Stephanos Kyrkanides

Summary

Publications

  1. pmc Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University, Stony Brook, NY 11894 8701, USA
    J Neuroinflammation 9:186. 2012
  2. doi request reprint The trigeminal retrograde transfer pathway in the treatment of neurodegeneration
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University, Stony Brook, NY 11794 8700, USA
    J Neuroimmunol 209:139-42. 2009
  3. pmc Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University Health Science Center, Stony Brook, NY 11794, USA
    J Neuroinflammation 8:112. 2011
  4. ncbi request reprint Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement without reduction
    Ioanna K Gidarakou
    Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Angle Orthod 74:684-90. 2004
  5. ncbi request reprint Ectodomain-Specific E-Cadherin Antibody Suppresses Skin SCC Growth and Reduces Tumor Grade: A Multitargeted Therapy Modulating RTKs and the PTEN-p53-MDM2 Axis
    Sabine M Brouxhon
    Authors Affiliations Departments of Emergency Medicine, Health Sciences Center, Stony Brook University, Stony Brook, New York
    Mol Cancer Ther 13:1791-802. 2014
  6. ncbi request reprint Mandibular asymmetry in adult patients with unilateral degenerative joint disease
    Panagiotis Kambylafkas
    Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Angle Orthod 75:305-10. 2005
  7. ncbi request reprint Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons
    Stephanos Kyrkanides
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
    Brain Res Mol Brain Res 119:1-9. 2003
  8. pmc Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways
    Sabine M Brouxhon
    Department of Emergency Medicine, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Clin Cancer Res 19:3234-46. 2013
  9. ncbi request reprint Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement with reduction
    Ioanna K Gidarakou
    Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Angle Orthod 74:212-9. 2004

Research Grants

  1. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
  2. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2004
  3. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2005
  4. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2006
  5. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007

Collaborators

  • Howard J Federoff
  • Sabine M Brouxhon
  • Ioanna K Gidarakou
  • Veena Raja
  • Li Ma
  • Andrew Silberfeld
  • Xiaofei Teng
  • Ross H Tallents
  • Panagiotis Kambylafkas
  • Mark E Moss
  • Scott Stein
  • Jason Cohen
  • Denise Trochesset
  • Stephen Byers
  • M Kerry O'Banion
  • Robert Clarke
  • Carmen Tornos

Detail Information

Publications9

  1. pmc Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University, Stony Brook, NY 11894 8701, USA
    J Neuroinflammation 9:186. 2012
    ..In conclusion, our results suggest that neuroinflammation is not sufficient to elicit neurodegeneration as long as neuronal function is restored...
  2. doi request reprint The trigeminal retrograde transfer pathway in the treatment of neurodegeneration
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University, Stony Brook, NY 11794 8700, USA
    J Neuroimmunol 209:139-42. 2009
    ..In conclusion, retrograde transfer along trigeminal sensory nerves may prove to be a valuable route of gene therapy administration for the treatment of lysosomal storage disorders and other neurodegenerative diseases...
  3. pmc Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University Health Science Center, Stony Brook, NY 11794, USA
    J Neuroinflammation 8:112. 2011
    ..The purpose of this study was to investigate whether localized peripheral inflammation, such as osteoarthritis, contributes to neuroinflammation and neurodegenerative disease in vivo...
  4. ncbi request reprint Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement without reduction
    Ioanna K Gidarakou
    Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Angle Orthod 74:684-90. 2004
    ..This study suggests that subjects with BDDN may manifest altered craniofacial morphology. The clinician should be aware of that possibility, especially for the growing patients and the surgical candidates...
  5. ncbi request reprint Ectodomain-Specific E-Cadherin Antibody Suppresses Skin SCC Growth and Reduces Tumor Grade: A Multitargeted Therapy Modulating RTKs and the PTEN-p53-MDM2 Axis
    Sabine M Brouxhon
    Authors Affiliations Departments of Emergency Medicine, Health Sciences Center, Stony Brook University, Stony Brook, New York
    Mol Cancer Ther 13:1791-802. 2014
    ..Mol Cancer Ther; 13(7); 1791-802. ©2014 AACR. ..
  6. ncbi request reprint Mandibular asymmetry in adult patients with unilateral degenerative joint disease
    Panagiotis Kambylafkas
    Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Angle Orthod 75:305-10. 2005
    ..The results suggest that subjects with UDJD may manifest lower face asymmetry. This can be of clinical value when adult patients exhibiting asymmetry are to be treated...
  7. ncbi request reprint Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons
    Stephanos Kyrkanides
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
    Brain Res Mol Brain Res 119:1-9. 2003
    ..Our observations indicate that relatively low doses of FIV(lacZ) administered intraperitoneally resulted in the transduction of immune cells in the brain, as well as a specific subset of cerebellar neurons...
  8. pmc Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways
    Sabine M Brouxhon
    Department of Emergency Medicine, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Clin Cancer Res 19:3234-46. 2013
    ....
  9. ncbi request reprint Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement with reduction
    Ioanna K Gidarakou
    Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Angle Orthod 74:212-9. 2004
    ..This study suggests that subjects with UDDR may manifest altered craniofacial morphology. The clinician should be aware of this possibility, especially for growing patients...

Research Grants5

  1. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  2. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  3. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2005
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  4. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2006
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  5. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..