Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in miceViviane Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
Learn Mem 16:28-37. 2009
..The NMDAR glycine site and DAO may be promising therapeutic targets to improve cognitive flexibility and inhibitory learning in psychiatric disorders such as schizophrenia and anxiety syndromes...
The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophreniaViviane Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
Neurosci Biobehav Rev 34:351-72. 2010
..Future pharmacological approaches for schizophrenia treatment may involve targeting enzymes that affect D-serine synthesis and metabolism...
- Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice
V Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Genes Brain Behav 9:11-25. 2010
..Diminished DAO activity and elevations in D-serine may serve as an effective therapeutic intervention for the treatment of psychiatric symptoms...
- Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
Viviane Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 860, 600 University Avenue, Toronto, ON, Canada, M5G 1X5
Psychopharmacology (Berl) 200:217-30. 2008
..Abnormal glutamatergic neurotransmission may contribute to these pathophysiological dimensions of schizophrenia...
- Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors
Viviane Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5
Pharmacol Biochem Behav 91:610-20. 2009
..Consequently, application of these treatments for amelioration of schizophrenic symptoms necessitates caution as an enhancement of comorbid anxiety disorders may result...
D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learningSteven Duffy
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Neuropsychopharmacology 33:1004-18. 2008
..By enhancing this form of synaptic plasticity, D-serine could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors...
- Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
Viviane Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Hum Mol Genet 18:3227-43. 2009
..Furthermore, analysis of SRR genetic variants in humans identified a robust association with schizophrenia. This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis...
- Contributions of the D-serine pathway to schizophrenia
Viviane Labrie
Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
Neuropharmacology 62:1484-503. 2012
..Abnormalities in D-serine availability may underlie glutamatergic dysfunction in schizophrenia, and the development of new treatments acting through the D-serine pathway may significantly improve outcomes for many schizophrenia patients...
- Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
Tatiana Lipina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Psychopharmacology (Berl) 179:54-67. 2005
..Research has implicated dysfunction of neurotransmission at the NMDA-type glutamate receptor in this disorder...
