Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammationStephanos Kyrkanides
Department of Children s Dentistry, Stony Brook University, Stony Brook, NY 11894 8701, USA
J Neuroinflammation 9:186. 2012
..In conclusion, our results suggest that neuroinflammation is not sufficient to elicit neurodegeneration as long as neuronal function is restored...
The trigeminal retrograde transfer pathway in the treatment of neurodegenerationStephanos Kyrkanides
Department of Children s Dentistry, Stony Brook University, Stony Brook, NY 11794 8700, USA
J Neuroimmunol 209:139-42. 2009
..In conclusion, retrograde transfer along trigeminal sensory nerves may prove to be a valuable route of gene therapy administration for the treatment of lysosomal storage disorders and other neurodegenerative diseases...
- Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
Stephanos Kyrkanides
Department of Children s Dentistry, Stony Brook University Health Science Center, Stony Brook, NY 11794, USA
J Neuroinflammation 8:112. 2011
..The purpose of this study was to investigate whether localized peripheral inflammation, such as osteoarthritis, contributes to neuroinflammation and neurodegenerative disease in vivo...
Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement without reductionIoanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 74:684-90. 2004
..This study suggests that subjects with BDDN may manifest altered craniofacial morphology. The clinician should be aware of that possibility, especially for the growing patients and the surgical candidates...
- Mandibular asymmetry in adult patients with unilateral degenerative joint disease
Panagiotis Kambylafkas
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 75:305-10. 2005
..The results suggest that subjects with UDJD may manifest lower face asymmetry. This can be of clinical value when adult patients exhibiting asymmetry are to be treated...
- Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons
Stephanos Kyrkanides
Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
Brain Res Mol Brain Res 119:1-9. 2003
..Our observations indicate that relatively low doses of FIV(lacZ) administered intraperitoneally resulted in the transduction of immune cells in the brain, as well as a specific subset of cerebellar neurons...
- Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement with reduction
Ioanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 74:212-9. 2004
..This study suggests that subjects with UDDR may manifest altered craniofacial morphology. The clinician should be aware of this possibility, especially for growing patients...
