serine could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors...
  7. pmc Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Hum Mol Genet 18:3227-43. 2009
    ..Furthermore, analysis of SRR genetic variants in humans identified a robust association with schizophrenia. This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis...
  8. doi request reprint Contributions of the D-serine pathway to schizophrenia
    Viviane Labrie
    Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
    Neuropharmacology 62:1484-503. 2012
    ..Abnormalities in D-serine availability may underlie glutamatergic dysfunction in schizophrenia, and the development of new treatments acting through the D-serine pathway may significantly improve outcomes for many schizophrenia patients...
  9. ncbi request reprint Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
    Tatiana Lipina
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Psychopharmacology (Berl) 179:54-67. 2005
    ..Research has implicated dysfunction of neurotransmission at the NMDA-type glutamate receptor in this disorder...